Details of the Target

General Information of Target

Target ID LDTP13429
Target Name Lariat debranching enzyme (DBR1)
Gene Name DBR1
Gene ID 51163
Synonyms
Lariat debranching enzyme; EC 3.1.4.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIP
EERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSF
VKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQ
VIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRF
QPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLE
KEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKT
VKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSG
TYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRD
HSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR
Target Bioclass
Enzyme
Family
Lariat debranching enzyme family
Subcellular location
Nucleus
Function
Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem.
Uniprot ID
Q9UK59
Ensemble ID
ENST00000260803.9
HGNC ID
HGNC:15594

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LUDLU1 SNV: p.I16M .
MELJUSO Insertion: p.P353KfsTer9 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y65(18.84)  LDD3495  [2]
BTD
 Probe Info  		C9(1.14)  LDD2117  [3]
AHL-Pu-1
 Probe Info  		C347(3.53)  LDD0170  [4]
IPM
 Probe Info  		C8(1.93)  LDD1702  [3]
DBIA
 Probe Info  		C139(0.95); C8(1.03); C9(0.99)  LDD0531  [5]
AMP probe
 Probe Info  		N.A.  LDD0200  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C139(0.00); C8(0.00); C347(0.00); C339(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C139(0.00); C51(0.00); C347(0.00); C339(0.00)  LDD0037  [7]
AOyne
 Probe Info  		9.20  LDD0443  [10]
NAIA_5
 Probe Info  		C37(0.00); C36(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C9(1.14)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C9(1.05)  LDD2152  [3]
 LDCM0025  4SU-RNA DM93 C347(3.53)  LDD0170  [4]
 LDCM0214  AC1 HCT 116 C139(0.95); C8(1.03); C9(0.99)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C8(0.87); C9(0.87)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C339(0.78); C347(0.30); C8(0.78); C9(0.78)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C339(0.91); C347(0.38); C8(0.69); C9(0.69)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C339(0.87); C347(0.79); C8(0.62); C9(0.62)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C339(0.85); C347(0.38); C8(0.55); C9(0.55)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C339(0.89); C347(0.63); C8(0.57); C9(0.57)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C339(0.83); C347(0.42); C8(0.60); C9(0.60)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C339(0.82); C347(0.36); C8(0.66); C9(0.66)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C339(0.94); C347(0.41); C8(0.56); C9(0.56)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C339(0.88); C347(0.28); C8(0.73); C9(0.73)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C339(0.89); C347(0.73); C8(0.67); C9(0.67)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C8(0.63); C9(0.63)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C339(0.84); C347(0.38); C8(0.64); C9(0.64)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C339(0.89); C347(0.40); C8(0.70); C9(0.70)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C339(1.11); C347(0.41); C8(0.58); C9(0.58)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C139(0.73); C339(1.16); C347(1.27)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C139(0.68); C339(1.04); C347(0.97)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C139(0.64); C339(0.90); C347(0.97)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C139(0.75); C339(1.04); C347(0.95)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C139(1.48); C339(0.95); C347(0.99)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C139(0.90); C339(0.84); C347(1.15)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C139(1.00); C339(0.81); C347(1.11)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C8(0.89); C9(0.89)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C139(0.59); C339(1.42); C347(1.21)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C139(0.81); C339(0.86); C347(0.86)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C139(0.85); C339(0.94); C347(1.04)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C139(0.68); C339(0.92); C347(0.72)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C139(1.01); C339(0.85); C347(0.75)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C139(1.02); C339(1.03); C347(0.99)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C139(0.69); C339(0.83); C347(1.38)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C139(0.64); C339(0.84); C347(0.86)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C139(0.57); C339(2.70); C347(2.72)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C139(0.73); C339(1.46); C347(1.65)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C139(0.45); C339(1.43); C347(1.66)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C139(0.64); C339(1.86); C347(1.77)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C139(0.78); C339(1.20); C347(1.03)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C139(0.73); C339(1.44); C347(1.43)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C139(0.73); C339(1.32); C347(0.91)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C139(0.57); C339(1.17); C347(0.97)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C139(0.61); C339(1.11); C347(0.88)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C139(0.70); C339(1.01); C347(0.91)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C139(0.59); C339(0.82); C347(0.42)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C139(0.53); C339(0.86); C347(0.50)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C8(0.75); C9(0.75)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C139(0.56); C339(0.83); C347(0.38)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C139(0.65); C339(1.05); C347(0.43)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C139(0.67); C339(0.89); C347(0.70)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C8(1.14); C9(1.14)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C8(1.24); C9(1.24)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C8(1.08); C9(1.08)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C8(1.33); C9(1.33)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C8(1.07); C9(1.07)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C8(1.14); C9(1.14)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C8(1.01); C9(1.01)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C8(0.83); C9(0.83)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C8(1.21); C9(1.21)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C8(1.06); C9(1.06)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C8(1.06); C9(1.06)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C8(1.10); C9(1.10)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C8(1.07); C9(1.07)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C8(1.39); C9(1.39)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C8(1.12); C9(1.12)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C8(1.18); C9(1.18)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C139(0.77); C339(0.82); C8(0.84); C9(0.84)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C8(0.73); C9(0.73); C139(1.02); C339(1.09)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C139(0.83); C8(0.85); C9(0.85); C339(0.99)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C139(0.97); C9(1.14); C8(1.15)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C139(0.74); C8(0.96); C9(0.96); C339(1.63)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C139(0.89); C8(0.96); C9(0.96); C339(1.10)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C139(0.75); C8(0.80); C9(0.80); C339(1.14)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C139(0.77); C8(0.79); C9(0.79); C339(0.98)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C139(0.74); C8(0.85); C9(0.85); C339(1.20)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C8(0.75); C9(0.75); C339(0.90); C347(0.94)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C347(0.72); C339(0.79); C8(1.04); C9(1.04)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C347(0.88); C8(0.93); C9(0.93); C339(0.95)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C347(0.77); C339(0.85); C8(1.20); C9(1.20)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C347(0.72); C339(0.88); C8(0.98); C9(0.98)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C139(1.05); C8(1.13); C9(1.16)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C347(0.56); C339(0.73); C8(0.95); C9(0.95)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C347(0.66); C339(0.74); C8(0.92); C9(0.92)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C347(0.47); C339(0.66); C8(0.75); C9(0.75)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C8(0.69); C9(0.69); C347(0.85); C339(0.88)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C8(0.69); C9(0.69); C339(0.81); C347(0.83)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C339(1.15); C347(1.22); C8(1.28); C9(1.28)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C347(0.79); C8(1.07); C9(1.07); C339(1.21)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C8(1.06); C9(1.06); C339(1.18); C347(1.64)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C347(0.61); C339(0.83); C8(1.21); C9(1.21)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C347(0.72); C339(0.72); C8(0.95); C9(0.95)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C139(1.03); C9(1.05); C8(1.12)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C8(0.86); C9(0.86); C347(0.88); C339(0.97)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C347(0.90); C8(1.14); C9(1.14); C339(1.36)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C347(0.85); C8(0.89); C9(0.89); C339(1.12)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C8(0.83); C9(0.83); C347(0.84); C339(1.14)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C8(1.00); C9(1.00); C339(1.15); C347(1.84)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C8(0.82); C9(0.82); C339(1.25); C347(1.99)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C8(0.85); C9(0.85); C139(1.45)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C8(0.89); C9(0.89); C139(1.21)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C8(1.13); C9(1.13); C139(1.24)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C8(0.93); C9(0.93); C139(1.34)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C9(0.92); C139(0.99); C8(1.08)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C8(0.91); C9(0.91); C139(1.39)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C8(1.00); C9(1.00); C139(1.21)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C8(1.05); C9(1.05); C139(1.31)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C8(0.69); C9(0.69); C139(1.16)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C8(0.94); C9(0.94); C139(1.24)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C8(0.57); C9(0.57); C139(0.95)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C8(0.76); C9(0.76); C139(1.20)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C139(1.07); C8(1.13); C9(1.13)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C139(1.01); C8(1.27); C9(1.27)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C8(0.88); C9(0.88); C139(0.89)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C8(0.88); C9(0.88)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C8(0.70); C9(0.70); C139(0.81)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C8(1.01); C9(1.01); C139(1.08)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C139(0.95); C8(0.98); C9(0.98)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C8(0.81); C9(0.81); C139(0.91)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C8(0.78); C9(0.78); C139(0.89)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C139(1.03); C8(1.12); C9(1.12)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C139(0.97); C8(1.29); C9(1.29)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C8(0.76); C9(0.76); C139(0.86)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C347(0.69); C8(0.90); C9(0.90); C139(1.42)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C347(0.87); C8(0.94); C9(0.94); C139(1.16)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C8(0.91); C9(0.91)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C8(0.45); C9(0.45); C347(0.52); C139(1.02)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C347(0.66); C8(1.24); C9(1.24); C139(1.31)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C8(0.49); C9(0.49); C139(1.11); C347(1.21)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C8(0.46); C9(0.46); C347(0.75); C139(1.24)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C347(0.57); C8(1.20); C9(1.20); C139(1.32)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C8(0.56); C9(0.56); C347(0.64); C139(1.05)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C347(0.91); C8(1.15); C9(1.15); C139(1.19)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C8(0.65); C9(0.65); C347(0.91); C139(1.38)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C8(0.74); C9(0.74); C347(0.80); C139(1.23)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C8(0.45); C9(0.45); C347(0.79); C139(1.29)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C8(0.87); C9(0.87)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C347(0.80); C139(1.44); C8(1.55); C9(1.55)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C347(0.67); C8(0.71); C9(0.71); C139(0.87)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C347(0.29); C8(0.92); C9(0.92); C139(0.94)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C339(0.61); C347(0.61); C139(0.98)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C139(0.99); C339(1.11); C347(1.11)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C339(0.65); C347(0.65); C139(0.83)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C339(0.53); C347(0.53); C139(1.16)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C339(0.53); C347(0.53); C139(1.13)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C339(0.51); C347(0.51); C139(0.94)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C339(0.53); C347(0.53); C139(0.86)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C339(0.46); C347(0.46); C139(0.84)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C339(0.67); C347(0.67); C139(1.20)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C339(0.60); C347(0.60); C139(0.98)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C339(0.78); C347(0.78); C139(0.93)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C139(0.89); C339(0.98); C347(0.98)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C339(0.48); C347(0.48); C139(1.44)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C139(0.95); C339(1.07); C347(1.07)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C339(0.40); C347(0.40); C139(0.92)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C8(0.15); C9(0.15); C347(0.28); C339(0.76)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C347(0.38); C8(0.72); C9(0.72); C339(0.81)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C8(0.95); C9(0.95)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C8(0.86); C9(0.86)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C8(0.78); C9(0.78)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.50  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C8(0.96); C9(0.96)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C8(0.64); C9(0.64)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C9(0.87); C139(1.01); C8(1.06)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C8(0.88); C9(0.88)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C8(0.94); C9(0.94)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C8(0.91); C9(0.91)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C8(0.79); C9(0.79)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C139(0.70); C8(0.82); C9(0.82); C339(0.87)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C8(0.42); C9(0.42); C139(0.52); C339(0.88)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C8(0.69); C9(0.69); C139(0.77); C339(0.88)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C8(0.59); C9(0.59); C139(0.80); C339(0.83)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C139(0.65); C8(0.87); C9(0.87); C339(1.10)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C8(0.80); C9(0.80)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C8(0.65); C9(0.65); C139(0.70); C339(0.77)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C339(0.81); C8(0.85); C9(0.85); C139(0.91)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C347(0.63); C339(0.69); C8(0.96); C9(0.96)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C347(0.59); C8(0.71); C9(0.71); C339(0.77)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C347(0.56); C339(0.72); C8(0.75); C9(0.75)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C347(0.67); C8(0.69); C9(0.69); C339(0.79)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C8(0.63); C9(0.63); C347(0.73); C339(0.77)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C8(0.54); C9(0.54); C347(0.59); C339(1.20)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C347(0.90); C8(0.95); C9(0.95); C339(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C8(0.95); C9(0.95); C347(0.98); C339(1.09)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C8(0.82); C9(0.82)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C347(0.80); C339(1.01); C8(1.16); C9(1.16)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C8(0.69); C9(0.69); C139(1.11)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C8(0.82); C9(0.82); C139(1.17)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C8(0.89); C9(0.89); C139(1.09)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C8(0.77); C9(0.77); C139(1.27)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C139(1.01); C8(1.05); C9(1.05)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C139(0.89); C8(1.00); C9(1.00)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C139(1.01); C8(1.12); C9(1.12)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C139(1.02); C8(1.28); C9(1.28)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C8(0.70); C9(0.70)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C8(0.84); C9(0.84)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C8(0.85); C9(0.85)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C8(0.60); C9(0.60)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C8(1.49); C9(1.49)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C8(1.07); C9(1.07)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C8(1.06); C9(1.06)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C8(0.87); C9(0.87)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C8(1.10); C9(1.10)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C8(1.45); C9(1.45)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C8(1.06); C9(1.06)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C8(0.98); C9(0.98)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C8(0.95); C9(0.95)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C8(0.86); C9(0.86)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C8(0.74); C9(0.74)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C8(1.17); C9(1.17)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C8(0.86); C9(0.86)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C8(1.29); C9(1.29)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C8(0.88); C9(0.88)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C8(1.18); C9(1.18)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C139(0.71)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C139(0.80)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C139(0.75)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C139(0.52)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C139(0.66)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C139(0.63)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C139(0.56)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C139(0.69)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C8(0.90); C9(0.90)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C139(0.66)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C139(0.80)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C139(0.40)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C139(0.51)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C139(0.63)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C139(0.43)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C339(0.54); C347(0.54); C8(1.46); C9(1.46)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C339(0.68); C347(0.68); C8(1.48); C9(1.48)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C339(0.79); C347(0.79); C8(1.34); C9(1.34)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C339(0.52); C347(0.52); C8(1.20); C9(1.20)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C8(0.90); C9(0.90)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C339(0.79); C347(0.79); C8(1.31); C9(1.31)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C339(0.62); C347(0.62); C8(1.26); C9(1.26)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C339(0.57); C347(0.57); C8(1.15); C9(1.15)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C339(1.32); C347(1.32); C8(1.16); C9(1.16)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C339(0.60); C347(0.60); C8(1.23); C9(1.23)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C339(0.87); C347(0.87); C8(1.17); C9(1.17)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C339(0.87); C347(0.87); C8(1.13); C9(1.13)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C339(0.71); C347(0.71); C8(1.10); C9(1.10)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C339(0.62); C347(0.62); C8(1.27); C9(1.27)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C339(0.71); C347(0.71); C8(1.10); C9(1.10)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C8(0.73); C9(0.73)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C339(0.89); C347(0.89); C8(1.07); C9(1.07)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C37(0.88); C8(1.29)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C37(0.91); C8(0.96)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C37(0.87); C8(1.49)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C37(0.94); C8(0.74)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C37(0.91); C8(1.00)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C37(0.98); C8(1.07)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C37(0.97); C8(0.98)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C37(0.93); C8(0.96)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C37(1.01); C8(1.48)  LDD1059  [5]
 LDCM0462  CL7 HCT 116 C8(0.88); C9(0.88)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C37(0.78); C8(1.09)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C37(0.87); C8(1.38)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C37(0.80); C8(1.03)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C37(0.88); C8(1.07)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C37(1.10); C8(1.11)  LDD1065  [5]
 LDCM0469  CL76 HCT 116 C339(1.42)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C339(0.91)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C339(1.00)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C339(1.20)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C8(0.57); C9(0.57)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C339(1.23)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C339(0.89)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C339(1.74)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C339(1.46)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C339(1.28)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C339(1.52)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C339(1.09)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C339(1.06)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C339(1.17)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C339(1.35)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C8(0.77); C9(0.77)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C339(0.98)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C139(0.93); C8(1.09); C9(1.10)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C139(0.94); C8(1.13); C9(1.21)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C139(0.94); C8(1.16); C9(1.16)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C139(0.91); C8(1.09); C9(0.98)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C139(0.89); C8(0.90); C9(0.89)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C139(0.90); C8(1.05); C9(1.03)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C139(0.87); C8(1.16); C9(1.12)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C139(0.89); C8(1.06); C9(0.92)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C139(1.06); C8(1.06); C9(0.95)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C139(1.07); C339(0.95); C9(1.01)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C8(1.93)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C37(0.99); C8(1.39)  LDD1066  [5]
 LDCM0427  Fragment51 HCT 116 C139(0.55)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C139(1.09); C339(1.02); C37(1.07)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C139(1.06); C339(1.05); C37(1.31)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C139(1.58)  LDD3310  [14]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C9(1.02)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C9(0.95)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C9(1.01); C8(0.84)  LDD2127  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C9(1.10)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C9(0.71)  LDD2140  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C8(0.75)  LDD2149  [3]

References

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2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840