Details of the Target

General Information of Target

Target ID LDTP07593
Target Name Fidgetin-like protein 1 (FIGNL1)
Gene Name FIGNL1
Gene ID 63979
Synonyms
Fidgetin-like protein 1; EC 3.6.4.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQTSSSRSVHLSEWQKNYFAITSGICTGPKADAYRAQILRIQYAWANSEISQVCATKLFK
KYAEKYSAIIDSDNVESGLNNYAENILTLAGSQQTDSDKWQSGLSINNVFKMSSVQKMMQ
AGKKFKDSLLEPALASVVIHKEATVFDLPKFSVCGSSQESDSLPNSAHDRDRTQDFPESN
RLKLLQNAQPPMVTNTARTCPTFSAPVGESATAKFHVTPLFGNVKKENHSSAKENIGLNV
FLSNQSCFPAACENPQRKSFYGSGTIDALSNPILNKACSKTEDNGPKEDSSLPTFKTAKE
QLWVDQQKKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKP
YGAGPTEPAHPVDERLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWP
MLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEK
MVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRIL
VVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQS
DAFSGADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDL
ELYENWNKTFGCGK
Target Bioclass
Enzyme
Family
AAA ATPase family
Subcellular location
Nucleus
Function
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic.
Uniprot ID
Q6PIW4
Ensemble ID
ENST00000356889.8
HGNC ID
HGNC:13286

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.Q508E .
CCK81 SNV: p.R509Q .
IGROV1 SNV: p.L328P .
IPC298 SNV: p.R334Ter .
LS180 Deletion: p.K309SfsTer16 .
OAW28 SNV: p.G237A .
RKO Deletion: p.K309SfsTer16 .
SW403 SNV: p.S243C .
ZR751 SNV: p.W666Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.99  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C200(11.35)  LDD0171  [2]
DBIA
 Probe Info  		C247(5.41); C252(5.41); C26(2.01)  LDD0080  [3]
ATP probe
 Probe Info  		K117(0.00); K123(0.00); K124(0.00)  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C26(0.00); C491(0.00)  LDD0037  [5]
Compound 10
 Probe Info  		C154(0.00); C200(0.00); C26(0.00)  LDD2216  [6]
Compound 11
 Probe Info  		C154(0.00); C200(0.00); C26(0.00)  LDD2213  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
TFBX
 Probe Info  		C672(0.00); C200(0.00)  LDD0148  [8]
VSF
 Probe Info  		N.A.  LDD0007  [7]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C200(11.35)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C200(1.24)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C200(0.95); C358(1.10)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C247(0.76); C252(0.76)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C247(0.80); C252(0.80)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C247(0.88); C252(0.88)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C247(0.74); C252(0.74)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C247(0.94); C252(0.94)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C247(0.94); C252(0.94)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C247(1.22); C252(1.22)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C247(0.79); C252(0.79)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C247(0.89); C252(0.89)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C247(0.79); C252(0.79)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C200(1.01); C358(1.10)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C247(1.12); C252(1.12)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C247(0.81); C252(0.81)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C247(0.83); C252(0.83)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C200(0.91)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C200(1.03)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C200(1.25)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C200(1.10)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C200(1.14)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C200(0.80)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C200(1.10)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C200(0.98); C358(1.03)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C200(0.90)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C200(1.46)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C200(0.97)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C200(0.82)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C200(1.10)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C200(1.16)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C200(1.03)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C200(1.07)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C247(1.15); C252(1.15)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C247(1.32); C252(1.32)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C247(1.40); C252(1.40)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C247(1.42); C252(1.42)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C247(1.11); C252(1.11)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C247(1.09); C252(1.09)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C247(0.98); C252(0.98)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C247(0.97); C252(0.97)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C247(0.88); C252(0.88)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C247(0.89); C252(0.89)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C247(0.89); C252(0.89)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C247(1.12); C252(1.12)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C200(1.03); C358(0.90)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C247(1.27); C252(1.27)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C247(0.70); C252(0.70)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C247(0.67); C252(0.67)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C200(1.04)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C200(0.89)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C200(0.87)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C200(0.87)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C200(0.88)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C200(0.80)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C200(0.89)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C358(0.94); C200(1.04)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C200(0.99)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C200(0.93)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C200(0.84)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C200(0.85)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C200(0.81)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C200(0.93)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C200(0.95)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C200(0.92)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C247(0.77); C252(0.77)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C247(0.85); C252(0.85)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C247(0.92); C252(0.92)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C200(1.15)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C247(0.91); C252(0.91)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C247(1.07); C252(1.07)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C247(0.79); C252(0.79)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C247(0.82); C252(0.82)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C247(0.69); C252(0.69)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C358(1.03)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C358(0.99)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C358(1.07)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C358(0.91)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C358(1.31)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C200(1.07)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C358(1.11)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C358(0.93)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C358(1.00)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C358(0.86)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C358(1.16)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C358(0.78)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C358(0.83)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C358(0.82)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C358(0.98)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C358(0.85)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C200(0.94)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C358(0.79)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C358(0.82)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C358(0.89)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C358(0.95)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C358(0.83)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C358(0.75)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C247(1.40); C26(0.68); C586(0.76)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C247(1.45); C26(0.57); C586(0.71)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C247(1.39); C26(0.69); C586(0.66)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C247(1.46); C26(0.83); C586(1.09)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C200(1.02)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C247(1.39); C26(0.80); C586(0.75)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C247(2.41); C26(0.80); C586(0.91)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C247(1.81); C26(1.03); C586(0.92)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C247(1.55); C26(1.00); C586(0.88)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C247(1.80); C26(0.78); C586(0.92)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C247(1.72); C26(0.91); C586(0.78)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C247(1.72); C26(0.89); C586(0.97)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C358(1.14)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C358(0.72)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C358(0.94)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C200(0.93); C358(1.27)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C358(1.05)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C358(0.97)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C358(0.98)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C358(0.77)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C358(0.92)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C358(0.94)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C358(0.69)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C358(0.85)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C200(1.09); C247(0.83); C586(1.66)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C200(1.03); C247(0.81); C586(1.25)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C358(0.97); C200(0.99)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C200(0.91); C247(1.15); C586(1.53)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C200(1.08); C247(1.05); C586(1.77)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C200(1.09); C247(1.10); C586(1.27)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C200(1.31); C247(0.89); C586(1.46)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C200(1.03); C247(0.81); C586(1.71)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C200(1.05); C247(1.04); C586(2.35)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C200(1.08); C247(0.99); C586(1.23)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C200(0.92); C247(1.18); C586(1.30)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C200(0.95); C247(1.07); C586(1.40)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C200(1.03); C247(0.99); C586(1.92)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C358(0.90); C200(1.10)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C200(1.15); C247(1.20); C586(1.71)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C200(1.02); C247(1.13); C586(1.39)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C200(1.20); C247(1.37); C586(2.02)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C358(0.88); C200(1.40)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C358(0.89); C200(1.22)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C358(1.03); C200(1.27)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C358(0.96); C200(1.34)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C358(1.02); C200(1.40)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C358(0.82); C200(1.45)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C358(0.95); C200(1.43)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C358(1.19); C200(1.34)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C358(0.96); C200(1.09)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C358(1.03); C200(1.18)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C200(1.13); C358(1.14)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C200(0.91); C358(1.40)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C358(1.06); C200(1.22)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C200(0.96); C358(1.22)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C358(1.14); C200(1.38)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C247(0.75); C252(0.75)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C247(0.73); C252(0.73)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C200(1.19); C358(1.11)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C200(1.07); C358(1.33)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C358(0.90); C200(1.05)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C247(0.95); C252(0.95)  LDD2171  [3]
 LDCM0632  CL-Sc Hep-G2 C154(20.00); C672(4.93); C26(0.79)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C358(1.17)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C358(1.00)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C200(1.04)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C200(0.85); C358(0.89)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C358(0.93); C200(1.10)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C200(0.91); C358(0.99)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C358(1.13); C200(1.18)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C247(0.88); C252(0.88)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C247(0.85); C252(0.85)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C247(0.94); C252(0.94)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C247(0.95); C252(0.95)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C247(0.94); C252(0.94)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C358(0.84)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C247(0.93); C252(0.93)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C247(0.89); C252(0.89)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C358(0.89)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C358(1.26)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C358(1.12)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C358(1.06)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C358(1.05)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C358(0.77)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C358(0.88)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C358(0.93)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C358(1.18)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C358(0.88)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C247(1.44); C26(1.07); C586(0.70)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C247(1.41); C26(0.65); C586(0.87)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C247(1.22); C26(0.73); C586(1.12)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C247(1.05); C26(1.17); C586(0.84)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C358(1.13)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C358(1.40)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C358(1.16)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C358(1.01)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C358(0.95)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C358(1.13)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C358(1.02)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C200(0.90); C247(0.98); C252(0.98); C358(1.05)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C247(0.97); C252(0.97); C358(1.09)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C247(0.80); C252(0.80); C358(1.04)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C247(0.94); C252(0.94); C358(1.06)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C358(1.04)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C247(1.10); C252(1.10); C358(1.12)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C247(0.98); C252(0.98); C358(1.06)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C358(1.11); C247(1.42); C252(1.42)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C247(0.84); C252(0.84); C358(1.05)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C247(1.00); C252(1.00); C358(1.10)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C247(1.15); C252(1.15); C358(1.14)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C247(0.85); C252(0.85); C358(1.13)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C247(1.09); C252(1.09); C358(1.11)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C247(1.04); C252(1.04); C358(1.06)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C247(1.21); C252(1.21); C358(1.04)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C358(0.97)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C247(0.93); C252(0.93); C358(1.19)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C358(1.04)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C200(1.01)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C200(1.19)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C200(1.15)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C200(1.04)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C200(0.86)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C200(0.93)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C200(1.21)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C358(1.11)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C200(0.84)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C200(1.31)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C200(0.81)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C200(0.86)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C200(0.95)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C200(1.22)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C358(0.82)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C358(0.74)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C358(0.84)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C358(1.22)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C358(0.92)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C358(0.81)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C358(0.73)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C358(1.04)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C358(0.87)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C358(0.88)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C358(0.70)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C358(0.75)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C358(0.79)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C358(0.87)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C358(0.66)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C358(0.97)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C358(0.77)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C358(1.13)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C358(1.03)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C358(1.17)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C358(0.99)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C358(1.03)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C358(0.92)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C358(1.14)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C358(1.01)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C358(1.13)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C358(1.12)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C358(1.10)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C358(1.14)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C358(1.35)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C358(1.06)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C358(1.05)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C200(1.02); C358(0.90)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C200(0.94); C358(1.24)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C200(1.08); C358(1.06)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C200(1.10); C358(0.82)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C358(1.08)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C200(1.15); C358(1.00)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C200(1.26); C358(0.78)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C200(0.99); C358(0.75)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C200(1.23); C358(0.94)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C200(1.02); C358(1.01)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C200(1.15); C358(0.80)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C200(1.01); C358(0.86)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C200(1.27); C358(0.75)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C200(1.08); C358(0.87)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C200(0.95); C358(0.96)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C358(1.30)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C200(1.10); C358(0.81)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C200(1.04)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C200(1.06)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C200(0.89)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C200(1.14)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C200(1.32)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C200(1.10)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C200(1.05)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C200(0.98)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C200(1.00)  LDD0811  [3]
 LDCM0625  F8 Ramos C200(1.39)  LDD2187  [11]
 LDCM0573  Fragment11 Ramos C200(10.70)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C200(0.70)  LDD2191  [11]
 LDCM0580  Fragment21 Ramos C200(0.62)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C200(0.63)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C200(0.59)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C200(0.90)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C200(0.80)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C200(0.68)  LDD2200  [11]
 LDCM0468  Fragment33 HCT 116 C358(1.13)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C200(0.47)  LDD2203  [11]
 LDCM0427  Fragment51 HCT 116 C200(0.95)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C200(1.31)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C200(0.65)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C200(1.55)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C200(1.18)  LDD2188  [11]
 LDCM0022  KB02 HCT 116 C247(5.41); C252(5.41); C26(2.01)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C247(2.86); C252(2.86); C26(1.07)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C247(5.02); C252(5.02); C26(1.59)  LDD0082  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C54(0.21)  LDD2206  [12]
 LDCM0021  THZ1 HCT 116 C247(0.95); C252(0.95)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrin beta-1-binding protein 1 (ITGB1BP1) . O14713
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.