Details of the Target

General Information of Target

Target ID LDTP07241
Target Name Protein TASOR 2 (TASOR2)
Gene Name TASOR2
Gene ID 54906
Synonyms
C10orf18; FAM208B; KIAA2006; Protein TASOR 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPPAHKSILERSENVLMSPWKGKLIVQDRMLCDIALWSTYGAMIPTQLPQELDFKYVMK
VSSLKKRLPEAAFRKQNYLEEKVCFQDLCFNLYEVELSNRQGENIDKLTECIKNKQLAII
KCLEDRGFFILLTSSALLSEPDFGGKQMGLHGLHLFRSPLSTGVKDLKVEDDISMKVIPI
LSTLNCALLETKKSLPEERIHPNTLVKRHFQELYKADRSPSLSVAPQDRMKDPTFLGKLP
SGFDLIPPAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPCVSDGICDAGFS
LVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKKRVFPLSPASNLRVQPKRKASMPHMVQ
SKKVNLCRPFPKRTASRADNSSDSPTTLKLVKGQFPQKRKRGAEVLTAQFVQKTKLDRKN
QEAPISKDVPVPTNAKRARKQEKSPVKTVPRAKPPVKKSPQKQRVNIVKGNENPRNRKQL
QPVKGETASKLQSEISRGCQEDGISINSVQPENTTAAHNDLPENSIVNYDSQALNMLADL
ALSSATSSTPVSEARNLHCSSELPQNDVLLSKENSLRGTSDHEYHRGVKTQKGELLPNPS
SDRKSNSGSDLTVSQDEESLVPCSQAPAKAQSALTEEMLESSDASQSSSVSVEHSYALLL
TEHSKKHLQEREILSPLFPRNGTKSPEAATPVGKVMPFRHQPGLLLQQKPPDDPVVKPKD
RPPSARVKKSSCSRIVLSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALHGPWNT
DLPDNVEEVKLLLHMWVALFYSNQNKIIRSSRKVVEHSNPAKYVSINSTLESCELREIEE
SLGLEKCSADSLLETNEISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCVQNEQKKTFAR
ECDPDTQEDQNFICSYNNEVTGEEAKQESLETSNLVLSGIGSTQTNGPSVPSEEEIVQPL
DSTRVASYSGTVTQATFTRTYDGPGSQPVICQSSVYGTLENKVDILDAAVQTKTGTLQDL
IQHGSPINNECHPSLERKDDNMGCAVINPEPITLTFEKNAHVPIQTEGVNTADERTTFKK
ELIKQVSPAASLRHPVSTSENARTQGLRDIPSLVVAGQKGTKYLCASSVGGETLDKAVCS
LQKETPLPVSLPSDKTMVMEALSLAKSSSHLSPSEEVRCTQDFLSQTQSLLGLSSEGLLE
LTQVEVDSSSASTTLGRQCSLNCISSGCHTSGDSLELRKNHKNGPNTENMNLEAFDSVFI
KQTSLSVSREVSLELSEEDSDIDLALTISPPTSPREEMPAGEIEQFEEAPFSNLELQDVA
EEIGEPEEVALTESREVSSADNVSVYPSVSEEPVENKERKGDNLQPVTLILSKENCTLEI
AEEINVTSDFPFDSVIEEVSPASSPEPPVPVKETRPYQAVTPCILKLHGTQCEKSNQISQ
CESEDLGITEKENVFVGPTHPVGQDNFTQVQQMQVSAEMPLILTDHPGRTGRPTLPGKVT
EEIVSSEHDEGLSFSGKVQCYGRELNQPASAAKCTGDFSPSPEKLVKSGNPLQPVSIENR
NLDLKHLVLESSEPPFGPRNVIENKSLSDTLVSTTAPSGIVNVSVKQQTSPKSSQNHLFP
GDLKTDEGIYLQVKSLTAASVDGAYSTQGCMCSVVPTLCSSSDNATLTHYVRPINAEPVF
QAQEIPAGRMASLLKNGEPEAELHKETTGPGTAGPQSNTTSSLKGERKAIHTLQDVSTCE
TKELLNVGVSSLCAGPYQNTADTKENLSKEPLASFVSESFDTSVCGIATEHVEIENSGEG
LRAEAGSETLGRDGEVGVNSDMHYELSGDSDLDLLGDCRNPRLDLEDSYTLRGSYTRKKD
VPTDGYESSLNFHNNNQEDWGCSSWVPGMETSLPPGHWTAAVKKEEKCVPPYVQIRDLHG
ILRTYANFSITKELKDTMRTSHGLRRHPSFSANCGLPSSWTSTWQVADDLTQNTLDLEYL
RFAHKLKQTIKNGDSQHSASSANVFPKESPTQISIGAFPSTKISEAPFLHPAPRSRSPLL
VTVVESDPRPQGQPRRGYTASSLDSSSSWRERCSHNRDLRNSQRNHTVSFHLNKLKYNST
VKESRNDISLILNEYAEFNKVMKNSNQFIFQDKELNDVSGEATAQEMYLPFPGRSASYED
IIIDVCTNLHVKLRSVVKEACKSTFLFYLVETEDKSFFVRTKNLLRKGGHTEIEPQHFCQ
AFHRENDTLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRAG
GFVISDDKILEAVTLVQLKEIIKILEKLNGNGRWKWLLHYRENKKLKEDERVDSTAHKKN
IMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTDKPTIPREV
FENSGILVTDVNNFIENIEKIAAPFRSSYW
Target Bioclass
Other
Family
TASOR family
Uniprot ID
Q5VWN6
Ensemble ID
ENST00000328090.9
HGNC ID
HGNC:23484

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.G947E .
CHL1 SNV: p.S1268N DBIA    Probe Info 
CORL23 SNV: p.W1880Ter .
DU145 SNV: p.A1803V DBIA    Probe Info 
GB1 SNV: p.H1241Y .
HCC15 SNV: p.L793I DBIA    Probe Info 
HCT116 SNV: p.S641P DBIA    Probe Info 
HCT15 SNV: p.K1858T .
HS936T SNV: p.A1803V DBIA    Probe Info 
HT115 SNV: p.E1558D .
KMCH1 Deletion: p.N1561TfsTer6 DBIA    Probe Info 
KMS12BM SNV: p.Y1521N DBIA    Probe Info 
KYSE30 Deletion: p.D1233_S1234delinsA .
MDAMB453 SNV: p.E637K .
MFE280 Deletion: p.T1121LfsTer9 DBIA    Probe Info 
MFE319 SNV: p.I1005T; p.P1173L; p.T2167A .
NCIH196 SNV: p.P1033H DBIA    Probe Info 
NUGC3 SNV: p.S802N .
SF295 SNV: p.K389N DBIA    Probe Info 
SNU478 SNV: p.M2147I DBIA    Probe Info 
SW620 SNV: p.D1994H .
TE8 SNV: p.N1746H DBIA    Probe Info 
WM115 SNV: p.T1066I .
WM2664 SNV: p.T1066I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.37  LDD0402  [1]
BTD
 Probe Info  		C1432(0.28)  LDD2089  [2]
AHL-Pu-1
 Probe Info  		C186(3.92)  LDD0169  [3]
Acrolein
 Probe Info  		N.A.  LDD0225  [4]
DBIA
 Probe Info  		C902(0.93); C914(0.93)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
NAIA_4
 Probe Info  		C186(0.00); C559(0.00); C889(0.00); C1432(0.00)  LDD2226  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		C739(0.00); C847(0.00); C1534(0.00); C186(0.00)  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		C122(0.00); C1534(0.00); C186(0.00); C559(0.00)  LDD0018  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C1739(0.00); C367(0.00); C186(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1432(1.11)  LDD2117  [2]
 LDCM0025  4SU-RNA HEK-293T C559(2.22)  LDD0172  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C186(3.92)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C1423(0.94); C2219(0.79); C902(1.13); C914(1.13)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1125(0.88); C1423(1.15); C2219(0.97); C902(1.00)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1125(0.78); C1139(0.79); C1423(1.12); C902(1.17)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1125(0.89); C1139(1.01); C1423(1.57); C902(1.14)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1125(0.83); C1139(0.78); C1423(1.20); C902(1.18)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1125(0.87); C1139(1.11); C1423(1.42); C902(1.02)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1125(0.88); C1139(0.82); C1423(1.19); C902(1.15)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1125(0.92); C1139(1.01); C1423(1.33); C902(1.22)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1125(0.91); C1139(1.18); C1423(1.27); C902(1.51)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1125(0.82); C1139(0.54); C1423(1.26); C902(1.19)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1125(0.80); C1139(1.24); C1423(1.21); C902(1.26)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1125(0.83); C1139(1.50); C1423(1.28); C902(1.24)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C1125(0.97); C1423(1.31); C2219(1.05); C902(1.14)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1125(0.89); C1139(1.11); C1423(1.47); C902(1.41)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1125(0.88); C1139(1.26); C1423(1.35); C902(1.31)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1125(0.95); C1139(0.79); C1423(1.28); C902(1.40)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1139(1.14); C1423(0.95); C2219(0.96); C902(0.97)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1139(0.97); C1423(1.19); C2219(1.05); C902(1.14)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1139(1.00); C1423(1.16); C2219(1.33); C902(1.22)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1139(1.27); C1423(0.99); C2219(1.08); C902(1.27)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1139(0.98); C1423(1.07); C2219(1.05); C902(1.18)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1139(1.07); C1423(1.02); C2219(1.08); C902(1.00)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1139(1.13); C1423(1.24); C2219(1.04); C902(1.03)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1125(0.89); C1423(1.03); C2219(0.69); C902(0.95)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1139(0.96); C1423(1.14); C2219(0.95); C902(0.87)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1139(0.92); C1423(1.00); C2219(0.81); C902(1.05)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1139(1.06); C1423(1.08); C2219(0.93); C902(1.14)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1139(0.77); C1423(0.93); C2219(0.84); C902(0.89)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1139(1.21); C1423(1.00); C2219(0.92); C902(1.08)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1139(0.97); C1423(1.09); C2219(0.89); C902(1.06)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1139(1.03); C1423(1.16); C2219(0.76); C902(1.27)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1139(1.08); C1423(1.02); C2219(0.86); C902(1.26)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C1423(1.26); C902(1.32); C914(1.32)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1423(0.81); C902(1.06); C914(1.06)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1423(0.96); C902(1.30); C914(1.30)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1423(1.15); C902(1.29); C914(1.29)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1423(1.05); C902(0.90); C914(0.90)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1423(1.13); C902(1.07); C914(1.07)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1423(1.29); C902(1.24); C914(1.24)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1423(1.12); C902(1.17); C914(1.17)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1423(1.13); C902(0.91); C914(0.91)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1423(1.16); C902(0.81); C914(0.81)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1423(1.23); C902(1.02); C914(1.02)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1423(1.28); C902(1.01); C914(1.01)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C1125(0.85); C1423(1.04); C2219(0.80); C902(1.01)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C1423(1.47); C902(1.07); C914(1.07)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1423(1.29); C902(1.01); C914(1.01)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1423(1.02); C902(0.84); C914(0.84)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C1125(1.07); C1139(1.13); C1423(1.22); C902(0.98)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C1423(0.83); C1125(0.92); C914(1.22); C902(1.26)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C1125(0.99); C914(1.03); C902(1.09); C1423(1.14)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C1423(0.89); C914(1.07); C991(1.12); C902(1.12)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C1423(0.83); C1125(0.96); C914(1.21); C902(1.22)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C1423(0.89); C1125(1.22); C914(1.42); C902(1.46)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C991(1.11); C902(1.19); C914(1.19); C1125(1.21)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C1125(0.77); C2219(0.88); C1423(0.99); C902(1.07)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C1423(0.80); C914(0.92); C902(0.93); C1125(1.11)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C1423(0.90); C914(0.99); C902(0.99); C1125(1.07)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C1423(0.89); C1125(1.14); C914(1.18); C902(1.19)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C1423(0.73); C1125(1.50); C991(1.65); C914(1.68)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C1125(1.29); C1139(1.48); C1423(0.81); C902(1.32)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C1125(1.25); C1139(1.73); C1423(0.82); C902(1.17)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C1125(1.17); C1139(1.30); C1423(0.92); C902(0.97)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C1125(1.19); C1139(1.20); C1423(0.66); C902(1.19)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C2219(0.90); C902(0.99); C914(0.99); C1125(1.01)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C902(1.06); C914(1.06); C2219(1.08); C1125(1.13)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C902(1.02); C914(1.02); C1125(1.03); C2219(1.06)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C902(0.83); C914(0.83); C2219(0.85); C1423(0.92)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C2219(0.84); C1125(0.99); C1423(1.13); C902(1.15)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C2219(0.81); C1125(0.96); C902(1.01); C914(1.01)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C2219(0.90); C902(0.96); C914(0.96); C1423(1.05)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C902(0.82); C914(0.82); C1125(0.91); C2219(0.99)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C902(0.83); C914(0.83); C2219(0.92); C1125(0.98)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C991(0.86); C902(0.87); C914(0.87); C1423(0.90)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C2219(0.81); C1423(0.82); C902(0.95); C914(0.95)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C1423(0.81); C991(1.01); C2219(1.05); C1139(1.23)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C1423(0.77); C2219(0.77); C991(0.90); C902(1.12)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1423(0.94); C1139(1.05); C902(1.07); C914(1.07)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C902(0.79); C914(0.79); C1423(0.80); C2219(0.98)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C2219(0.91); C1139(0.97); C1423(1.01); C902(1.23)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C1423(0.73); C2219(1.01); C902(1.06); C914(1.06)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1423(0.87); C2219(1.00); C1139(1.05); C902(1.38)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C2219(0.88); C991(0.88); C1423(0.90); C1139(1.13)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1423(0.95); C1139(1.03); C2219(1.09); C991(1.16)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C1139(0.80); C1423(0.92); C902(1.00); C914(1.00)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C1139(0.78); C991(0.79); C1423(0.94); C902(0.95)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C1139(0.82); C1423(0.86); C902(1.01); C914(1.01)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C1423(0.86); C1139(0.94); C902(1.01); C914(1.01)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1423(0.98); C902(0.98); C914(0.98); C1139(1.01)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C1423(0.79); C902(0.93); C914(0.93); C2219(1.00)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C1139(1.01); C1423(1.04); C902(1.10); C914(1.10)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C1139(0.88); C902(1.04); C914(1.04); C1423(1.08)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C1139(0.91); C902(0.97); C914(0.97); C2219(1.09)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C2219(1.01); C902(1.02); C914(1.02); C1139(1.03)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C2219(0.88); C1139(0.97); C991(0.98); C1423(0.98)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C2219(0.94); C1423(1.13); C1139(1.16); C902(1.24)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C902(1.04); C914(1.04); C2219(1.06); C1423(1.46)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C2219(0.94); C902(1.17); C914(1.17); C1423(1.17)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C2219(0.96); C902(0.97); C914(0.97); C1423(1.35)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C2219(0.97); C902(1.19); C914(1.19); C1423(1.81)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C902(0.79); C914(0.79); C1423(0.80); C2219(0.81)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C2219(0.82); C902(1.43); C914(1.43); C1423(1.58)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C2219(0.90); C902(0.98); C914(0.98); C1423(1.58)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C2219(0.86); C902(1.04); C914(1.04); C1423(1.61)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C2219(0.96); C902(1.25); C914(1.25); C1423(1.57)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C2219(0.78); C902(1.29); C914(1.29); C1423(1.52)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C2219(1.18); C1423(1.28); C902(1.58); C914(1.58)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C2219(1.06); C1423(1.52); C902(1.90); C914(1.90)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C2219(1.01); C1423(1.07); C1139(1.37); C902(1.39)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C2219(0.84); C1423(1.21); C1139(1.36); C902(1.54)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C2219(1.15); C1423(1.21); C1139(1.38); C902(1.51)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C2219(0.91); C1125(0.97); C1423(1.08); C991(1.19)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1423(1.09); C2219(1.15); C902(1.26); C914(1.26)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1423(1.04); C902(1.07); C914(1.07); C2219(1.21)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C2219(1.05); C1423(1.14); C1139(1.37); C902(1.68)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1423(1.09); C2219(1.24); C902(1.25); C914(1.25)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C2219(1.08); C1423(1.24); C902(1.30); C914(1.30)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C902(0.78); C914(0.78); C2219(1.01); C1139(1.03)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C902(0.73); C914(0.73); C1139(0.99); C1423(1.06)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C902(0.81); C914(0.81); C2219(1.03); C1139(1.15)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C902(0.89); C914(0.89); C1139(1.02); C1423(1.19)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C902(0.83); C914(0.83); C1423(0.83); C2219(1.18)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C902(0.91); C914(0.91); C2219(0.96); C1125(0.97)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C902(0.89); C914(0.89); C1139(1.08); C1423(1.22)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C902(0.74); C914(0.74); C1423(0.75); C1139(1.10)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C902(0.94); C914(0.94); C2219(1.05); C1423(1.10)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C1423(1.04); C2219(1.04); C902(1.27); C914(1.27)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C1423(0.86); C2219(0.92); C902(0.92); C914(0.92)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C2219(1.04); C1423(1.11); C902(1.29); C914(1.29)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C1423(0.90); C902(1.01); C914(1.01); C1139(1.24)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1423(1.01); C902(1.10); C914(1.10); C2219(1.19)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C902(0.87); C914(0.87); C1139(1.06); C1423(1.07)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C902(0.83); C914(0.83); C2219(1.04); C1423(1.17)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C1125(0.83); C2219(1.03); C902(1.06); C914(1.06)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C1423(0.88); C902(0.97); C914(0.97); C2219(1.16)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C902(0.77); C914(0.77); C2219(0.84); C1139(0.99)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C1423(0.87); C2219(1.16); C902(1.26); C914(1.26)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C739(1.00); C1423(1.19); C991(1.24); C2219(1.29)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C739(0.86); C2219(1.15); C991(1.17); C1423(1.26)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C991(0.98); C902(0.99); C914(0.99); C1423(1.09)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C739(0.98); C991(1.00); C2219(1.11); C1423(1.12)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C739(0.87); C991(0.93); C1423(1.03); C2219(1.04)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C739(0.85); C1423(1.06); C2219(1.12); C991(1.14)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C991(1.07); C739(1.10); C1423(1.17); C2219(1.34)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C991(0.89); C739(0.99); C1423(1.07); C902(1.10)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C739(1.01); C2219(1.10); C1423(1.26); C991(1.31)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C739(0.93); C2219(1.12); C1423(1.28); C1139(1.52)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C739(0.91); C991(1.09); C2219(1.17); C1423(1.19)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C991(0.80); C902(1.05); C914(1.05); C1139(1.13)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C739(0.95); C991(0.97); C2219(1.03); C1423(1.09)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C991(1.03); C739(1.11); C1139(1.22); C1423(1.25)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C2219(1.09); C739(1.11); C1423(1.36); C902(1.44)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C1139(0.95); C1125(1.01); C902(1.09); C914(1.09)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C1139(0.66); C1125(0.84); C991(1.05); C902(1.09)  LDD0683  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C1432(0.77)  LDD2113  [2]
 LDCM0248  AKOS034007472 HCT 116 C1125(0.95); C1423(0.94); C2219(0.75); C902(1.00)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C1125(1.02); C1423(1.06); C2219(1.07); C902(1.10)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C1125(0.80); C2219(0.97); C1423(1.25); C902(1.62)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C902(0.93); C914(0.93)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C1432(0.21)  LDD2091  [2]
 LDCM0630  CCW28-3 231MFP C833(0.10)  LDD2214  [12]
 LDCM0632  CL-Sc Hep-G2 C739(20.00)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C991(0.90); C739(0.92); C902(1.04); C914(1.04)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C1139(0.78); C991(0.98); C1423(1.05); C739(1.11)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C1423(0.85); C2219(0.97); C902(1.01); C914(1.01)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C1125(0.72); C2219(0.97); C902(1.26); C914(1.26)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C1125(0.74); C2219(0.98); C902(1.05); C914(1.05)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C1125(0.80); C1423(0.92); C2219(0.94); C991(1.00)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C2219(0.82); C1125(0.86); C1423(1.06); C991(1.13)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C902(0.80); C914(0.80); C2219(0.92); C1125(0.99)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C902(0.80); C914(0.80); C1125(0.98); C2219(1.09)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C902(0.89); C914(0.89); C1125(1.01); C2219(1.22)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C902(0.76); C914(0.76); C1125(1.04); C2219(1.15)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C902(1.03); C914(1.03); C1125(1.12); C2219(1.26)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C1139(1.01); C739(1.06); C991(1.26); C1423(1.28)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C902(0.72); C914(0.72); C1125(0.98); C2219(1.02)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C902(0.80); C914(0.80); C1125(0.97); C2219(1.01)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C2219(0.85); C1423(0.94); C991(0.99); C1139(1.04)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C2219(0.95); C1423(0.96); C1139(0.96); C902(1.20)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1139(0.78); C902(1.00); C914(1.00); C1423(1.18)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C1423(0.99); C1139(0.99); C902(1.07); C914(1.07)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1423(0.89); C902(0.92); C914(0.92); C2219(0.93)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C2219(0.94); C1423(1.23); C902(1.34); C914(1.34)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1423(0.83); C991(0.93); C902(0.99); C914(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1423(0.94); C1139(1.01); C991(1.09); C902(1.09)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C991(1.23); C739(1.29); C1423(1.29); C1139(1.32)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C991(0.86); C1139(0.99); C902(1.00); C914(1.00)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C2219(1.11); C1423(1.29); C902(2.07); C914(2.07)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C902(1.02); C914(1.02); C2219(1.04); C1423(1.36)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C2219(1.08); C1423(1.22); C902(1.41); C914(1.41)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C2219(1.08); C902(1.37); C914(1.37); C1423(1.47)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C902(1.02); C914(1.02); C1139(1.03); C2219(1.15)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C902(0.96); C914(0.96); C1139(0.96); C1423(1.02)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1139(0.98); C1423(0.99); C902(1.00); C914(1.00)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C2219(0.99); C1423(1.10); C902(1.40); C914(1.40)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C991(0.91); C739(0.97); C1139(1.04); C1423(1.13)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C1139(0.93); C1423(1.09); C902(1.14); C914(1.14)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C739(0.83); C1423(1.13); C1139(1.15); C902(1.40)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C1125(0.72); C1423(1.07); C991(1.21); C902(1.23)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C1125(0.81); C902(1.08); C914(1.08); C1423(1.10)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C1125(0.82); C1423(0.97); C991(0.97); C1139(1.00)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C1125(0.84); C991(0.90); C1423(1.01); C1139(1.10)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C739(0.93); C1139(1.00); C1423(1.02); C902(1.02)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C1125(0.86); C991(1.02); C1139(1.17); C1423(1.21)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C991(0.76); C1125(0.84); C1423(1.05); C1139(1.07)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1125(0.78); C991(0.82); C1139(0.85); C1423(0.87)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C1125(0.97); C1423(1.11); C1139(1.33); C991(1.49)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C991(0.89); C1423(0.97); C1139(0.97); C1125(0.98)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1125(0.92); C1139(0.87); C1423(0.98); C2219(2.06)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1125(0.97); C1139(1.03); C1423(0.97); C2219(1.61)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1125(0.81); C1139(0.99); C1423(0.91); C2219(1.65)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1125(0.86); C1139(1.00); C1423(0.86); C2219(1.89)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1125(0.93); C1139(1.19); C1423(1.03); C2219(1.26)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1139(0.82); C1423(0.88); C739(1.00); C902(1.25)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1125(0.89); C1139(0.87); C1423(0.96); C2219(2.31)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1139(0.83); C1423(1.10); C2219(1.71); C739(0.96)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1125(1.05); C1139(0.91); C1423(1.04); C739(0.80)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1125(0.91); C1139(0.93); C1423(1.22); C739(0.96)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1125(0.67); C1139(0.66); C1423(1.17); C739(1.20)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1125(1.10); C1139(0.97); C1423(1.20); C739(1.05)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1125(1.13); C1139(0.83); C1423(1.20); C739(0.89)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1125(1.04); C1139(1.04); C1423(1.30); C739(0.84)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1125(1.18); C1139(1.09); C1423(1.09); C739(0.82)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1139(0.99); C1423(1.46); C739(0.88); C902(1.35)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1125(0.88); C1139(0.91); C1423(1.16); C739(0.87)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1125(1.07); C1139(0.85); C1423(1.35); C739(1.02)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1125(0.73); C1139(0.81); C1423(1.45); C739(0.87)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1125(0.94); C1139(0.84); C1423(1.25); C739(0.96)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1125(1.06); C1139(1.11); C1423(1.13); C739(0.88)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1125(1.17); C1139(0.88); C1423(1.20); C739(0.99)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1423(1.00); C2219(1.25); C739(0.99); C902(0.78)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1423(0.76); C2219(1.06); C739(0.94); C902(0.81)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1423(0.98); C2219(0.99); C739(1.01); C902(0.84)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1423(0.78); C2219(1.03); C739(1.06); C902(1.01)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1139(1.02); C1423(0.87); C739(0.85); C902(1.25)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1423(0.97); C2219(0.94); C739(0.95); C902(0.87)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1423(0.79); C2219(0.98); C739(0.95); C902(0.88)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1423(1.19); C2219(1.04); C739(1.24); C902(1.11)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1423(1.05); C2219(1.17); C739(0.90); C902(1.13)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1423(0.98); C2219(0.76); C739(0.89); C902(0.99)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1423(0.87); C2219(1.00); C739(0.85); C902(1.01)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1423(0.95); C2219(0.84); C739(0.94); C902(0.94)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1423(0.98); C2219(0.94); C739(0.83); C902(0.93)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1423(0.87); C2219(0.80); C739(1.10); C902(1.03)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1423(0.87); C2219(1.01); C739(0.98); C902(0.92)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1139(0.91); C1423(0.79); C739(0.84); C902(1.36)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1423(0.83); C2219(0.93); C739(0.98); C902(0.96)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1423(1.04); C2219(1.31); C902(1.13); C914(1.13)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1423(1.10); C2219(1.30); C902(1.10); C914(1.10)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1423(1.37); C2219(1.67); C902(1.21); C914(1.21)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1423(1.33); C2219(1.53); C902(1.32); C914(1.32)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1423(1.09); C2219(1.08); C902(0.98); C914(0.98)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1423(1.25); C2219(1.14); C902(1.31); C914(1.31)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1423(1.58); C2219(1.10); C902(1.30); C914(1.30)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1423(1.30); C2219(1.06); C902(1.08); C914(1.08)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1423(1.10); C2219(1.32); C902(1.07); C914(1.07)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1139(1.21); C1423(0.83); C739(0.97); C902(1.30)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1423(1.17); C2219(0.99); C902(1.10); C914(1.10)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1423(1.32); C2219(0.94); C902(1.18); C914(1.18)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1423(1.30); C2219(0.98); C902(1.10); C914(1.10)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1423(1.41); C2219(1.02); C902(1.19); C914(1.19)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1423(1.41); C2219(1.01); C902(1.36); C914(1.36)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1423(1.16); C2219(1.17); C902(1.07); C914(1.07)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1423(1.32); C2219(0.86); C902(0.89); C914(0.89)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1423(1.19); C2219(1.10); C902(1.00); C914(1.00)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1423(1.09); C2219(1.14); C902(1.19); C914(1.19)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1139(1.16); C1423(0.98); C739(0.88); C902(1.59)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1423(1.09); C2219(1.10); C902(1.13); C914(1.13)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1423(1.08); C2219(1.07); C902(1.11); C914(1.11)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1423(0.95); C2219(1.17); C902(1.36); C914(1.36)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1423(0.98); C2219(1.03); C902(1.14); C914(1.14)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1423(1.14); C2219(1.35); C902(1.19); C914(1.19)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1423(1.21); C2219(0.89); C902(0.93); C914(0.93)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1423(1.18); C2219(1.09); C902(0.78); C914(0.78)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1423(1.02); C2219(0.94); C902(0.85); C914(0.85)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1423(1.12); C2219(1.04); C902(1.36); C914(1.36)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1423(0.98); C2219(1.12); C902(1.40); C914(1.40)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1139(1.00); C1423(0.96); C739(0.92); C902(1.11)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1423(1.33); C2219(0.99); C902(0.65); C914(0.65)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1423(0.90); C2219(0.99); C902(0.98); C914(0.98)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1423(0.87); C2219(0.91); C902(0.83); C914(0.83)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1423(0.82); C2219(0.97); C902(0.77); C914(0.77)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1423(0.86); C2219(1.16); C902(1.14); C914(1.14)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1423(0.97); C2219(0.99); C902(0.93); C914(0.93)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1423(0.90); C2219(1.16); C902(1.15); C914(1.15)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1423(1.00); C2219(1.16); C902(0.99); C914(0.99)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1423(0.84); C2219(1.06); C902(0.87); C914(0.87)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1423(0.74); C2219(1.05); C902(0.91); C914(0.91)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C1139(1.07); C1534(1.41); C1423(1.05); C1125(1.17)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C559(1.12); C1520(0.70)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C1423(1.23); C2219(1.33); C902(1.10); C914(1.10)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C1125(0.95); C1139(0.83); C1423(1.48); C739(0.90)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C2219(1.77); C902(4.66); C914(4.66); C1139(2.00)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C2219(1.79); C902(2.67); C914(2.67); C1139(1.65)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C2219(3.32); C902(2.52); C914(2.52); C1139(1.91)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1432(0.33)  LDD2121  [2]
 LDCM0109  NEM HeLa N.A.  LDD0225  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1432(0.28)  LDD2089  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1432(0.60)  LDD2096  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1432(0.95)  LDD2099  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1432(1.15)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1432(0.95)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1432(1.41)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1432(0.61)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1432(1.09)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1432(0.73)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1432(0.83)  LDD2111  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1432(0.94)  LDD2118  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1432(0.86)  LDD2120  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1432(1.01)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1432(1.02)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1432(1.32)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1432(0.99)  LDD2127  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1432(0.89)  LDD2128  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1432(0.84)  LDD2135  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1432(1.00)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1432(0.94)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1432(0.69)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1432(1.42)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1432(2.35)  LDD2144  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1432(12.09)  LDD2145  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1432(0.77)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1432(1.31)  LDD2148  [2]
 LDCM0021  THZ1 HCT 116 C902(1.09); C914(1.09)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Replication factor C subunit 5 (RFC5) Activator 1 small subunits family P40937
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Serine/threonine-protein kinase Nek6 (NEK6) NEK Ser/Thr protein kinase family Q9HC98
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
MyoD family inhibitor (MDFI) MDFI family Q99750
Secretory carrier-associated membrane protein 1 (SCAMP1) SCAMP family O15126
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enhancer of rudimentary homolog (ERH) E(R) family P84090
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Other
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATR-interacting protein (ATRIP) ATRIP family Q8WXE1
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Progranulin (GRN) Granulin family P28799
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Kelch-like protein 40 (KLHL40) KLHL40 family Q2TBA0
Protein LDOC1 (LDOC1) LDOC1 family O95751
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
tRNA-splicing endonuclease subunit Sen15 (TSEN15) SEN15 family Q8WW01
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Armadillo repeat-containing protein 7 (ARMC7) . Q9H6L4
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Heat shock factor 2-binding protein (HSF2BP) . O75031
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Rhombotin-1 (LMO1) . P25800
RING finger protein 11 (RNF11) . Q9Y3C5
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402