Details of the Target

General Information of Target

Target ID LDTP15784
Target Name F-box/LRR-repeat protein 18 (FBXL18)
Gene Name FBXL18
Gene ID 80028
Synonyms
FBL18; F-box/LRR-repeat protein 18; F-box and leucine-rich repeat protein 18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAIPITVLDCDLLLYGRGHRTLDRFKLDDVTDEYLMSMYGFPRQFIYYLVELLGANLSRP
TQRSRAISPETQVLAALGFYTSGSFQTRMGDAIGISQASMSRCVANVTEALVERASQFIR
FPADEASIQALKDEFYGLAGMPGVMGVVDCIHVAIKAPNAEDLSYVNRKGLHSLNCLMVC
DIRGTLMTVETNWPGSLQDCAVLQQSSLSSQFEAGMHKDSWLLGDSSFFLRTWLMTPLHI
PETPAEYRYNMAHSATHSVIEKTFRTLCSRFRCLDGSKGALQYSPEKSSHIILACCVLHN
ISLEHGMDVWSSPMTGPMEQPPEEEYEHMESLDLEADRIRQELMLTHFS
Target Bioclass
Enzyme
Function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Uniprot ID
Q96ME1
Ensemble ID
ENST00000382368.8
HGNC ID
HGNC:21874

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K138(9.09)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
Probe 1
 Probe Info  		Y78(18.52)  LDD3495  [3]
m-APA
 Probe Info  		9.75  LDD0403  [4]
BTD
 Probe Info  		C129(1.37)  LDD2093  [5]
AHL-Pu-1
 Probe Info  		C468(4.88)  LDD0169  [6]
DBIA
 Probe Info  		C406(9.10)  LDD0209  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C104(0.00); C406(0.00); C557(0.00); C129(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C406(0.00); C557(0.00); C353(0.00); C356(0.00)  LDD0036  [8]
IPIAA_L
 Probe Info  		C382(0.00); C356(0.00)  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C104(0.00); C406(0.00); C557(0.00); C423(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		0.00; C104(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C406(0.00); C423(0.00)  LDD0148  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [2]
AOyne
 Probe Info  		14.90  LDD0443  [13]
NAIA_5
 Probe Info  		C406(0.00); C557(0.00); C423(0.00); C129(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C129(0.70)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C63(0.84)  LDD2117  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C129(1.37)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C129(0.95)  LDD2131  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C468(4.88)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C104(1.10); C406(0.84); C513(0.68)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C190(0.95); C191(0.95); C406(1.03); C513(1.18)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C104(1.10); C190(0.92); C191(0.92); C406(0.76)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C104(0.83); C190(0.71); C191(0.71); C406(0.83)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C104(0.70); C190(0.85); C191(0.85); C406(0.78)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C104(0.95); C190(0.95); C191(0.95); C406(0.82)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C104(0.54); C190(0.81); C191(0.81); C406(0.79)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C104(0.79); C190(0.76); C191(0.76); C406(0.75)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C104(0.71); C190(0.73); C191(0.73); C406(0.78)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C104(0.62); C190(0.84); C191(0.84); C406(1.07)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C104(0.80); C190(0.94); C191(0.94); C406(0.89)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C104(0.64); C190(1.34); C191(1.34); C406(0.98)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C190(0.83); C191(0.83); C406(0.93); C513(1.13)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C104(0.75); C190(0.79); C191(0.79); C406(0.78)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C104(0.63); C190(0.71); C191(0.71); C406(0.82)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C104(0.64); C190(0.97); C191(0.97); C406(0.95)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C406(1.01); C513(1.05)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C406(0.97); C513(0.83)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C406(1.02); C513(0.85)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C406(0.95); C513(0.90)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C406(1.01); C513(1.18)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C406(1.16); C513(0.90)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C406(1.10); C513(1.20)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C190(0.98); C191(0.98); C406(1.04); C513(1.26)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C406(0.89); C513(1.05)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C406(1.21); C513(1.22)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C406(0.87); C513(1.15)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C406(0.92); C513(1.05)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C406(1.14); C513(1.12)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C406(1.12); C513(0.97)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C406(1.09); C513(0.95)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C406(1.07); C513(0.96)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C190(1.62); C191(1.62); C406(1.37); C513(0.81)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C190(1.45); C191(1.45); C406(1.33); C513(0.88)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C190(1.25); C191(1.25); C406(1.20); C513(0.74)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C190(1.21); C191(1.21); C406(1.24); C513(0.73)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C190(1.28); C191(1.28); C406(0.97); C513(0.80)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C190(1.17); C191(1.17); C406(1.12); C513(0.74)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C190(1.25); C191(1.25); C406(1.16); C513(0.63)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C190(1.26); C191(1.26); C406(1.09); C513(0.81)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C190(1.15); C191(1.15); C406(1.24); C513(0.72)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C190(1.33); C191(1.33); C406(1.39); C513(0.71)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C190(1.32); C191(1.32); C406(1.15); C513(0.70)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C190(1.17); C191(1.17); C406(1.11); C513(0.70)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C190(0.75); C191(0.75); C406(0.85); C513(1.07)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C190(1.30); C191(1.30); C406(1.24); C513(0.67)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C190(1.28); C191(1.28); C406(1.12); C513(0.76)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C190(1.16); C191(1.16); C406(1.11); C513(0.66)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C190(1.15); C191(1.15); C406(0.97); C513(0.88)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C406(0.92); C513(1.01); C190(1.20); C191(1.20)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C406(0.96); C513(1.51); C190(1.60); C191(1.60)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C406(0.89); C513(0.90); C190(1.15); C191(1.15)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C406(0.90); C513(1.14); C190(1.35); C191(1.35)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C406(0.93); C190(1.25); C191(1.25); C513(1.67)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C406(0.88); C190(0.98); C191(0.98); C513(1.02)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C190(0.96); C191(0.96); C406(1.03); C513(1.19)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C406(1.02); C513(1.25); C190(1.49); C191(1.49)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C406(0.97); C190(0.97); C191(0.97); C513(1.31)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C406(0.94); C513(0.96); C190(1.12); C191(1.12)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C406(0.90); C513(1.08); C190(1.27); C191(1.27)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C190(1.82); C191(1.82); C406(0.91); C513(1.10)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C190(1.56); C191(1.56); C406(0.99); C513(1.61)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C190(1.11); C191(1.11); C406(1.08); C513(1.61)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C190(1.42); C191(1.42); C406(1.04); C513(1.40)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C190(0.95); C191(0.95); C513(0.95); C104(1.05)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C513(0.88); C406(0.91); C190(0.95); C191(0.95)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C104(0.85); C423(0.91); C190(1.04); C191(1.04)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C513(0.79); C104(0.85); C406(0.96)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C104(0.79); C190(0.97); C191(0.97); C406(1.05)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C190(0.93); C191(0.93); C104(1.00); C423(1.01)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C104(0.90); C190(0.93); C191(0.93); C423(0.96)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C104(0.78); C190(0.94); C191(0.94); C513(0.96)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C104(0.84); C190(1.01); C191(1.01); C513(1.06)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C190(0.92); C191(0.92); C423(0.99); C406(1.04)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C406(0.81); C190(0.82); C191(0.82); C423(1.16)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C190(0.84); C191(0.84); C406(0.91); C423(1.20)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C406(0.87); C190(0.93); C191(0.93); C423(0.98)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C406(0.79); C190(0.85); C191(0.85); C423(1.18)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C513(0.91); C104(0.98); C406(1.00)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C406(0.81); C190(0.90); C191(0.90); C423(1.20)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C190(0.78); C191(0.78); C406(0.81); C423(1.28)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C406(0.77); C190(0.85); C191(0.85); C423(1.45)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C190(0.86); C191(0.86); C406(0.96); C423(1.45)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C406(0.86); C190(0.89); C191(0.89); C423(1.07)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C423(0.82); C166(0.85); C406(0.95); C513(1.00)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C166(0.91); C423(0.92); C406(0.93); C190(1.18)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C423(0.97); C166(0.97); C406(0.99); C190(1.26)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C166(0.92); C406(0.93); C423(1.06); C513(1.17)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C166(0.97); C423(0.98); C406(1.00); C190(1.03)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C513(0.95); C406(1.03); C104(1.10)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C166(0.87); C406(0.96); C423(1.06); C513(1.06)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C406(0.94); C166(1.02); C423(1.05); C190(1.14)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C406(1.05); C513(1.12); C423(1.19); C190(1.23)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C406(0.83); C423(0.85); C190(0.90); C191(0.90)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C406(0.94); C423(0.95); C166(1.01); C513(1.08)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C406(0.93); C423(0.96); C513(1.02); C190(1.08)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C513(0.87); C190(0.93); C191(0.93); C406(0.96)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C166(0.92); C513(0.95); C423(0.99); C406(1.00)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C190(0.59); C191(0.59); C166(0.69); C406(0.85)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C166(0.77); C513(0.93); C406(0.94); C190(0.97)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C513(1.00); C406(1.02); C104(1.29)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C166(0.76); C190(0.95); C191(0.95); C406(0.99)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C166(0.94); C513(1.03); C406(1.04); C423(1.05)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C513(0.90); C190(1.06); C191(1.06); C406(1.06)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C190(0.92); C191(0.92); C166(0.95); C513(1.01)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C166(0.84); C190(0.92); C191(0.92); C513(0.95)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C166(0.85); C190(0.88); C191(0.88); C406(1.02)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C166(0.51); C190(0.68); C191(0.68); C406(0.88)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C190(0.50); C191(0.50); C166(0.63); C423(0.70)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C190(0.46); C191(0.46); C166(0.52); C406(0.79)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C190(0.66); C191(0.66); C406(0.80); C166(0.81)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C190(0.94); C191(0.94); C406(0.98); C513(1.13)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C190(0.39); C191(0.39); C406(0.63); C166(0.75)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C190(0.29); C191(0.29); C406(0.58); C166(0.63)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C190(0.55); C191(0.55); C406(0.69); C166(0.75)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C190(0.44); C191(0.44); C406(0.60); C166(0.64)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C190(0.48); C191(0.48); C406(0.69); C166(0.86)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C190(0.61); C191(0.61); C406(0.79); C166(0.85)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C190(0.56); C191(0.56); C406(0.74); C166(0.81)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C190(0.38); C191(0.38); C406(0.59); C166(0.62)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C423(0.90); C190(0.91); C191(0.91); C406(0.91)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C406(0.87); C190(0.89); C191(0.89); C423(0.96)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C513(0.94); C190(0.96); C191(0.96); C406(0.98)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C190(0.81); C191(0.81); C406(0.91); C423(1.18)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C423(1.04); C406(1.08); C190(1.13); C191(1.13)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C406(1.02); C423(1.09); C190(1.09); C191(1.09)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C190(0.82); C191(0.82); C406(0.93); C513(1.11)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C406(0.88); C190(0.90); C191(0.90); C423(1.14)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C406(0.77); C190(0.81); C191(0.81); C423(1.07)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C190(1.02); C191(1.02); C406(1.08); C423(1.12)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C423(0.83); C513(0.93); C406(0.99); C190(1.04)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C190(0.80); C191(0.80); C406(0.84); C423(0.95)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C423(0.95); C513(1.02); C190(1.07); C191(1.07)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C513(0.90); C190(0.96); C191(0.96); C406(0.98)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C406(0.97); C423(0.97); C190(1.06); C191(1.06)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C423(0.77); C406(0.95); C190(1.11); C191(1.11)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C406(0.79); C190(0.80); C191(0.80); C513(1.04)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C190(0.83); C191(0.83); C406(0.90); C166(1.18)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C166(0.84); C190(0.86); C191(0.86); C406(0.87)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C166(0.89); C406(0.93); C190(1.02); C191(1.02)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C190(1.00); C191(1.00); C406(1.09); C166(1.12)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C166(0.84); C406(0.99); C190(1.00); C191(1.00)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C406(1.09); C190(1.11); C191(1.11); C513(1.12)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C406(0.91); C190(0.97); C191(0.97); C513(1.16)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C406(1.09); C513(1.19); C190(1.22); C191(1.22)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C406(0.97); C190(1.01); C191(1.01); C513(1.29)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C166(0.96); C190(1.03); C191(1.03); C406(1.12)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C190(0.94); C191(0.94); C406(1.02); C166(1.14)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C166(0.79); C406(1.04); C190(1.07); C191(1.07)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C190(0.70); C191(0.70); C406(0.75); C166(0.83)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C166(0.87); C406(0.98); C190(1.07); C191(1.07)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C166(0.90); C406(0.93); C190(0.94); C191(0.94)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C406(0.55); C190(0.74); C191(0.74); C104(0.84)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C513(0.67); C104(0.71); C190(0.72); C191(0.72)  LDD0683  [14]
 LDCM0248  AKOS034007472 HCT 116 C190(0.95); C191(0.95); C406(1.04); C513(1.14)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C190(0.83); C191(0.83); C406(0.95); C513(1.35)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C190(0.87); C191(0.87); C406(0.97); C513(1.11)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 9.75  LDD0403  [4]
 LDCM0020  ARS-1620 HCC44 C406(1.00)  LDD2171  [14]
 LDCM0630  CCW28-3 231MFP C468(1.77)  LDD2214  [15]
 LDCM0367  CL1 HCT 116 C423(0.79); C190(1.02); C191(1.02); C513(1.09)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C423(0.84); C406(0.87); C190(0.94); C191(0.94)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C513(0.75); C104(0.85); C406(0.96)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C190(0.87); C191(0.87); C406(1.00); C513(1.10)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C190(1.00); C191(1.00); C406(1.12); C513(1.16)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C190(0.94); C191(0.94); C406(1.05); C513(1.06)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C190(0.83); C191(0.83); C406(0.95); C513(1.16)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C104(0.78); C513(0.95); C406(0.97); C190(0.98)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C104(0.73); C423(0.82); C190(0.83); C191(0.83)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C104(0.84); C190(0.96); C191(0.96); C406(1.03)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C104(0.60); C190(1.02); C191(1.02); C513(1.04)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C104(0.82); C423(0.94); C406(0.96); C513(0.99)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C513(0.80); C423(0.90); C190(0.94); C191(0.94)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C104(0.92); C513(0.98); C406(1.02); C423(1.08)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C513(0.90); C406(0.97); C190(1.01); C191(1.01)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C190(0.92); C191(0.92); C406(0.93); C423(0.99)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C406(0.83); C190(0.93); C191(0.93); C423(0.94)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C406(0.81); C190(1.05); C191(1.05); C423(1.17)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C406(0.82); C190(0.87); C191(0.87); C423(1.08)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C190(0.87); C191(0.87); C406(0.90); C423(1.23)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C513(0.82); C166(0.87); C406(0.90); C190(0.94)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C406(0.85); C423(0.97); C190(1.04); C191(1.04)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C406(0.79); C166(0.86); C423(0.90); C190(1.15)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C190(0.93); C191(0.93); C423(0.99); C406(1.04)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C166(0.96); C406(1.01); C423(1.06); C513(1.15)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C166(0.69); C423(0.81); C406(0.84); C513(0.85)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C190(0.78); C191(0.78); C166(0.83); C406(0.89)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C513(0.81); C166(0.96); C423(1.04); C190(1.15)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C513(0.84); C190(0.86); C191(0.86); C166(0.93)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C190(0.70); C191(0.70); C423(0.83); C406(0.84)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C190(0.66); C191(0.66); C166(0.73); C406(0.79)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C190(0.64); C191(0.64); C166(0.71); C406(0.74)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C190(0.65); C191(0.65); C166(0.74); C406(0.84)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C190(0.73); C191(0.73); C406(0.89); C513(0.91)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C423(0.98); C406(1.00); C190(1.06); C191(1.06)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C190(0.91); C191(0.91); C513(0.93); C423(1.03)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C513(0.85); C406(0.90); C190(0.90); C191(0.90)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C513(0.81); C190(0.86); C191(0.86); C406(0.87)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C190(0.39); C191(0.39); C406(0.61); C513(0.75)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C190(0.62); C191(0.62); C406(0.79); C513(0.88)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C406(0.88); C190(0.93); C191(0.93); C513(0.98)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C190(0.86); C191(0.86); C406(0.86); C513(1.09)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C190(0.84); C191(0.84); C406(0.96); C513(1.05)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C190(0.65); C191(0.65); C406(0.80); C513(0.86)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C513(0.81); C190(0.89); C191(0.89); C406(0.91)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C513(0.83); C406(0.83); C190(0.84); C191(0.84)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C190(0.98); C191(0.98); C406(0.84); C513(0.86)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C190(0.87); C191(0.87); C406(0.82); C513(0.77)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C190(0.82); C191(0.82); C406(0.88); C513(1.08)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C190(0.70); C191(0.70); C406(0.74); C513(0.89)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C190(0.74); C191(0.74); C406(0.80); C513(0.95)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C190(1.14); C191(1.14); C406(0.98); C423(1.05)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C190(0.86); C191(0.86); C406(0.93); C513(0.94)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C406(1.04); C513(1.15)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C190(0.78); C191(0.78); C406(0.90); C513(0.98)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C190(1.13); C191(1.13); C406(1.07); C513(0.94)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C190(0.87); C191(0.87); C406(0.94); C513(1.17)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C190(0.90); C191(0.90); C406(0.94); C513(1.16)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C190(1.06); C191(1.06); C406(1.00); C513(1.21)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C190(1.04); C191(1.04); C406(1.07); C513(1.39)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C190(1.01); C191(1.01); C406(1.01); C513(1.03)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C190(1.32); C191(1.32); C406(1.05); C423(0.92)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C190(1.08); C191(1.08); C406(1.13); C513(0.83)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C190(0.89); C191(0.89); C406(0.99); C513(1.02)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C190(1.14); C191(1.14); C406(1.10); C513(1.07)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C190(0.76); C191(0.76); C406(0.98); C513(1.03)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C190(0.95); C191(0.95); C406(0.93); C513(1.40)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C190(0.94); C191(0.94); C406(0.95); C513(1.16)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C190(1.39); C191(1.39); C406(0.97); C513(0.85)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C190(1.66); C191(1.66); C406(0.98); C513(0.79)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C190(1.23); C191(1.23); C406(1.04); C513(1.01)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C190(1.77); C191(1.77); C406(1.02); C513(1.03)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C190(0.89); C191(0.89); C406(1.03); C423(1.01)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C190(1.50); C191(1.50); C406(1.11); C513(1.29)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C190(1.44); C191(1.44); C406(1.24); C513(1.13)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C190(1.46); C191(1.46); C406(1.00); C513(0.94)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C190(1.25); C191(1.25); C406(1.00); C513(0.99)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C190(1.63); C191(1.63); C406(1.05); C513(1.01)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C190(1.44); C191(1.44); C406(1.05); C513(0.91)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C190(1.39); C191(1.39); C406(1.04); C513(0.84)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C190(2.01); C191(2.01); C406(1.11); C513(1.08)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C190(1.30); C191(1.30); C406(1.03); C513(0.95)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C190(1.55); C191(1.55); C406(1.08); C513(1.07)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C190(0.82); C191(0.82); C406(0.84); C423(1.02)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C190(1.25); C191(1.25); C406(0.99); C513(1.06)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C406(1.05); C513(0.97)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C406(0.97); C513(0.77)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C406(0.93); C513(0.95)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C406(1.00); C513(1.17)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C406(1.14); C513(1.03)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C406(0.91); C513(1.16)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C406(1.03); C513(0.97)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C406(0.77); C513(0.92)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C406(0.71); C513(1.18)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C190(0.91); C191(0.91); C406(0.97); C423(1.10)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C406(0.83); C513(0.89)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C406(0.99); C513(0.75)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C406(0.94); C513(1.10)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C406(0.87); C513(1.33)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C406(0.95); C513(0.85)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C406(0.78)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C406(1.00)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C406(0.97)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C406(1.02)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C190(1.02); C191(1.02); C406(1.28); C423(1.05)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C406(0.73)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C406(0.99)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C406(0.93)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C406(0.92)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C406(0.91)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C406(0.99)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C406(1.01)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C406(0.93)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C406(0.99)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C406(0.87)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C190(0.93); C191(0.93); C406(0.92); C423(1.00)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C406(1.27)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C104(1.29); C406(1.01); C513(0.85)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C104(1.03); C406(1.01); C513(0.85)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C104(0.99); C406(0.94); C513(0.79)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C104(0.91); C406(0.93); C513(0.72)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C104(1.07); C406(1.04); C513(0.94)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C104(0.97); C406(0.94); C513(0.82)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C104(0.91); C406(0.88); C513(0.78)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C104(1.13); C406(0.96); C513(0.75)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C104(0.95); C406(0.92); C513(0.85)  LDD0811  [14]
 LDCM0495  E2913 HEK-293T C63(0.98); C406(0.88); C613(1.29); C383(1.13)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C129(1.28)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C406(0.85); C513(0.99)  LDD0785  [14]
 LDCM0427  Fragment51 HCT 116 C190(1.18); C191(1.18); C406(1.15); C513(0.98)  LDD0744  [14]
 LDCM0022  KB02 HEK-293T C406(1.00); C423(0.94); C383(1.05)  LDD1492  [16]
 LDCM0023  KB03 Jurkat C406(9.10)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C63(2.79)  LDD3310  [17]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C129(1.14)  LDD2121  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C129(1.37)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C129(1.05)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C63(0.84)  LDD2107  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C129(1.58)  LDD2119  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C129(1.09); C63(0.65)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C63(0.92)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C129(0.81)  LDD2128  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C63(1.46)  LDD2136  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C129(1.48)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C129(1.05)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C129(0.94)  LDD2150  [5]
 LDCM0021  THZ1 HCT 116 C406(1.00)  LDD2173  [14]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840