Details of the Target

General Information of Target

Target ID LDTP06430
Target Name Cdc42-interacting protein 4 (TRIP10)
Gene Name TRIP10
Gene ID 9322
Synonyms
CIP4; STOT; STP; Cdc42-interacting protein 4; Protein Felic; Salt tolerant protein; hSTP; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAK
DDPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEG
RRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRS
HMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELE
VVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSL
GTPSDGRPELRGPGRSRTKRWPFGKKNKPRPPPLSPLGGPVPSALPNGPPSPRSGRDPLA
ILSEISKSVKPRLASFRSLRGSRGTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQ
REALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRG
DSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTS
PIGHCVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTL
N
Target Type
Literature-reported
Target Bioclass
Other
Family
FNBP1 family
Subcellular location
Cytoplasm, perinuclear region; Cytoplasm, cytoskeleton
Function
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
TTD ID
T94364
Uniprot ID
Q15642
DrugMap ID
TTKHTGE
Ensemble ID
ENST00000313244.14
HGNC ID
HGNC:12304

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.R311P .
JURKAT SNV: p.Q208Ter .
MFE296 SNV: p.R196G DBIA    Probe Info 
MFE319 Deletion: p.P332HfsTer31 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K110(7.14); K114(8.39); K173(1.32); K44(7.69)  LDD0277  [1]
BTD
 Probe Info  		C99(0.95)  LDD1699  [2]
Probe 1
 Probe Info  		Y590(7.08); Y595(11.56)  LDD3495  [3]
HHS-475
 Probe Info  		Y595(0.71)  LDD0264  [4]
IPM
 Probe Info  		C248(2.86)  LDD1701  [2]
Acrolein
 Probe Info  		N.A.  LDD0226  [5]
DBIA
 Probe Info  		C99(0.99)  LDD0531  [6]
5E-2FA
 Probe Info  		H203(0.00); H181(0.00)  LDD2235  [7]
m-APA
 Probe Info  		H203(0.00); H181(0.00)  LDD2231  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		30.70  LDD1785  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C99(1.26)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C99(0.99)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C99(1.18)  LDD0532  [6]
 LDCM0216  AC100 PaTu 8988t C99(1.00)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C99(1.00)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C99(0.96)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C99(1.01)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C99(0.93)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C99(1.06)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C99(0.97)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C99(0.90)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C99(0.91)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C99(1.01)  LDD1104  [6]
 LDCM0226  AC11 HCT 116 C99(1.32)  LDD0543  [6]
 LDCM0227  AC110 PaTu 8988t C99(0.81)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C99(1.05)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C99(0.93)  LDD1108  [6]
 LDCM0230  AC113 HCT 116 C99(0.81)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C99(0.73)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C99(0.82)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C99(0.78)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C99(0.82)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C99(0.88)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C99(0.84)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C99(1.14)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C99(0.62)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C99(0.95)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C99(0.86)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C99(0.82)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C99(1.02)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C99(0.89)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C99(1.02)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C99(0.96)  LDD0562  [6]
 LDCM0246  AC128 PaTu 8988t C99(1.01)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C99(1.01)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C99(0.87)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C99(1.09)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C99(1.02)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C99(1.37)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C99(1.19)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C99(1.25)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C99(1.21)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C99(1.22)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C99(0.97)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C99(1.08)  LDD1137  [6]
 LDCM0259  AC14 HCT 116 C99(1.14)  LDD0576  [6]
 LDCM0260  AC140 PaTu 8988t C99(1.04)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C99(0.88)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C99(0.97)  LDD1141  [6]
 LDCM0263  AC143 HCT 116 C99(0.76)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C99(0.93)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C99(0.91)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C99(0.85)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C99(1.03)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C99(0.68)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C99(0.67)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C99(1.05)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C99(0.85)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C99(0.92)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C99(0.68)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C99(0.42)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C99(0.74)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C99(0.71)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C99(0.75)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C99(0.73)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C99(1.02)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C99(0.92)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C99(0.87)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C99(1.01)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C99(0.99)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C99(0.98)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C99(1.02)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C99(0.91)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C99(0.98)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C99(1.00)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C99(1.00)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C99(0.91)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C99(0.90)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C99(0.91)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C99(1.11)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C99(0.93)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C99(0.90)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C99(0.96)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C99(0.88)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C99(0.93)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C99(0.96)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C99(0.98)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C99(0.89)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C99(1.04)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C99(1.13)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C99(0.99)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C99(1.04)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C99(0.95)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C99(1.01)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C99(1.02)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C99(0.99)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C99(0.97)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C99(0.97)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C99(1.10)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C99(1.08)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C99(1.09)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C99(1.08)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C99(1.04)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C99(1.04)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C99(1.05)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C99(1.03)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C99(1.13)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C99(1.10)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C99(1.28)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C99(1.06)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C99(0.99)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C99(0.93)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C99(1.04)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C99(0.84)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C99(0.88)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C99(0.83)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C99(0.79)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C99(0.95)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C99(0.97)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C99(1.05)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C99(0.99)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C99(0.91)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C99(0.93)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C99(1.03)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C99(0.89)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C99(1.14)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C99(0.99)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C99(1.05)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C99(1.04)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C99(0.99)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C99(0.94)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C99(0.90)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C99(1.04)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C99(0.94)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C99(1.01)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C99(1.22)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C99(0.87)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C99(0.93)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C99(0.84)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C99(0.81)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C99(0.81)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C99(0.82)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C99(0.88)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C99(0.91)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C99(0.77)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C99(0.97)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C99(0.81)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C99(0.83)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C99(0.77)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C99(0.79)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C99(0.80)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C99(0.82)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C99(0.79)  LDD0681  [6]
 LDCM0365  AC98 PaTu 8988t C99(0.83)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C99(0.88)  LDD1245  [6]
 LDCM0248  AKOS034007472 HCT 116 C99(1.31)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C99(1.16)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C99(1.19)  LDD0592  [6]
 LDCM0367  CL1 HCT 116 C99(0.87)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C99(0.90)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C99(1.06)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C99(1.03)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C99(1.26)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C99(1.15)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C99(1.22)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C99(0.94)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C99(0.90)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C99(0.95)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C99(1.10)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C99(0.96)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C99(0.92)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C99(1.00)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C99(0.88)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C99(1.01)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C99(0.87)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C99(0.90)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C99(0.90)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C99(0.93)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C99(1.29)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C99(1.01)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C99(1.05)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C99(0.86)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C99(1.04)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C99(1.00)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C99(1.03)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C99(1.08)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C99(1.12)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C99(0.94)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C99(0.90)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C99(0.83)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C99(1.11)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C99(0.86)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C99(0.85)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C99(0.89)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C99(1.00)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C99(0.82)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C99(0.73)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C99(0.92)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C99(0.88)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C99(0.88)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C99(0.91)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C99(1.31)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C99(0.93)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C99(0.91)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C99(0.95)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C99(0.96)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C99(0.96)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C99(0.89)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C99(0.98)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C99(0.92)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C99(0.96)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C99(1.00)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C99(0.97)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C99(0.85)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C99(1.08)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C99(1.08)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C99(1.07)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C99(1.04)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C99(1.04)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C99(0.81)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C99(0.95)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C99(1.03)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C99(1.14)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C99(1.12)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C99(1.08)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C99(1.10)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C99(0.76)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C99(0.71)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C99(0.82)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C99(1.11)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C99(0.93)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C99(1.11)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C99(0.95)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C99(0.97)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C99(0.64)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C99(0.84)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C99(0.91)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C99(0.73)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C99(0.74)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C99(0.98)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C99(1.01)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C99(0.84)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C99(0.96)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C99(1.01)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C99(1.18)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C99(1.21)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C99(1.02)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C99(1.15)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C99(1.28)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C99(1.15)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C99(1.04)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C99(0.95)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C99(0.96)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C99(1.18)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C99(1.10)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C99(1.11)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C99(1.06)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C99(1.07)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C99(0.90)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C99(0.85)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C99(0.91)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C99(0.98)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C99(0.84)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C99(0.81)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C99(0.96)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C99(1.04)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C99(1.01)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C99(1.14)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C99(0.94)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C99(0.87)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C99(0.97)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C99(1.04)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C99(1.45)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C99(0.82)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C99(0.96)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C99(0.94)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C99(0.84)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C99(0.92)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C99(0.93)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C99(0.90)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C99(0.93)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C99(0.98)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C99(1.02)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C99(0.98)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C99(0.93)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C99(1.14)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C99(1.17)  LDD0744  [6]
 LDCM0116  HHS-0101 DM93 Y595(0.71)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y595(0.50)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y595(0.91)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y595(0.71)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y595(0.45)  LDD0268  [4]
 LDCM0022  KB02 42-MG-BA C99(1.62)  LDD2244  [12]
 LDCM0023  KB03 MDA-MB-231 C248(2.86)  LDD1701  [2]
 LDCM0024  KB05 HMCB C248(2.30); C99(2.44)  LDD3312  [12]
 LDCM0109  NEM HeLa N.A.  LDD0226  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C99(2.23)  LDD2120  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C99(1.00)  LDD2123  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C99(1.61)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C99(1.14)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C99(1.48)  LDD2140  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX3 (DTX3) Deltex family Q8N9I9
Rho-related GTP-binding protein RhoJ (RHOJ) Rho family Q9H4E5
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) . P78325
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C11 (HOXC11) Abd-B homeobox family O43248
Homeobox protein Nkx-2.5 (NKX2-5) NK-2 homeobox family P52952
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Homeobox protein MOX-1 (MEOX1) . P50221
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Undifferentiated embryonic cell transcription factor 1 (UTF1) . Q5T230
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 6 (FASLG) Tumor necrosis factor family P48023
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cdc42-interacting protein 4 (TRIP10) FNBP1 family Q15642
Disheveled-associated activator of morphogenesis 1 (DAAM1) Formin homology family Q9Y4D1
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Actin-binding protein WASF1 (WASF1) SCAR/WAVE family Q92558
Splicing factor 3A subunit 2 (SF3A2) SF3A2 family Q15428
Actin nucleation-promoting factor WASL (WASL) . O00401
Rho GTPase-activating protein 17 (ARHGAP17) . Q68EM7
SH3 domain-binding protein 1 (SH3BP1) . Q9Y3L3
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840