Details of the Target

General Information of Target

Target ID LDTP11348
Target Name GTP-binding protein 2 (GTPBP2)
Gene Name GTPBP2
Gene ID 54676
Synonyms
GTP-binding protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYQSLALAASPRQAAYADSGSFLHAPGAGSPMFVPPARVPSMLSYLSGCEPSPQPPELAA
RPGWAQTATADSSAFGPGSPHPPAAHPPGATAFPFAHSPSGPGSGGSAGGRDGSAYQGAL
LPREQFAAPLGRPVGTSYSATYPAYVSPDVAQSWTAGPFDGSVLHGLPGRRPTFVSDFLE
EFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRAG
LCCTNCHTTNTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKTIAKA
RGSSGSTRNASASPSAVASTDSSAATSKAKPSLASPVCPGPSMAPQASGQEDDSLAPGHL
EFKFEPEDFAFPSTAPSPQAGLRGALRQEAWCALALA
Target Bioclass
Enzyme
Family
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, GTPBP1 subfamily
Uniprot ID
Q9BX10
Ensemble ID
ENST00000307114.11
HGNC ID
HGNC:4670

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.H264R .
COLO800 Insertion: p.Q589LfsTer33 DBIA    Probe Info 
HEC1 SNV: p.R335W DBIA    Probe Info 
HEC1B SNV: p.R335W .
HL60 SNV: p.V5G .
HT115 SNV: p.T549A DBIA    Probe Info 
IPC298 SNV: p.S232N .
MCC26 SNV: p.E247Q .
MEWO Insertion: p.Q589delinsPKKK DBIA    Probe Info 
REH SNV: p.G16R; p.L59F .
SNU5 SNV: p.G22S DBIA    Probe Info 
SW1116 SNV: p.G341A DBIA    Probe Info 
SW948 SNV: p.Ter603LextTer17 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.41  LDD0402  [1]
STPyne
 Probe Info  		K571(10.00)  LDD0277  [2]
NAIA_5
 Probe Info  		C249(0.47)  LDD2227  [3]
AHL-Pu-1
 Probe Info  		C13(2.73)  LDD0169  [4]
DBIA
 Probe Info  		C36(1.06); C450(0.98)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
VSF
 Probe Info  		N.A.  LDD0007  [8]
AOyne
 Probe Info  		14.40  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C13(2.73)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C36(0.90)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C36(0.92)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C36(1.11)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C36(1.16)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C36(1.05)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C36(1.24)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C36(1.05)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C36(1.19)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C36(1.30)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C36(1.22)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C36(1.09)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C36(0.87)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C36(0.97)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C36(0.92)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C36(1.02)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C36(1.00)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C36(1.01)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C36(1.10)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C36(1.14)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C36(1.20)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C36(1.23)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C36(1.22)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C36(1.28)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C36(0.93)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C36(1.11)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C36(1.37)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C36(1.11)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C36(1.12)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C36(1.22)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C36(1.04)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C36(1.25)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C36(1.34)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C36(1.13)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C36(1.11)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C36(1.11)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C36(0.95)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C36(1.11)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C36(1.14)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C36(1.12)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C36(1.04)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C36(1.00)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C36(1.02)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C36(0.94)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C36(0.96)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C36(0.89)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C36(1.04)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C36(1.09)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C36(1.13)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C36(1.15)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C36(1.24)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C36(1.14)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C36(1.29)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C36(1.20)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C36(1.55)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C36(1.35)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C36(0.91)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C36(1.02)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C36(1.14)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C36(1.14)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C36(1.86)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C36(1.21)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C36(1.32)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C36(1.07)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C36(1.09)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C36(1.01)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C36(1.16)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C36(1.10)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C36(0.96)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C36(1.03)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C36(1.24)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C36(1.11)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C36(1.11)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C36(1.10)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C36(0.93)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C36(1.12)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C36(1.09)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C36(1.24)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C36(1.34)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C36(0.98)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C36(1.20)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C36(1.05)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C36(1.32)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C36(0.99)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C36(1.02)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C36(0.93); C450(0.85)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C36(1.18); C450(0.75)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C36(1.05); C450(0.78)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C36(1.12); C450(0.83)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C36(0.99); C450(0.88)  LDD0898  [5]
 LDCM0301  AC4 HCT 116 C36(1.18)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C36(1.30); C450(0.89)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C36(1.01); C450(0.82)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C36(1.08); C450(0.81)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C36(1.05); C450(0.99)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C36(1.04); C450(0.87)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C36(1.15); C450(0.85)  LDD0905  [5]
 LDCM0308  AC46 HCT 116 C36(0.94)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C36(0.98)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C36(1.00)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C36(1.07)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C36(1.04)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C36(1.17)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C36(1.02)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C36(0.95)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C36(1.13)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C36(1.04)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C36(1.19)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C36(1.29)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C36(1.05)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C36(1.15)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C36(1.14)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C36(1.12)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C36(1.20)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C36(1.08)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C36(1.04)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C36(1.04)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C36(1.11)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C36(0.79)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C36(0.81)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C36(0.86)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C36(1.13)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C36(1.14)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C36(0.98)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C36(1.15)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C36(1.01)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C36(1.18)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C36(1.48)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C36(1.35)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C36(1.59)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C36(1.21)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C36(1.16)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C36(1.16)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C36(1.18)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C36(0.99)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C36(1.10)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C36(1.18)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C36(1.45)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C36(1.56)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C36(1.49)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C36(1.33)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C36(1.14)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C36(1.05)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C36(1.26)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C36(1.27)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C36(0.99)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C36(1.43)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C36(1.47)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C36(1.36)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C36(1.09)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C36(1.10)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C36(1.30)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C36(1.69)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C36(1.44)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C36(1.12)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C36(0.98)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C36(1.00)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C36(0.94)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.82  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C36(1.06); C450(0.98)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C249(0.47)  LDD2227  [3]
 LDCM0367  CL1 HCT 116 C36(1.17)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C36(0.96)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C36(0.92)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C36(0.90)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C36(1.00)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C36(0.93)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C36(0.85)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C36(1.03)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C36(1.17)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C36(1.00)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C36(1.03)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C36(1.16)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C36(1.05)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C36(1.12)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C36(1.15)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C36(1.10)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C36(1.13)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C36(1.16)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C36(1.15)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C36(1.07)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C36(1.07); C450(0.89)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C36(0.96); C450(0.92)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C36(1.07); C450(0.82)  LDD0987  [5]
 LDCM0390  CL12 HCT 116 C36(1.00)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C36(0.97); C450(0.95)  LDD0989  [5]
 LDCM0392  CL121 HCT 116 C36(1.07)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C36(0.95)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C36(1.16)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C36(1.08)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C36(0.99)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C36(0.86)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C36(0.89)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C36(1.24)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C36(0.90)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C36(0.89)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C36(0.93)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C36(0.93)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C36(1.62)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C36(1.54)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C36(1.15)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C36(1.06)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C36(0.89)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C36(1.03)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C36(1.48)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C36(1.23)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C36(1.51)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C36(1.69)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C36(0.92)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C36(1.21)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C36(1.04)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C36(0.97)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C36(0.92)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C36(1.01)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C36(1.41)  LDD1299  [5]
 LDCM0421  CL32 HCT 116 C36(1.12)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C36(1.11)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C36(0.96)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C36(1.03)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C36(0.94)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C36(0.93)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C36(1.06)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C36(0.86)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C36(1.08)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C36(1.01)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C36(0.82)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C36(0.94)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C36(0.84)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C36(0.92)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C36(1.11)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C36(0.91)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C36(0.91)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C36(0.96)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C36(0.81)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C36(0.98)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C36(1.06)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C36(0.97)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C36(0.99)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C36(1.04)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C36(0.96)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C36(0.98)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C36(0.98)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C36(1.01)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C36(0.91)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C36(1.00)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C36(0.97)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C36(1.00)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C36(1.02)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C36(1.15)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C36(1.02)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C36(1.00)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C36(1.13)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C36(1.09)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C36(1.08)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C36(1.27)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C36(0.99)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C36(1.12)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C36(1.13)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C36(1.14)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C36(1.12)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C36(1.13)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C36(0.94)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C36(0.81)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C36(0.96)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C36(0.95)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C36(2.47)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C36(0.90)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C36(0.86)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C36(0.95)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C36(1.01)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C36(1.09)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C36(0.94)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C36(0.84)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C36(0.88)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C36(0.96)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C36(1.08)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C36(0.93)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C36(0.86)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C36(1.09)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C36(1.15)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C36(1.32)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C36(1.18)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C36(1.19)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C36(1.23)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C36(1.14)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C36(1.05)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C36(1.00)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C249(0.91); C36(0.82)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C36(1.16)  LDD1702  [11]
 LDCM0625  F8 Ramos C249(1.41); C36(1.22)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C249(1.11); C36(1.12)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C249(1.17); C36(13.40)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C249(1.22); C36(0.81)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C249(0.89); C36(0.99)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C249(1.00); C36(1.03)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C249(1.12); C36(1.19)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C249(0.97); C36(0.99)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C249(0.88); C36(1.05)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C249(0.91); C36(1.01)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C249(0.18); C36(0.69)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C249(0.91); C36(1.27)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C249(0.90); C36(0.93)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C249(1.03); C36(1.10)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C36(1.08)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C249(1.09); C36(0.90)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C249(0.96); C36(0.93)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C36(0.96)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C249(1.27); C36(1.28)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C249(1.09); C36(1.66)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C249(1.20); C36(1.04)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C249(1.49); C36(1.05)  LDD2188  [12]
 LDCM0022  KB02 HCT 116 C36(2.18)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C36(1.45)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C36(2.14)  LDD0082  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Protein arginine N-methyltransferase 6 (PRMT6) Protein arginine N-methyltransferase family Q96LA8
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
GPN-loop GTPase 3 (GPN3) GPN-loop GTPase family Q9UHW5
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
GTP-binding protein 2 (GTPBP2) Classic translation factor GTPase family Q9BX10
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
PRKCA-binding protein (PICK1) . Q9NRD5
U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70) . P08621

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578