Details of the Target

General Information of Target

Target ID LDTP07493
Target Name Phostensin (PPP1R18)
Gene Name PPP1R18
Gene ID 170954
Synonyms
HKMT1098; KIAA1949; Phostensin; Protein phosphatase 1 F-actin cytoskeleton-targeting subunit; Protein phosphatase 1 regulatory subunit 18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATIPDWKLQLLARRRQEEASVRGREKAERERLSQMPAWKRGLLERRRAKLGLSPGEPSP
VLGTVEAGPPDPDESAVLLEAIGPVHQNRFIRQERQQQQQQQQRSEELLAERKPGPLEAR
ERRPSPGEMRDQSPKGRESREERLSPRETRERRLGIGGAQELSLRPLEARDWRQSPGEVG
DRSSRLSEAWKWRLSPGETPERSLRLAESREQSPRRKEVESRLSPGESAYQKLGLTEAHK
WRPDSRESQEQSLVQLEATEWRLRSGEERQDYSEECGRKEEWPVPGVAPKETAELSETLT
REAQGNSSAGVEAAEQRPVEDGERGMKPTEGWKWTLNSGKAREWTPRDIEAQTQKPEPPE
SAEKLLESPGVEAGEGEAEKEEAGAQGRPLRALQNCCSVPSPLPPEDAGTGGLRQQEEEA
VELQPPPPAPLSPPPPAPTAPQPPGDPLMSRLFYGVKAGPGVGAPRRSGHTFTVNPRRSV
PPATPATPTSPATVDAAVPGAGKKRYPTAEEILVLGGYLRLSRSCLAKGSPERHHKQLKI
SFSETALETTYQYPSESSVLEELGPEPEVPSAPNPPAAQPDDEEDEEELLLLQPELQGGL
RTKALIVDESCRR
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Function [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton.; [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton.
Uniprot ID
Q6NYC8
Ensemble ID
ENST00000274853.8
HGNC ID
HGNC:29413

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.G56E DBIA    Probe Info 
HCT116 SNV: p.P499L DBIA    Probe Info 
HT SNV: p.L413P .
JURKAT Deletion: p.G517AfsTer89 .
KMS12BM SNV: p.G158E DBIA    Probe Info 
NCIH1993 SNV: p.Q97E .
NCIH358 SNV: p.Q97E DBIA    Probe Info 
OVK18 Insertion: p.Q103dup DBIA    Probe Info 
SNGM SNV: p.R41Ter DBIA    Probe Info 
SW403 SNV: p.E220D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K191(10.00); K232(0.81); K240(1.07); K40(7.44)  LDD0277  [2]
BTD
 Probe Info  		C611(1.34)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C276(4.95)  LDD0171  [4]
DBIA
 Probe Info  		C276(1.08); C396(1.07); C397(1.07); C611(1.07)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C611(0.00); C276(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		C397(0.00); C396(0.00); C611(0.00)  LDD0027  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C276(0.70)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C276(0.84)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C276(1.49)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C611(1.31)  LDD2152  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C276(4.95)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C611(1.14); C276(1.41); C396(0.91); C397(0.91)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C611(1.39); C276(1.24); C396(1.23); C397(1.12)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C611(1.11); C276(0.88); C396(1.07); C397(1.07)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C611(1.06); C276(0.99); C396(1.21); C397(1.21)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C611(1.09); C276(0.91); C396(0.95); C397(0.95)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C611(1.45); C276(1.06); C396(1.17); C397(1.17)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C611(1.19); C276(1.01); C396(1.09); C397(1.09)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C611(1.30); C276(1.38); C396(1.09); C397(1.09)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C611(1.45); C276(1.31); C396(1.19); C397(1.19)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C611(1.32); C276(2.28); C396(1.16); C397(1.16)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C611(1.13); C276(0.85); C396(0.88); C397(0.88)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C611(0.97); C276(0.78); C396(1.01); C397(1.01)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C611(1.45); C276(1.24); C396(0.82); C397(0.87)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C611(1.09); C276(1.09); C396(1.15); C397(1.15)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C611(1.01); C276(1.05); C396(0.97); C397(0.97)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C611(1.27); C276(0.93); C396(1.09); C397(1.09)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C611(1.01); C276(1.10); C396(0.74); C397(0.74)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C611(1.25); C276(1.20); C396(0.93); C397(0.93)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C611(1.33); C276(1.47); C396(1.00); C397(1.00)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C611(1.45); C276(1.35); C396(0.99); C397(0.99)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C611(1.27); C276(1.26); C396(0.86); C397(0.86)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C611(1.21); C276(1.13); C396(0.94); C397(0.94)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C611(1.39); C276(1.05); C396(1.13); C397(1.13)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C611(1.13); C276(1.02); C396(0.89); C397(0.99)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C611(1.34); C276(1.25); C396(1.02); C397(1.02)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C611(1.07); C276(1.06); C396(0.83); C397(0.83)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C611(1.22); C276(1.22); C396(0.94); C397(0.94)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C611(1.05); C276(1.08); C396(0.99); C397(0.99)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C611(1.03); C276(1.05); C396(0.88); C397(0.88)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C611(1.15); C276(1.11); C396(0.86); C397(0.86)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C611(1.42); C276(1.38); C396(1.04); C397(1.04)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C611(1.41); C276(1.42); C396(0.89); C397(0.89)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C611(1.27); C276(0.96); C396(0.97); C397(0.97)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C611(0.79); C276(0.94); C396(0.82); C397(0.82)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C611(1.07); C276(1.39); C396(1.06); C397(1.06)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C611(0.79); C276(1.04); C396(0.95); C397(0.95)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C611(0.90); C276(1.26); C396(1.07); C397(1.07)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C611(0.99); C276(1.13); C396(0.97); C397(0.97)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C611(1.07); C276(1.38); C396(1.20); C397(1.20)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C611(0.98); C276(1.16); C396(1.14); C397(1.14)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C611(1.03); C276(1.49); C396(1.12); C397(1.12)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C611(0.97); C276(1.11); C396(0.91); C397(0.91)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C611(1.13); C276(1.51); C396(1.47); C397(1.47)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C611(1.04); C276(1.66); C396(1.33); C397(1.33)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C611(1.27); C276(1.03); C396(1.12); C397(1.05)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C611(1.11); C276(1.41); C396(1.43); C397(1.43)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C611(1.09); C276(1.51); C396(1.47); C397(1.47)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C611(0.92); C276(1.54); C396(1.35); C397(1.35)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C611(1.19); C276(1.23); C396(1.38); C397(1.38)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C396(1.11); C397(1.16); C611(1.49); C276(1.57)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C396(0.98); C397(1.03); C611(1.22); C276(1.34)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C396(1.05); C397(1.06); C611(1.43); C276(1.51)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C397(0.88); C396(1.02); C276(1.30); C611(1.57)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C396(0.92); C397(1.01); C276(1.79); C611(2.17)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C396(1.25); C397(1.42); C276(1.69); C611(1.80)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C397(0.68); C396(0.70); C276(1.23); C611(1.48)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C396(0.98); C397(1.01); C611(1.24); C276(1.31)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C611(1.19); C397(1.19); C396(1.22); C276(1.46)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C396(0.91); C397(1.03); C276(1.44); C611(1.56)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C396(0.91); C397(1.22); C276(2.61); C611(3.28)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C611(1.49); C276(1.51); C396(1.32); C397(1.41)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C611(1.46); C276(1.50); C396(1.09); C397(1.17)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C611(1.12); C276(1.19); C396(0.96); C397(1.07)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C611(1.01); C276(1.29); C396(1.02); C397(1.13)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C396(0.92); C397(0.97); C276(1.20); C611(1.23)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C611(1.02); C397(1.08); C396(1.26); C276(2.22)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C396(1.00); C611(1.02); C397(1.30); C276(1.60)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C396(0.89); C397(0.89); C611(1.12); C276(1.46)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C611(0.94); C397(1.11); C396(1.14); C276(1.44)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C611(0.93); C396(1.03); C397(1.04); C276(1.79)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C396(0.89); C397(1.07); C276(1.08); C611(1.29)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C396(0.88); C397(1.05); C611(1.06); C276(1.52)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C396(0.84); C611(0.94); C397(0.99); C276(1.27)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C276(0.88); C396(0.94); C397(0.94); C611(1.22)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C396(0.93); C397(0.93); C276(1.21); C611(1.39)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C396(0.78); C397(0.78); C276(1.30); C611(1.65)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C396(1.32); C397(1.32); C276(1.62); C611(1.63)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C396(1.23); C397(1.23); C611(1.47); C276(1.59)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C396(0.82); C397(0.82); C611(1.11); C276(1.64)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C396(0.88); C397(0.88); C611(1.35); C276(1.81)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C396(0.94); C397(0.94); C276(1.32); C611(1.39)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C396(1.43); C397(1.43); C611(1.97); C276(2.08)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C396(1.10); C397(1.10); C276(1.67); C611(1.77)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C396(1.18); C397(1.18); C276(1.42); C611(2.27)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C611(0.82); C276(0.92); C396(1.10); C397(1.10)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C611(0.75); C276(1.07); C396(1.16); C397(1.16)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C611(0.67); C276(1.04); C396(1.11); C397(1.11)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C611(0.91); C276(0.96); C396(1.24); C397(1.24)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C396(1.08); C397(1.08); C611(1.11); C276(1.71)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C396(0.93); C397(0.93); C611(1.32); C276(1.48)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C276(1.02); C611(1.15); C396(1.90); C397(1.90)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C611(0.88); C276(1.11); C396(1.24); C397(1.24)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C611(1.07); C276(1.14); C396(1.16); C397(1.16)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C611(1.04); C276(1.23); C396(1.49); C397(1.49)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C611(0.91); C276(0.98); C396(1.18); C397(1.18)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C276(1.14); C611(1.25); C396(2.08); C397(2.08)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C396(0.88); C611(1.24); C276(1.31)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C396(0.85); C276(0.96); C611(1.27)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C611(1.23); C396(1.27); C276(1.37)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C396(1.07); C276(1.07); C611(1.93)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C396(0.90); C397(0.90); C611(1.18); C276(1.52)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C276(0.82); C396(1.53); C611(1.98)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C276(0.83); C611(1.02); C396(1.38)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C276(1.01); C396(1.17); C611(1.27)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C396(0.75); C276(0.98); C611(1.39)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C396(1.09); C276(1.24); C611(1.50)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C396(0.90); C276(1.81); C611(2.07)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C396(0.82); C276(1.12); C611(4.09)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C276(0.94); C396(0.97); C397(0.97); C611(1.52)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C396(0.92); C397(0.92); C276(1.02); C611(1.68)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C396(1.02); C397(1.02); C276(1.05); C611(1.62)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C397(1.07); C396(1.13); C276(1.30); C611(1.33)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C276(0.90); C396(1.08); C397(1.08); C611(1.48)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C276(1.07); C396(1.09); C397(1.09); C611(1.38)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C396(1.14); C397(1.14); C276(1.48); C611(1.80)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C276(0.94); C396(1.29); C397(1.29); C611(1.44)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C276(1.00); C396(1.31); C397(1.31); C611(1.79)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C276(0.80); C611(1.03); C396(1.10); C397(1.10)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C276(0.65); C396(0.96); C397(0.96); C611(0.99)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C276(0.91); C611(1.47); C396(1.61); C397(1.61)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C276(0.86); C611(1.21); C396(1.28); C397(1.28)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C276(0.78); C396(1.01); C397(1.01); C611(1.30)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C396(0.84); C397(0.91); C276(1.02); C611(1.14)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C396(1.05); C397(1.05); C276(1.20); C611(1.31)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C276(0.80); C396(0.91); C397(0.91); C611(1.08)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C276(0.66); C396(1.02); C397(1.02); C611(1.46)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C276(0.81); C396(1.00); C397(1.00); C611(2.06)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C276(0.84); C396(0.89); C397(0.89); C611(1.68)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C276(0.77); C396(1.35); C397(1.35); C611(2.95)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C396(0.87); C397(0.87); C276(0.98); C611(1.38)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C276(0.90); C396(1.28); C397(1.28); C611(1.33)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C276(0.62); C396(1.12); C397(1.12); C611(1.35)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C276(0.75); C396(1.17); C397(1.17); C611(1.29)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C396(0.84); C397(0.87); C276(1.19); C611(1.36)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C276(0.84); C396(1.16); C397(1.16); C611(1.36)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C276(0.76); C396(1.20); C397(1.20); C611(1.25)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C276(0.86); C396(1.02); C397(1.02); C611(2.68)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C396(0.87); C397(0.87); C611(1.71); C276(1.75)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C396(1.02); C397(1.02); C611(1.49); C276(1.89)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C396(0.98); C397(0.98); C276(1.25); C611(1.33)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C396(1.02); C397(1.02); C611(1.16); C276(1.23)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C396(0.93); C397(0.93); C611(1.04); C276(1.20)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C396(0.71); C397(0.71); C611(1.13); C276(1.34)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C396(1.04); C397(1.04); C611(1.45); C276(1.69)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C396(0.86); C397(0.86); C611(0.95); C276(0.97)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C396(1.05); C397(1.05); C611(1.79); C276(2.59)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C396(1.06); C397(1.06); C611(1.69); C276(2.23)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C611(1.16); C396(1.28); C397(1.28); C276(1.70)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C396(1.15); C397(1.15); C276(1.29); C611(1.30)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C396(1.03); C397(1.03); C611(1.27); C276(1.45)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C396(1.23); C397(1.23); C611(1.41); C276(1.84)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C396(1.25); C397(1.25); C611(1.66); C276(1.95)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C276(2.15); C396(2.29); C397(2.29); C611(2.94)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C396(0.84); C397(0.84); C276(1.01); C611(1.10)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C276(0.26)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C611(1.09); C276(0.93); C396(0.90); C397(0.95)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C396(0.72); C397(0.81); C611(1.17); C276(1.28)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C396(0.67); C397(0.73); C276(2.06); C611(2.69)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.94  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C276(1.08); C396(1.07); C397(1.07); C611(1.07)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C611(0.91); C276(1.06); C396(1.14); C397(1.14)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C396(1.02); C397(1.02); C611(1.77); C276(2.27)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C396(1.01); C397(1.01); C611(1.25); C276(1.57)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C276(1.42); C611(1.46); C397(10.60); C396(10.66)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C396(1.03); C276(1.03); C611(1.07); C397(1.07)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C397(0.68); C396(0.68); C276(1.00); C611(1.08)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C397(1.08); C396(1.27); C276(1.27); C611(1.33)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C396(1.06); C397(1.07); C611(1.33); C276(1.54)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C396(0.89); C397(1.07); C611(1.28); C276(2.00)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C396(0.96); C397(1.07); C611(1.53); C276(1.53)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C396(0.82); C397(1.00); C611(1.40); C276(2.04)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C396(1.10); C397(1.20); C611(1.68); C276(2.05)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C396(1.20); C397(1.20); C276(1.33); C611(2.04)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C396(0.83); C397(0.97); C611(1.29); C276(2.23)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C397(0.94); C396(0.99); C611(1.36); C276(1.53)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C611(1.05); C276(1.10); C396(1.17); C397(1.17)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C396(0.90); C397(0.90); C276(1.57); C611(1.69)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C396(1.25); C397(1.25); C611(1.37); C276(1.50)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C396(0.92); C397(0.92); C611(1.48); C276(1.49)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C396(0.97); C397(0.97); C276(0.99); C611(1.43)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C396(2.30); C397(2.30); C276(2.40); C611(3.05)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C611(0.96); C276(1.26); C396(1.26); C397(1.26)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C611(1.11); C396(1.39); C397(1.39); C276(1.60)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C396(1.20); C397(1.20); C276(1.74); C611(2.34)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C611(1.03); C276(1.04); C396(1.37); C397(1.37)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C396(0.92); C611(1.00); C276(1.59)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C276(0.99); C611(1.21); C396(1.90)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C396(1.23); C611(1.35); C276(1.38)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C396(1.21); C611(1.69); C276(1.87)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C276(0.79); C611(0.90); C396(0.96); C397(0.96)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C276(0.71); C396(1.06); C397(1.06); C611(1.10)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C276(0.89); C396(0.94); C397(0.94); C611(0.97)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C276(0.82); C396(1.01); C397(1.01); C611(1.72)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C396(0.97); C397(0.97); C276(1.37); C611(1.49)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C396(1.07); C397(1.07); C611(1.26); C276(1.29)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C396(1.11); C397(1.11); C276(1.19); C611(1.62)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C396(1.04); C397(1.04); C611(1.20); C276(1.58)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C396(0.77); C397(0.77); C276(0.89); C611(0.95)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C396(0.92); C397(0.92); C276(1.01); C611(1.24)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C396(0.90); C397(0.90); C611(1.15); C276(1.65)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C276(0.85); C611(0.99); C396(1.21); C397(1.21)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C396(1.02); C397(1.02); C611(1.24); C276(1.91)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C396(0.97); C397(0.97); C611(1.44); C276(1.90)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C396(0.96); C397(0.96); C276(2.55); C611(3.98)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C396(0.88); C397(0.88); C611(1.28); C276(1.68)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C396(0.92); C397(0.92); C611(1.71); C276(1.85)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C611(1.56); C276(2.13); C396(1.00); C397(1.00)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C611(1.20); C276(1.45); C396(0.95); C397(0.95)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C611(1.12); C276(1.47); C396(0.95); C397(0.95)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C611(1.56); C276(1.87); C396(1.02); C397(1.02)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C611(1.33); C276(1.59); C396(1.06); C397(1.06)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C611(1.11); C276(1.09); C396(1.14); C397(1.14)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C611(1.25); C276(1.32); C396(1.05); C397(1.05)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C611(1.20); C276(1.59); C396(1.19); C397(1.19)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C611(1.47); C276(1.90); C396(1.10); C397(1.10)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C611(1.48); C276(1.72); C396(1.18); C397(1.18)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C611(1.80); C276(1.89); C396(0.75); C397(0.75)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C611(1.68); C276(2.17); C396(0.88); C397(0.88)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C611(1.71); C276(2.38); C396(0.66); C397(0.66)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C611(2.32); C276(3.17); C396(0.77); C397(0.77)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C611(2.11); C276(2.42); C396(0.97); C397(0.97)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C611(1.18); C276(1.49); C396(1.07); C397(1.07)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C611(1.59); C276(2.41); C396(1.23); C397(1.23)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C611(1.53); C276(1.96); C396(0.85); C397(0.85)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C611(3.44); C276(3.30); C396(0.63); C397(0.63)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C611(2.41); C276(2.68); C396(0.98); C397(0.98)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C611(2.24); C276(2.76); C396(0.67); C397(0.67)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C611(3.08); C276(2.72); C396(0.80); C397(0.80)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C611(0.95); C276(0.87); C396(1.03); C397(1.10)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C611(0.86); C276(0.94); C396(0.98); C397(0.92)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C611(0.81); C276(0.93); C396(1.06); C397(0.95)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C611(0.98); C276(0.66); C396(0.97); C397(0.94)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C611(1.15); C276(1.03); C396(1.12); C397(1.12)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C611(0.91); C276(1.02); C396(1.08); C397(1.07)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C611(0.92); C276(0.83); C396(0.90); C397(0.93)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C611(0.95); C276(1.07); C396(1.31); C397(1.16)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C611(0.84); C276(1.00); C396(1.04); C397(1.14)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C611(0.91); C276(0.98); C396(1.26); C397(1.06)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C611(0.90); C276(1.02); C396(1.00); C397(0.93)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C611(1.02); C276(0.83); C396(0.86); C397(0.94)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C611(0.83); C276(1.05); C396(0.99); C397(0.93)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C611(0.89); C276(0.98); C396(0.93); C397(0.93)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C611(1.06); C276(0.98); C396(0.82); C397(0.85)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C611(1.39); C276(1.03); C396(1.24); C397(1.24)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C611(1.12); C276(0.94); C396(0.91); C397(0.88)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C611(1.06); C276(1.03); C396(0.81); C397(0.81)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C611(0.95); C276(1.16); C396(0.91); C397(0.91)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C611(1.12); C276(1.55); C396(0.88); C397(0.88)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C611(1.18); C276(1.43); C396(0.68); C397(0.68)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C611(0.97); C276(1.17); C396(0.67); C397(0.67)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C611(1.52); C276(1.59); C396(0.76); C397(0.76)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C611(1.36); C276(1.47); C396(0.63); C397(0.63)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C611(1.27); C276(1.18); C396(0.75); C397(0.75)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C611(0.99); C276(1.20); C396(0.85); C397(0.85)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C611(1.77); C276(1.39); C396(1.07); C397(1.07)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C611(1.21); C276(1.25); C396(0.96); C397(0.96)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C611(1.27); C276(1.48); C396(0.67); C397(0.67)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C611(1.10); C276(1.31); C396(0.72); C397(0.72)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C611(1.08); C276(1.40); C396(0.77); C397(0.77)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C611(1.13); C276(1.24); C396(0.84); C397(0.84)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C611(1.29); C276(0.94); C396(0.83); C397(0.83)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C611(1.06); C276(0.82); C396(0.85); C397(0.85)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C611(1.30); C276(1.18); C396(0.91); C397(0.91)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C611(1.89); C276(0.95); C396(0.99); C397(0.99)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C611(2.60); C276(1.80); C396(1.54); C397(1.54)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C611(1.17); C276(0.73); C396(0.77); C397(0.77)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C611(1.49); C276(1.34); C396(0.76); C397(0.76)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C611(3.64); C276(0.91); C396(0.66); C397(0.66)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C611(2.09); C276(1.18); C396(0.85); C397(0.85)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C611(4.79); C276(1.24); C396(1.01); C397(1.01)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C611(1.26); C276(1.11); C396(0.81); C397(0.81)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C611(1.00); C276(0.63); C396(0.81); C397(0.81)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C611(1.23); C276(0.68); C396(0.84); C397(0.84)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C611(2.02); C276(0.82); C396(0.87); C397(0.87)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C611(5.89); C276(1.30); C396(1.06); C397(1.06)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C611(1.41); C276(1.21); C396(1.13); C397(1.13)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C611(1.02); C276(0.85); C396(0.87); C397(0.87)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C611(1.32); C276(1.47); C396(0.88); C397(0.88)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C611(1.15); C276(1.35); C396(0.89); C397(0.89)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C611(1.15); C276(1.82); C396(0.80); C397(0.80)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C611(1.46); C276(1.74); C396(1.03); C397(1.03)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C611(1.46); C276(1.96); C396(0.85); C397(0.85)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C611(1.35); C276(1.87); C396(0.95); C397(0.95)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C611(1.11); C276(1.55); C396(1.04); C397(1.04)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C611(1.30); C276(1.81); C396(0.90); C397(0.90)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C611(1.18); C276(1.62); C396(0.82); C397(0.82)  LDD0811  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C611(1.02)  LDD1702  [3]
 LDCM0625  F8 Ramos C611(1.07)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C611(4.43)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C611(0.01)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C611(0.75)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C611(0.92)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C611(0.66)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C611(0.62)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C611(0.88)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C611(0.99)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C611(0.90)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C611(0.92)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C611(1.04)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C611(0.82)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C611(0.86)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C611(1.04); C276(1.73); C396(0.79); C397(0.79)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C611(0.87)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C611(0.74)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C611(1.66); C276(5.14); C396(0.84); C397(0.84)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C611(1.02)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C611(1.05)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C611(0.77)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C611(0.77)  LDD2188  [12]
 LDCM0022  KB02 HCT 116 C276(2.58)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C276(1.23)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C276(1.61)  LDD0082  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C276(0.37)  LDD2102  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C611(1.05)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C276(0.71)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C611(0.96)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C611(1.04); C276(1.02)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C276(1.15)  LDD2100  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C276(0.77)  LDD2104  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C611(1.01); C276(1.12)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C276(0.76)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C611(0.50)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C276(1.81)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C611(1.00)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C276(0.92)  LDD2114  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C611(2.13)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C611(1.14)  LDD2120  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C611(0.89)  LDD2129  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C611(1.02); C276(1.05)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C611(1.34)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C611(1.03); C276(1.05)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C276(0.76)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C611(1.08); C276(2.25)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C611(2.43)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C611(0.93)  LDD2146  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C611(0.91); C276(1.10)  LDD2153  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
tRNA modification GTPase GTPBP3, mitochondrial (GTPBP3) TrmE GTPase family Q969Y2
E3 ubiquitin-protein ligase TRIM62 (TRIM62) TRIM/RBCC family Q9BVG3
E3 ubiquitin-protein ligase TRIM69 (TRIM69) TRIM/RBCC family Q86WT6
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cilium assembly protein DZIP1 (DZIP1) DZIP C2H2-type zinc-finger protein family Q86YF9
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 52 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-3 (ACTN3) Alpha-actinin family Q08043
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Coiled-coil domain-containing protein 88B (CCDC88B) CCDC88 family A6NC98
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Eukaryotic translation initiation factor 3 subunit L (EIF3L) EIF-3 subunit L family Q9Y262
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Desmin (DES) Intermediate filament family P17661
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Peripherin (PRPH) Intermediate filament family P41219
Vimentin (VIM) Intermediate filament family P08670
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Large ribosomal subunit protein mL38 (MRPL38) Phosphatidylethanolamine-binding protein family Q96DV4
Protein Spindly (SPDL1) Spindly family Q96EA4
Testis-expressed protein 11 (TEX11) SPO22 family Q8IYF3
Syntaxin-11 (STX11) Syntaxin family O75558
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Actin-binding Rho-activating protein (ABRA) . Q8N0Z2
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Heat shock factor 2-binding protein (HSF2BP) . O75031
Huntingtin-associated protein 1 (HAP1) . P54257
Myomegalin (PDE4DIP) . Q5VU43
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Protein KASH5 (KASH5) . Q8N6L0
Vinexin (SORBS3) . O60504
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578