Details of the Target

General Information of Target

Target ID LDTP12905
Target Name Denticleless protein homolog (DTL)
Gene Name DTL
Gene ID 51514
Synonyms
CDT2; CDW1; DCAF2; L2DTL; RAMP; Denticleless protein homolog; DDB1- and CUL4-associated factor 2; Lethal(2) denticleless protein homolog; Retinoic acid-regulated nuclear matrix-associated protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNKLYIGNLNESVTPADLEKVFAEHKISYSGQFLVKSGYAFVDCPDEHWAMKAIETFSGK
VELQGKRLEIEHSVPKKQRSRKIQIRNIPPQLRWEVLDSLLAQYGTVENCEQVNTESETA
VVNVTYSNREQTRQAIMKLNGHQLENHALKVSYIPDEQIAQGPENGRRGGFGSRGQPRQG
SPVAAGAPAKQQQVDIPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAA
EKAISVHSTPEGCSSACKMILEIMHKEAKDTKTADEVPLKILAHNNFVGRLIGKEGRNLK
KVEQDTETKITISSLQDLTLYNPERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSL
QSHLIPGLNLAAVGLFPASSSAVPPPPSSVTGAAPYSSFMQAPEQEMVQVFIPAQAVGAI
IGKKGQHIKQLSRFASASIKIAPPETPDSKVRMVIITGPPEAQFKAQGRIYGKLKEENFF
GPKEEVKLETHIRVPASAAGRVIGKGGKTVNELQNLTAAEVVVPRDQTPDENDQVIVKII
GHFYASQMAQRKIRDILAQVKQQHQKGQSNQAQARRK
Target Type
Literature-reported
Target Bioclass
Other
Family
WD repeat cdt2 family
Subcellular location
Nucleus
Function
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1.
TTD ID
T89521
Uniprot ID
Q9NZJ0
DrugMap ID
TT8396I
Ensemble ID
ENST00000366991.5
HGNC ID
HGNC:30288

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.G393C DBIA    Probe Info 
HEP3B217 SNV: p.K564Q DBIA    Probe Info 
MEWO SNV: p.S259F DBIA    Probe Info 
NUGC3 SNV: p.A665V .
SKMEL5 SNV: p.P440L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K144(5.26)  LDD0277  [2]
DA-P3
 Probe Info  		9.22  LDD0181  [3]
AHL-Pu-1
 Probe Info  		C544(11.09)  LDD0170  [4]
HHS-465
 Probe Info  		Y320(6.44)  LDD2237  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
DBIA
 Probe Info  		C544(1.20); C438(0.98); C454(0.98); C450(0.97)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C136(0.00); C157(0.00); C141(0.00); C379(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C136(0.00); C157(0.00); C379(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C136(0.00); C157(0.00); C379(0.00); C710(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
Compound 10
 Probe Info  		C157(0.00); C379(0.00); C544(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
ENE
 Probe Info  		C544(0.00); C141(0.00)  LDD0006  [11]
IPM
 Probe Info  		C141(0.00); C710(0.00)  LDD0005  [11]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C136(0.00); C544(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C544(11.09)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C544(5.33)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C141(0.70); C157(0.75); C450(0.91); C454(0.91)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C141(0.91); C438(1.12); C450(1.12); C544(0.99)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C141(1.59); C157(0.87); C438(0.80); C450(0.80)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C141(1.32); C157(0.73); C438(0.95); C450(0.95)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C141(1.72); C157(0.85); C438(0.93); C450(0.93)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C141(1.55); C157(0.84); C438(1.02); C450(1.02)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C141(1.41); C157(0.76); C438(0.91); C450(0.91)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C141(1.66); C157(0.83); C438(0.91); C450(0.91)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C141(1.68); C157(0.77); C438(1.16); C450(1.16)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C141(1.25); C157(0.78); C438(1.02); C450(1.01)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C141(1.64); C157(1.09); C438(1.03); C450(0.81)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C141(2.06); C157(0.90); C438(0.88); C450(0.77)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C141(0.67); C438(1.30); C450(1.30); C544(1.48)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C141(1.44); C157(0.75); C438(0.95); C450(0.81)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C141(1.27); C157(0.79); C438(0.87); C450(0.81)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C141(1.22); C157(0.72); C438(0.81); C450(0.91)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C136(0.61); C157(1.05); C438(0.86); C454(0.86)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C136(0.73); C157(1.23); C438(1.24); C454(1.28)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C136(0.73); C157(1.08); C438(1.14); C454(1.29)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C136(0.71); C157(1.30); C438(1.18); C454(1.22)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C136(0.69); C157(1.24); C438(0.86); C454(0.92)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C136(0.86); C157(1.29); C438(0.78); C454(0.93)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C136(0.91); C157(2.38); C438(0.72); C454(0.80)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C141(0.71); C438(1.12); C450(1.12); C544(0.91)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C136(0.71); C157(1.42); C438(0.80); C454(0.86)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C136(0.81); C157(1.24); C438(0.90); C454(0.83)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C136(0.79); C157(1.91); C438(0.82); C454(0.86)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C136(0.57); C157(1.53); C438(0.80); C454(0.81)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C136(0.73); C157(1.61); C438(1.05); C454(0.96)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C136(0.81); C157(1.77); C438(0.94); C454(0.89)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C136(0.94); C157(1.45); C438(1.08); C454(1.13)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C136(0.83); C157(1.11); C438(0.94); C454(0.94)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C141(1.38); C157(1.16); C438(1.03); C454(1.03)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C141(0.69); C157(1.00); C438(0.87); C454(0.87)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C141(1.09); C157(1.37); C438(1.17); C454(1.17)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C141(0.75); C157(1.22); C438(0.87); C454(0.87)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C141(0.80); C157(1.01); C438(0.57); C454(0.57)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C141(0.88); C157(1.23); C438(0.81); C454(0.81)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C141(1.08); C157(1.17); C438(0.87); C454(0.87)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C141(1.06); C157(1.36); C438(0.78); C454(0.78)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C141(1.04); C157(1.29); C438(0.90); C454(0.90)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C141(0.93); C157(1.11); C438(0.67); C454(0.67)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C141(0.96); C157(1.15); C438(0.78); C454(0.78)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C141(0.92); C157(1.33); C438(0.95); C454(0.95)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C141(0.59); C438(1.16); C450(1.16); C544(0.92)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C141(0.99); C157(1.46); C438(1.00); C454(1.00)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C141(0.95); C157(1.22); C438(1.04); C454(1.04)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C141(0.67); C157(1.22); C438(0.71); C454(0.71)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C438(1.10); C450(0.94); C454(1.14); C544(1.21)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C454(1.35); C438(1.56); C450(1.75); C544(1.77)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C450(1.04); C454(1.05); C438(1.10); C544(1.13)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C454(1.16); C438(1.28); C544(1.40); C450(1.46)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C454(1.43); C438(1.56); C450(1.66); C544(2.18)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C450(1.57); C544(1.73); C454(1.80); C438(1.83)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C454(1.38); C438(1.58); C544(1.71); C450(1.97)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C141(0.65); C544(0.93); C438(1.04); C450(1.04)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C544(1.08); C454(1.17); C438(1.20); C450(1.30)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C544(1.07); C454(1.37); C438(1.38); C450(1.46)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C454(1.39); C438(1.57); C544(1.62); C450(1.69)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C454(1.96); C438(2.31); C450(2.85); C544(3.89)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C438(1.70); C450(1.72); C454(1.64); C544(2.28)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C438(1.71); C450(2.09); C454(1.53); C544(1.63)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C438(1.39); C450(1.78); C454(1.16); C544(1.64)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C438(1.88); C450(1.87); C454(1.78); C544(1.77)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C544(0.39); C438(0.65); C454(0.65); C157(0.96)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C544(0.44); C438(0.73); C454(0.73); C157(0.86)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C544(0.44); C438(0.69); C454(0.69); C157(0.79)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C157(0.55); C141(0.68); C450(0.92); C454(0.92)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C544(0.38); C438(0.55); C454(0.55); C157(0.92)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C544(0.38); C438(0.71); C454(0.71); C157(0.72)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C544(0.27); C438(0.81); C454(0.81); C157(0.87)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C544(0.50); C438(0.60); C454(0.60); C157(0.65)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C544(0.38); C438(0.58); C454(0.58); C157(0.87)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C136(0.96); C157(1.20)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C136(1.08); C157(1.19)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C157(1.11); C136(1.28)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C157(1.25); C136(1.38)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C157(1.05); C136(1.22)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C141(0.69); C157(0.88); C450(0.94); C454(0.94)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C157(1.01); C136(1.16)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C136(1.02); C157(1.17)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C157(1.47); C136(1.59)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C157(0.90); C136(1.45)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C157(0.68); C136(1.15)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C157(1.08)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C157(1.22)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C157(1.11)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C157(1.09)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C157(1.08)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C141(0.66); C157(0.84); C544(0.99); C450(1.02)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C157(1.02)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C157(1.10)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C157(1.40)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C157(1.59)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C157(1.21)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C157(1.15)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C157(1.24)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C157(1.08)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C157(1.00)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C157(0.78)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C141(0.59); C157(0.70); C544(0.93); C450(0.99)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C157(0.90)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C157(0.72)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C157(0.75)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C157(0.87)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C157(0.89)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C157(0.84)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C157(0.74)  LDD0636  [7]
 LDCM0320  AC57 HEK-293T C141(1.05); C438(0.90)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C141(0.91); C438(1.25)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C141(1.04); C438(1.15)  LDD0920  [7]
 LDCM0323  AC6 HCT 116 C544(0.91); C438(1.19); C450(1.19); C141(1.32)  LDD0640  [7]
 LDCM0324  AC60 HEK-293T C141(2.96); C438(0.90)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C141(1.64); C438(0.97)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C141(1.10); C438(1.04)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C141(1.58); C438(0.86)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C141(1.05); C438(0.85)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C141(1.39); C438(1.02)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C141(1.03); C438(0.98)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C141(1.07); C438(0.89)  LDD0929  [7]
 LDCM0332  AC68 HCT 116 C438(1.00); C454(1.00); C544(1.14)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C438(1.40); C454(1.40); C544(1.45)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C438(0.99); C450(0.99); C544(1.03); C141(1.97)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C438(1.30); C454(1.30); C544(1.32)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C544(0.98); C438(1.00); C454(1.00)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C438(1.48); C454(1.48); C544(1.58)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C438(1.86); C454(1.86); C544(2.09)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C438(1.50); C454(1.50); C544(1.61)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C438(2.22); C454(2.22); C544(2.27)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C438(1.34); C454(1.34); C544(1.48)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C544(1.56); C438(1.64); C454(1.64)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C544(1.28); C438(1.34); C454(1.34)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C544(1.21); C438(1.23); C454(1.23)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C438(0.91); C450(0.91); C544(1.04); C141(1.47)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C438(1.34); C454(1.34); C544(1.39)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C438(1.14); C454(1.14); C544(1.16)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C438(1.59); C454(1.59); C544(2.16)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C136(1.05); C438(1.65); C450(1.65)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C136(1.02); C438(1.41); C450(1.41)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C438(0.85); C450(0.85); C136(1.01)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C136(0.97); C438(1.31); C450(1.31)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C136(0.95); C438(1.64); C450(1.64)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C136(0.86); C438(1.61); C450(1.61)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C136(0.98); C438(1.95); C450(1.95)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C438(0.75); C450(0.75); C136(0.87)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C136(0.97); C438(1.70); C450(1.70)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C136(0.84); C438(1.82); C450(1.82)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C136(0.87); C438(1.10); C450(1.10)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C136(0.97); C438(2.03); C450(2.03)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C136(1.13); C438(1.79); C450(1.79)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C136(0.92); C438(2.52); C450(2.52)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C136(0.96); C438(2.07); C450(2.07)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C157(0.84); C438(1.96); C450(1.96); C141(2.34)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C438(0.80); C450(0.80); C157(0.82); C544(0.86)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C141(0.55); C438(1.02); C450(1.02); C544(1.08)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C141(0.88); C544(1.17); C438(1.39); C450(1.39)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C141(0.88); C544(0.96); C438(1.06); C450(1.06)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C544(1.20); C438(0.98); C454(0.98); C450(0.97)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HCT 116 C136(0.89); C157(0.93); C544(1.11); C141(1.44)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C544(0.89); C141(0.97); C136(1.01); C157(1.24)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C157(0.68); C141(0.89); C450(1.09); C454(1.09)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C544(0.88); C141(1.14); C438(1.31); C450(1.31)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C544(1.06); C438(1.31); C450(1.31); C141(9.82)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C544(0.81); C141(0.96); C438(1.26); C450(1.26)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C544(0.89); C141(1.13); C438(1.43); C450(1.43)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C544(0.51); C438(0.70); C454(0.70); C157(0.80)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C544(0.37); C438(0.54); C454(0.54); C157(0.71)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C544(0.49); C438(0.74); C454(0.74); C157(0.86)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C544(0.38); C438(0.64); C454(0.64); C157(0.69)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C438(0.69); C454(0.69); C544(0.72); C157(1.01)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C157(0.78); C136(0.87); C544(1.03); C141(2.34)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C544(0.46); C438(0.60); C454(0.60); C157(0.88)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C544(0.47); C157(0.68); C438(0.71); C454(0.71)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C157(0.86); C136(1.12)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C157(0.89); C136(1.16)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C157(0.71); C136(0.97)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C157(0.75); C136(0.94)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C157(0.97); C136(1.15)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C157(1.10)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C157(1.30)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C157(1.23)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C141(0.76); C157(0.83); C544(0.94); C136(1.12)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C157(1.10)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C157(0.94)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C157(0.75)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C157(0.80)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C157(1.10)  LDD0712  [7]
 LDCM0396  CL125 HEK-293T C141(1.10); C438(1.19)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C141(1.37); C438(0.85)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C141(0.99); C438(2.04)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C141(0.96); C438(1.23)  LDD0997  [7]
 LDCM0400  CL13 HCT 116 C157(0.84); C544(0.89); C141(0.93); C136(1.00)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C141(0.84); C157(0.85); C544(0.96); C136(1.14)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C136(0.92); C544(0.93); C157(0.99); C141(1.93)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C438(0.99); C454(0.99); C544(1.23)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C438(0.74); C454(0.74); C544(0.98)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C544(1.01); C438(1.38); C454(1.38)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C544(0.93); C438(1.14); C454(1.14)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C544(0.95); C136(1.02); C157(1.22); C141(1.23)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C544(1.00); C438(1.14); C454(1.14)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C544(1.05); C438(2.01); C454(2.01)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C544(0.81); C438(1.42); C454(1.42)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C544(1.04); C438(1.50); C454(1.50)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C544(1.21); C438(1.30); C454(1.30)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C438(1.35); C454(1.35); C544(1.19)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C438(1.47); C454(1.47); C544(1.18)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C438(1.35); C454(1.35); C544(0.92)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C438(1.17); C454(1.17); C544(1.06)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C438(1.26); C454(1.26); C544(1.09)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C141(1.16); C136(0.80); C157(0.77); C544(1.09)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C438(1.54); C454(1.54); C544(1.04)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C141(2.47)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C141(1.18); C544(1.57)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C141(1.53); C544(1.48)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C141(1.68); C544(0.87)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C141(1.13); C544(1.06)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C141(1.91); C544(0.72)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C141(1.22); C544(0.95)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C141(1.04); C544(1.01)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C141(10.85); C136(1.21); C157(0.93); C544(0.91)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C141(4.17); C544(1.10)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C141(0.92); C544(0.90)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C141(1.35); C544(0.81)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C141(1.11); C544(0.85)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C141(1.65); C544(0.95)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C141(3.63); C544(0.89)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C141(1.08); C157(0.99); C438(0.71); C450(0.59)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C141(1.23); C157(1.07); C438(0.69); C450(0.58)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C141(1.01); C157(0.83); C438(0.86); C450(0.59)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C141(1.03); C157(1.08); C438(1.00); C450(0.56)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C141(1.01); C136(1.06); C157(0.97); C544(0.88)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C141(1.11); C157(0.92); C438(0.89); C450(0.66)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C141(1.12); C157(0.88); C438(0.88); C450(0.63)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C141(0.88); C157(1.04); C438(1.02); C450(1.04)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C141(1.42); C157(0.85); C438(1.26); C450(0.90)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C141(1.04); C157(0.85); C438(0.86); C450(0.81)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C141(0.69); C157(0.92); C438(0.96); C450(0.67)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C141(1.04); C157(0.90); C438(0.83); C450(0.67)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C141(1.42); C157(0.87); C438(0.87); C450(0.55)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C141(0.68); C157(1.19); C438(1.02); C450(0.73)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C141(0.95); C157(1.04); C438(0.99); C450(0.73)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C141(1.10); C136(0.89); C157(0.89); C544(1.11)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C141(1.07); C157(1.02); C438(1.02); C450(0.69)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C141(1.25); C157(1.59)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C141(1.45); C157(1.09)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C141(1.63); C157(0.91)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C141(2.73); C157(1.05)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C141(1.39); C157(0.86)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C141(2.61); C157(0.83)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C141(1.60); C157(0.89)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C141(1.76); C157(0.69)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C141(1.47); C157(0.93)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C141(1.16); C136(0.93); C157(0.96); C544(0.74)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C141(1.37); C157(0.93)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C141(2.99); C157(0.88)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C141(1.19); C157(0.86)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C141(2.19); C157(1.06)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C141(1.75); C157(1.00)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C157(0.70); C544(0.77)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C157(0.72); C544(0.74)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C157(0.78); C544(1.24)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C157(0.79); C544(0.66)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C141(1.15); C136(1.02); C157(0.92); C544(1.57)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C157(0.88); C544(0.87)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C157(0.61); C544(0.76)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C157(0.65); C544(0.56)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C157(0.60); C544(0.79)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C157(0.52); C544(1.07)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C157(0.65); C544(0.78)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C157(0.66); C544(0.81)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C157(0.46); C544(0.60)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C157(0.62); C544(0.73)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C157(0.52); C544(0.65)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C141(2.03); C136(0.87); C157(0.93); C544(1.02)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C157(0.59); C544(0.97)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C141(0.90); C157(0.59); C450(0.67); C454(0.67)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C141(1.64); C157(0.77); C450(0.61); C454(0.61)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C141(0.91); C157(0.61); C450(0.77); C454(0.77)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C141(1.03); C157(0.76); C450(0.90); C454(0.90)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C141(6.95); C157(0.98); C450(0.85); C454(0.85)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C141(0.95); C157(0.70); C450(0.82); C454(0.82)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C141(1.23); C157(0.59); C450(0.96); C454(0.96)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C141(1.25); C157(0.53); C450(0.91); C454(0.91)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C141(1.02); C157(0.64); C450(0.83); C454(0.83)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C544(1.06); C559(0.81); C141(2.48); C710(0.98)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C157(0.76)  LDD1702  [16]
 LDCM0625  F8 Ramos C544(1.05)  LDD2187  [17]
 LDCM0574  Fragment12 Ramos C544(1.24)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C544(0.82)  LDD2192  [17]
 LDCM0579  Fragment20 Ramos C544(0.98)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C544(0.93)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C544(1.17)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C544(0.89)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C544(0.72)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C544(1.19)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C544(0.90)  LDD2200  [17]
 LDCM0468  Fragment33 HCT 116 C141(1.73); C157(0.75)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C544(0.62)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C544(1.16)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C141(20.00); C544(1.10)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C544(1.22)  LDD2204  [17]
 LDCM0569  Fragment7 Ramos C544(1.46)  LDD2186  [17]
 LDCM0022  KB02 HCT 116 C571(6.87); C590(6.87); C589(6.87)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C571(2.35); C590(2.35); C589(2.35)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C571(5.12); C590(5.12); C589(5.12)  LDD0082  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C544(0.24)  LDD2207  [18]
 LDCM0029  Quercetin HEK-293T 9.22  LDD0181  [3]
 LDCM0021  THZ1 HCT 116 C589(1.09); C571(1.50); C573(1.50); C590(1.50)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-binding protein 1 (DDB1) DDB1 family Q16531

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.