Details of the Target

General Information of Target

Target ID LDTP07256
Target Name Terminal uridylyltransferase 7 (TUT7)
Gene Name TUT7
Gene ID 79670
Synonyms
HS2; KIAA1711; ZCCHC6; Terminal uridylyltransferase 7; TUTase 7; EC 2.7.7.52; Zinc finger CCHC domain-containing protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDTAKPYFVKRTKDRGTMDDDDFRRGHPQQDYLIIDDHAKGHGSKMEKGLQKKKITPGN
YGNTPRKGPCAVSSNPYAFKNPIYSQPAWMNDSHKDQSKRWLSDEHTGNSDNWREFKPGP
RIPVINRQRKDSFQENEDGYRWQDTRGCRTVRRLFHKDLTSLETTSEMEAGSPENKKQRS
RPRKPRKTRNEENEQDGDLEGPVIDESVLSTKELLGLQQAEERLKRDCIDRLKRRPRNYP
TAKYTCRLCDVLIESIAFAHKHIKEKRHKKNIKEKQEEELLTTLPPPTPSQINAVGIAID
KVVQEFGLHNENLEQRLEIKRIMENVFQHKLPDCSLRLYGSSCSRLGFKNSDVNIDIQFP
AIMSQPDVLLLVQECLKNSDSFIDVDADFHARVPVVVCREKQSGLLCKVSAGNENACLTT
KHLTALGKLEPKLVPLVIAFRYWAKLCSIDRPEEGGLPPYVFALMAIFFLQQRKEPLLPV
YLGSWIEGFSLSKLGNFNLQDIEKDVVIWEHTDSAAGDTGITKEEAPRETPIKRGQVSLI
LDVKHQPSVPVGQLWVELLRFYALEFNLADLVISIRVKELVSRELKDWPKKRIAIEDPYS
VKRNVARTLNSQPVFEYILHCLRTTYKYFALPHKITKSSLLKPLNAITCISEHSKEVINH
HPDVQTKDDKLKNSVLAQGPGATSSAANTCKVQPLTLKETAESFGSPPKEEMGNEHISVH
PENSDCIQADVNSDDYKGDKVYHPETGRKNEKEKVGRKGKHLLTVDQKRGEHVVCGSTRN
NESESTLDLEGFQNPTAKECEGLATLDNKADLDGESTEGTEELEDSLNHFTHSVQGQTSE
MIPSDEEEEDDEEEEEEEEPRLTINQREDEDGMANEDELDNTYTGSGDEDALSEEDDELG
EAAKYEDVKECGKHVERALLVELNKISLKEENVCEEKNSPVDQSDFFYEFSKLIFTKGKS
PTVVCSLCKREGHLKKDCPEDFKRIQLEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQ
AREHIRQNLESFIRQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTI
EELARVLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAI
DPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPPVIPVLQEIYKGEK
KPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRR
KSLLTTFKKQWTSKYIVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRVFGIPVKGFPK
DYPSKMEYFFDPDVLTEGELAPNDRCCRICGKIGHFMKDCPMRRKVRRRRDQEDALNQRY
PENKEKRSKEDKEIHNKYTEREVSTKEDKPIQCTPQKAKPMRAAADLGREKILRPPVEKW
KRQDDKDLREKRCFICGREGHIKKECPQFKGSSGSLSSKYMTQGKASAKRTQQES
Target Bioclass
Enzyme
Family
DNA polymerase type-B-like family
Subcellular location
Cytoplasm
Function
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms. Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A. In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing. Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult . TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules.
Uniprot ID
Q5VYS8
Ensemble ID
ENST00000375960.6
HGNC ID
HGNC:25817

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.F1299S DBIA    Probe Info 
CMK SNV: p.Y1212N DBIA    Probe Info 
DETROIT562 SNV: p.P185S DBIA    Probe Info 
HCT15 SNV: p.I1353N DBIA    Probe Info 
HEC1 SNV: p.D450Y DBIA    Probe Info 
HT115 SNV: p.S638F; p.V1104A DBIA    Probe Info 
JHH7 SNV: p.D386G .
JURKAT SNV: p.Q536H .
KASUMI2 SNV: p.E824K DBIA    Probe Info 
LNCaP clone FGC SNV: p.D21G DBIA    Probe Info 
NCIH2286 SNV: p.R592P .
OE33 SNV: p.E935K DBIA    Probe Info 
OVK18 SNV: p.A463V DBIA    Probe Info 
SHP77 SNV: p.R1458K .
SW620 SNV: p.D144Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C775(2.77); C649(2.13)  LDD0170  [2]
Acrolein
 Probe Info  		H761(0.00); H1254(0.00)  LDD0225  [3]
DBIA
 Probe Info  		C343(1.24); C690(1.08)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C343(0.00); C1413(0.00); C621(0.00); C775(0.00)  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		C1158(0.00); C343(0.00); C417(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
IPM
 Probe Info  		C690(0.00); C70(0.00); C649(0.00); C343(0.00)  LDD0147  [8]
TFBX
 Probe Info  		C398(0.00); C343(0.00)  LDD0148  [8]
VSF
 Probe Info  		C775(0.00); C800(0.00); C690(0.00); C1413(0.00)  LDD0007  [9]
AOyne
 Probe Info  		12.80  LDD0443  [10]
NAIA_5
 Probe Info  		C1453(0.00); C978(0.00); C70(0.00); C775(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C775(2.77); C649(2.13)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C934(3.74); C775(5.95); C649(6.91); C1413(5.88)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C343(1.16); C1005(0.97); C1008(0.97); C1062(0.99)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C343(0.75); C1005(0.95); C1008(0.95); C1148(0.66)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C343(1.17); C1148(1.00); C417(1.02); C690(0.85)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C343(1.36); C1148(0.90); C417(0.97); C690(0.90)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C343(0.95); C1148(0.94); C417(1.08); C690(0.91)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C343(1.20); C1148(1.05); C417(0.95); C690(0.99)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C343(0.66); C1148(0.97); C417(0.97); C690(0.93)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C343(0.94); C1148(1.04); C417(1.04); C690(0.94)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C343(1.03); C1148(1.03); C417(0.95); C690(0.92)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C343(0.68); C1148(0.81); C417(0.99); C690(0.88)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C343(0.76); C1148(0.94); C417(0.97); C690(0.80)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C343(0.56); C1148(1.04); C417(1.06); C690(0.88)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C343(0.71); C1005(0.90); C1008(0.90); C1148(0.70)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C343(0.79); C1148(1.05); C417(0.92); C690(0.98)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C343(0.66); C1148(0.77); C417(0.97); C690(1.05)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C343(0.68); C1148(0.89); C417(0.93); C690(0.95)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C343(0.92); C1148(0.92); C417(1.04); C690(1.11)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C343(1.03); C1148(0.82); C417(0.91); C690(1.10)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C343(1.10); C1148(1.01); C417(1.17); C690(1.06)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C343(0.93); C1148(0.83); C417(1.17); C690(1.13)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C343(1.11); C1148(0.87); C417(0.94); C690(1.05)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C343(0.82); C1148(0.82); C417(1.11); C690(1.17)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C343(1.05); C1148(0.72); C417(0.98); C690(1.08)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C343(0.61); C1005(0.99); C1008(0.99); C1148(0.72)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C343(0.85); C1148(1.08); C417(1.15); C690(1.20)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C343(0.77); C1148(1.20); C417(1.05); C690(1.15)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C343(0.92); C1148(0.89); C417(0.84); C690(1.07)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C343(0.93); C1148(1.38); C417(0.84); C690(1.15)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C343(0.83); C1148(0.97); C417(0.88); C690(1.14)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C343(0.87); C1148(1.07); C417(1.05); C690(1.17)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C343(0.79); C1148(1.06); C417(0.98); C690(1.16)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C343(0.75); C1148(0.96); C417(0.92); C690(1.08)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C343(0.87); C1148(1.18)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C343(1.07); C1148(1.13)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C343(1.18); C1148(1.18)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C343(1.08); C1148(1.23)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C343(1.12); C1148(1.11)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C343(1.27); C1148(1.12)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C343(1.18); C1148(1.43)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C343(1.13); C1148(0.97)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C343(1.17); C1148(1.13)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C343(1.08); C1148(1.13)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C343(1.42); C1148(1.30)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C343(1.26); C1148(1.07)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C343(0.53); C1005(1.13); C1008(1.13); C1148(0.93)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C343(1.49); C1148(1.23)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C343(1.42); C1148(1.26)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C343(1.27); C1148(1.16)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C343(1.08); C775(1.04); C417(1.05); C690(1.08)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C417(0.81); C1005(0.92); C1008(0.92); C343(1.03)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C417(0.85); C775(0.94); C690(0.99); C343(1.00)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C1005(0.86); C1008(0.86); C343(0.98); C417(1.01)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C775(0.85); C1005(0.92); C1008(0.92); C343(0.95)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C417(0.90); C343(0.95); C775(1.12); C1005(1.13)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C1005(0.83); C1008(0.83); C417(0.91); C343(1.02)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C343(0.61); C1158(0.63); C1005(0.89); C1008(0.89)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C343(0.96); C417(0.97); C690(1.01); C1005(1.06)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C343(0.91); C417(0.93); C1005(1.00); C1008(1.00)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C417(0.89); C343(0.93); C1005(0.94); C1008(0.94)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C417(0.93); C690(0.98); C343(0.99); C775(1.17)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C343(0.85); C1005(1.10); C1008(1.10); C417(0.92)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C343(1.09); C1005(0.94); C1008(0.94); C417(0.91)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C343(0.97); C1005(0.79); C1008(0.79); C417(1.11)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C343(0.98); C1005(0.90); C1008(0.90); C417(0.90)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C1062(0.48); C1076(0.48); C1158(0.54); C690(0.83)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C1158(0.70); C690(0.83); C1005(0.93); C1008(0.93)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C1062(0.53); C1076(0.53); C1005(0.71); C1008(0.71)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C1148(0.67); C690(0.98); C1158(0.98); C1005(1.00)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C1062(0.52); C1076(0.52); C1158(0.72); C1005(0.84)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C1062(0.63); C1076(0.63); C1158(0.63); C690(0.75)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C1158(0.82); C1062(0.86); C1076(0.86); C1005(0.88)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C1062(0.47); C1076(0.47); C1005(0.74); C1008(0.74)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C1062(0.52); C1076(0.52); C1158(0.85); C690(0.87)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C417(0.93); C1148(0.96); C1158(1.01); C690(1.11)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C417(0.83); C1158(0.88); C1148(0.91); C690(1.12)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C1158(0.77); C417(0.88); C1148(1.04); C690(1.07)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C1158(0.81); C417(0.97); C690(1.00); C1148(1.04)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C417(0.71); C1158(0.83); C343(1.01); C690(1.02)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C1148(0.54); C1005(0.94); C1008(0.94); C775(0.98)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C1158(0.77); C417(0.81); C775(0.84); C690(1.02)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C1158(0.80); C775(0.88); C417(0.90); C1148(1.03)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C1158(0.61); C343(0.72); C417(0.76); C775(1.02)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C1158(0.67); C417(0.96); C343(0.99); C775(1.08)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C1158(0.66); C417(0.80); C343(1.00); C690(1.10)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C417(0.81); C343(0.92); C1158(0.97); C1148(0.98)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C775(0.85); C343(0.87); C417(0.88); C1148(0.91)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C343(0.85); C775(0.89); C417(0.96); C690(1.18)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C417(0.86); C343(0.96); C1148(1.04); C775(1.04)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C417(0.77); C775(0.90); C1148(0.92); C343(1.00)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C1148(0.56); C1005(0.84); C1008(0.84); C775(0.90)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C417(0.77); C1158(1.05); C343(1.11); C1148(1.21)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C1148(0.76); C775(0.84); C417(0.85); C343(1.04)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C417(0.82); C775(0.95); C1158(1.06); C690(1.08)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C417(0.83); C775(0.93); C343(0.97); C1158(1.07)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C417(0.73); C775(0.95); C1148(1.05); C1158(1.07)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C417(0.76); C1158(1.06); C690(1.12); C775(1.12)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C1148(0.99); C690(1.07); C343(1.17); C417(1.22)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C1148(0.90); C690(0.97); C343(1.12); C417(1.16)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C690(0.99); C1148(1.03); C417(1.07); C343(1.13)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C1148(1.07); C690(1.18); C343(1.27); C417(1.38)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C1148(0.58); C775(0.84); C1005(0.86); C1008(0.86)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C690(1.07); C417(1.09); C343(1.16); C1148(1.19)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C417(0.89); C1148(0.94); C690(0.98); C343(1.18)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C417(0.92); C690(0.93); C1148(0.96); C343(1.12)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C417(1.00); C343(1.00); C690(1.06); C1148(1.17)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C690(0.85); C1148(1.00); C343(1.02); C417(1.32)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C417(0.99); C1148(1.02); C690(1.16); C343(1.21)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C690(0.76); C417(0.99); C343(1.18); C1148(1.26)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C1158(0.70); C690(0.89); C1148(0.99); C343(1.28)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C1158(0.64); C690(0.84); C1148(1.09); C343(1.26)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C1158(0.75); C1148(0.95); C690(1.00); C775(1.37)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C1158(0.51); C1148(0.81); C1005(0.93); C1008(0.93)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C1158(0.89); C1148(0.93); C690(0.95); C775(1.29)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C690(0.92); C1158(0.95); C1148(0.96); C343(1.12)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C1148(0.90); C690(0.91); C1158(0.98); C343(1.29)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C690(0.87); C1148(0.93); C1158(1.16); C343(1.29)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C1158(0.83); C690(0.93); C1148(0.95); C343(1.33)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C1158(0.86); C1148(0.91); C690(0.92); C775(0.98)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C775(0.93); C1148(0.96); C1158(1.03); C690(1.04)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C690(0.93); C1148(0.96); C1158(1.13); C775(1.16)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C417(0.90); C343(0.94); C1062(0.95); C1076(0.95)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C343(0.72); C417(0.96); C1005(1.00); C1008(1.00)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C1158(0.76); C1148(0.80); C1005(0.99); C1008(0.99)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C1062(0.80); C1076(0.80); C1005(0.87); C1008(0.87)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C343(0.81); C1062(0.91); C1076(0.91); C690(0.94)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C1062(0.91); C1076(0.91); C417(0.94); C343(1.01)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C343(1.10); C1062(0.93); C1076(0.93); C417(0.93)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C1062(0.94); C1076(0.94); C417(0.96); C343(0.98)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C343(0.80); C417(0.91); C1062(1.00); C1076(1.00)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C1158(0.90); C417(0.95); C1005(1.02); C1008(1.02)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C417(0.75); C1005(0.90); C1008(0.90); C343(0.93)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C417(0.86); C343(0.92); C690(1.10); C1062(1.15)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C417(0.85); C1062(0.91); C1076(0.91); C343(1.06)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C1148(0.48); C1158(0.73); C343(0.94); C1005(0.96)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C343(0.85); C417(0.90); C1158(1.00); C1062(1.05)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C1005(0.55); C1008(0.55); C343(0.85); C417(0.86)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C417(0.92); C1062(0.98); C1076(0.98); C343(1.05)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C1062(0.81); C1076(0.81); C775(1.15); C690(1.20)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C1062(0.91); C1076(0.91); C690(0.95); C1158(1.00)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C1062(0.62); C1076(0.62); C1158(0.79); C690(0.85)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C1062(0.65); C1076(0.65); C690(0.92); C1158(0.96)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C775(0.63); C1158(0.79); C690(0.90); C1062(1.11)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C1062(0.71); C1076(0.71); C690(0.87); C1158(0.90)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C1062(0.60); C1076(0.60); C1158(0.82); C343(0.84)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C775(0.66); C1158(0.77); C343(0.93); C690(0.94)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C1062(0.75); C1076(0.75); C1158(0.89); C343(0.94)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C1062(0.60); C1076(0.60); C1158(0.89); C343(0.95)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C775(0.72); C1158(0.86); C690(0.91); C1062(0.92)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C690(0.85); C1158(0.85); C775(0.92); C343(0.93)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C1062(0.81); C1076(0.81); C1158(0.93); C343(1.07)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C1158(0.75); C343(0.78); C1062(0.84); C1076(0.84)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C1062(0.74); C1076(0.74); C1158(0.83); C690(0.98)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C775(0.68); C1148(0.96); C690(0.98); C417(1.02)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C775(0.75); C690(0.79); C1148(0.83); C417(1.13)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C343(0.74); C1005(1.14); C1008(1.14); C1148(0.86)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C1158(0.56); C1148(0.91); C1005(0.91); C1008(0.91)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C343(0.53); C1158(0.62); C1148(0.79); C1005(0.90)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C343(1.24); C690(1.08)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C1413(20.00); C649(20.00); C911(20.00); C649(0.49)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C343(0.91); C1158(0.97); C1062(1.01); C1076(1.01)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C343(0.78); C1005(0.95); C1008(0.95); C1148(0.99)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C1148(0.76); C1005(0.81); C1008(0.81); C690(0.91)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C1158(0.58); C1148(0.81); C1005(0.97); C1008(0.97)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C1158(0.65); C343(0.71); C1148(0.84); C1005(1.10)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C1148(0.66); C343(0.69); C1158(0.84); C1005(1.01)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C343(0.63); C1158(0.65); C1148(0.81); C1005(0.94)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C1158(0.72); C690(0.76); C1062(0.82); C1076(0.82)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C1158(0.54); C1062(0.64); C1076(0.64); C690(0.75)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C1062(0.55); C1076(0.55); C1158(0.66); C690(0.81)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C1158(0.56); C1062(0.58); C1076(0.58); C690(0.86)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C1158(0.70); C1062(0.72); C1076(0.72); C690(0.74)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C343(0.93); C1148(1.01); C1062(1.01); C1076(1.01)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C1062(0.50); C1076(0.50); C1158(0.55); C690(0.74)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C1062(0.54); C1076(0.54); C1158(0.71); C690(0.75)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C1158(0.79); C417(0.86); C775(1.07); C690(1.08)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C417(0.69); C343(0.78); C1158(0.80); C690(1.09)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C417(0.60); C343(0.72); C1158(0.98); C690(1.05)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C417(0.77); C1158(0.80); C343(0.85); C1148(1.15)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C1158(0.79); C417(0.95); C343(1.12); C775(1.13)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C417(0.75); C690(1.06); C1148(1.16); C1158(1.31)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C775(0.91); C1148(0.92); C417(1.07); C343(1.07)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C417(0.80); C1148(1.01); C1158(1.10); C775(1.12)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C343(0.73); C775(0.82); C1062(0.99); C1076(0.99)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C775(0.77); C417(0.84); C343(1.00); C1148(1.01)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C1158(0.88); C417(1.03); C343(1.05); C690(1.08)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C1148(0.98); C690(0.99); C417(1.12); C343(1.14)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C690(0.83); C1148(0.93); C1158(0.94); C417(1.06)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C690(0.89); C1148(1.05); C343(1.12); C1158(1.36)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C1148(0.89); C690(0.89); C775(1.01); C343(1.04)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C1158(0.80); C690(0.81); C775(0.98); C1148(1.02)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C690(0.83); C1158(0.91); C1148(1.01); C775(1.14)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C1158(0.68); C690(0.84); C1148(0.96); C775(1.25)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C343(0.75); C775(0.82); C1062(1.00); C1076(1.00)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C775(0.44); C343(0.75); C1062(0.79); C1076(0.79)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C775(0.43); C343(0.94); C1148(0.98); C1005(1.11)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C1158(0.54); C1148(0.77); C417(0.87); C1005(0.89)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C1158(0.47); C1148(0.81); C417(0.97); C690(1.09)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C417(0.88); C1148(0.96); C1005(1.01); C1008(1.01)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C1158(0.46); C1148(0.89); C417(0.98); C343(1.02)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C343(0.91); C1148(1.03); C1005(1.07); C1008(1.07)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C1158(0.53); C1005(0.86); C1008(0.86); C1148(0.87)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C1158(0.52); C417(0.75); C1148(0.85); C1005(0.91)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C1158(0.76); C417(0.87); C343(1.08); C1005(1.19)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C1158(0.41); C1005(0.87); C1008(0.87); C1148(0.94)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C343(0.76); C1005(1.00); C1008(1.00); C1148(0.91)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C343(0.63); C1005(0.83); C1008(0.83); C1148(0.82)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C343(0.77); C1005(0.88); C1008(0.88); C1148(0.84)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C343(0.65); C1005(0.87); C1008(0.87); C1148(0.85)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C343(0.69); C1005(0.92); C1008(0.92); C1148(0.85)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C343(0.64); C1005(0.91); C1008(0.91); C1148(0.97)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C343(0.80); C1005(0.88); C1008(0.88); C1062(1.25)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C343(0.62); C1005(0.97); C1008(0.97); C1148(1.15)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C343(0.87); C1148(1.10); C1158(0.97); C417(1.12)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C343(1.05); C1148(1.12); C1158(0.95); C690(1.13)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C343(1.01); C1148(0.94); C1158(0.88); C690(0.84)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C343(1.24); C1148(1.09); C1158(0.91); C690(0.93)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C343(1.03); C1148(1.23); C1158(0.99); C690(1.00)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C343(1.06); C1148(1.19); C1158(0.92); C690(0.84)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C343(1.08); C1148(1.42); C1158(0.85); C690(1.01)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C343(1.16); C1148(1.21); C1158(1.14); C690(1.07)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C343(0.85); C1005(1.23); C1008(1.23); C1062(1.08)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C343(0.98); C1148(1.24); C1158(0.82); C690(0.89)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C343(1.04); C1148(1.47); C1158(0.92); C690(0.97)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C343(2.14); C1148(1.67); C1158(0.83); C690(0.79)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C343(1.29); C1148(1.44); C1158(1.05); C690(0.95)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C343(1.27); C1148(1.17); C1158(0.97); C690(0.97)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C343(1.52); C1148(1.09); C1158(1.01); C690(1.06)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C343(1.07); C1148(0.90); C417(1.06); C690(0.95)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C343(1.31); C1148(1.06); C417(0.94); C690(1.02)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C343(1.09); C1148(1.07); C417(1.00); C690(1.01)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C343(0.97); C1148(1.19); C417(1.10); C690(1.08)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C343(0.75); C1005(1.11); C1008(1.11); C1062(0.94)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C343(1.03); C1148(1.11); C417(1.01); C690(0.93)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C343(0.96); C1148(1.01); C417(1.02); C690(0.98)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C343(0.83); C1148(0.95); C417(0.97); C690(1.21)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C343(0.80); C1148(1.18); C417(0.89); C690(0.87)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C343(0.77); C1148(0.95); C417(1.02); C690(1.21)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C343(0.70); C1148(1.26); C417(1.08); C690(0.87)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C343(0.90); C1148(1.30); C417(0.96); C690(0.81)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C343(0.74); C1148(1.10); C417(1.11); C690(0.90)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C343(0.79); C1148(1.14); C417(1.03); C690(1.00)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C343(0.91); C1148(1.12); C417(1.01); C690(1.10)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C343(0.85); C1005(1.09); C1008(1.09); C1062(1.12)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C343(0.87); C1148(1.25); C417(1.03); C690(0.99)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C343(1.20); C1005(0.78); C1008(0.78); C1158(1.10)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C343(1.19); C1005(0.73); C1008(0.73); C1158(1.04)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C343(1.37); C1005(0.66); C1008(0.66); C1158(0.77)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C343(1.35); C1005(0.71); C1008(0.71); C1158(0.79)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C343(1.19); C1005(0.82); C1008(0.82); C1158(1.04)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C343(1.85); C1005(0.70); C1008(0.70); C1158(0.72)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C343(1.47); C1005(0.72); C1008(0.72); C1158(0.75)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C343(1.23); C1005(0.74); C1008(0.74); C1158(1.37)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C343(1.05); C1005(0.81); C1008(0.81); C1158(0.84)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C343(0.84); C1005(0.94); C1008(0.94); C1062(0.76)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C343(1.14); C1005(0.77); C1008(0.77); C1158(0.87)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C343(2.17); C1005(0.64); C1008(0.64); C1158(1.03)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C343(1.16); C1005(0.87); C1008(0.87); C1158(1.08)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C343(1.20); C1005(0.67); C1008(0.67); C1158(1.07)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C343(1.54); C1005(0.71); C1008(0.71); C1158(0.73)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C343(1.05); C1062(1.42); C1076(1.42); C690(1.08)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C343(1.20); C1062(1.14); C1076(1.14); C690(0.89)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C343(0.83); C1062(0.92); C1076(0.92); C690(1.13)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C343(1.12); C1062(1.00); C1076(1.00); C690(1.25)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C343(1.09); C1005(1.03); C1008(1.03); C1062(1.06)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C343(0.86); C1062(0.89); C1076(0.89); C690(1.12)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C343(0.85); C1062(1.02); C1076(1.02); C690(1.08)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C343(0.68); C1062(1.02); C1076(1.02); C690(1.22)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C343(0.79); C1062(0.95); C1076(0.95); C690(1.29)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C343(0.69); C1062(1.26); C1076(1.26); C690(1.37)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C343(0.79); C1062(0.72); C1076(0.72); C690(0.95)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C343(0.70); C1062(0.91); C1076(0.91); C690(0.86)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C343(0.62); C1062(1.12); C1076(1.12); C690(1.08)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C343(0.65); C1062(0.94); C1076(0.94); C690(1.29)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C343(0.67); C1062(0.97); C1076(0.97); C690(1.46)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C343(0.82); C1005(1.04); C1008(1.04); C1062(0.70)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C343(0.69); C1062(1.11); C1076(1.11); C690(0.78)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C343(1.95); C1005(0.91); C1008(0.91); C1062(1.08)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C343(1.13); C1005(0.96); C1008(0.96); C1062(0.97)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C343(1.07); C1005(0.90); C1008(0.90); C1062(1.07)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C343(1.83); C1005(0.80); C1008(0.80); C1062(1.06)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C343(1.92); C1005(0.74); C1008(0.74); C1062(0.86)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C343(1.06); C1005(0.93); C1008(0.93); C1062(0.99)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C343(1.18); C1005(0.87); C1008(0.87); C1062(1.21)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C343(1.40); C1005(0.83); C1008(0.83); C1062(1.09)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C343(5.86); C1005(0.87); C1008(0.87); C1062(1.06)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C775(1.03); C343(0.92); C1413(1.16); C417(1.15)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C417(3.07); C70(1.78); C775(1.40); C1413(1.28)  LDD1702  [12]
 LDCM0625  F8 Ramos C343(1.26); C1413(2.05); C398(0.59); C775(1.25)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C343(1.53); C1413(0.92); C398(0.58); C417(0.32)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C343(0.94); C1413(7.46); C398(1.71); C775(20.00)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C343(13.31); C1413(0.69); C398(0.61); C417(0.52)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C343(1.13); C1413(0.87); C398(0.87); C70(1.08)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C343(1.35); C1413(0.72); C775(0.25); C417(0.86)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C343(0.97); C1413(0.68); C398(0.76); C775(0.96)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C343(1.18); C1413(0.92); C398(0.86); C775(1.64)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C343(1.13); C1413(1.49); C398(0.71); C417(0.28)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C343(1.04); C1413(1.01); C398(0.88); C70(1.11)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C343(1.22); C1413(0.46); C398(0.67); C775(0.81)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C343(1.21); C1413(1.11); C398(0.91); C775(1.14)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C343(0.90); C1413(2.50); C398(1.23); C417(0.43)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C343(5.48); C1413(1.39); C398(0.52); C417(0.38)  LDD2201  [13]
 LDCM0468  Fragment33 HCT 116 C343(1.15); C1005(0.79); C1008(0.79); C1158(0.83)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C343(1.18); C1413(1.11); C398(1.00); C775(3.95)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C343(0.93); C1413(0.77); C398(0.96); C775(0.48)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C343(1.17); C1148(2.52); C1158(0.87); C690(1.07)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C343(1.13); C1413(1.24); C398(1.19)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C343(1.31); C1413(1.59); C398(1.26); C775(0.95)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C343(1.12); C1413(0.89); C398(0.74); C775(0.51)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C343(1.37); C1413(0.89); C398(0.92); C775(0.47)  LDD2188  [13]
 LDCM0022  KB02 HCT 116 C690(1.49); C775(1.54)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C690(1.22); C775(1.01)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C690(1.56); C775(1.54)  LDD0082  [4]
 LDCM0109  NEM HeLa H761(0.00); H1254(0.00)  LDD0225  [3]
 LDCM0021  THZ1 HCT 116 C690(1.08); C343(0.94)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Optineurin (OPTN) . Q96CV9
Wolframin (WFS1) . O76024
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Prelamin-A/C (LMNA) Intermediate filament family P02545
Vimentin (VIM) Intermediate filament family P08670
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Merlin (NF2) . P35240
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578