Details of the Target

General Information of Target

Target ID LDTP10609
Target Name AP-4 complex accessory subunit Tepsin (TEPSIN)
Gene Name TEPSIN
Gene ID 146705
Synonyms
C17orf56; ENTHD2; AP-4 complex accessory subunit Tepsin; ENTH domain-containing protein 2; Epsin for AP-4; Tetra-epsin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESNLSGLVPAAGLVPALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQT
VFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCPVCLQFFTLTLMNLYFAQV
VFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRRRAQPWALLLVRVLVSD
SLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTAL
ALAPQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRP
PQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTRCQDQAATTTVSTPPHR
RDPPPSPTEYPGPSPPHPRPLCQVCLPLLAQDPGGRGYPLLWPAPCCSCHSELVPSP
Target Bioclass
Transporter and channel
Subcellular location
Golgi apparatus, trans-Golgi network membrane
Function Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.
Uniprot ID
Q96N21
Ensemble ID
ENST00000300714.7
HGNC ID
HGNC:26458

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C479(2.49)  LDD0170  [1]
DBIA
 Probe Info  		C295(0.96)  LDD0078  [2]
NAIA_4
 Probe Info  		C52(0.00); C302(0.00); C479(0.00); C493(0.00)  LDD2226  [3]
NAIA_5
 Probe Info  		C302(0.00); C493(0.00)  LDD2224  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0151  [6]
IPM
 Probe Info  		N.A.  LDD0005  [5]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C479(2.49)  LDD0170  [1]
 LDCM0214  AC1 HCT 116 C352(0.88)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C295(1.32); C352(1.07)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C295(0.66)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C295(0.64)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C295(0.75)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C295(0.74)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C295(0.58)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C295(0.88)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C295(0.75)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C295(0.59)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C295(0.64)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C295(0.80)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C295(0.96); C352(0.85)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C295(0.75)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C295(0.82)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C295(0.74)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C295(0.98); C352(0.85)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C295(1.04); C352(1.16)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C295(1.28); C352(1.27)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C295(1.72); C352(1.12)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C295(1.25); C352(1.02)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C295(1.25); C352(1.07)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C295(1.50); C352(1.13)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C295(1.02); C352(1.03)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C295(1.19); C352(0.88)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C295(1.15); C352(0.92)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C295(1.40); C352(1.15)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C295(1.00); C352(0.82)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C295(1.11); C352(1.03)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C295(1.14); C352(1.05)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C295(1.20); C352(1.05)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C295(1.14); C352(1.12)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C295(1.03); C352(1.28)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C295(1.12); C352(1.18)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C295(1.06); C352(1.28)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C295(0.92); C352(1.17)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C295(1.00); C352(1.16)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C295(1.01); C352(1.73)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C295(1.10); C352(1.70)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C295(0.85); C352(1.35)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C295(0.76); C352(1.30)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C295(0.91); C352(1.33)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C295(0.78); C352(0.91)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C295(0.96); C352(1.29)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C295(1.29); C352(0.99)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C295(1.01); C352(1.29)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C295(0.97); C352(1.12)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C295(1.11); C352(1.60)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C295(0.90)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C295(1.88)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C295(1.31)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C295(1.50)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C295(2.00)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C295(1.84)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C295(2.07)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C352(1.04); C295(1.31)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C295(1.46)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C295(1.26)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C295(1.14)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C295(2.24)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C295(1.07)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C295(1.63)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C295(1.02)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C295(0.78)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C295(0.90)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C295(0.78)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C295(0.94)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C352(1.11)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C295(1.01)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C295(0.88)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C295(0.82)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C295(0.79)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C295(1.39)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C295(1.15); C352(1.20)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C352(1.18); C295(1.66)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C295(0.69); C352(1.70)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C295(1.31); C352(1.80)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C295(0.75); C352(2.01)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C352(1.09)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C295(0.65); C352(2.05)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C295(0.83); C352(1.13)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C295(0.91); C352(1.27)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C295(0.58); C352(1.15)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C295(0.41); C352(1.36)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C352(0.86); C295(1.27)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C352(0.76); C295(1.22)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C352(0.86); C295(1.31)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C295(0.86); C352(0.90)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C352(0.78); C295(1.33)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C352(0.97)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C352(0.75); C295(0.91)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C352(0.87); C295(1.22)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C352(0.85); C295(0.89)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C352(0.82); C295(1.08)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C352(0.79); C295(0.86)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C352(0.71); C295(0.88)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C295(1.99)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C295(1.45)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C295(1.38)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C295(0.85)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C352(0.90)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C295(0.83)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C295(0.74)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C295(0.88)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C295(0.72)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C295(1.02)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C295(0.84)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C295(0.71)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C295(1.13); C352(1.34)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C295(0.84); C352(0.89)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C352(1.17); C295(1.71)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C295(1.31); C352(1.49)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C352(1.19); C295(1.28)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C352(1.16); C295(1.28)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C352(1.24); C295(1.44)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C352(1.15); C295(1.17)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C352(1.28); C295(1.75)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C352(1.12); C295(1.31)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C352(0.83); C295(1.10)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C352(1.08); C295(1.48)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C295(1.24); C352(1.25)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C352(0.96); C295(1.56)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C352(0.91); C295(1.33)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C352(1.06); C295(1.46)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C352(1.32); C295(1.79)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C352(1.12); C295(1.58)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C352(1.43); C295(2.18)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C295(1.30); C352(1.47)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C352(0.98); C295(2.58)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C352(0.92); C295(1.25)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C352(0.98); C295(1.41)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C352(1.01); C295(1.17)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C295(0.90); C352(1.10)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C295(1.28); C352(1.40)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C352(1.10); C295(1.52)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C352(1.16); C295(1.75)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C352(1.05); C295(2.09)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C352(1.03); C295(1.31)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C352(1.00); C295(1.37)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C295(1.00); C352(1.05)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C295(0.85); C352(0.88)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C295(0.80); C352(1.05)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C295(0.81); C352(0.92)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C352(0.86); C295(1.12)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C295(0.88); C352(1.01)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C352(0.78); C295(1.34)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C352(1.10); C295(1.30)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C295(0.78); C352(1.07)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C352(0.81); C295(0.84)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C352(0.85); C295(0.95)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C352(0.84); C295(1.09)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C352(1.01); C295(1.33)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C295(0.83)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C295(0.99)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C295(1.21); C352(1.11)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C352(0.98); C295(1.11)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C352(1.25); C295(1.50)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C295(0.96)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C31(20.00); C52(4.03); C352(2.04); C302(0.20)  LDD2227  [3]
 LDCM0367  CL1 HCT 116 C295(0.86)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C295(0.71)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C352(0.93)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C352(0.96); C295(1.45)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C295(0.94); C352(1.07)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C352(1.07); C295(1.10)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C295(1.06); C352(1.06)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C295(0.65)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C295(0.67)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C295(0.66)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C295(0.91)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C295(0.84)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C295(0.65)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C295(0.61)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C295(0.81)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C295(1.31); C352(1.45)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C295(0.79); C352(1.11)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C295(0.48); C352(1.23)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C295(0.49); C352(1.52)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C295(0.42); C352(1.55)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C295(0.64); C352(0.66)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C352(0.81); C295(1.14)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C352(0.86); C295(1.69)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C295(0.56)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C352(0.73); C295(1.28)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C295(0.91)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C295(0.71)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C295(0.77)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C295(0.91)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C352(1.36); C295(1.40)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C295(1.09); C352(1.11)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C352(1.07); C295(1.39)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C352(1.22); C295(1.29)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C295(0.61)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C295(0.63)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C295(0.69)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C352(1.00); C295(1.08)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C352(0.99); C295(1.26)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C352(1.06); C295(1.30)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C352(0.95); C295(1.41)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C295(0.83)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C352(0.92); C295(1.55)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C352(0.87); C295(1.33)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C352(0.97); C295(1.31)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C352(1.00); C295(1.18)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C295(1.13); C352(1.19)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C295(1.29); C352(0.87)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C295(1.01); C352(0.98)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C295(1.14); C352(1.31)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C295(1.11); C352(0.72)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C295(0.98); C352(0.81)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C295(0.63)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C295(0.98); C352(0.79)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C295(1.13); C352(0.80)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C295(1.20); C352(1.22)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C295(1.41); C352(1.16)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C295(1.18); C352(1.05)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C295(0.75); C352(1.25)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C295(0.91); C352(1.11)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C295(0.87); C352(1.21)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C295(0.89); C352(1.03)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C295(0.60)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C295(0.84); C352(0.98)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C295(0.72); C352(1.10)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C295(1.05); C352(0.98)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C295(0.89); C352(1.02)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C295(0.86); C352(1.12)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C295(1.07); C352(1.19)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C352(1.01)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C352(1.15)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C352(1.09)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C352(0.80)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C295(0.87)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C352(0.83)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C352(0.75)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C352(0.86)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C352(0.89)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C352(0.79)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C352(0.94)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C352(0.70)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C352(0.85)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C352(0.81)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C352(0.82)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C295(0.76)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C352(0.83)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C295(1.05); C352(1.05)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C295(0.90); C352(0.90)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C295(1.17); C352(1.17)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C295(0.92); C352(0.92)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C295(1.15); C352(1.15)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C295(0.80); C352(0.80)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C295(0.75); C352(0.75)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C295(0.64); C352(0.64)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C295(0.70); C352(0.70)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C295(1.12)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C295(0.96); C352(0.96)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C295(0.88); C352(0.88)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C295(1.03); C352(1.03)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C295(0.87); C352(0.87)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C295(0.90); C352(0.90)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C352(1.00)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C352(1.50)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C352(1.28)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C352(1.37)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C295(0.62)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C352(1.61)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C352(1.20)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C352(1.30)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C352(0.87)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C352(1.05)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C352(0.99)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C352(1.32)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C352(1.11)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C352(1.13)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C352(1.39)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C295(0.73)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C352(1.16)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C352(1.23)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C352(1.13)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C352(0.86)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C352(0.78)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C352(1.08)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C352(1.33)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C352(1.28)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C352(0.90)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C352(1.02)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C295(1.01); C493(1.35); C243(1.11); C31(1.03)  LDD1698  [8]
 LDCM0625  F8 Ramos C295(1.55); C52(0.84)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C295(2.08)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C295(4.30); C52(16.55); C493(10.68)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C295(2.02)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C295(1.12)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C295(1.38); C493(0.78)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C295(1.18)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C295(1.06)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C295(0.72)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C295(0.78)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C295(0.81); C52(0.45); C493(0.69)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C295(1.33)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C295(1.21)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C295(1.58)  LDD2201  [9]
 LDCM0468  Fragment33 HEK-293T C295(0.60); C352(0.60)  LDD1066  [2]
 LDCM0596  Fragment38 Ramos C295(1.46)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C295(1.20); C52(1.44); C493(0.71)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C295(1.22); C352(0.89)  LDD0744  [2]
 LDCM0614  Fragment56 Ramos C295(1.59)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C295(1.76); C493(0.96)  LDD2186  [9]
 LDCM0022  KB02 HEK-293T C295(1.01); C493(1.10); C302(0.87); C352(1.10)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C493(12.57)  LDD0209  [10]
 LDCM0024  KB05 OAW-42 C243(2.41)  LDD3369  [11]
 LDCM0627  NUDT7-COV-1 HEK-293T C52(6.57); C493(1.57); C302(0.14)  LDD2206  [12]
 LDCM0628  OTUB2-COV-1 HEK-293T C302(0.95)  LDD2207  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Methionine adenosyltransferase 2 subunit beta (MAT2B) DTDP-4-dehydrorhamnose reductase family Q9NZL9
Neuroglobin (NGB) Globin family Q9NPG2
Lysozyme g-like protein 2 (LYG2) Glycosyl hydrolase 23 family Q86SG7
Histone acetyltransferase type B catalytic subunit (HAT1) HAT1 family O14929
Baculoviral IAP repeat-containing protein 7 (BIRC7) IAP family Q96CA5
Protein KHNYN (KHNYN) N4BP1 family O15037
NADPH-dependent diflavin oxidoreductase 1 (NDOR1) NADPH-dependent diflavin oxidoreductase NDOR1 family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family Q9UHB4
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Uridine diphosphate glucose pyrophosphatase NUDT14 (NUDT14) Nudix hydrolase family O95848
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) Nudix hydrolase family O43809
Proteasome subunit alpha type-6 (PSMA6) Peptidase T1A family P60900
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Serine/threonine-protein kinase LMTK1 (AATK) Tyr protein kinase family Q6ZMQ8
Dual specificity phosphatase 29 (DUSP29) Protein-tyrosine phosphatase family Q68J44
Dual specificity protein phosphatase 4 (DUSP4) Protein-tyrosine phosphatase family Q13115
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase TRIM50 (TRIM50) TRIM/RBCC family Q86XT4
E3 ubiquitin-protein ligase TRIM68 (TRIM68) TRIM/RBCC family Q6AZZ1
tRNA-splicing endonuclease subunit Sen2 (TSEN2) TRNA-intron endonuclease family Q8NCE0
BTB/POZ domain-containing protein 3 (BTBD3) . Q9Y2F9
E3 ubiquitin-protein ligase RNF135 (RNF135) . Q8IUD6
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex subunit beta-1 (AP4B1) Adaptor complexes large subunit family Q9Y6B7
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Chloride intracellular channel protein 3 (CLIC3) Chloride channel CLIC family O95833
Neuron-specific calcium-binding protein hippocalcin (HPCA) Recoverin family P84074
SEC14-like protein 4 (SEC14L4) . Q9UDX3
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Zinc finger protein 629 (ZNF629) Krueppel C2H2-type zinc-finger protein family Q9UEG4
Teashirt homolog 3 (TSHZ3) Teashirt C2H2-type zinc-finger protein family Q63HK5
Mesogenin-1 (MSGN1) . A6NI15
Paired box protein Pax-9 (PAX9) . P55771
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Olfactory receptor 6B1 (OR6B1) G-protein coupled receptor 1 family O95007
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tapasin-related protein (TAPBPL) . Q9BX59
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ciliary neurotrophic factor (CNTF) CNTF family P26441
Other
Click To Hide/Show 56 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acyl-CoA-binding domain-containing protein 7 (ACBD7) ACBD7 family Q8N6N7
Apolipoprotein L6 (APOL6) Apolipoprotein L family Q9BWW8
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14) Bcl-2 family Q9BZR8
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Cyclin-dependent kinase 2-interacting protein (CINP) CINP family Q9BW66
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Cyclin-C (CCNC) Cyclin family P24863
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Cilium assembly protein DZIP1L (DZIP1L) DZIP C2H2-type zinc-finger protein family Q8IYY4
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (GNG13) G protein gamma family Q9P2W3
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Mediator of RNA polymerase II transcription subunit 18 (MED18) Mediator complex subunit 18 family Q9BUE0
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Nuclear receptor 2C2-associated protein (NR2C2AP) NR2C2AP family Q86WQ0
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771
tRNA-splicing endonuclease subunit Sen15 (TSEN15) SEN15 family Q8WW01
Pre-mRNA-splicing factor SLU7 (SLU7) SLU7 family O95391
Heat shock protein beta-7 (HSPB7) Small heat shock protein (HSP20) family Q9UBY9
U6 snRNA-associated Sm-like protein LSm3 (LSM3) SnRNP Sm proteins family P62310
Thyroid hormone-inducible hepatic protein (THRSP) SPOT14 family Q92748
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
rRNA-processing protein UTP23 homolog (UTP23) UTP23/FCF1 family Q9BRU9
Vacuolar protein sorting-associated protein 26C (VPS26C) VPS26 family O14972
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (ASAP3) . Q8TDY4
Bcl-2-like protein 15 (BCL2L15) . Q5TBC7
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
Complement C1q tumor necrosis factor-related protein 4 (C1QTNF4) . Q9BXJ3
Differentially expressed in FDCP 6 homolog (DEF6) . Q9H4E7
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Heat shock factor 2-binding protein (HSF2BP) . O75031
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Placental protein 13-like (LGALS14) . Q8TCE9
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) . Q9HB19
Protocadherin beta-3 (PCDHB3) . Q9Y5E6
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) . P46940
TBC1 domain family member 13 (TBC1D13) . Q9NVG8
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25) . Q9BV90
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (ZRSR2) . Q15696
Vinexin (SORBS3) . O60504
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.