Details of the Target

General Information of Target

Target ID LDTP14096
Target Name Ankyrin repeat and SOCS box protein 1 (ASB1)
Gene Name ASB1
Gene ID 51665
Synonyms
KIAA1146; Ankyrin repeat and SOCS box protein 1; ASB-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ
MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV
ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI
TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL
YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL
RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSI
FRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSID
TLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLR
SDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
Target Bioclass
Other
Family
Ankyrin SOCS box (ASB) family
Function
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates Notch-induced ubiquitination and degradation of TCF3/E2A and JAK2. May play a role in testis development.
Uniprot ID
Q9Y576
Ensemble ID
ENST00000264607.9
HGNC ID
HGNC:16011

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K161(10.00); K21(1.03)  LDD0277  [1]
DBIA
 Probe Info  		C93(5.01)  LDD0204  [2]
IA-alkyne
 Probe Info  		C238(0.68)  LDD2189  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C238(0.99); C29(0.95); C36(0.95)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C222(1.08); C29(1.12); C301(0.75); C36(1.12)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C29(0.86); C36(0.86)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C29(0.96); C36(0.96)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C29(0.69); C36(0.69)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C29(0.79); C36(0.79)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C29(0.78); C36(0.78)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C29(0.82); C36(0.82)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C29(0.93); C36(0.93)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C29(1.03); C36(0.98)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C29(0.92); C36(0.84)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C29(0.71); C36(0.87)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C222(1.17); C29(1.14); C301(0.58); C36(1.14)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C29(0.93); C36(0.88)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C29(0.95); C36(0.84)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C29(0.83); C36(0.89)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C238(1.25); C29(0.94); C36(0.94)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C238(1.25); C29(0.89); C36(0.89)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C238(0.81); C29(0.92); C36(0.92)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C238(1.01); C29(0.87); C36(0.87)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C238(1.21); C29(0.89); C36(0.89)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C238(1.31); C29(0.88); C36(0.88)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C238(1.24); C29(0.92); C36(0.92)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C222(0.85); C29(1.09); C301(0.67); C36(1.09)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C238(1.31); C29(0.94); C36(0.94)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C238(1.24); C29(0.95); C36(0.95)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C238(1.13); C29(0.90); C36(0.90)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C238(1.14); C29(0.95); C36(0.95)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C238(1.10); C29(0.98); C36(0.98)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C238(1.13); C29(0.95); C36(0.95)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C238(1.03); C29(0.90); C36(0.90)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C238(1.06); C29(0.96); C36(0.96)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C29(0.87); C36(0.87)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C29(0.77); C36(0.77)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C29(0.66); C36(0.66)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C29(0.73); C36(0.73)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C29(0.85); C36(0.85)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C29(0.94); C36(0.94)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C29(0.78); C36(0.78)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C29(0.83); C36(0.83)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C29(0.92); C36(0.92)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C29(0.90); C36(0.90)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C29(0.76); C36(0.76)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C29(0.83); C36(0.83)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C222(1.20); C29(1.10); C301(0.89); C36(1.10)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C29(0.95); C36(0.95)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C29(0.85); C36(0.85)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C29(0.86); C36(0.86)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C29(1.05); C36(1.05)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C36(1.14); C29(1.21)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C36(1.17); C29(1.23)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C29(1.30); C36(1.33)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C36(1.13); C29(1.22)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C36(1.16); C29(1.26)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C29(1.42); C36(1.48)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C222(1.03); C29(1.11); C36(1.11); C301(1.20)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C29(1.03); C36(1.09)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C36(1.18); C29(1.20)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C29(1.16); C36(1.22)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C29(1.39); C36(1.46)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C29(1.25); C36(1.19)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C29(1.25); C36(1.28)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C29(1.18); C36(1.26)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C29(1.58); C36(1.42)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C29(0.76); C36(0.76); C301(1.13)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C301(0.88); C29(0.97); C36(0.97)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C29(0.88); C36(0.88); C301(1.12)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C29(0.80); C36(0.80); C238(0.82)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C301(0.89); C29(1.73); C36(1.73)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C301(0.90); C29(1.52); C36(1.52)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C29(0.69); C36(0.69); C301(1.02)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C301(0.92); C29(1.38); C36(1.38)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C29(0.85); C36(0.85); C301(0.99)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C301(0.99); C238(1.10); C29(1.13); C36(1.13)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C238(1.10); C29(1.20); C36(1.20); C301(1.37)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C29(1.18); C36(1.18); C301(1.21); C238(1.23)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C238(1.20); C29(1.28); C36(1.28); C301(1.50)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C29(1.21); C36(1.21); C238(1.45); C301(1.79)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C29(1.00); C36(1.00); C238(1.12)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C29(1.22); C36(1.22); C238(1.43); C301(1.69)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C238(1.14); C29(1.29); C36(1.29); C301(1.49)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C29(1.03); C36(1.03); C238(1.24); C301(1.48)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C238(1.06); C29(1.12); C36(1.12); C301(1.40)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C238(1.03); C29(1.10); C36(1.10); C301(1.27)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C301(0.85); C238(0.99); C29(1.17); C36(1.17)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C301(0.91); C238(1.01); C29(1.14); C36(1.14)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C301(0.94); C238(1.01); C29(1.26); C36(1.26)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C238(1.08); C29(1.21); C36(1.21); C301(1.25)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C301(1.10); C29(1.20); C36(1.20); C238(1.40)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C29(0.85); C36(0.85); C238(0.97)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C238(0.88); C29(1.12); C36(1.12); C301(1.18)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C238(0.83); C29(1.03); C36(1.03); C301(1.34)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C238(0.84); C29(0.99); C36(0.99); C301(1.32)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C238(0.95); C29(1.11); C36(1.11); C301(1.66)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C238(0.88); C301(0.98); C29(1.06); C36(1.06)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C301(0.91); C29(1.02); C36(1.02); C238(1.08)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C29(1.01); C36(1.01)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C29(1.10); C36(1.10)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C29(1.18); C36(1.18)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C29(0.88); C36(0.88)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C29(0.78); C36(0.78); C238(1.02)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C29(0.85); C36(0.85)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C29(1.14); C36(1.14)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C29(0.89); C36(0.89)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C29(0.96); C36(0.96)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C29(1.03); C36(1.03)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C29(0.97); C36(0.97)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C29(1.09); C36(1.09)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C238(0.85); C29(0.86); C36(0.86)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C238(0.78); C29(0.90); C36(0.90)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C238(0.96); C29(0.98); C36(0.98)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C301(0.95); C29(1.11); C36(1.11); C222(1.33)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C238(0.90); C29(1.15); C36(1.15)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C238(0.75); C29(1.63); C36(1.63)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C29(1.04); C36(1.04); C238(1.06)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C238(0.90); C29(0.99); C36(0.99)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C29(0.93); C36(0.93); C238(1.30)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C29(0.91); C36(0.91); C238(1.00)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C29(0.91); C36(0.91); C238(1.10)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C29(0.87); C36(0.87); C238(1.13)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C238(0.36); C29(0.84); C36(0.84)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C238(0.54); C29(0.77); C36(0.77)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C301(0.83); C29(1.02); C36(1.02); C222(1.03)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C238(0.46); C29(0.71); C36(0.71)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C238(0.50); C29(0.86); C36(0.86)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C238(0.50); C29(0.70); C36(0.70)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C238(0.52); C29(0.88); C36(0.88)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C238(0.60); C29(0.88); C36(0.88)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C238(0.68); C29(0.92); C36(0.92)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C238(0.52); C29(0.74); C36(0.74)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C238(0.40); C29(0.86); C36(0.86)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C238(0.64); C29(0.86); C36(0.86)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C238(0.43); C29(0.81); C36(0.81)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C222(0.88); C301(1.00); C29(1.05); C36(1.05)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C238(0.64); C29(0.82); C36(0.82)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C238(0.38); C29(0.86); C36(0.86)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C238(0.48); C29(0.86); C36(0.86)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C29(1.19); C36(1.19)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C29(1.60); C36(1.60)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C29(1.65); C36(1.65)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C29(1.51); C36(1.51)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C29(1.17); C36(1.17)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C29(1.31); C36(1.31)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C29(1.28); C36(1.28)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C29(2.07); C36(2.07)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C29(1.50); C36(1.50)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C29(1.26); C36(1.26)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C29(1.10); C36(1.10)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C29(1.11); C36(1.11)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C29(1.31); C36(1.31)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C29(1.13); C36(1.13)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C29(1.34); C36(1.34)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C29(0.94); C36(0.94)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C29(0.82); C36(0.82)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C222(1.00); C29(1.03); C301(0.70); C36(1.03)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C301(0.77); C29(1.05); C36(1.05); C222(1.19)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C29(1.00); C36(1.00); C301(1.01); C222(1.06)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C73(1.12); C79(1.12)  LDD2171  [5]
 LDCM0102  BDHI 8 Jurkat C93(5.01)  LDD0204  [2]
 LDCM0367  CL1 HCT 116 C222(0.84); C29(0.86); C36(0.86); C301(1.09)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C301(0.86); C222(0.89); C238(1.86); C29(1.91)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C29(0.65); C36(0.65); C238(0.86)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C301(1.06); C29(1.16); C36(1.16); C222(1.17)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C301(0.81); C29(1.00); C36(1.00); C222(1.25)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C301(0.83); C222(0.91); C29(1.16); C36(1.16)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C301(0.76); C29(1.06); C36(1.06); C222(1.12)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C29(0.56); C36(0.56); C301(1.07)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C29(0.76); C36(0.76); C301(0.92)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C29(0.69); C36(0.69); C301(0.91)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C29(0.74); C36(0.74); C301(0.96)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C29(0.88); C36(0.88); C301(0.88)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C301(0.84); C222(0.96); C29(1.01); C36(1.01)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C301(1.26); C29(1.29); C36(1.29)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C29(0.77); C36(0.77); C301(0.99)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C238(1.01); C301(1.07); C29(1.19); C36(1.19)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C238(1.15); C29(1.16); C36(1.16); C301(1.40)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C29(1.28); C36(1.28); C238(1.32); C301(1.37)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C29(1.10); C36(1.10); C238(1.13); C301(1.28)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C238(1.00); C29(1.10); C36(1.10); C301(1.28)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C238(0.68); C29(1.17); C36(1.17); C301(1.55)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C29(0.94); C36(0.94); C238(1.01); C301(1.39)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C29(0.98); C36(0.98); C238(1.18); C301(1.60)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C301(0.80); C222(0.99); C29(1.07); C36(1.07)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C238(0.80); C29(1.09); C36(1.09); C301(1.26)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C29(1.76); C36(1.76)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C29(0.96); C36(0.96)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C29(1.28); C36(1.28)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C29(1.01); C36(1.01)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C238(0.94); C29(1.12); C36(1.12)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C29(0.87); C36(0.87); C238(0.89)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C238(1.00); C29(1.21); C36(1.21)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C238(0.97); C29(0.97); C36(0.97)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C29(0.80); C36(0.80); C222(0.92); C301(1.05)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C222(0.74); C301(1.00); C238(1.23); C29(1.30)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C29(0.88); C36(0.88); C301(1.02); C222(1.16)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C29(1.18); C36(1.18)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C29(0.73); C36(0.73)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C29(0.98); C36(0.98)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C29(0.93); C36(0.93)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C222(0.64); C29(0.88); C36(0.88); C238(1.31)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C29(0.95); C36(0.95)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C29(0.86); C36(0.86)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C29(0.86); C36(0.86)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C29(0.96); C36(0.96)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C29(0.98); C36(0.98)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C29(0.91); C36(0.91)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C29(1.06); C36(1.06)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C29(0.78); C36(0.78)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C29(0.91); C36(0.91)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C29(0.98); C36(0.98)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C238(1.31); C222(0.79); C29(0.95); C301(0.83)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C29(0.89); C36(0.89)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C79(1.37); C238(1.32); C222(1.19); C29(0.88)  LDD1299  [5]
 LDCM0421  CL32 HCT 116 C29(1.10); C36(1.10)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C29(1.13); C36(1.13)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C29(0.86); C36(0.86)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C29(1.21); C36(1.21)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C29(0.79); C36(0.79)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C29(0.99); C36(0.99)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C29(1.19); C36(1.19)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C238(1.14); C222(0.88); C29(0.80); C301(0.96)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C29(1.07); C36(1.07)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C29(1.12); C36(1.12)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C29(1.17); C36(1.17)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C29(1.22); C36(1.22)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C29(0.91); C36(0.91)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C29(1.07); C36(1.07)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C222(0.43); C29(0.84); C301(1.06); C36(0.84)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C222(0.96); C29(0.78); C301(1.05); C36(0.78)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C222(0.37); C29(0.89); C301(0.99); C36(0.89)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C222(0.48); C29(0.87); C301(0.85); C36(0.87)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C238(1.36); C222(0.80); C29(0.98); C301(1.45)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C222(0.63); C29(0.93); C301(0.88); C36(0.93)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C222(0.50); C29(0.90); C301(1.03); C36(0.90)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C222(0.40); C29(0.91); C301(1.08); C36(0.91)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C222(0.40); C29(0.84); C301(1.67); C36(0.84)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C222(1.13); C29(0.79); C301(1.04); C36(0.79)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C222(0.64); C29(0.76); C301(0.86); C36(0.76)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C222(0.58); C29(0.79); C301(1.09); C36(0.79)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C222(0.64); C29(0.77); C301(1.18); C36(0.77)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C222(0.53); C29(0.78); C301(0.98); C36(0.78)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C222(0.76); C29(0.86); C301(1.05); C36(0.86)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C238(1.71); C222(0.92); C29(1.03); C301(0.92)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C222(0.71); C29(0.90); C301(1.07); C36(0.90)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C29(0.75); C36(0.75)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C29(0.68); C36(0.68)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C29(0.69); C36(0.69)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C29(0.82); C36(0.82)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C29(0.78); C36(0.78)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C29(0.65); C36(0.65)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C29(0.95); C36(0.95)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C29(0.71); C36(0.71)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C29(0.66); C36(0.66)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C238(1.73); C222(0.87); C29(1.00); C301(1.17)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C29(0.80); C36(0.80)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C29(0.80); C36(0.80)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C29(0.83); C36(0.83)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C29(0.71); C36(0.71)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C29(0.83); C36(0.83)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C238(0.93); C222(1.76); C29(0.78); C36(0.78)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C238(2.50); C222(1.05); C29(0.81); C36(0.81)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C238(1.48); C222(0.98); C29(0.94); C36(0.94)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C238(2.03); C222(1.07); C29(0.86); C36(0.86)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C238(2.12); C222(1.38); C29(1.30); C301(1.24)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C238(1.80); C222(2.76); C29(0.93); C36(0.93)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C238(1.68); C222(1.19); C29(0.89); C36(0.89)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C238(1.89); C222(2.04); C29(0.81); C36(0.81)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C238(1.77); C222(1.64); C29(0.77); C36(0.77)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C238(2.68); C222(1.83); C29(1.02); C36(1.02)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C238(2.02); C222(1.33); C29(0.93); C36(0.93)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C238(1.27); C222(1.15); C29(0.80); C36(0.80)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C238(1.84); C222(0.99); C29(0.84); C36(0.84)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C238(2.26); C222(1.37); C29(0.89); C36(0.89)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C238(2.62); C222(2.63); C29(0.87); C36(0.87)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C238(1.49); C222(0.82); C29(1.21); C301(0.98)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C238(20.00); C222(1.29); C29(0.83); C36(0.83)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C238(1.22); C29(0.80); C36(0.80)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C238(1.05); C29(0.82); C36(0.82)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C238(0.96); C29(0.77); C36(0.77)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C238(0.80); C29(0.84); C36(0.84)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C238(0.94); C29(0.87); C36(0.87)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C238(1.09); C29(0.75); C36(0.75)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C238(1.27); C29(0.79); C36(0.79)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C238(1.21); C29(0.85); C36(0.85)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C238(0.93); C29(0.73); C36(0.73)  LDD0811  [5]
 LDCM0572  Fragment10 Ramos C238(0.68)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C238(3.55)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C238(1.60)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C238(0.86)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C238(1.04)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C238(1.10)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C238(0.83)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C238(0.51)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C238(0.81)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C238(0.78)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C238(1.12)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C238(0.84)  LDD2200  [3]
 LDCM0590  Fragment32 Ramos C238(0.99)  LDD2201  [3]
 LDCM0468  Fragment33 HCT 116 C29(0.70); C36(0.70)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C238(0.63)  LDD2203  [3]
 LDCM0427  Fragment51 HCT 116 C29(1.07); C36(1.07)  LDD0744  [5]
 LDCM0614  Fragment56 Ramos C238(0.79)  LDD2205  [3]
 LDCM0022  KB02 42-MG-BA C222(2.43)  LDD2244  [6]
 LDCM0023  KB03 Jurkat C29(61.51); C36(61.51)  LDD0209  [2]
 LDCM0024  KB05 MKN-1 C222(1.60)  LDD3331  [6]
 LDCM0021  THZ1 HCT 116 C73(1.12); C79(1.12)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-5 (CUL5) Cullin family Q93034
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840