Details of the Target

General Information of Target

Target ID LDTP08354
Target Name Corepressor interacting with RBPJ 1 (CIR1)
Gene Name CIR1
Gene ID 9541
Synonyms
CIR; Corepressor interacting with RBPJ 1; CBF1-interacting corepressor; Recepin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMG
DERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFG
IQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFA
LKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDR
KKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCS
GHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSR
THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRND
SRSHGTDLYRGEKMYREHPGGTHTKVTQRE
Target Bioclass
Other
Subcellular location
Nucleus speckle
Function
May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Uniprot ID
Q86X95
Ensemble ID
ENST00000342016.8
HGNC ID
HGNC:24217

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HGC27 SNV: p.S20F DBIA    Probe Info 
NCIH1793 SNV: p.M43L .
NCIH358 SNV: p.E320V DBIA    Probe Info 
SKMEL30 SNV: p.S259F DBIA    Probe Info 
YSCCC SNV: p.R360T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C10(2.58)  LDD0169  [1]
DBIA
 Probe Info  		C299(23.04)  LDD0204  [2]
IA-alkyne
 Probe Info  		C10(5.15)  LDD1705  [3]
W1
 Probe Info  		C10(0.61)  LDD0239  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C10(2.17)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C10(2.58)  LDD0169  [1]
 LDCM0214  AC1 HCT 116 C10(0.85)  LDD0531  [8]
 LDCM0215  AC10 HEK-293T C10(0.90)  LDD0813  [8]
 LDCM0216  AC100 HCT 116 C10(1.07)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C10(1.14)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C10(1.10)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C10(1.34)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C10(0.99)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C10(1.41)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C10(1.41)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C10(1.15)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C10(1.13)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C10(0.96)  LDD0542  [8]
 LDCM0226  AC11 HEK-293T C10(0.97)  LDD0824  [8]
 LDCM0227  AC110 HCT 116 C10(1.16)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C10(1.11)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C10(1.08)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C10(0.88)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C10(0.92)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C10(0.78)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C10(1.06)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C10(0.75)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C10(0.77)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C10(1.10)  LDD0553  [8]
 LDCM0237  AC12 HEK-293T C10(0.93)  LDD0835  [8]
 LDCM0238  AC120 HCT 116 C10(1.20)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C10(0.70)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C10(0.97)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C10(0.69)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C10(0.89)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C10(0.98)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C10(0.82)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C10(0.77)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C10(0.44)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C10(0.45)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C10(0.54)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C10(0.49)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C10(0.52)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C10(0.51)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C10(0.60)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C10(0.58)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C10(0.60)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C10(0.68)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C10(0.73)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C10(0.64)  LDD0575  [8]
 LDCM0259  AC14 HEK-293T C10(1.13)  LDD0857  [8]
 LDCM0260  AC140 HCT 116 C10(0.63)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C10(0.64)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C10(0.52)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C10(1.18)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C10(1.01)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C10(0.87)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C10(0.85)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C10(0.76)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C10(0.82)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C10(0.87)  LDD0586  [8]
 LDCM0270  AC15 HEK-293T C10(0.94)  LDD0868  [8]
 LDCM0271  AC150 HCT 116 C10(1.14)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C10(1.34)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C10(0.92)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C10(1.07)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C10(1.08)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C10(1.23)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C10(1.04)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C10(1.10)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C10(0.58)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C10(0.86)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C10(0.72)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C10(0.81)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C10(0.75)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C10(0.70)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C10(0.62)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C10(0.52)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C10(0.52)  LDD0601  [8]
 LDCM0285  AC25 HEK-293T C10(1.06); C299(1.22)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C10(1.01)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C10(0.97)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C10(1.01); C299(1.03)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C10(0.97)  LDD1528  [9]
 LDCM0290  AC3 HCT 116 C10(0.79)  LDD0607  [8]
 LDCM0291  AC30 HEK-293T C10(0.92)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C10(0.90)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C10(0.99)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C10(0.94); C299(1.07)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C10(1.00)  LDD1534  [9]
 LDCM0296  AC35 HCT 116 C10(1.02)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C10(1.05)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C10(1.04)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C10(1.16)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C10(1.16)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C10(0.69)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C10(1.07)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C10(1.07)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C10(1.15)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C10(1.35)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C10(0.95)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C10(1.03)  LDD0624  [8]
 LDCM0308  AC46 HEK-293T C10(1.09)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C10(0.92)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C10(1.09)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C10(0.91)  LDD0909  [8]
 LDCM0312  AC5 HCT 116 C10(0.69)  LDD0629  [8]
 LDCM0313  AC50 HEK-293T C10(1.04)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C10(1.06)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C10(1.13)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C10(0.96)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C10(1.15)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C10(1.24)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C10(0.89)  LDD0917  [8]
 LDCM0320  AC57 HCT 116 C10(1.16)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C10(1.05)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C10(1.42)  LDD0639  [8]
 LDCM0323  AC6 HEK-293T C10(1.19)  LDD0921  [8]
 LDCM0324  AC60 HCT 116 C10(1.75)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C10(1.09)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C10(1.31)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C10(1.56)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C10(1.68)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C10(1.39)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C10(0.92)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C10(1.57)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C10(1.04)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C10(0.97)  LDD0650  [8]
 LDCM0334  AC7 HEK-293T C10(0.94)  LDD0932  [8]
 LDCM0335  AC70 HCT 116 C10(1.33)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C10(1.06)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C10(1.32)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C10(1.34)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C10(1.17)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C10(1.10)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C10(1.22)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C10(1.02)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C10(0.98)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C10(1.13)  LDD0661  [8]
 LDCM0345  AC8 HEK-293T C10(0.94)  LDD0943  [8]
 LDCM0346  AC80 HCT 116 C10(1.13)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C10(1.32)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C10(1.18)  LDD0665  [8]
 LDCM0365  AC98 HCT 116 C10(1.20)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C10(1.10)  LDD0683  [8]
 LDCM0248  AKOS034007472 HEK-293T C10(1.11)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C10(1.00)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C10(1.35)  LDD0873  [8]
 LDCM0020  ARS-1620 HCC44 C10(0.92)  LDD2171  [8]
 LDCM0102  BDHI 8 Jurkat C299(23.04)  LDD0204  [2]
 LDCM0367  CL1 HEK-293T C10(1.10)  LDD0965  [8]
 LDCM0368  CL10 HEK-293T C10(1.09)  LDD0966  [8]
 LDCM0369  CL100 HCT 116 C10(0.98)  LDD0686  [8]
 LDCM0370  CL101 HEK-293T C10(1.08)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C10(1.35)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C10(0.91)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C10(0.92)  LDD0971  [8]
 LDCM0374  CL105 HCT 116 C10(0.62)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C10(0.58)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C10(0.61)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C10(0.54)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C10(0.70)  LDD0695  [8]
 LDCM0379  CL11 HEK-293T C10(0.88)  LDD0977  [8]
 LDCM0380  CL110 HCT 116 C10(0.45)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C10(0.59)  LDD0698  [8]
 LDCM0382  CL112 HEK-293T C10(1.03); C299(1.45)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C10(1.05)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C10(0.89)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C10(0.94)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C10(0.96); C299(1.24)  LDD1590  [9]
 LDCM0387  CL117 HCT 116 C10(1.15)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C10(1.26)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C10(1.27)  LDD0706  [8]
 LDCM0390  CL12 HEK-293T C10(1.02)  LDD0988  [8]
 LDCM0391  CL120 HCT 116 C10(1.10)  LDD0708  [8]
 LDCM0392  CL121 HEK-293T C10(1.25)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C10(1.04)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C10(1.10)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C10(1.03)  LDD0993  [8]
 LDCM0396  CL125 HCT 116 C10(1.14)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C10(1.24)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C10(1.41)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C10(0.88)  LDD0716  [8]
 LDCM0400  CL13 HEK-293T C10(0.92)  LDD0998  [8]
 LDCM0401  CL14 HEK-293T C10(1.07)  LDD0999  [8]
 LDCM0402  CL15 HEK-293T C10(1.29)  LDD1000  [8]
 LDCM0403  CL16 HCT 116 C10(0.98)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C10(1.13)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C10(1.01)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C10(0.99)  LDD0723  [8]
 LDCM0407  CL2 HEK-293T C10(1.14)  LDD1005  [8]
 LDCM0408  CL20 HCT 116 C10(1.15)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C10(0.97)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C10(0.99)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C10(1.10)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C10(0.88)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C10(0.93)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C10(1.07)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C10(0.88)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C10(1.08)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C10(1.05)  LDD0734  [8]
 LDCM0418  CL3 HEK-293T C10(1.03)  LDD1016  [8]
 LDCM0419  CL30 HCT 116 C10(1.03)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C10(0.92)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C10(1.09)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C10(1.12)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C10(0.96)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C10(0.98)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C10(0.85)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C10(0.79)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C10(0.97)  LDD0745  [8]
 LDCM0429  CL4 HEK-293T C10(1.50)  LDD1027  [8]
 LDCM0430  CL40 HCT 116 C10(0.88)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C10(0.90)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C10(0.74)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C10(0.88)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C10(0.76)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C10(0.82)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C10(0.96)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C10(1.03)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C10(0.78)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C10(0.79)  LDD0756  [8]
 LDCM0440  CL5 HEK-293T C10(1.21)  LDD1038  [8]
 LDCM0441  CL50 HCT 116 C10(0.78)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C10(0.94)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C10(0.81)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C10(0.69)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C10(0.73)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C10(0.63)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C10(0.70)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C10(0.75)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C10(0.94)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C10(0.85)  LDD0767  [8]
 LDCM0451  CL6 HEK-293T C10(1.19)  LDD1049  [8]
 LDCM0452  CL60 HCT 116 C10(0.94)  LDD0769  [8]
 LDCM0453  CL61 HEK-293T C10(0.93)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C10(1.06)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C10(1.41)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C10(0.69)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C10(0.75)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C10(1.16)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C10(0.88)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C10(0.94)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C10(1.19)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C10(0.83)  LDD1060  [8]
 LDCM0463  CL70 HEK-293T C10(0.74)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C10(0.82)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C10(1.31)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C10(1.24)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C10(1.43)  LDD1065  [8]
 LDCM0469  CL76 HCT 116 C10(0.77)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C10(0.76)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C10(0.85)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C10(0.70)  LDD0789  [8]
 LDCM0473  CL8 HEK-293T C10(1.01)  LDD1071  [8]
 LDCM0474  CL80 HCT 116 C10(0.72)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C10(0.64)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C10(0.61)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C10(0.68)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C10(0.96)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C10(0.91)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C10(0.87)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C10(0.66)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C10(0.72)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C10(0.78)  LDD0800  [8]
 LDCM0484  CL9 HEK-293T C10(0.85)  LDD1082  [8]
 LDCM0485  CL90 HCT 116 C10(0.76)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C10(0.99)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C10(0.95)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C10(0.72)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C10(1.00)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C10(0.96)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C10(0.81)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C10(0.87)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C10(1.01)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C10(0.87)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C10(1.01)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C10(2.24)  LDD1702  [10]
 LDCM0468  Fragment33 HEK-293T C10(0.84)  LDD1066  [8]
 LDCM0427  Fragment51 HCT 116 C10(0.85)  LDD0744  [8]
 LDCM0022  KB02 HEK-293T C10(0.93)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C10(0.92)  LDD1497  [9]
 LDCM0024  KB05 HMCB C10(1.87)  LDD3312  [11]
 LDCM0021  THZ1 HCT 116 C10(0.92)  LDD2173  [8]
 LDCM0112  W16 Hep-G2 C10(0.61)  LDD0239  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleotidyltransferase MB21D2 (MB21D2) Mab-21 family Q8IYB1
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Serine/arginine-rich splicing factor 1 (SRSF1) Splicing factor SR family Q07955
Serine/arginine-rich splicing factor 2 (SRSF2) Splicing factor SR family Q01130
Splicing factor U2AF 35 kDa subunit (U2AF1) Splicing factor SR family Q01081
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840