Details of the Target

General Information of Target

Target ID LDTP13838
Target Name F-box/WD repeat-containing protein 1A (BTRC)
Gene Name BTRC
Gene ID 8945
Synonyms
BTRCP; FBW1A; FBXW1A; F-box/WD repeat-containing protein 1A; E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVG
HAVLAINGMDVNGRYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFA
IGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDF
ALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis. SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. Mediates ubiquitination of REST, thereby leading to its proteasomal degradation. SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis. SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF.
Uniprot ID
Q9Y297
Ensemble ID
ENST00000370187.8
HGNC ID
HGNC:1144

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.D435H .
Ishikawa (Heraklio) 02 ER SNV: p.M223V .
NCIH23 SNV: p.R605K .
P31FUJ SNV: p.T109I .
SNGM Deletion: p.R594VfsTer14 .
SNU1 SNV: p.Q143P .
SW620 SNV: p.H382Q .
TOV21G SNV: p.P3Q .
U118MG SNV: p.M160L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]
DBIA
 Probe Info  		C87(1.20); C94(1.20)  LDD0078  [2]
IPM
 Probe Info  		C495(0.00); C212(0.00)  LDD2156  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C314
 Probe Info  		11.39  LDD1981  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C206(1.18); C212(1.18); C495(0.89); C83(0.81)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C206(1.38); C212(1.38); C495(1.08); C83(0.95)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C206(0.68); C212(0.68); C456(0.36); C471(0.96)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C206(0.62); C212(0.62); C456(0.49); C471(1.00)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C206(0.70); C212(0.70); C456(0.43); C471(1.00)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C206(0.57); C212(0.57); C456(0.30); C471(1.19)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C206(0.68); C212(0.68); C456(0.31); C471(1.06)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C206(0.61); C212(0.61); C456(0.32); C471(0.82)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C206(0.64); C212(0.64); C456(0.31); C471(1.04)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C206(0.65); C212(0.75); C456(0.37); C471(0.93)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C206(0.69); C212(0.71); C456(0.61); C471(0.74)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C206(0.70); C212(0.73); C456(0.28); C471(0.81)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C206(1.45); C212(1.45); C495(0.84); C83(1.07)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C206(0.66); C212(0.69); C456(0.21); C471(0.89)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C206(0.64); C212(0.67); C456(0.23); C471(0.80)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C206(0.63); C212(0.69); C456(0.40); C471(1.04)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C206(1.04); C212(1.05); C471(1.78); C495(1.09)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C206(1.01); C212(1.02); C471(1.17); C495(1.18)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C206(0.94); C212(0.95); C471(1.03); C495(1.13)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C206(0.90); C212(0.90); C471(1.10); C495(1.25)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C206(0.93); C212(0.93); C471(1.38); C495(1.20)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C206(1.00); C212(1.01); C471(1.41); C495(1.03)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C206(1.07); C212(1.06); C471(1.07); C495(1.26)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C206(1.38); C212(1.38); C495(0.79); C83(1.01)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C206(0.94); C212(0.95); C471(1.13); C495(1.49)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C206(0.98); C212(0.97); C471(1.17); C495(0.97)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C206(1.12); C212(1.12); C471(1.16); C495(1.00)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C206(0.92); C212(0.87); C471(0.89); C495(1.06)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C206(1.05); C212(1.06); C471(1.13); C495(1.02)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C206(1.14); C212(1.14); C471(1.27); C495(1.04)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C206(1.02); C212(1.00); C471(1.58); C495(1.07)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C206(0.93); C212(0.93); C471(1.46); C495(1.19)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C206(1.24); C212(1.24); C495(1.06); C498(0.94)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C206(1.57); C212(1.57); C495(1.04); C498(1.06)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C206(1.45); C212(1.45); C495(1.02); C498(0.96)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C206(1.11); C212(1.11); C495(1.11); C498(1.07)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C206(1.22); C212(1.22); C495(1.20); C498(1.21)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C206(1.46); C212(1.46); C495(1.15); C498(1.14)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C206(0.90); C212(0.90); C495(1.11); C498(1.02)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C206(1.13); C212(1.13); C495(0.94); C498(0.83)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C206(1.03); C212(1.03); C495(1.03); C498(0.99)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C206(1.06); C212(1.06); C495(1.04); C498(1.06)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C206(0.68); C212(0.68); C495(1.01); C498(0.97)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C206(0.91); C212(0.91); C495(0.97); C498(0.97)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C206(1.54); C212(1.54); C495(0.97); C83(0.83)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C206(0.83); C212(0.83); C495(0.95); C498(0.92)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C206(0.77); C212(0.77); C495(0.95); C498(0.92)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C206(1.19); C212(1.19); C495(1.09); C498(1.06)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C206(1.03); C212(1.03); C495(0.97); C498(0.90)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C87(0.71); C83(0.80); C206(0.97); C212(0.97)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C87(0.58); C83(0.68); C498(0.94); C206(0.96)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C87(0.65); C83(0.78); C206(0.99); C212(0.99)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C83(0.79); C87(0.87); C206(0.92); C212(0.92)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C87(0.70); C498(0.90); C206(0.93); C212(0.93)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C87(0.66); C206(0.79); C212(0.79); C498(0.86)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C83(1.09); C206(1.19); C212(1.19); C495(1.47)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C87(0.69); C206(0.92); C212(0.92); C83(0.92)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C87(0.71); C206(0.82); C212(0.82); C83(1.01)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C87(0.68); C498(0.92); C83(0.94); C206(0.96)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C87(0.57); C206(0.81); C212(0.81); C498(0.84)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C206(0.92); C212(0.92); C495(0.95); C498(0.92)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C206(0.92); C212(0.92); C495(0.98); C498(0.95)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C206(1.07); C212(1.07); C495(0.97); C498(1.08)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C206(1.05); C212(1.05); C495(0.97); C498(1.10)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C83(0.89); C498(0.90); C495(1.02); C206(1.04)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C498(0.73); C83(0.83); C495(0.95); C206(1.01)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C498(0.68); C83(0.70); C495(0.87); C206(1.06)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C83(0.75); C495(0.93); C87(0.98); C94(0.98)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C83(0.83); C495(0.99); C206(1.00); C212(1.00)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C83(0.76); C498(0.87); C495(0.89); C206(1.01)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C498(0.67); C83(0.69); C495(0.85); C206(0.98)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C498(0.71); C83(0.71); C206(1.00); C212(1.00)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C498(0.71); C83(0.76); C206(1.02); C212(1.02)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C206(0.84); C212(0.84); C495(0.84); C498(0.84)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C83(0.66); C206(0.75); C212(0.75); C498(0.83)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C83(0.73); C206(0.80); C212(0.80); C495(0.89)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C206(0.77); C212(0.77); C495(0.79); C498(0.80)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C206(0.58); C212(0.58); C498(0.76); C495(0.79)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C495(0.74); C87(0.86); C94(0.86); C83(1.03)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C206(0.63); C212(0.63); C495(0.83); C498(0.86)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C206(0.73); C212(0.73); C498(0.87); C495(0.90)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C206(0.63); C212(0.63); C83(0.78); C498(0.78)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C206(0.75); C212(0.75); C498(0.79); C495(0.93)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C206(0.68); C212(0.68); C83(0.72); C456(0.83)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C83(1.00); C495(1.10); C498(1.10); C206(1.11)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C83(0.85); C206(0.99); C212(0.99); C495(1.10)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C83(0.80); C495(1.03); C498(1.03); C206(1.13)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C83(0.81); C206(0.95); C212(0.95); C495(1.16)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C471(0.72); C83(0.73); C206(1.00); C212(1.00)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C83(0.69); C495(0.76); C87(0.85); C94(0.85)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C471(0.81); C83(0.96); C206(0.98); C212(0.98)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C83(0.84); C206(0.88); C212(0.88); C471(0.98)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C83(0.65); C471(0.77); C206(0.93); C212(0.93)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C471(0.64); C206(0.89); C212(0.89); C83(0.99)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C83(0.72); C206(0.99); C212(0.99); C495(1.10)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C83(0.70); C206(0.93); C212(0.93); C471(0.93)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C471(0.67); C206(0.95); C212(0.95); C498(1.13)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C471(0.76); C498(0.77); C495(0.89); C206(0.91)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C471(0.83); C495(1.03); C206(1.11); C212(1.11)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C471(0.55); C498(0.72); C206(0.73); C212(0.73)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C495(0.72); C83(0.76); C87(0.88); C94(0.88)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C471(0.60); C498(0.75); C206(0.78); C212(0.78)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C471(0.58); C206(1.03); C212(1.03); C498(1.19)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C471(0.72); C206(0.81); C212(0.81); C498(0.88)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C498(0.87); C206(0.89); C212(0.89); C495(0.93)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C206(0.80); C212(0.80); C471(0.80); C498(0.82)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C498(0.75); C495(0.86); C206(0.92); C212(0.92)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C471(0.68); C498(0.72); C206(0.77); C212(0.77)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C83(0.90); C206(0.91); C212(0.91); C498(0.97)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C206(0.85); C212(0.85); C498(0.90); C495(0.93)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C206(0.86); C212(0.86); C498(0.87); C495(0.91)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C83(0.86); C206(0.91); C212(0.91); C495(1.52)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C498(0.90); C206(0.91); C212(0.91); C495(1.01)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C206(0.95); C212(0.95); C495(1.02); C498(1.12)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C498(0.81); C495(0.84); C206(0.87); C212(0.87)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C498(0.98); C206(0.99); C212(0.99); C495(1.03)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C498(0.88); C495(0.91); C206(0.96); C212(0.96)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C83(0.72); C206(0.99); C212(0.99); C498(1.01)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C83(0.94); C206(1.05); C212(1.05); C495(1.09)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C83(0.63); C498(0.68); C495(0.80); C206(0.80)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C206(0.98); C212(0.98); C495(1.10); C83(1.11)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C498(0.98); C206(1.03); C212(1.03); C495(1.07)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C83(0.84); C495(1.13); C206(1.18); C212(1.18)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C206(0.88); C212(0.88); C83(1.12); C498(1.20)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C206(1.00); C212(1.00); C498(1.07); C495(1.09)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C206(0.97); C212(0.97); C498(1.04); C495(1.17)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C206(0.99); C212(0.99); C498(1.26); C495(1.51)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C206(0.97); C212(0.97); C498(1.27); C495(1.59)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C206(0.92); C212(0.92); C498(1.25); C495(1.78)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C206(1.18); C212(1.18); C495(1.24); C83(1.32)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C498(1.03); C206(1.09); C212(1.09); C495(1.32)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C498(1.02); C495(1.05); C206(1.17); C212(1.17)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C206(0.91); C212(0.91); C498(1.03); C495(1.23)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C83(0.96); C206(1.07); C212(1.07); C495(1.16)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C206(0.97); C212(0.97); C495(1.12); C498(1.20)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C495(1.04); C206(1.07); C212(1.07); C498(1.14)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C206(0.92); C212(0.92); C498(1.47); C495(1.69)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C498(0.82); C206(1.04); C212(1.04); C495(1.40)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C498(0.72); C206(1.05); C212(1.05); C83(1.22)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C206(1.02); C212(1.02); C498(1.17); C495(1.28)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C206(0.95); C212(0.95); C498(0.95); C495(1.19)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C206(1.05); C212(1.05); C498(1.06); C83(1.08)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C206(1.01); C212(1.01); C498(1.10); C495(1.11)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C498(1.04); C206(1.04); C212(1.04); C495(1.10)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C498(0.90); C495(0.91); C83(0.93); C206(1.02)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C498(0.87); C206(1.06); C212(1.06); C495(1.31)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C498(0.81); C206(0.95); C212(0.95); C495(0.97)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C498(0.93); C206(1.03); C212(1.03); C495(1.03)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C498(1.20); C83(1.23); C206(1.32); C212(1.32)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C206(1.06); C212(1.06); C83(1.29); C495(1.46)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C83(1.10); C206(1.11); C212(1.11); C495(1.26)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C206(0.90); C212(0.90); C498(0.96); C495(1.47)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C456(0.17); C498(0.34); C206(0.47); C212(0.47)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C456(0.30); C206(0.67); C212(0.67); C498(0.81)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C206(1.38); C212(1.38); C495(0.78); C83(0.80)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C495(0.83); C83(0.84); C206(1.50); C212(1.50)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C206(0.88); C212(0.88); C83(0.97); C495(1.18)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C87(1.20); C94(1.20)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C83(0.86); C212(1.03); C206(1.04); C495(1.11)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C212(0.93); C206(0.96); C498(1.07); C456(1.09)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C87(0.56); C94(0.56); C83(0.86); C495(0.87)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C83(1.01); C495(1.04); C206(1.14); C212(1.14)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C83(0.83); C495(1.02); C206(1.22); C212(1.22)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C83(0.96); C495(1.03); C206(1.49); C212(1.49)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C83(0.98); C495(1.00); C206(1.28); C212(1.28)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C83(0.69); C206(1.00); C212(1.00); C495(1.08)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C83(0.90); C206(0.94); C212(0.94); C498(1.03)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C83(0.72); C206(0.99); C212(0.99); C495(1.12)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C498(0.80); C83(0.89); C206(0.98); C212(0.98)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C498(0.67); C83(0.73); C206(0.95); C212(0.95)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C498(0.99); C212(0.99); C206(1.00); C456(1.01)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C83(0.80); C498(0.91); C206(0.96); C212(0.96)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C498(0.76); C83(0.80); C206(0.91); C212(0.91)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C206(0.86); C212(0.86); C495(0.88); C498(0.89)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C206(0.63); C212(0.63); C498(0.85); C456(0.85)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C206(0.64); C212(0.64); C498(0.80); C83(0.80)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C206(0.62); C212(0.62); C83(0.92); C498(0.97)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C206(0.72); C212(0.72); C83(0.82); C498(0.85)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C495(0.89); C498(0.89); C206(0.96); C212(0.96)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C83(0.74); C471(0.82); C206(0.96); C212(0.96)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C471(0.80); C206(0.92); C212(0.92); C495(0.93)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C456(0.76); C498(0.81); C212(1.00); C206(1.01)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C471(0.84); C83(0.84); C206(0.89); C212(0.89)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C471(0.74); C206(1.03); C212(1.03); C495(1.95)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C471(0.73); C498(0.84); C206(0.88); C212(0.88)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C471(0.78); C498(0.83); C206(0.90); C212(0.90)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C471(0.68); C498(0.74); C206(0.82); C212(0.82)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C495(0.99); C498(1.01); C206(1.08); C212(1.08)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C206(0.97); C212(0.97); C498(0.98); C83(1.03)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C206(0.98); C212(0.98); C498(1.11); C495(1.12)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C498(0.86); C495(0.89); C206(0.90); C212(0.90)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C212(0.95); C206(0.96); C83(0.99); C498(1.03)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C206(0.99); C212(1.00); C83(1.08); C495(1.12)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C206(0.95); C212(0.96); C456(1.10); C83(1.21)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C456(0.79); C206(0.83); C212(0.83); C87(1.04)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C456(0.67); C83(0.83); C87(1.01); C94(1.01)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C456(0.69); C83(0.73); C87(0.96); C94(0.96)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C498(0.90); C87(0.93); C94(0.93); C206(1.00)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C83(0.84); C206(1.05); C212(1.06); C495(1.19)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C456(0.67); C87(0.88); C94(0.88); C498(0.89)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C456(0.77); C206(0.80); C212(0.80); C498(0.83)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C87(0.69); C94(0.69); C206(0.80); C212(0.80)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C456(0.86); C206(0.89); C212(0.89); C495(1.06)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C456(0.76); C498(0.79); C87(0.83); C94(0.83)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C206(1.17); C212(1.17); C456(0.93); C495(1.17)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C206(1.00); C212(1.00); C456(0.58); C495(1.15)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C206(1.14); C212(1.14); C456(0.78); C495(1.09)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C206(0.90); C212(0.90); C456(0.92); C495(1.57)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C206(0.77); C212(0.77); C456(0.71); C495(1.13)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C206(0.96); C212(0.97); C456(1.15); C495(1.11)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C206(0.77); C212(0.77); C456(0.87); C495(1.20)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C206(0.85); C212(0.85); C456(0.69); C495(1.31)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C206(0.94); C212(0.94); C456(0.82); C495(1.43)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C206(0.87); C212(0.87); C456(0.89); C495(1.72)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C206(0.80); C212(0.80); C456(0.74); C495(1.68)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C206(0.87); C212(0.87); C456(0.52); C495(1.80)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C206(0.99); C212(0.99); C456(0.60); C495(1.56)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C206(0.99); C212(0.99); C456(0.82); C495(1.60)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C206(0.84); C212(0.84); C456(0.79); C495(1.50)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C206(0.95); C212(0.94); C456(1.20); C495(1.23)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C206(0.90); C212(0.90); C456(0.60); C495(1.77)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C206(0.83); C212(0.83); C456(0.88); C495(1.66)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C206(1.00); C212(1.00); C456(0.55); C495(2.76)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C206(0.84); C212(0.84); C456(0.56); C495(1.77)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C206(1.00); C212(1.00); C456(0.60); C495(1.51)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C206(0.99); C212(0.99); C456(0.62); C495(1.52)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C206(0.88); C212(0.88); C495(1.13)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C206(0.88); C212(0.88); C495(0.97)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C206(0.75); C212(0.75); C495(0.95)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C206(0.96); C212(0.96); C495(1.05)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C206(1.02); C212(1.03); C456(1.39); C495(1.11)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C206(0.90); C212(0.90); C495(0.97)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C206(0.97); C212(0.97); C495(1.09)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C206(0.74); C212(0.74); C495(1.18)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C206(0.89); C212(0.89); C495(1.19)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C206(0.89); C212(0.89); C495(1.01)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C206(0.96); C212(0.96); C495(0.90)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C206(0.98); C212(0.98); C495(1.09)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C206(1.02); C212(1.02); C495(0.91)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C206(0.82); C212(0.82); C495(1.00)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C206(1.13); C212(1.13); C495(0.95)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C206(1.00); C212(1.01); C456(1.39); C495(1.05)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C206(0.76); C212(0.76); C495(1.12)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C206(1.01); C212(0.89); C495(1.05); C498(1.03)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C206(1.00); C212(0.92); C495(1.07); C498(1.27)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C206(1.08); C212(0.91); C495(1.06); C498(1.03)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C206(1.22); C212(1.00); C495(0.97); C498(0.92)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C206(1.09); C212(0.99); C495(0.96); C498(0.92)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C206(1.11); C212(1.01); C495(1.14); C498(1.06)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C206(1.12); C212(0.97); C495(1.11); C498(1.08)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C206(1.00); C212(0.90); C495(1.08); C498(1.34)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C206(1.08); C212(0.95); C495(1.17); C498(1.29)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C206(1.05); C212(1.07); C456(1.18); C495(0.96)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C206(1.02); C212(0.92); C495(0.97); C498(1.04)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C206(1.00); C212(0.88); C495(1.06); C498(1.01)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C206(1.10); C212(0.94); C495(1.18); C498(1.47)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C206(1.03); C212(0.94); C495(0.99); C498(1.01)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C206(1.05); C212(0.87); C495(1.06); C498(0.94)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C206(1.03); C212(1.03); C495(1.22); C498(1.35)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C206(0.88); C212(0.88); C495(1.27); C498(1.54)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C206(0.90); C212(0.90); C495(1.04); C498(1.02)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C206(0.93); C212(0.93); C495(1.06); C498(0.95)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C206(0.90); C212(0.91); C456(0.75); C495(1.14)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C206(1.12); C212(1.12); C495(1.03); C498(1.01)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C206(0.91); C212(0.91); C495(1.06); C498(0.86)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C206(0.92); C212(0.92); C495(0.94); C498(0.79)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C206(0.89); C212(0.89); C495(0.87); C498(0.89)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C206(0.91); C212(0.91); C495(0.97); C498(1.01)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C206(0.93); C212(0.93); C495(1.02); C498(1.12)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C206(0.98); C212(0.98); C495(0.99); C498(0.99)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C206(0.93); C212(0.93); C495(1.71); C498(2.43)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C206(0.95); C212(0.95); C495(1.00); C498(1.02)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C206(0.92); C212(0.92); C495(1.02); C498(0.96)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C206(0.96); C212(0.95); C456(0.85); C495(1.16)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C206(1.09); C212(1.09); C495(1.47); C498(1.47)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C206(1.15); C212(1.15); C495(1.36); C83(1.03)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C206(1.26); C212(1.26); C495(1.21); C83(0.96)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C206(1.16); C212(1.16); C495(1.00); C83(1.00)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C206(0.90); C212(0.90); C495(1.06); C83(0.97)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C206(1.01); C212(1.01); C495(1.09); C83(0.85)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C206(1.22); C212(1.22); C495(1.03); C83(0.82)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C206(1.14); C212(1.14); C495(1.11); C83(0.87)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C206(1.12); C212(1.12); C495(1.07); C83(0.88)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C206(1.08); C212(1.08); C495(0.68); C83(0.76)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C471(1.04); C206(1.00); C495(0.92)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C206(1.05); C212(0.91); C495(1.35); C498(1.12)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C206(0.90); C212(0.90); C456(0.63); C495(1.93)  LDD0744  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]
 LDCM0022  KB02 HCT 116 C87(5.05); C94(5.05); C206(6.96); C212(6.96)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C87(2.84); C94(2.84); C206(6.98); C212(6.98)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C87(4.49); C94(4.49); C206(3.29); C212(3.29)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C87(0.98); C94(0.98); C495(0.96); C498(0.89)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) Complex I 51 kDa subunit family P49821
Cullin-1 (CUL1) Cullin family Q13616
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
COP9 signalosome complex subunit 6 (COPS6) Peptidase M67A family Q7L5N1
Serine/threonine-protein kinase PLK4 (PLK4) Ser/Thr protein kinase family O00444
Wee1-like protein kinase (WEE1) Ser/Thr protein kinase family P30291
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) STE Ser/Thr protein kinase family Q02750
Tyrosine-protein phosphatase non-receptor type 18 (PTPN18) Protein-tyrosine phosphatase family Q99952
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208
E3 ubiquitin-protein ligase TRIM36 (TRIM36) TRIM/RBCC family Q9NQ86
E3 ubiquitin-protein ligase TRIM9 (TRIM9) TRIM/RBCC family Q9C026
Endoribonuclease ZC3H12A (ZC3H12A) ZC3H12 family Q5D1E8
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Disks large homolog 1 (DLG1) MAGUK family Q12959
Cellular tumor antigen p53 (TP53) P53 family P04637
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Transcription factor NF-E2 45 kDa subunit (NFE2) BZIP family Q16621
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485
Zinc finger protein GLI2 (GLI2) GLI C2H2-type zinc-finger protein family P10070
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
RE1-silencing transcription factor (REST) . Q13127
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-10 receptor subunit alpha (IL10RA) Type II cytokine receptor family Q13651
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
APC membrane recruitment protein 1 (AMER1) Amer family Q5JTC6
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Progranulin (GRN) Granulin family P28799
NHS-like protein 2 (NHSL2) NHS family Q5HYW2
Transforming acidic coiled-coil-containing protein 1 (TACC1) TACC family O75410
NEDD8 (NEDD8) Ubiquitin family Q15843
Axin-2 (AXIN2) . Q9Y2T1
Centrosomal protein of 68 kDa (CEP68) . Q76N32
Innate immunity activator protein (INAVA) . Q3KP66
Ras association domain-containing protein 5 (RASSF5) . Q8WWW0

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402