Details of the Target

General Information of Target

Target ID LDTP11409
Target Name Solute carrier family 26 member 6 (SLC26A6)
Gene Name SLC26A6
Gene ID 65010
Synonyms
Solute carrier family 26 member 6; Anion exchange transporter; Pendrin-like protein 1; Pendrin-L1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIIPSLEELDSLKYSDLQNLAKSLGLRANLRATKLLKALKGYIKHEARKGNENQDESQTS
ASSCDETEIQISNQEEAERQPLGHVTKTRRRCKTVRVDPDSQQNHSEIKISNPTEFQNHE
KQESQDLRATAKVPSPPDEHQEAENAVSSGNRDSKVPSEGKKSLYTDESSKPGKNKRTAI
TTPNFKKLHEAHFKEMESIDQYIERKKKHFEEHNSMNELKQQPINKGGVRTPVPPRGRLS
VASTPISQRRSQGRSCGPASQSTLGLKGSLKRSAISAAKTGVRFSAATKDNEHKRSLTKT
PARKSAHVTVSGGTPKGEAVLGTHKLKTITGNSAAVITPFKLTTEATQTPVSNKKPVFDL
KASLSRPLNYEPHKGKLKPWGQSKENNYLNQHVNRINFYKKTYKQPHLQTKEEQRKKREQ
ERKEKKAKVLGMRRGLILAED
Target Bioclass
Transporter and channel
Family
SLC26A/SulP transporter (TC 2.A.53) family
Subcellular location
Cell membrane
Function
Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.; [Isoform 4]: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.
Uniprot ID
Q9BXS9
Ensemble ID
ENST00000383733.7
HGNC ID
HGNC:14472

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.S558I DBIA    Probe Info 
HEC1B SNV: p.S608L .
IGR1 SNV: p.S500F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C628(2.23)  LDD0168  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C628(1.34)  LDD0078  [3]
IA-alkyne
 Probe Info  		C628(0.00); C685(0.00); C62(0.00)  LDD0165  [4]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]
W1
 Probe Info  		N.A.  LDD0236  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C628(2.23)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C628(2.33)  LDD0169  [1]
 LDCM0214  AC1 HCT 116 C628(1.28)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C628(1.73)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C628(0.97)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C628(0.80)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C628(0.92)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C628(1.06)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C628(1.07)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C628(1.16)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C628(0.92)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C628(1.05)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C628(1.28)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C628(0.95)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C628(1.29)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C628(1.04)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C628(0.81)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C628(0.85)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C628(1.18)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C628(1.45)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C628(1.32)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C628(1.38)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C628(1.28)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C628(1.23)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C628(1.29)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C628(1.43)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C628(1.22)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C628(1.21)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C628(1.36)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C628(1.02)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C628(0.94)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C628(1.31)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C628(1.79)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C628(1.75)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C628(2.39)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C628(1.22)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C628(1.38)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C628(1.30)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C628(1.69)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C628(1.30)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C628(1.28)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C628(1.98)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C628(1.23)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C628(1.01)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C628(1.44)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C628(1.58)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C628(1.62)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C628(1.52)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C628(2.38)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C628(1.02)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C628(1.03)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C628(1.31)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C628(0.98)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C628(1.30)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C628(1.51)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C628(1.88)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C628(1.72)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C628(1.46)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C628(1.25)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C628(0.79)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C628(1.45)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C628(3.44)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C628(1.21)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C628(1.18)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C628(1.10)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C628(0.70)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C628(1.04)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C628(0.94)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C628(0.80)  LDD1517  [8]
 LDCM0279  AC2 HCT 116 C628(1.17)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C628(0.97)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C628(0.91); C708(1.06); C565(0.97)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C628(1.00); C565(0.92)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C628(0.97)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C628(1.00)  LDD1523  [8]
 LDCM0285  AC25 HCT 116 C628(1.07)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C628(1.13)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C628(1.39)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C628(1.38)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C628(1.20)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C628(1.15)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C628(1.25)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C628(1.33)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C628(1.64)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C628(1.36)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C628(1.55)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C628(1.08)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C628(0.64)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C628(0.65)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C628(1.12)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C628(1.20)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C628(1.32)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C628(1.36)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C628(0.86)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C628(0.94)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C628(0.82)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C628(0.92)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C628(1.14)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C628(1.00)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C628(0.99)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C628(0.96)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C628(0.87)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C628(1.57)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C628(0.94)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C628(0.76)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C628(0.83)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C628(0.79)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C628(0.88)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C628(0.88)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C628(0.93)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C628(1.51)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C628(1.98)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C628(2.24)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C628(1.49)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C628(1.89)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C628(2.34)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C628(2.51)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C628(1.93)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C628(2.22)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C628(2.36)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C628(2.04)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C628(2.01)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C628(0.93)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C628(1.05)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C628(1.09)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C628(0.88)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C628(1.04)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C628(0.92)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C628(1.49)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C628(1.17)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C628(1.24)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C628(1.02)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C628(1.04)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C628(0.63)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C628(0.91)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C628(1.31)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C628(1.24)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C628(0.81)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C628(1.66)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C628(1.66)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C628(2.10)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C628(1.46)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C628(1.28)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C628(0.92)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C628(1.13)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C628(1.19)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C628(0.86)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C628(1.66)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C628(1.85)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C628(1.15)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C628(0.86)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C628(0.94)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C628(1.33)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C628(1.84)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C628(1.42)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C628(1.08)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C628(1.19)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C628(1.25)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C628(1.60)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C628(1.34)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C628(0.82)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C628(1.34)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C628(1.21)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C628(1.24)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C628(1.12)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C628(0.78)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C628(1.12)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C628(0.96); C708(1.04)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C628(0.97)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C628(0.97)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C628(0.94); C708(0.90)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C628(0.97); C708(0.99)  LDD1582  [8]
 LDCM0379  CL11 HCT 116 C628(1.05)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C628(0.96)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C628(0.98)  LDD1585  [8]
 LDCM0382  CL112 HCT 116 C628(1.11)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C628(1.47)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C628(1.16)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C628(1.30)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C628(1.40)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C628(1.41)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C628(0.94)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C628(1.16)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C628(1.02)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C628(1.05)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C628(0.82)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C628(0.78)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C628(0.81)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C628(0.84)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C628(2.06)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C628(1.35)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C628(1.32)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C628(1.84)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C628(1.19)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C628(0.94)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C628(1.06)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C628(1.01)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C628(1.33)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C628(1.58)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C628(1.42)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C628(0.85)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C628(1.38)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C628(1.92)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C628(2.63)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C628(1.28)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C628(1.95)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C628(1.66)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C628(1.34)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C628(1.30)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C628(1.45)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C628(1.51)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C628(0.82)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C628(1.47)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C628(1.38)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C628(1.32)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C628(1.90)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C628(1.62)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C628(1.50)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C628(2.48)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C628(1.72)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C628(1.96)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C628(0.83)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C628(2.39)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C628(1.36)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C628(3.53)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C628(1.85)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C628(1.93)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C628(2.45)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C628(1.09); C565(1.00)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C628(1.09)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C628(1.08)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C628(0.97); C708(1.49)  LDD1643  [8]
 LDCM0440  CL5 HCT 116 C628(1.00)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C628(1.01)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C628(0.96); C708(0.80)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C628(0.96)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C628(0.92)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C628(1.10)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C628(1.02)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C628(0.99); C708(1.19); C565(1.04)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C628(1.08); C565(0.94)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C628(1.09)  LDD1653  [8]
 LDCM0451  CL6 HCT 116 C628(0.99)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C628(1.01)  LDD1655  [8]
 LDCM0453  CL61 HCT 116 C628(0.94)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C628(1.07)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C628(1.56)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C628(1.46)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C628(1.28)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C628(1.58)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C628(1.44)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C628(1.64)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C628(0.90)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C628(1.04)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C628(1.34)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C628(1.56)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C628(0.94)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C628(1.19)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C628(1.41)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C628(1.31)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C628(1.48)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C628(1.04)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C628(1.44)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C628(1.32)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C628(1.51)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C628(1.17)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C628(1.80)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C628(2.22)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C628(2.62)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C628(1.32)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C628(1.49)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C628(1.17)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C628(2.19)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C628(1.45)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C628(1.07)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C628(1.41)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C628(1.17)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C628(1.14)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C628(1.06)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C628(1.09)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C628(1.17)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C628(1.09)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C628(1.26)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C628(1.20)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C628(1.21)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C628(1.07)  LDD1698  [8]
 LDCM0625  F8 Ramos C628(1.85)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C628(1.31)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C628(6.03)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C628(0.94)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C628(1.31)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C628(1.44)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C628(0.99)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C628(1.02)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C628(1.12)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C628(1.04)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C628(0.81)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C628(1.41)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C628(0.96)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C628(1.62)  LDD2201  [9]
 LDCM0468  Fragment33 HCT 116 C628(1.19)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C628(0.69)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C628(1.24)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C628(2.72)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C628(1.16)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C628(1.23)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C628(1.45)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C628(0.99)  LDD2188  [9]
 LDCM0022  KB02 HCT 116 C628(1.70)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C628(1.32)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C628(1.42)  LDD0082  [3]
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]
 LDCM0021  THZ1 HCT 116 C628(1.06)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-2 (AQP2) MIP/aquaporin (TC 1.A.8) family P41181
CD81 antigen (CD81) Tetraspanin (TM4SF) family P60033
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L2 (APOL2) Apolipoprotein L family Q9BQE5
BET1 homolog (BET1) BET1 family O15155
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Serotransferrin (TF) Transferrin family P02787
Protein SNORC (SNORC) . Q6UX34

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578