Details of the Target

General Information of Target

Target ID LDTP11719
Target Name NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1)
Gene Name WWP1
Gene ID 11059
Synonyms
NEDD4-like E3 ubiquitin-protein ligase WWP1; EC 2.3.2.26; Atrophin-1-interacting protein 5; AIP5; HECT-type E3 ubiquitin transferase WWP1; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYG
FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPID
PEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMR
IMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQ
HLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPL
ERGQVQMSDPRAPIPRGPVTPGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQ
GPPMHHASGHDTRGPSSHEMRGGPLGDPRLLIGEPRGPMIDQRGLPMDGRGGRDSRAMET
RAMETEVLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPVPSSRGPMTGGIQGPGP
INIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQGAGIQGGGMQGAGIQGVSIQG
GGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQ
SILILKEQIQKSTGAS
Target Type
Literature-reported
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
TTD ID
T91154
Uniprot ID
Q9H0M0
DrugMap ID
TTBWMKT
Ensemble ID
ENST00000265428.4
HGNC ID
HGNC:17004

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DAOY SNV: p.Q431Ter DBIA    Probe Info 
HCT15 SNV: p.L789I .
HT115 SNV: p.F678L; p.R819Q .
IGR1 Insertion: p.T469NfsTer10 DBIA    Probe Info 
JURKAT SNV: p.S444L .
LNCaP clone FGC SNV: p.V257I DBIA    Probe Info 
NCIH446 SNV: p.G171Ter .
TOV21G SNV: p.A449T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C890(1.62)  LDD1700  [1]
NAIA_5
 Probe Info  		C335(2.54)  LDD2227  [2]
DBIA
 Probe Info  		C335(1.42)  LDD0080  [3]
IA-alkyne
 Probe Info  		C854(0.00); C890(0.00)  LDD0167  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C890(0.44)  LDD2095  [1]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C890(0.99)  LDD2130  [1]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C890(1.06)  LDD2117  [1]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C890(1.11)  LDD2152  [1]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C890(0.35)  LDD2132  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C890(2.18)  LDD0372  [5]
 LDCM0214  AC1 HCT 116 C335(1.25); C854(1.06); C890(0.95)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C335(1.32); C854(1.21); C890(1.51)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C854(0.95); C890(0.95)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C854(0.79); C890(0.92)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C854(0.73); C890(1.08)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C854(0.82); C890(1.41)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C854(0.84); C890(1.01)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C854(0.81); C890(1.02)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C854(0.84); C890(1.09)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C854(0.89); C890(1.14)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C854(0.87); C890(0.96)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C854(0.82); C890(0.94)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C335(1.35); C854(1.05); C890(1.30)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C854(0.76); C890(0.92)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C854(0.74); C890(1.08)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C854(0.78); C890(1.06)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C335(1.03); C854(0.92); C890(1.06)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C335(1.06); C854(0.92); C890(1.00)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C335(1.42); C854(0.92); C890(1.13)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C335(1.44); C854(0.84); C890(1.12)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C335(1.46); C854(0.99); C890(1.13)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C335(1.06); C854(0.90); C890(1.09)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C335(1.22); C854(0.91); C890(1.07)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C335(1.36); C854(1.08); C890(1.27)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C335(1.28); C854(0.87); C890(1.22)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C335(1.15); C854(1.34); C890(0.92)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C335(1.28); C854(1.13); C890(0.95)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C335(1.44); C854(1.19); C890(1.05)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C335(1.17); C854(1.21); C890(0.97)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C335(1.01); C854(1.02); C890(1.03)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C335(1.19); C854(1.15); C890(1.12)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C335(1.61); C854(1.07); C890(0.99)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C854(1.55); C890(1.18)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C854(1.35); C890(1.27)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C854(1.21); C890(1.25)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C854(1.21); C890(1.14)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C854(1.23); C890(1.14)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C854(1.19); C890(1.16)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C854(1.36); C890(1.25)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C854(1.26); C890(1.25)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C854(1.18); C890(1.16)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C854(1.16); C890(1.28)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C854(1.53); C890(1.24)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C854(1.27); C890(1.09)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C335(1.16); C854(0.92); C890(1.30)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C854(1.19); C890(1.31)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C854(1.33); C890(1.27)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C854(1.18); C890(1.07)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C335(0.85); C890(0.98); C854(1.07)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C854(1.08); C890(1.20); C335(1.88)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C335(1.15); C890(1.18); C854(1.30)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C854(0.99); C890(1.20); C335(2.15)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C854(1.14); C890(1.22); C335(2.14)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C854(1.09); C890(1.36); C335(2.82)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C854(0.96); C890(1.27); C335(2.32)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C854(1.12); C335(1.24); C890(1.25)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C890(1.08); C854(1.09); C335(1.26)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C854(1.00); C335(1.22); C890(1.26)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C854(1.06); C890(1.29); C335(2.13)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C854(1.04); C890(1.52); C335(2.74)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C335(1.76); C854(1.43); C890(1.13)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C335(1.57); C854(1.09); C890(1.18)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C335(0.92); C854(1.07); C890(1.07)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C335(1.72); C854(0.98); C890(1.11)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C890(0.96); C335(1.07); C854(1.17)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C890(1.06); C854(1.16); C335(1.32)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C890(0.93); C335(1.19); C854(1.27)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C890(0.96); C854(1.14); C335(1.25)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C335(1.05); C890(1.12); C854(1.22)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C890(1.00); C335(1.10); C854(1.24)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C890(0.85); C335(1.07); C854(1.08)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C890(0.95); C335(1.08); C854(1.28)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C890(0.96); C335(1.04); C854(1.28)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C335(0.78); C890(0.93); C854(1.08)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C854(1.03); C335(1.03); C890(1.04)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C335(0.89); C854(0.95); C890(0.98)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C854(1.02); C890(1.07); C335(1.92)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C854(0.92); C335(1.11); C890(1.12)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C890(0.86); C854(1.03); C335(1.25)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C854(0.92); C890(1.10); C335(1.27)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C890(1.03); C854(1.06); C335(1.15)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C854(0.91); C890(1.19); C335(1.49)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C854(0.86); C890(0.97); C335(1.06)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C854(0.93); C890(1.12); C335(1.38)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C335(0.80); C854(1.18); C890(1.26)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C890(0.94); C335(0.97); C854(0.98)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C854(0.80); C335(0.90); C890(1.01)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C890(0.94); C335(0.99); C854(1.08)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C335(1.00); C890(1.01); C854(1.27)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C890(0.89); C854(1.18); C335(1.29)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C854(0.94); C890(1.10); C335(1.12)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C854(0.73); C335(1.01); C890(1.02)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C854(0.93); C890(1.07); C335(1.12)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C854(0.80); C890(1.02); C335(1.24)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C854(0.87); C335(1.04); C890(1.08)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C854(0.75); C335(1.09); C890(1.11)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C854(0.87); C890(1.05)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C854(1.02); C890(1.07)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C854(1.05); C890(1.06)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C854(0.92); C890(1.35)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C890(0.93); C335(1.05); C854(1.25)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C854(0.93); C890(1.12)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C890(0.92); C854(1.05)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C890(0.98); C854(1.12)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C890(0.92); C854(1.04)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C890(0.95); C854(1.31)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C854(0.85); C890(1.09)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C854(1.00); C890(1.20)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C854(0.87); C335(0.97); C890(1.22)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C854(0.83); C890(0.93); C335(1.06)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C854(0.85); C335(1.13); C890(1.36)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C854(0.89); C890(1.13); C335(1.18)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C854(0.77); C335(1.20); C890(1.61)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C854(0.80); C335(0.89); C890(1.36)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C854(0.82); C335(1.02); C890(1.35)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C854(0.80); C335(1.31); C890(1.35)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C854(0.81); C335(1.15); C890(1.22)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C854(0.97); C335(1.08); C890(1.31)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C854(1.01); C335(1.05); C890(1.19)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C854(0.83); C335(1.03); C890(1.17)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C335(0.69); C854(0.99); C890(1.06)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C335(0.80); C854(1.04); C890(1.19)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C854(1.10); C335(1.18); C890(1.28)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C854(1.03); C335(1.12); C890(1.17)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C335(0.79); C890(1.08); C854(1.12)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C854(0.94); C890(1.03); C335(1.09)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C854(0.99); C335(1.13); C890(1.29)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C854(1.01); C890(1.18); C335(1.20)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C854(1.01); C890(1.43); C335(2.47)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C335(0.89); C854(1.04); C890(1.20)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C335(0.77); C854(0.92); C890(1.10)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C854(0.96); C890(1.02); C335(1.03)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C335(0.86); C854(0.95); C890(1.08)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C854(1.00); C335(1.16); C890(1.42)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C335(0.82); C854(0.94); C890(1.05)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C854(1.06); C890(1.06); C335(1.22)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C854(0.95); C890(1.26); C335(1.29)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C854(0.82); C890(0.93)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C854(0.97); C890(1.05)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C854(0.89); C890(0.96)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C854(0.90); C890(1.07)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C890(0.79); C854(1.00)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C854(1.06); C890(1.12)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C854(0.91); C890(1.02)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C890(0.94); C854(1.28)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C890(0.85); C854(0.91)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C890(0.87); C854(0.89)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C890(0.93); C854(1.04)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C854(1.03); C890(1.04)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C854(0.87); C890(0.97)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C890(0.89); C854(1.03)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C854(0.83); C890(0.95)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C854(0.66); C890(1.13)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C854(0.86); C890(1.01)  LDD0683  [3]
 LDCM0545  Acetamide MDA-MB-231 C890(0.43)  LDD2138  [1]
 LDCM0248  AKOS034007472 HCT 116 C335(1.09); C854(1.11); C890(1.12)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C854(1.03); C890(1.11); C335(1.17)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C854(1.03); C890(1.83); C335(2.01)  LDD0592  [3]
 LDCM0498  BS-3668 MDA-MB-231 C890(0.68)  LDD2091  [1]
 LDCM0632  CL-Sc Hep-G2 C335(2.54)  LDD2227  [2]
 LDCM0367  CL1 HCT 116 C854(0.91); C890(1.13)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C854(0.99); C890(1.28)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C890(0.87); C854(1.03); C335(1.20)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C854(0.88); C890(1.25); C335(1.29)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C854(1.01); C335(1.05); C890(1.07)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C335(0.99); C854(1.17); C890(1.29)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C335(0.99); C854(1.08); C890(1.11)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C854(1.02); C890(1.05); C335(1.35)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C890(1.18); C335(1.36); C854(1.66)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C854(1.20); C890(1.21); C335(1.25)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C890(1.08); C854(1.27); C335(1.82)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C890(0.97); C854(1.04); C335(1.37)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C854(1.00); C890(1.09)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C890(1.07); C854(1.22); C335(1.47)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C890(1.03); C335(1.10); C854(1.14)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C335(0.96); C854(1.01); C890(1.03)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C854(0.94); C890(1.11); C335(1.14)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C854(0.81); C890(1.03); C335(1.06)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C854(0.85); C890(1.04); C335(1.18)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C854(0.91); C335(0.95); C890(1.04)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C890(1.06); C335(1.28); C854(1.30)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C854(0.84); C335(1.14); C890(1.14)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C854(0.94); C890(1.07); C335(1.18)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C854(0.99); C890(1.18)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C854(0.85); C890(1.05); C335(1.08)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C854(0.75); C890(0.92)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C854(0.84); C890(1.04)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C890(1.00); C854(1.04)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C854(0.83); C890(0.95)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C890(1.03); C854(1.05); C335(1.08)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C335(0.92); C890(1.27); C854(1.50)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C335(1.03); C854(1.04); C890(1.10)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C854(0.84); C335(1.09); C890(1.25)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C854(1.01); C890(1.08)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C854(0.97); C890(1.07)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C890(1.08); C854(1.14)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C890(0.90); C854(0.92)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C854(0.97); C890(1.09)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C854(0.73); C890(1.05)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C854(0.89); C890(0.98)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C854(0.94); C890(1.21)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C854(0.78); C890(1.20)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C854(0.92); C890(1.00)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C854(0.88); C890(1.25)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C854(0.83); C890(1.17)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C854(0.83); C890(1.16)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C854(0.93); C890(1.07)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C854(0.87); C890(1.01)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C854(0.84); C890(1.05)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C854(0.77); C890(0.93)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C854(0.77); C890(1.03)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C854(1.07); C890(1.05)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C854(0.96); C890(1.04)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C335(0.97); C854(0.95); C890(0.94)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C335(0.94); C854(0.87); C890(0.94)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C335(1.19); C854(0.87); C890(1.07)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C335(1.38); C854(0.86); C890(1.12)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C335(1.23); C854(0.84); C890(0.88)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C335(1.48); C854(0.92); C890(1.03)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C335(1.15); C854(0.88); C890(1.18)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C335(1.14); C854(1.04); C890(1.07)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C854(0.87); C890(1.06)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C335(1.17); C854(0.94); C890(0.96)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C335(1.07); C854(0.95); C890(0.87)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C335(1.48); C854(1.07); C890(0.87)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C335(1.15); C854(0.91); C890(0.92)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C335(1.31); C854(0.90); C890(1.00)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C335(1.18); C854(0.99); C890(0.92)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C335(1.23); C854(0.82); C890(1.03)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C335(1.41); C854(0.82); C890(1.16)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C335(1.25); C854(0.83); C890(0.94)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C335(1.06); C854(0.96); C890(0.96)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C854(1.08); C890(1.13)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C335(1.03); C854(0.93); C890(0.94)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C335(1.42); C854(0.94); C890(0.93)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C335(1.47); C854(0.83); C890(1.13)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C335(1.19); C854(0.86); C890(1.31)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C335(1.48); C854(0.89); C890(1.05)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C335(1.10); C854(1.08); C890(0.99)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C335(1.10); C854(0.88); C890(1.18)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C335(1.10); C854(0.96); C890(1.12)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C335(1.35); C854(0.82); C890(0.94)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C335(1.21); C854(1.00); C890(0.92)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C854(0.86); C890(1.02)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C335(1.51); C854(0.85); C890(1.01)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C335(1.21); C854(0.98); C890(1.14)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C335(1.16); C854(1.05); C890(1.25)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C335(1.00); C854(1.08); C890(1.17)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C335(1.04); C854(1.02); C890(1.11)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C335(1.09); C854(1.03); C890(1.03)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C335(1.00); C854(1.16); C890(1.15)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C335(0.98); C854(1.05); C890(1.11)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C335(0.87); C854(1.02); C890(1.11)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C335(1.01); C854(0.85); C890(1.04)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C854(0.99); C890(1.38)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C335(1.01); C854(1.03); C890(0.93)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C335(0.96); C854(1.05); C890(0.99)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C335(1.13); C854(1.04); C890(1.04)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C335(1.06); C854(1.03); C890(0.99)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C335(0.99); C854(1.05); C890(1.04)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C335(0.80); C854(1.12); C890(1.19)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C335(0.97); C854(1.09); C890(1.28)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C335(0.91); C854(1.02); C890(1.16)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C335(0.91); C854(1.12); C890(1.33)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C854(0.94); C890(1.33)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C335(0.76); C854(0.98); C890(1.21)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C335(0.91); C854(1.24); C890(1.23)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C335(0.84); C854(1.24); C890(1.28)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C335(1.06); C854(1.25); C890(1.46)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C335(0.96); C854(1.06); C890(1.43)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C335(0.94); C854(1.27); C890(1.12)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C335(0.98); C854(1.31); C890(1.21)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C335(0.90); C854(1.36); C890(1.24)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C335(0.80); C854(1.36); C890(1.29)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C335(0.85); C854(1.14); C890(1.36)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C854(0.86); C890(1.08)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C335(1.02); C854(1.37); C890(0.96)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C335(1.15); C854(1.13); C890(1.00)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C335(0.82); C854(1.32); C890(1.09)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C335(1.04); C854(1.22); C890(1.04)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C335(1.33); C854(1.16); C890(0.87)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C335(1.07); C854(1.13); C890(1.08)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C335(1.22); C854(1.12); C890(1.25)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C335(1.37); C854(1.02); C890(0.97)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C335(1.32); C854(1.17); C890(0.86)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C335(1.02); C854(1.09); C890(1.32)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C890(1.17); C854(1.08)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C335(1.42); C854(1.09); C890(0.98)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C335(1.20); C854(0.94); C890(0.99)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C335(1.42)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C335(1.34)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C335(1.88)  LDD0082  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C890(1.07)  LDD2093  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C890(1.17)  LDD2099  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C890(1.00)  LDD2107  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C890(1.23)  LDD2111  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C890(1.03); C854(1.00)  LDD2123  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C890(1.13)  LDD2127  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C890(1.13)  LDD2136  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C890(1.22)  LDD2137  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C890(1.62)  LDD1700  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C890(1.70)  LDD2144  [1]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C890(0.53)  LDD2150  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin domain-containing protein 1 (ARRDC1) Arrestin family Q8N5I2
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) RRM CPSF6/7 family Q16630

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 14 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 103582 Antisense drug D09GRF
Isis 103601 Antisense drug D0V8KZ
Isis 103612 Antisense drug D0I8BN
Isis 103613 Antisense drug D0M2PZ
Isis 103615 Antisense drug D04CLQ
Isis 103616 Antisense drug D01NSO
Isis 103619 Antisense drug D08IBR
Isis 103620 Antisense drug D0T5RJ
Isis 103621 Antisense drug D0K8XK
Isis 103622 Antisense drug D0TS6S
Isis 103624 Antisense drug D06GOO
Isis 103629 Antisense drug D0P2AR
Isis 103631 Antisense drug D0AD7L
Isis 103635 Antisense drug D0Y9ZR

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402