Details of the Target

General Information of Target

Target ID LDTP06372
Target Name Ubiquitin-protein ligase E3C (UBE3C)
Gene Name UBE3C
Gene ID 9690
Synonyms
KIAA0010; KIAA10; Ubiquitin-protein ligase E3C; EC 2.3.2.26; HECT-type ubiquitin transferase E3C; Homologous to E6AP carboxyl terminus homologous protein 2; HectH2; RTA-associated ubiquitin ligase; RAUL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYR
DRKQQYSIQRSAFDRCATLSQSGGAFPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLYQN
LIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCNDDSLNVALPMRMLEVFSSENT
YLPVLQDASYVVSVIEQILHYMIHNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLEN
VLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFIIPALADAQTVFPYEPFLNA
LLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEEGLLVYLRVLQTFLSQLPVSPASAS
CHDSASDSEEESEEADKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEE
VFTTMASVCHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQ
VISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLE
ELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQ
LFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIG
PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFL
DGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNEL
LKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA
GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVV
ELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEI
QVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSR
PPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGF
ELS
Target Bioclass
Enzyme
Family
UBE3C family
Function
E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains. Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome. Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins. Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages. Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome. Catalyzes ubiquitination and degradation of CAND2.
Uniprot ID
Q15386
Ensemble ID
ENST00000348165.10
HGNC ID
HGNC:16803

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.P477R .
CCK81 Deletion: p.K603RfsTer6
SNV: p.G83R		 DBIA    Probe Info 
HCT15 SNV: p.L859I .
HT115 SNV: p.A1073V .
IGR37 SNV: p.S350F DBIA    Probe Info 
IGR39 SNV: p.S350F DBIA    Probe Info 
MDAMB157 SNV: p.I752F DBIA    Probe Info 
MOLT4 SNV: p.R495Ter; p.N788S IA-alkyne    Probe Info 
RKO SNV: p.N1037S DBIA    Probe Info 
TE4 SNV: p.E743Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y1061(4.65)  LDD3495  [2]
BTD
 Probe Info  		C140(0.69)  LDD2089  [3]
AHL-Pu-1
 Probe Info  		C590(2.39); C395(2.02)  LDD0170  [4]
HHS-475
 Probe Info  		Y1030(1.07)  LDD0264  [5]
DBIA
 Probe Info  		C140(2.62); C1051(1.13); C1018(1.23)  LDD0080  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C429(0.00); C1034(0.00); C1018(0.00); C158(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C429(0.00); C1018(0.00); C252(0.00); C140(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C429(0.00); C1034(0.00); C1018(0.00); C936(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
WYneN
 Probe Info  		C1051(0.00); C140(0.00)  LDD0021  [9]
IPM
 Probe Info  		C1051(0.00); C622(0.00); C140(0.00); C152(0.00)  LDD0005  [9]
STPyne
 Probe Info  		N.A.  LDD0009  [9]
TFBX
 Probe Info  		C1034(0.00); C395(0.00); C158(0.00); C553(0.00)  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
AOyne
 Probe Info  		10.60  LDD0443  [13]
NAIA_5
 Probe Info  		C429(0.00); C1018(0.00); C395(0.00); C140(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [14]
FFF probe2
 Probe Info  		5.89  LDD0463  [14]
STS-2
 Probe Info  		N.A.  LDD0138  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C590(2.39); C395(2.02)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C590(4.45)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C1018(0.89); C1051(1.11); C140(1.08); C622(1.02)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C1018(0.89); C1051(0.93); C140(0.92); C151(0.92)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C1018(0.95); C1051(1.00); C140(1.48); C151(1.11)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C1018(0.91); C1051(0.97); C140(0.95); C151(1.04)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C1018(0.87); C1051(1.02); C140(1.12); C151(0.93)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C1018(1.07); C1051(1.01); C140(1.01); C151(1.00)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C1018(0.89); C1051(0.94); C140(1.17); C151(1.02)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C1018(0.90); C1051(0.92); C140(1.05); C151(0.89)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C1018(1.02); C1051(0.96); C140(1.12); C151(1.06)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C1018(1.00); C1051(1.05); C140(1.25); C151(0.93)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C1018(1.05); C1051(0.98); C140(1.20); C151(1.01)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C1018(1.00); C1051(0.95); C140(1.08); C151(1.15)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C1018(0.95); C1051(0.99); C140(1.06); C151(0.74)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C1018(1.05); C1051(0.96); C140(0.91); C151(1.01)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C1018(0.95); C1051(1.04); C140(1.03); C151(1.14)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C1018(1.04); C1051(1.04); C140(1.01); C151(1.01)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C1018(0.97); C1051(0.93); C140(0.93); C151(1.14)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C1018(0.93); C1051(0.75); C140(0.78); C151(0.95)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C1018(1.03); C1051(0.90); C140(0.80); C151(0.97)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C1018(0.96); C1051(0.99); C140(0.80); C151(1.02)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C1018(0.93); C1051(1.70); C140(0.78); C151(1.02)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C1018(0.94); C1051(1.08); C140(0.81); C151(1.14)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C1018(0.96); C1051(1.15); C140(0.80); C151(0.98)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C1018(0.93); C1051(0.93); C140(1.06); C151(1.01)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C1018(1.04); C1051(0.76); C140(0.80); C151(1.06)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C1018(0.99); C1051(2.65); C140(0.89); C151(1.19)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C1018(0.97); C1051(0.86); C140(0.82); C151(1.08)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C1018(0.84); C1051(1.20); C140(0.87); C151(1.29)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C1018(0.94); C1051(1.58); C140(0.81); C151(1.09)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C1018(0.97); C1051(0.83); C140(0.84); C151(1.02)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C1018(1.03); C1051(0.86); C140(0.80); C151(1.05)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C1018(0.92); C1051(1.29); C140(0.80); C151(1.16)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C1018(1.09); C1051(1.14); C140(1.32); C151(1.24)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C1018(1.27); C1051(1.04); C140(1.05); C151(1.22)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C1018(1.12); C1051(1.09); C140(1.14); C151(1.14)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C1018(1.16); C1051(1.11); C140(1.04); C151(1.02)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C1018(1.28); C1051(1.15); C140(1.05); C151(1.26)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C1018(1.21); C1051(1.13); C140(1.07); C151(1.27)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C1018(1.40); C1051(1.30); C140(1.00); C151(1.01)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C1018(1.24); C1051(1.20); C140(1.12); C151(1.27)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C1018(1.19); C1051(1.14); C140(1.15); C151(1.08)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C1018(1.22); C1051(1.21); C140(1.13); C151(1.01)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C1018(1.56); C1051(1.27); C140(1.14); C151(1.23)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C1018(1.38); C1051(1.25); C140(1.06); C151(1.08)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C1018(0.96); C1051(0.84); C140(0.97); C151(1.01)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C1018(1.66); C1051(1.32); C140(1.09); C151(1.31)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C1018(1.49); C1051(1.31); C140(1.16); C151(1.17)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C1018(1.29); C1051(1.11); C140(1.09); C151(1.24)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C622(0.83); C1018(0.85); C140(0.87); C1051(1.05)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C622(0.71); C140(0.86); C1018(0.87); C395(0.89)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C395(0.74); C158(0.92); C140(0.94); C1018(0.98)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C622(0.81); C395(0.90); C1018(0.92); C140(0.92)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C622(0.80); C140(0.86); C1018(0.89); C395(0.96)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C622(1.01); C140(1.09); C395(1.15); C936(1.28)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C622(0.87); C140(0.91); C395(0.94); C936(1.15)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C1051(0.80); C151(0.90); C140(0.94); C622(0.94)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C622(0.77); C395(0.89); C140(0.95); C158(1.05)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C1018(0.79); C622(0.85); C140(0.88); C158(0.99)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C622(0.74); C140(0.87); C395(0.88); C1018(0.91)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C622(0.89); C1018(1.04); C395(1.13); C936(1.24)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C1018(1.03); C1051(1.14); C140(0.87); C158(1.26)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C1018(0.92); C1051(1.10); C140(0.92); C158(1.23)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C1018(0.90); C1051(1.08); C140(0.99); C158(1.04)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C1018(0.82); C1051(0.98); C140(0.91); C158(1.28)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C622(0.79); C151(0.87); C1018(0.97); C152(0.98)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C622(0.74); C151(0.91); C152(0.99); C140(1.09)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C151(0.83); C622(0.84); C152(0.94); C1018(1.07)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C1018(0.88); C140(1.05); C622(1.08); C1051(1.08)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C151(0.79); C622(0.85); C152(0.89); C936(0.99)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C151(0.78); C622(0.78); C152(0.90); C1018(1.04)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C622(0.79); C151(0.93); C152(0.97); C936(1.07)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C622(0.74); C151(0.84); C152(0.85); C1018(0.99)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C622(0.86); C151(0.99); C152(1.04); C1018(1.06)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C1051(0.85); C622(0.86); C151(0.92); C140(0.94)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C1051(0.83); C140(0.89); C622(0.89); C152(0.91)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C140(0.82); C622(0.85); C936(0.98); C152(0.99)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C622(0.79); C1051(0.86); C140(0.94); C1018(0.96)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C140(0.80); C622(0.83); C1051(0.87); C151(0.89)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C140(0.95); C1018(0.96); C1051(1.03); C622(1.08)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C622(0.82); C1051(0.83); C140(0.85); C936(0.85)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C622(0.74); C140(0.84); C152(0.90); C151(0.92)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C140(0.82); C622(0.83); C1051(0.87); C151(0.94)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C140(0.82); C622(0.87); C936(0.87); C151(0.93)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C622(0.77); C936(0.83); C140(0.87); C151(0.89)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C76(0.77); C1051(0.83); C152(0.92); C622(0.94)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C1051(0.79); C936(0.84); C1018(0.90); C622(0.91)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C936(0.79); C1051(0.83); C395(0.87); C1018(0.87)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C152(0.85); C936(0.86); C1051(0.87); C622(0.89)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C1051(0.85); C936(0.87); C152(0.93); C622(0.94)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C1018(0.87); C140(1.02); C1051(1.10); C622(1.15)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C936(0.74); C152(0.81); C395(0.82); C622(0.89)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C1018(0.77); C936(0.81); C622(0.85); C152(0.92)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C936(0.79); C1018(0.80); C622(0.91); C1051(0.92)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C1018(0.74); C936(0.81); C1051(0.82); C622(0.89)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C936(0.81); C395(0.86); C1018(0.93); C622(0.94)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C936(0.77); C622(0.82); C1018(0.85); C395(0.93)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C76(0.64); C936(0.81); C1018(0.93); C140(0.96)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C76(0.56); C936(0.94); C1051(0.99); C140(1.05)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C76(0.86); C1051(0.94); C936(1.07); C140(1.08)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C76(0.74); C936(0.77); C1051(1.17); C1018(1.17)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C1018(0.91); C140(1.08); C1051(1.10); C622(1.11)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C76(0.60); C936(0.90); C140(1.12); C1051(1.16)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C1051(0.85); C76(0.86); C936(0.97); C140(1.06)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C936(0.84); C76(0.87); C1051(0.98); C140(1.00)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C936(0.75); C76(0.82); C1018(0.98); C1051(1.04)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C76(0.63); C1018(1.05); C140(1.07); C1051(1.07)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C936(0.75); C76(1.03); C1051(1.16); C140(1.18)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C76(0.77); C936(0.82); C1018(1.36); C1051(1.40)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C151(0.85); C152(0.85); C936(0.85); C622(0.93)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C151(0.80); C152(0.80); C936(0.81); C140(1.07)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C936(0.74); C151(0.84); C152(0.84); C622(0.94)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C622(0.75); C151(0.90); C140(0.91); C1051(0.95)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C936(0.65); C151(0.73); C152(0.73); C622(0.93)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C936(0.71); C151(0.86); C152(0.86); C622(0.95)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C936(0.71); C151(1.03); C152(1.03); C622(1.06)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C936(0.71); C151(0.89); C152(0.89); C622(0.94)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C936(0.68); C151(1.04); C152(1.04); C622(1.05)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C936(0.73); C140(1.08); C1051(1.14); C622(1.19)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C936(0.91); C1051(1.07); C140(1.09); C622(1.11)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C936(0.68); C622(1.03); C1051(1.09); C151(1.20)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C152(0.93); C936(0.94); C1018(0.97); C622(1.00)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C152(0.85); C622(0.90); C151(0.94); C1018(0.96)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C151(0.84); C152(0.93); C936(0.96); C622(0.97)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C151(0.87); C152(0.88); C1018(0.96); C936(1.02)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C622(0.95); C1018(0.99); C1051(1.01); C152(1.01)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C936(0.89); C1018(0.91); C622(0.93); C151(1.00)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C936(0.86); C151(0.91); C622(0.96); C152(1.01)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C151(0.91); C152(0.91); C622(1.06); C1018(1.08)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C622(0.86); C936(0.90); C152(0.98); C151(1.02)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C1018(0.95); C151(0.97); C622(0.97); C1051(1.05)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C936(0.90); C152(0.91); C151(0.95); C1018(0.96)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C1018(0.91); C152(0.92); C936(0.92); C622(0.95)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C936(0.90); C1018(0.95); C152(0.99); C140(1.06)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C1051(0.83); C151(0.84); C936(0.86); C140(0.92)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C1018(0.93); C936(0.96); C622(1.00); C151(1.00)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C1018(0.82); C622(0.97); C936(0.97); C140(0.99)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C936(0.90); C152(1.04); C151(1.06); C622(1.13)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C936(0.59); C140(0.75); C622(0.89); C1051(1.04)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C936(0.66); C622(0.78); C140(0.83); C1051(1.08)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C936(0.62); C140(0.74); C622(0.81); C76(0.91)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C936(0.70); C622(0.73); C140(0.82); C1051(0.99)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C622(0.85); C936(0.99); C158(1.00); C140(1.02)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C622(0.77); C936(0.92); C158(0.99); C140(1.00)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C936(0.67); C622(0.74); C140(0.79); C76(0.91)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C936(0.85); C1051(0.97); C1018(0.98); C140(1.01)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C936(0.67); C140(0.78); C76(0.84); C1051(0.96)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C936(0.77); C622(0.81); C140(0.92); C1018(1.02)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C936(0.70); C622(0.72); C76(0.78); C140(0.82)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C936(0.58); C622(0.69); C140(0.72); C76(0.80)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C76(0.63); C936(0.79); C622(0.79); C1018(0.96)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C936(0.70); C622(0.82); C140(0.91); C1051(0.99)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C936(0.56); C140(0.73); C622(0.75); C76(0.88)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C395(0.60); C622(0.68); C76(0.78); C140(0.94)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C395(0.62); C76(0.70); C622(0.85); C1018(1.03)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C1018(1.03); C1051(0.98); C140(1.05); C151(1.10)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C151(0.82); C936(0.84); C152(0.87); C140(0.96)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C1051(0.85); C140(0.96); C151(0.98); C622(1.01)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C1018(1.00)  LDD2171  [6]
 LDCM0498  BS-3668 MDA-MB-231 C140(0.72)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C252(20.00); C140(1.97); C395(0.94)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C936(0.85); C140(0.92); C1018(0.95); C76(1.03)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C936(0.84); C140(0.87); C1051(0.93); C1018(1.05)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C1018(0.90); C622(0.95); C140(1.01); C1051(1.18)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C140(0.86); C622(0.88); C151(0.88); C152(0.93)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C622(0.89); C1018(0.94); C140(0.95); C152(1.00)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C151(0.86); C152(0.90); C1051(0.91); C936(0.95)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C151(0.90); C152(0.91); C140(0.95); C622(0.96)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C622(0.78); C151(0.86); C152(0.95); C1051(1.11)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C622(0.78); C151(0.81); C152(0.94); C1018(1.08)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C151(0.72); C622(0.75); C152(0.86); C1018(1.07)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C622(0.74); C151(0.96); C152(1.00); C1018(1.15)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C151(0.67); C622(0.74); C152(0.80); C1018(0.97)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C622(0.95); C1018(0.98); C1051(0.99); C158(1.01)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C151(0.77); C622(0.84); C152(0.92); C395(0.99)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C622(0.77); C151(0.81); C152(0.91); C395(1.10)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C622(0.84); C140(0.89); C151(0.89); C1018(0.93)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C622(0.71); C151(0.83); C140(0.86); C936(0.93)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C622(0.79); C151(0.81); C936(0.87); C140(0.89)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C622(0.79); C140(0.80); C936(0.85); C151(0.92)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C936(0.80); C622(0.84); C151(0.89); C395(0.90)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C622(0.83); C936(0.90); C395(0.93); C1051(1.00)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C936(0.83); C1051(0.88); C1018(0.92); C622(0.96)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C76(0.73); C622(0.84); C936(0.89); C1018(0.93)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C936(0.82); C140(0.87); C1051(0.91); C1018(1.02)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C622(0.86); C1018(0.86); C936(0.87); C395(0.92)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C76(0.68); C936(0.72); C140(0.80); C1051(0.83)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C936(0.74); C76(0.76); C140(1.06); C1018(1.09)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C76(0.90); C936(0.98); C140(1.12); C1018(1.27)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C76(0.68); C936(0.75); C140(1.12); C1051(1.17)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C936(0.95); C140(1.00); C151(1.00); C152(1.00)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C936(0.85); C622(0.92); C1018(0.92); C151(0.97)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C936(0.83); C151(0.83); C152(0.83); C622(0.90)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C936(0.78); C622(0.91); C151(0.92); C152(0.92)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C936(0.81); C1051(0.90); C1018(0.95); C151(0.96)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C151(0.82); C152(0.82); C936(0.84); C140(0.96)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C140(0.99); C1018(1.00); C1051(1.02); C936(1.03)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C140(0.63); C936(0.82); C76(0.83); C622(0.83)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C140(0.74); C622(0.91); C395(0.93); C1018(0.93)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C140(0.81); C1051(0.86); C622(0.87); C1018(0.88)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C140(0.86); C1018(0.92); C395(0.94); C622(0.95)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C936(0.79); C140(0.84); C1018(0.85); C76(0.92)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C140(0.75); C622(0.92); C936(0.93); C1051(0.93)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C140(0.86); C1018(0.92); C1051(0.97); C622(1.03)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C622(0.94); C936(0.96); C1051(0.98); C1018(1.09)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C936(0.79); C622(0.84); C140(0.85); C395(0.90)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C1018(0.96); C1051(0.93); C140(0.85); C151(1.10)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C1018(0.93); C1051(1.01); C140(1.03); C151(1.03)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C1018(0.99); C1051(0.99); C140(0.99); C151(0.98)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C1018(0.91); C1051(0.92); C140(0.82); C151(0.99)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C1018(0.96); C1051(0.94); C140(0.82); C151(1.08)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C1018(0.99); C1051(0.89); C140(0.82); C151(1.15)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C1018(0.91); C1051(1.09); C140(0.79); C151(0.97)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C1018(0.95); C1051(0.98); C140(1.17); C151(1.00)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C1018(0.91); C1051(0.98); C140(1.02); C158(1.18)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C1018(0.90); C1051(1.34); C140(1.02); C158(1.12)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C1018(0.82); C1051(1.18); C140(0.95); C158(1.11)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C1018(0.96); C1051(1.32); C140(1.04); C158(1.15)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C1018(0.98); C1051(0.93); C140(0.96); C158(0.97)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C1018(0.89); C1051(1.08); C140(1.00); C158(1.21)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C1018(1.05); C1051(1.06); C140(0.97); C158(1.11)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C1018(1.11); C1051(1.21); C140(1.13); C158(1.00)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C1018(0.87); C1051(1.36); C140(0.91); C151(1.11)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C1018(1.10); C1051(1.02); C140(1.06); C158(1.09)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C1018(0.94); C1051(1.04); C140(1.00); C158(1.08)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C1018(1.19); C1051(1.08); C140(1.42); C158(0.99)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C1018(1.13); C1051(1.22); C140(1.23); C158(1.22)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C1018(0.99); C1051(1.12); C140(1.10); C158(1.05)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C1018(1.07); C1051(1.07); C140(1.20); C158(1.27)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C1018(1.00); C140(1.01); C151(1.28); C152(1.28)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C1018(1.18); C140(1.01); C151(1.32); C152(1.32)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C1018(1.09); C140(1.07); C151(1.09); C152(1.09)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C1018(0.99); C140(1.05); C151(1.05); C152(1.05)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C1018(0.79); C1051(0.87); C140(0.91); C151(0.95)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C1018(1.05); C140(0.98); C151(0.97); C152(0.97)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C1018(0.97); C140(0.98); C151(1.07); C152(1.07)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C1018(0.91); C140(0.91); C151(0.87); C152(0.87)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C1018(1.14); C140(0.99); C151(0.95); C152(0.95)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C1018(0.99); C140(1.00); C151(1.06); C152(1.06)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C1018(1.09); C140(1.03); C151(1.57); C152(1.57)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C1018(1.09); C140(1.14); C151(1.11); C152(1.11)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C1018(1.05); C140(0.97); C151(1.25); C152(1.25)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C1018(0.88); C140(1.05); C151(0.94); C152(0.94)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C1018(1.01); C140(1.00); C151(1.18); C152(1.18)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C1018(0.81); C1051(0.94); C140(0.80); C151(0.86)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C1018(1.08); C140(1.07); C151(1.04); C152(1.04)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C1018(1.06); C140(0.95); C151(0.84); C152(0.86)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C1018(1.06); C140(1.00); C151(0.84); C152(0.82)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C1018(0.98); C140(0.91); C151(0.91); C152(0.88)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C1018(1.06); C140(0.84); C151(0.83); C152(0.80)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C1018(0.99); C140(1.05); C151(0.95); C152(0.91)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C1018(1.11); C140(0.98); C151(1.07); C152(1.00)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C1018(1.09); C140(1.04); C151(0.98); C152(0.91)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C1018(0.98); C140(1.00); C151(0.91); C152(0.91)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C1018(0.88); C140(0.86); C151(0.85); C152(0.80)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C1018(0.93); C1051(0.85); C140(0.97); C151(1.02)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C1018(1.10); C140(0.92); C151(0.79); C152(0.82)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C1018(1.06); C140(0.94); C151(0.84); C152(0.87)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C1018(1.05); C140(0.98); C151(0.98); C152(0.93)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C1018(1.04); C140(1.17); C151(0.82); C152(0.83)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C1018(1.04); C140(1.04); C151(0.82); C152(0.83)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C1018(0.97); C1051(1.08); C140(1.01); C395(0.98)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C1018(0.89); C1051(1.08); C140(1.31); C395(1.08)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C1018(1.01); C1051(1.13); C140(0.86); C395(1.14)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C1018(1.02); C1051(1.23); C140(0.92); C395(1.25)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C1018(0.90); C1051(1.12); C140(1.27); C151(1.34)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C1018(0.89); C1051(1.10); C140(0.93); C395(1.05)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C1018(0.91); C1051(1.10); C140(1.08); C395(1.02)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C1018(1.05); C1051(1.25); C140(1.09); C395(1.43)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C1018(1.03); C1051(1.27); C140(0.95); C395(1.39)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C1018(1.08); C1051(1.45); C140(0.91); C395(1.53)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C1018(0.93); C1051(1.21); C140(1.04); C395(1.05)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C1018(0.98); C1051(1.11); C140(0.95); C395(1.02)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C1018(0.95); C1051(1.20); C140(0.92); C395(1.09)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C1018(1.02); C1051(1.23); C140(1.01); C395(1.15)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C1018(1.20); C1051(1.45); C140(1.14); C395(1.63)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C1018(1.07); C1051(1.09); C140(0.90); C151(0.77)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C1018(0.81); C1051(1.32); C140(1.09); C395(0.96)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C1018(1.01); C1051(1.15); C140(0.97); C622(1.02)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C1018(0.97); C1051(2.01); C140(1.08); C622(1.12)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C1018(0.88); C1051(1.14); C140(1.15); C622(1.13)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C1018(0.91); C1051(1.13); C140(0.90); C622(1.09)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C1018(0.91); C1051(1.19); C140(0.97); C622(0.92)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C1018(0.88); C1051(1.13); C140(0.93); C622(1.01)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C1018(0.91); C1051(1.12); C140(0.88); C622(1.07)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C1018(0.96); C1051(1.46); C140(0.95); C622(0.89)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C1018(0.91); C1051(1.08); C140(0.96); C622(1.01)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C936(1.01); C252(1.44); C1034(0.99); C622(0.85)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C936(6.33); C395(4.13); C1018(3.10); C622(2.77)  LDD1702  [3]
 LDCM0625  F8 Ramos C140(0.86); C1051(0.10); C1018(1.66); C158(0.95)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C1018(0.93); C158(1.37)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C1051(2.88); C1018(10.20); C252(0.83)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C1018(0.97)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C140(1.61); C1018(0.71); C158(0.65)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C140(3.18); C1018(0.60); C252(1.73)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C140(6.48); C1018(1.32)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C140(1.97); C1018(0.54); C158(1.01); C252(2.03)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C140(1.49); C158(0.96)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C140(1.00); C1018(0.63); C158(0.88); C252(0.60)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C140(1.27); C1018(1.07); C158(0.63); C252(1.17)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C140(1.44); C1018(0.85); C158(0.89); C252(0.79)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C140(1.69); C1018(0.96); C158(1.05)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C1018(1.38)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C1018(1.00); C140(1.04); C151(0.90); C152(0.87)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C140(2.18); C1018(0.66); C158(0.63)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C1051(2.01); C1018(2.72)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C1018(1.08); C1051(1.56); C140(1.46); C158(2.01)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C1018(0.71); C158(1.18)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C140(1.07); C1018(0.58)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C1051(0.48); C1018(1.98)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C1018(1.82)  LDD2188  [17]
 LDCM0116  HHS-0101 DM93 Y1030(1.07)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y1030(0.53)  LDD0265  [5]
 LDCM0120  HHS-0701 DM93 Y1030(1.99)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C140(2.62); C1051(1.13); C1018(1.23)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C140(1.78); C1051(1.14); C1018(1.13)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C140(1.56); C1051(1.40); C1018(1.00)  LDD0082  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C140(0.69)  LDD2089  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1051(0.98)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C936(1.08)  LDD2098  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1051(1.08)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1051(1.09)  LDD2129  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1051(0.93)  LDD2137  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C140(0.84)  LDD2141  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C140(0.60)  LDD2150  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C158(0.60)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C140(1.25); C158(0.52)  LDD2207  [18]
 LDCM0021  THZ1 HCT 116 C1018(1.00)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.