Details of the Target

General Information of Target

Target ID LDTP11577
Target Name Protein sprouty homolog 4 (SPRY4)
Gene Name SPRY4
Gene ID 81848
Synonyms
Protein sprouty homolog 4; Spry-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF
SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
Target Bioclass
Other
Family
Sprouty family
Subcellular location
Cytoplasm
Function
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin.
Uniprot ID
Q9C004
Ensemble ID
ENST00000434127.3
HGNC ID
HGNC:15533

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 Deletion: p.R174GfsTer85 .
HEC1 SNV: p.P78L DBIA    Probe Info 
HEC1B SNV: p.T86A .
MEWO SNV: p.P246L DBIA    Probe Info 
MOLT4 Deletion: p.R174GfsTer85 .
NALM6 SNV: p.P72S .
REH SNV: p.N183S .
SKMM2 SNV: p.R174L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		C138(0.00); C283(0.00)  LDD0241  [2]
BTD
 Probe Info  		C138(1.17)  LDD2101  [3]
AHL-Pu-1
 Probe Info  		C138(4.28)  LDD0169  [4]
DBIA
 Probe Info  		C159(1.30); C162(1.30)  LDD0078  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [6]
W1
 Probe Info  		N.A.  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C138(4.28)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C138(0.80); C159(0.91); C162(0.93); C283(0.73)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C138(1.02); C159(0.99); C162(0.99); C283(1.21)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C138(0.94); C159(0.89); C162(0.89); C283(1.06)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C138(0.83); C159(0.87); C162(0.87); C283(1.18)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C138(0.94); C159(0.98); C162(0.98); C283(1.16)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C138(1.05); C159(1.12); C162(1.10); C283(1.30)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C138(0.90); C159(0.98); C162(0.98); C283(1.08)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C138(0.93); C159(1.09); C162(1.08); C283(1.23)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C138(0.90); C159(1.02); C162(1.00); C283(1.21)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C138(0.98); C159(0.79); C162(1.18); C283(1.06)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C138(1.09); C159(0.80); C162(0.95); C283(1.15)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C138(0.99); C159(0.75); C162(0.86); C283(1.12)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C138(1.06); C159(1.03); C162(1.03); C283(1.16)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C138(1.14); C159(0.78); C162(0.89); C283(1.31)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C138(1.01); C159(0.78); C162(0.90); C283(1.23)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C138(1.06); C159(0.80); C162(1.05); C283(1.18)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C159(1.01); C162(1.01); C283(0.91)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C159(1.08); C162(1.08); C283(0.90)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C159(1.22); C162(1.22); C283(0.89)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C159(1.25); C162(1.25); C283(1.03)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C159(1.04); C162(1.04); C283(1.12)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C159(1.12); C162(1.12); C283(1.04)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C159(1.03); C162(1.03); C283(1.04)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C138(1.00); C159(0.90); C162(0.90); C283(1.08)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C159(1.19); C162(1.19); C283(0.97)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C159(1.06); C162(1.06); C283(1.23)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C159(1.16); C162(1.16); C283(1.05)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C159(0.99); C162(0.99); C283(1.03)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C159(1.05); C162(1.05); C283(1.12)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C159(1.05); C162(1.05); C283(0.93)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C159(1.19); C162(1.19); C283(0.91)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C159(1.10); C162(1.10); C283(1.06)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C159(1.08); C162(1.08); C283(0.61)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C159(0.68); C162(0.68); C283(0.58)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C159(0.84); C162(0.84); C283(0.68)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C159(0.70); C162(0.70); C283(0.77)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C159(0.74); C162(0.74); C283(0.65)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C159(0.86); C162(0.86); C283(0.70)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C159(0.88); C162(0.88); C283(0.81)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C159(0.94); C162(0.94); C283(0.65)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C159(0.91); C162(0.91); C283(0.93)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C159(0.89); C162(0.89); C283(0.85)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C159(0.98); C162(0.98); C283(1.52)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C159(0.82); C162(0.82); C283(0.87)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C138(0.87); C159(0.97); C162(0.97); C283(1.30)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C159(0.88); C162(0.88); C283(1.21)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C159(0.92); C162(0.92); C283(1.10)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C159(0.80); C162(0.80); C283(0.85)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C162(0.97); C159(0.97); C138(1.11); C283(1.12)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C138(0.92); C162(1.14); C159(1.17); C283(1.19)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C162(0.99); C159(1.01); C138(1.03); C283(1.11)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C162(1.04); C159(1.08); C138(1.09); C283(1.26)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C138(0.96); C162(1.12); C159(1.14); C283(1.31)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C162(1.29); C138(1.41); C159(1.54); C283(1.54)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C162(1.09); C159(1.24); C283(1.36); C138(1.43)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C138(0.87); C283(0.91); C159(0.94); C162(0.94)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C162(1.00); C159(1.04); C138(1.11); C283(1.18)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C138(0.96); C162(1.03); C159(1.09); C283(1.12)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C138(0.97); C162(1.22); C159(1.27); C283(1.34)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C162(1.36); C138(1.46); C159(1.48); C283(1.52)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C138(0.93); C159(1.08); C162(1.04); C283(1.23)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C138(1.09); C159(1.21); C162(1.13); C283(1.23)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C138(1.15); C159(1.05); C162(1.00); C283(1.11)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C138(1.06); C159(1.04); C162(0.97); C283(1.05)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C283(0.78); C159(0.91); C162(0.94); C138(0.97)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C159(0.91); C162(0.98); C283(1.14); C138(1.18)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C159(0.90); C283(0.94); C162(0.95); C138(1.00)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C283(0.76); C162(0.82); C159(0.83); C138(0.89)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C138(1.06); C283(1.08); C159(1.15); C162(1.23)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C159(0.95); C162(1.02); C283(1.03); C138(1.07)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C283(0.92); C138(1.03); C159(1.06); C162(1.12)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C159(0.86); C162(0.88); C138(0.97); C283(1.02)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C159(0.87); C162(0.88); C283(0.93); C138(0.95)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C138(0.91); C283(0.95); C159(1.20); C162(1.22)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C283(1.00); C138(1.10); C159(1.16); C162(1.18)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C138(1.14); C283(1.15); C159(1.16); C162(1.20)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C159(1.14); C138(1.20); C162(1.23); C283(1.27)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C138(1.15); C283(1.20); C159(1.21); C162(1.25)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C283(0.72); C138(0.79); C162(0.80); C159(0.80)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C138(1.14); C159(1.22); C162(1.23); C283(1.25)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C138(1.07); C283(1.10); C162(1.14); C159(1.15)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C159(1.19); C162(1.20); C138(1.24); C283(1.27)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C138(1.05); C283(1.20); C159(1.31); C162(1.39)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C159(1.13); C138(1.14); C162(1.17); C283(1.53)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C283(0.89); C138(0.91); C159(0.95); C162(0.95)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C138(0.87); C159(1.02); C162(1.02); C283(1.05)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C283(0.81); C138(0.94); C159(1.14); C162(1.14)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C138(0.96); C159(0.99); C162(0.99); C283(1.11)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C283(0.99); C138(1.00); C159(1.05); C162(1.05)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C283(0.66); C138(0.76); C162(0.90); C159(0.90)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C283(1.00); C138(1.06); C159(1.24); C162(1.24)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C283(0.85); C138(0.95); C159(1.11); C162(1.11)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C159(1.01); C162(1.01); C138(1.03); C283(1.09)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C283(0.82); C138(1.03); C159(1.11); C162(1.11)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C283(0.75); C138(1.02); C159(1.11); C162(1.11)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C283(0.74); C138(1.06); C159(1.21); C162(1.21)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C162(0.94); C159(0.97); C138(1.12); C283(1.13)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C283(1.03); C138(1.05); C162(1.07); C159(1.08)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C162(0.94); C159(0.96); C138(1.06); C283(1.09)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C283(1.12); C162(1.34); C159(1.37); C138(1.38)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C283(0.65); C138(0.75); C159(0.87); C162(0.88)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C283(1.15); C162(1.20); C159(1.24); C138(1.33)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C138(0.92); C162(0.93); C159(0.95); C283(1.10)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C138(1.04); C162(1.06); C159(1.06); C283(1.12)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C162(1.00); C159(1.02); C283(1.04); C138(1.22)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C283(1.08); C138(1.20); C162(1.25); C159(1.28)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C283(1.09); C159(1.31); C162(1.32); C138(1.37)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C283(1.20); C162(1.42); C159(1.44); C138(1.57)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C283(0.83); C162(1.02); C159(1.05); C138(1.09)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C283(0.98); C162(1.04); C159(1.06); C138(1.14)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C283(1.06); C162(1.10); C159(1.11); C138(1.15)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C159(0.99); C162(0.99); C138(1.05); C283(1.09)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C162(1.08); C159(1.10); C138(1.16); C283(1.20)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C283(0.94); C159(1.03); C162(1.06); C138(1.09)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C138(1.00); C283(1.07); C162(1.12); C159(1.14)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C138(0.97); C162(1.02); C159(1.05); C283(1.24)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C283(1.11); C162(1.11); C138(1.14); C159(1.15)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C283(1.01); C162(1.02); C159(1.03); C138(1.19)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C162(0.97); C159(0.99); C283(1.02); C138(1.12)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C138(1.04); C162(1.05); C159(1.07); C283(1.25)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C162(1.00); C159(1.07); C138(1.18)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C162(0.99); C159(1.07); C138(1.21)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C159(0.95); C162(0.95); C283(0.96); C138(1.07)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C162(1.22); C159(1.25); C138(1.28)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C162(0.81); C159(0.90); C138(1.14)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C162(0.86); C159(0.94); C138(1.22)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C162(1.05); C159(1.14); C138(1.55)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C162(1.04); C159(1.16); C138(1.39)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C162(1.17); C159(1.31); C138(1.57)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C162(0.87); C159(0.96); C138(1.17)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C162(0.98); C159(1.05); C138(1.20)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C162(0.86); C159(0.93); C138(1.06)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C162(0.79); C159(0.90); C138(1.18)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C283(0.96); C138(0.99); C159(1.00); C162(1.00)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C162(0.85); C159(0.95); C138(1.17)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C162(0.79); C159(0.88); C138(1.08)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C162(1.10); C159(1.25); C138(1.51)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C159(1.26); C162(1.26); C138(1.36); C283(1.40)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C138(1.24); C159(1.24); C162(1.24); C283(1.47)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C159(1.05); C162(1.05); C138(1.21); C283(1.25)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C159(1.01); C162(1.01); C138(1.16); C283(1.17)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C159(0.94); C162(0.94); C283(1.09); C138(1.11)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C159(1.06); C162(1.06); C138(1.06); C283(1.30)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C159(1.07); C162(1.07); C138(1.16); C283(1.23)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C159(1.02); C162(1.02); C283(1.03); C138(1.12)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C283(1.23); C159(1.35); C162(1.35); C138(1.44)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C283(1.27); C159(1.29); C162(1.29); C138(1.42)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C159(1.10); C162(1.10); C283(1.15); C138(1.21)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C159(0.99); C162(0.99); C283(1.13); C138(1.15)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C159(0.96); C162(0.96); C138(1.10); C283(1.25)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C159(1.09); C162(1.09); C283(1.15); C138(1.28)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C159(1.17); C162(1.17); C138(1.44); C283(1.49)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C138(1.00); C162(1.17); C159(1.20); C283(1.25)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C162(0.82); C159(0.84); C138(0.98); C283(1.19)  LDD0683  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C138(0.92)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C138(1.05); C159(0.84); C162(0.84); C283(0.98)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C159(1.04); C162(1.04); C138(1.05); C283(1.15)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C283(0.95); C138(1.01); C159(1.26); C162(1.26)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.74  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C159(1.30); C162(1.30)  LDD0078  [5]
 LDCM0367  CL1 HCT 116 C159(0.90); C162(0.90); C283(0.92); C138(1.06)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C138(1.01); C159(1.06); C162(1.06); C283(1.07)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C283(0.62); C138(0.81); C159(0.91); C162(0.93)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C283(0.82); C138(0.95); C159(1.10); C162(1.10)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C283(0.83); C159(0.94); C162(0.94); C138(0.95)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C138(0.88); C159(0.89); C162(0.89); C283(0.99)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C159(0.84); C162(0.84); C283(0.87); C138(0.92)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C283(0.86); C159(0.89); C162(0.94); C138(1.09)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C159(0.90); C162(0.96); C283(1.07); C138(1.22)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C159(0.89); C162(0.93); C283(1.03); C138(1.23)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C159(0.88); C283(0.88); C162(0.95); C138(1.22)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C159(0.89); C162(0.93); C283(0.94); C138(1.11)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C138(1.06); C283(1.26); C159(1.43); C162(1.43)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C283(0.79); C159(0.83); C162(0.83); C138(1.02)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C283(0.88); C159(0.89); C162(0.94); C138(1.04)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C159(0.96); C162(0.97); C138(1.04); C283(1.11)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C138(1.11); C159(1.17); C162(1.21); C283(1.26)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C162(1.04); C159(1.06); C138(1.11); C283(1.29)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C138(1.11); C159(1.17); C162(1.17); C283(1.24)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C138(1.07); C159(1.20); C283(1.21); C162(1.25)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C283(1.08); C138(1.35); C159(1.45); C162(1.45)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C283(0.85); C159(1.06); C162(1.06); C138(1.09)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C283(0.73); C138(1.02); C159(1.10); C162(1.10)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C138(1.10); C283(1.29); C159(1.41); C162(1.41)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C283(0.83); C138(0.92); C159(1.10); C162(1.10)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C283(1.03); C138(1.10); C162(3.10); C159(3.11)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C162(1.00); C159(1.05); C138(1.16); C283(1.28)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C162(1.00); C159(1.05); C283(1.22); C138(1.26)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C162(1.12); C159(1.13); C283(1.16); C138(1.29)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C162(0.88); C159(0.91); C283(1.04); C138(1.10)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C162(0.91); C159(0.92); C138(1.05); C283(1.12)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C162(1.00); C159(1.01); C138(1.10); C283(1.19)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C283(0.93); C162(1.16); C159(1.18); C138(1.20)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C138(1.03); C283(1.10); C159(1.12); C162(1.12)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C159(0.92); C162(0.92); C283(0.93); C138(0.97)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C138(0.95); C283(1.15); C159(1.31); C162(1.31)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C138(0.99); C283(1.02); C159(1.40); C162(1.40)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C283(0.96); C138(0.98); C159(1.12); C162(1.12)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C283(0.98); C138(1.07); C159(1.37); C162(1.37)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C283(1.08); C138(1.09); C159(1.33); C162(1.33)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C283(0.97); C159(0.99); C162(0.99); C138(1.08)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C138(1.01); C283(1.08); C159(1.49); C162(1.49)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C138(1.02); C283(1.25); C159(1.45); C162(1.45)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C138(1.21); C283(1.60); C159(1.91); C162(1.91)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C138(1.04); C283(1.12); C159(1.39); C162(1.39)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C138(0.95); C159(1.67); C162(1.67); C283(1.35)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C138(0.93); C159(1.58); C162(1.58); C283(1.18)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C138(0.88); C159(1.38); C162(1.38); C283(1.07)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C138(0.99); C159(1.39); C162(1.39); C283(1.05)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C138(0.95); C159(1.42); C162(1.42); C283(1.10)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C138(1.06); C159(1.48); C162(1.48); C283(1.14)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C138(1.06); C159(1.03); C162(1.03); C283(1.00)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C138(0.74); C159(1.34); C162(1.34); C283(0.94)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C138(1.03); C159(0.97); C162(0.97); C283(0.93)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C138(1.02); C159(1.02); C162(1.02); C283(0.96)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C138(1.02); C159(1.03); C162(1.03); C283(0.96)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C138(1.21); C159(1.11); C162(1.11); C283(0.80)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C138(1.24); C159(1.12); C162(1.12); C283(1.09)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C138(1.15); C159(1.01); C162(1.01); C283(1.30)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C138(1.26); C159(1.14); C162(1.14); C283(1.02)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C138(1.26); C159(1.17); C162(1.17); C283(1.13)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C138(1.10); C159(1.14); C162(1.14); C283(1.10)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C138(1.10); C159(1.10); C162(1.10); C283(1.50)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C138(1.09); C159(1.03); C162(1.03); C283(0.85)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C138(1.43); C159(1.22); C162(1.22); C283(1.15)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C138(1.16); C159(1.20); C162(1.20); C283(0.87)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C138(1.07); C159(1.09); C162(1.09); C283(0.97)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C138(1.17); C159(1.17); C162(1.17); C283(0.81)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C138(0.93); C159(0.82); C162(0.82); C283(0.88)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C138(0.92); C159(0.85); C162(0.85); C283(0.96)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C138(0.99); C159(0.83); C162(0.82); C283(0.92)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C138(0.91); C159(0.92); C162(0.92); C283(0.91)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C138(1.00); C159(1.08); C162(1.08); C283(1.03)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C138(0.99); C159(0.80); C162(0.80); C283(0.88)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C138(0.89); C159(0.89); C162(0.88); C283(0.87)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C138(0.92); C159(0.98); C162(0.97); C283(0.87)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C138(0.99); C159(0.82); C162(0.83); C283(1.13)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C138(0.88); C159(0.91); C162(0.92); C283(0.87)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C138(0.88); C159(0.92); C162(0.93); C283(0.91)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C138(0.90); C159(0.98); C162(0.99); C283(0.98)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C138(0.93); C159(0.85); C162(0.85); C283(0.88)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C138(0.84); C159(0.88); C162(0.88); C283(0.80)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C138(0.90); C159(0.89); C162(0.90); C283(0.85)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C138(1.00); C159(1.04); C162(1.04); C283(1.11)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C138(0.90); C159(0.89); C162(0.89); C283(1.00)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C138(1.06); C159(0.98); C162(0.98); C283(0.94)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C138(1.06); C159(1.00); C162(1.00); C283(1.05)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C138(1.15); C159(1.03); C162(1.03); C283(1.21)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C138(1.22); C159(1.08); C162(1.08); C283(1.17)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C138(1.05); C159(1.00); C162(1.00); C283(1.05)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C138(1.31); C159(1.29); C162(1.29); C283(1.31)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C138(1.24); C159(1.28); C162(1.28); C283(1.18)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C138(1.20); C159(1.15); C162(1.15); C283(1.11)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C138(1.11); C159(1.02); C162(1.02); C283(0.97)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C138(1.03); C159(1.29); C162(1.29); C283(1.06)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C138(1.08); C159(1.03); C162(1.03); C283(1.01)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C138(1.23); C159(1.05); C162(1.05); C283(1.13)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C138(1.14); C159(1.03); C162(1.03); C283(0.97)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C138(1.10); C159(1.01); C162(1.01); C283(1.05)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C138(1.20); C159(1.09); C162(1.09); C283(1.14)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C138(0.96); C159(0.95); C162(0.95); C283(1.20)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C138(1.11); C159(0.89); C162(0.89); C283(1.26)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C138(1.05); C159(1.13); C162(1.13); C283(1.16)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C138(1.00); C159(1.18); C162(1.18); C283(1.15)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C138(1.27); C159(1.41); C162(1.41); C283(1.37)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C138(0.99); C159(0.95); C162(0.95); C283(1.05)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C138(1.02); C159(0.98); C162(0.98); C283(1.05)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C138(0.96); C159(1.29); C162(1.29); C283(1.00)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C138(1.08); C159(1.08); C162(1.08); C283(1.14)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C138(1.01); C159(1.29); C162(1.29); C283(1.22)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C138(0.95); C159(0.99); C162(0.99); C283(1.16)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C138(1.01); C159(0.88); C162(0.88); C283(1.17)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C138(1.01); C159(0.96); C162(0.96); C283(1.22)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C138(0.94); C159(1.08); C162(1.08); C283(1.15)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C138(1.07); C159(1.51); C162(1.51); C283(1.11)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C138(1.10); C159(1.05); C162(1.05); C283(1.04)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C138(0.96); C159(0.68); C162(0.68); C283(1.38)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C138(1.03); C159(0.88); C162(0.88); C283(1.09)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C138(0.98); C159(0.83); C162(0.84); C283(1.09)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C138(0.77); C159(0.82); C162(0.83); C283(0.83)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C138(0.80); C159(0.83); C162(0.85); C283(0.86)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C138(0.85); C159(0.78); C162(0.78); C283(1.09)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C138(0.84); C159(0.96); C162(0.98); C283(1.06)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C138(0.97); C159(0.90); C162(0.91); C283(0.99)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C138(0.94); C159(0.85); C162(0.86); C283(0.75)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C138(0.82); C159(0.98); C162(0.99); C283(0.66)  LDD0811  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C283(2.27); C138(1.41)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C138(1.17); C159(1.17); C162(1.17); C283(1.03)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C138(1.58); C159(1.50); C162(1.50); C283(2.23)  LDD0744  [5]
 LDCM0022  KB02 22RV1 C138(1.66)  LDD2243  [7]
 LDCM0023  KB03 22RV1 C138(2.36)  LDD2660  [7]
 LDCM0024  KB05 SKMEL24 C138(2.91)  LDD3323  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C138(1.17)  LDD2101  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C138(0.96)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C138(0.72)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C138(2.34)  LDD2119  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C138(1.20)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C138(1.13)  LDD2135  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C138(1.00)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C138(0.93)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C138(0.85)  LDD2148  [3]
 LDCM0021  THZ1 HCT 116 C159(1.29); C162(1.29); C283(1.14)  LDD2173  [5]
 LDCM0112  W16 Hep-G2 C283(0.55)  LDD0239  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
Cathepsin D (CTSD) Peptidase A1 family P07339
Caspase-6 (CASP6) Peptidase C14A family P55212
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Dual specificity testis-specific protein kinase 1 (TESK1) TKL Ser/Thr protein kinase family Q15569
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transthyretin (TTR) Transthyretin family P02766
E3 ubiquitin-protein ligase CBL (CBL) . P22681
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
POU domain, class 4, transcription factor 2 (POU4F2) POU transcription factor family Q12837
Homeobox protein VENTX (VENTX) . O95231
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Progranulin (GRN) Granulin family P28799
Keratin-associated protein 5-11 (KRTAP5-11) KRTAP type 5 family Q6L8G4
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Gelsolin (GSN) Villin/gelsolin family P06396
Collagen alpha-1(VIII) chain (COL8A1) . P27658
Four and a half LIM domains protein 2 (FHL2) . Q14192
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Nuclear transport factor 2 (NUTF2) . P61970
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Stress-induced-phosphoprotein 1 (STIP1) . P31948
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840