Details of the Target

General Information of Target

Target ID LDTP14797
Target Name Vacuolar fusion protein CCZ1 homolog (CCZ1)
Gene Name CCZ1
Gene ID 221960
Synonyms
C7orf28A; Vacuolar fusion protein CCZ1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MTRGNQRELARQKNMKKQSDSVKGKRRDDGLSAAARKQRDSEIMQQKQKKANEKKEEPK
Target Bioclass
Other
Family
CCZ1 family
Subcellular location
Lysosome membrane
Function Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.
Uniprot ID
P86791
Ensemble ID
ENST00000325974.9
HGNC ID
HGNC:21691

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y380(5.38)  LDD0260  [1]
BTD
 Probe Info  		C296(0.73)  LDD2099  [2]
AHL-Pu-1
 Probe Info  		C358(2.54)  LDD0168  [3]
HHS-482
 Probe Info  		Y380(1.52)  LDD0285  [4]
HHS-465
 Probe Info  		Y380(10.00)  LDD2237  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
DBIA
 Probe Info  		C471(0.88); C65(0.90)  LDD0531  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [9]
IPM
 Probe Info  		C358(0.00); C65(0.00)  LDD2156  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C358(2.54)  LDD0168  [3]
 LDCM0214  AC1 HCT 116 C471(0.88); C65(0.90)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C65(1.17)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C65(1.18)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C65(1.21)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C65(0.88)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C65(0.97)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C65(0.96)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C65(1.09)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C65(0.99)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C65(1.11)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C65(1.19)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C65(0.89)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C65(1.15)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C65(1.19)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C65(0.99)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C65(0.87)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C65(1.03)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C65(1.18)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C65(1.15)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C65(1.03)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C65(0.94)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C65(1.00)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C65(1.05)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C65(1.14)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C65(1.14)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C65(0.68)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C65(0.95)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C65(0.68)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C65(0.79)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C65(1.24)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C65(1.19)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C65(0.97)  LDD0562  [7]
 LDCM0259  AC14 HCT 116 C65(1.04)  LDD0576  [7]
 LDCM0263  AC143 HCT 116 C65(0.93)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C65(0.98)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C65(1.02)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C65(1.14)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C65(0.94)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C65(1.74)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C65(1.36)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C65(1.13)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C65(1.14)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C65(1.19)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C65(1.26)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C65(1.54)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C65(1.01)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C65(1.41)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C65(1.09)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C65(1.18)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C65(1.01)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C65(1.02)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C65(1.11)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C65(0.96); C471(0.98)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C65(1.06)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C65(1.21)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C65(1.04)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C65(1.09)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C65(1.01)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C65(0.84)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C65(0.78)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C65(0.79)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C65(0.72)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C65(0.72)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C471(0.88); C65(1.18)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C65(0.79)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C65(1.05)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C65(0.90)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C65(0.93)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C65(0.65)  LDD0612  [7]
 LDCM0301  AC4 HCT 116 C471(0.97); C65(1.14)  LDD0618  [7]
 LDCM0308  AC46 HCT 116 C65(0.91)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C65(1.06)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C65(1.11)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C65(0.85)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C471(0.84); C65(1.06)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C65(1.14)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C65(0.98)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C65(0.81)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C65(1.13)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C65(1.33)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C65(1.09)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C65(1.40)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C65(1.08)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C65(1.31)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C65(1.22)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C65(1.04)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C65(1.14)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C65(1.12)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C65(1.01)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C65(1.13)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C65(1.18)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C65(1.02)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C65(1.09)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C65(1.10)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C65(0.81)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C65(0.88)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C65(1.06)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C65(1.00)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C65(0.78)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C65(0.98)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C65(1.02)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C65(0.97)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C65(1.03)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C65(0.91)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C65(0.97)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C65(0.81)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C65(0.89)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C65(1.01)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C65(0.88)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C65(1.02)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C65(0.90)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C65(1.07)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C65(1.18)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C65(1.14)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C65(1.06)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C65(0.99)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C65(1.38)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C65(1.04)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C65(1.01)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C65(1.08)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C65(0.94)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C65(0.93)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C65(1.14)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C65(1.06)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C65(1.25)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C65(1.00)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C65(1.02)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C65(0.96)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C65(1.23)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C65(1.12)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C65(1.09)  LDD0592  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C65(20.00)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C471(0.94)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C471(1.48)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C471(0.83); C65(0.95)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C65(0.86)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C65(0.95)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C65(0.98)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C65(1.02)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C65(0.98)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C65(1.17)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C65(1.05)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C65(1.12)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C65(0.98)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C471(0.98)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C65(1.07)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C65(1.10)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C65(0.83)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C65(0.94)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C65(0.86)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C65(0.98)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C65(0.87)  LDD0703  [7]
 LDCM0390  CL12 HCT 116 C471(1.30)  LDD0707  [7]
 LDCM0392  CL121 HCT 116 C65(1.08)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C65(1.45)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C65(1.52)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C65(0.94)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C65(1.11)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C65(1.13)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C65(1.04)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C65(1.12)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C471(1.03)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C471(1.11)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C471(1.09)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C471(0.84); C65(1.03)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C471(0.88); C65(1.20)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C471(0.90); C65(1.07)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C471(0.97); C65(1.27)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C471(0.93)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C471(1.06); C65(1.29)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C471(1.22); C65(1.58)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C471(1.18); C65(1.22)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C471(1.05); C65(1.11)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C471(1.02); C65(1.20)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C471(0.99); C65(1.14)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C471(0.95); C65(1.10)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C471(0.91); C65(1.05)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C471(1.01); C65(1.22)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C471(1.04); C65(1.40)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C471(1.06)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C471(0.98); C65(1.17)  LDD0736  [7]
 LDCM0429  CL4 HCT 116 C471(0.92)  LDD0746  [7]
 LDCM0436  CL46 HCT 116 C471(0.90)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C471(0.98)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C471(1.11)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C471(1.41)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C471(1.03)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C471(1.69)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C471(1.10)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C471(0.85)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C471(1.43)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C471(0.77)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C471(1.38)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C471(1.15)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C471(1.27)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C471(1.01)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C471(1.48)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C471(0.94)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C471(0.86)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C471(1.01); C65(1.01)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C471(0.85); C65(1.00)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C471(0.98); C65(1.13)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C471(1.07); C65(1.01)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C471(1.16); C65(1.14)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C471(1.12); C65(0.97)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C471(1.16); C65(1.16)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C471(0.99); C65(1.13)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C471(0.82); C65(0.96)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C471(1.08)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C471(0.94); C65(0.98)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C471(0.99); C65(1.03)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C471(1.15); C65(0.94)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C471(1.16); C65(1.10)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C471(1.04); C65(1.02)  LDD0784  [7]
 LDCM0469  CL76 HEK-293T C65(1.15)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C65(1.03)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C65(0.90)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C65(1.05)  LDD1070  [7]
 LDCM0473  CL8 HCT 116 C471(1.33)  LDD0790  [7]
 LDCM0474  CL80 HEK-293T C65(0.84)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C65(0.93)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C65(0.86)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C65(0.83)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C65(0.93)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C65(0.90)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C65(0.94)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C65(1.03)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C65(1.14)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C65(0.97)  LDD1081  [7]
 LDCM0484  CL9 HCT 116 C471(0.99)  LDD0801  [7]
 LDCM0485  CL90 HEK-293T C65(1.03)  LDD1083  [7]
 LDCM0486  CL91 HCT 116 C471(0.94); C65(1.02)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C471(0.90); C65(0.86)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C471(0.99); C65(1.02)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C471(1.13); C65(0.93)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C471(1.15); C65(1.00)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C471(1.02); C65(1.01)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C471(1.00); C65(1.02)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C471(0.94); C65(1.04)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C471(0.85); C65(0.85)  LDD0811  [7]
 LDCM0468  Fragment33 HCT 116 C471(1.03); C65(0.95)  LDD0785  [7]
 LDCM0123  JWB131 DM93 Y380(1.52)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y380(0.59)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y380(1.34)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y380(1.70)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y380(1.30)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y380(0.59)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y380(1.02)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y380(0.52)  LDD0292  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C296(0.73)  LDD2099  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C296(0.46)  LDD2109  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C296(1.02)  LDD2119  [2]

References

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2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.