Details of the Target

General Information of Target

Target ID LDTP06277
Target Name Mortality factor 4-like protein 2 (MORF4L2)
Gene Name MORF4L2
Gene ID 9643
Synonyms
KIAA0026; MRGX; Mortality factor 4-like protein 2; MORF-related gene X protein; Protein MSL3-2; Transcription factor-like protein MRGX
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSRKQGSQPRGQQSAEEENFKKPTRSNMQRSKMRGASSGKKTAGPQQKNLEPALPGRWG
GRSAENPPSGSVRKTRKNKQKTPGNGDGGSTSEAPQPPRKKRARADPTVESEEAFKNRME
VKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDNKEYAVN
EVVAGIKEYFNVMLGTQLLYKFERPQYAEILLAHPDAPMSQVYGAPHLLRLFVRIGAMLA
YTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASDYKVASAEYHRKAL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Uniprot ID
Q15014
Ensemble ID
ENST00000360458.5
HGNC ID
HGNC:16849

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.80  LDD0402  [1]
STPyne
 Probe Info  		K144(0.47)  LDD0277  [2]
DBIA
 Probe Info  		C165(0.93)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		10.60  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C165(1.12)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C165(1.21)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C165(1.00)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C165(1.00)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C165(0.94)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C165(1.07)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C165(0.97)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C165(1.02)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C165(1.10)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C165(1.02)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C165(0.89)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C165(0.85)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C165(1.17)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C165(1.05)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C165(0.96)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C165(0.98)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C165(0.87)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C165(0.93)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C165(1.32)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C165(1.17)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C165(0.98)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C165(0.98)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C165(1.02)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C165(1.08)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C165(0.83)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C165(1.00)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C165(0.91)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C165(0.95)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C165(1.01)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C165(1.13)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C165(1.08)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C165(1.12)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C165(1.05)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C165(0.98)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C165(1.16)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C165(1.05)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C165(1.24)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C165(1.08)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C165(1.15)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C165(1.14)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C165(1.20)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C165(1.18)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C165(1.21)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C165(1.34)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C165(1.16)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C165(1.31)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C165(1.28)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C165(1.06)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C165(1.21)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C165(1.27)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C165(1.24)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C165(1.32)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C165(1.33)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C165(1.67)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C165(1.50)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C165(1.21)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C165(1.31)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C165(1.26)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C165(1.42)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C165(1.89)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C165(1.42)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C165(1.32)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C165(1.16)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C165(1.05)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C165(1.02)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C165(1.01)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C165(1.05)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C165(1.20)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C165(1.04)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C165(1.01)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C165(1.20)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C165(0.98)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C165(1.00)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C165(1.07)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C165(1.29)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C165(1.19)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C165(1.44)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C165(1.27)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C165(1.15)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C165(1.27)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C165(1.24)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C165(1.48)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C165(1.25)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C165(1.26)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C165(1.26)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C165(1.22)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C165(1.41)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C165(1.25)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C165(1.22)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C165(1.11)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C165(1.10)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C165(1.24)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C165(1.07)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C165(1.20)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C165(1.26)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C165(1.16)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C165(1.37)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C165(0.93)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C165(1.11)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C165(1.24)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C165(1.19)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C165(1.22)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C165(1.04)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C165(1.10)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C165(1.16)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C165(1.20)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C165(1.30)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C165(1.10)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C165(0.74)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C165(0.91)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C165(0.98)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C165(1.18)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C165(1.18)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C165(0.86)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C165(0.92)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C165(1.00)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C165(1.02)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C165(1.00)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C165(1.01)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C165(0.87)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C165(0.84)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C165(0.83)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C165(1.02)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C165(1.07)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C165(0.78)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C165(1.02)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C165(1.11)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C165(0.90)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C165(1.06)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C165(0.89)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C165(0.94)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C165(0.84)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C165(0.92)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C165(1.15)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C165(0.89)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C165(0.95)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C165(0.97)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C165(1.01)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C165(1.01)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C165(1.14)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C165(1.13)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C165(0.90)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C165(0.92)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C165(1.08)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C165(1.11)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C165(1.13)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C165(1.11)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C165(0.88)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C165(1.21)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C165(0.98)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C165(1.09)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C165(1.17)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C165(1.14)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C165(0.96)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C165(1.10)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C165(1.10)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C165(1.49)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 9.53  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C165(0.93)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C165(1.86)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C165(0.81)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C165(1.03)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C165(1.10)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C165(1.10)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C165(1.03)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C165(0.89)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C165(0.99)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C165(0.84)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C165(0.93)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C165(1.08)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C165(0.99)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C165(1.16)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C165(0.96)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C165(0.99)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C165(1.01)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C165(1.03)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C165(1.26)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C165(1.07)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C165(1.07)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C165(1.16)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C165(1.15)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C165(1.28)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C165(1.18)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C165(1.18)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C165(1.24)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C165(1.42)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C165(1.21)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C165(1.40)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C165(1.05)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C165(0.82)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C165(0.70)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C165(1.01)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C165(0.90)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C165(1.06)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C165(0.89)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C165(0.97)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C165(0.97)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C165(0.90)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C165(1.09)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C165(0.95)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C165(0.89)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C165(1.12)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C165(1.27)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C165(1.21)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C165(1.06)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C165(1.16)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C165(1.02)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C165(1.02)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C165(1.12)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C165(1.15)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C165(1.24)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C165(0.80)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C165(1.18)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C165(0.83)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C165(0.87)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C165(1.01)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C165(0.96)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C165(1.12)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C165(0.81)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C165(1.41)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C165(0.99)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C165(0.83)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C165(1.11)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C165(1.05)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C165(1.57)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C165(1.10)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C165(1.09)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C165(1.24)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C165(0.78)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C165(0.87)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C165(0.81)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C165(0.93)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C165(0.97)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C165(0.88)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C165(0.89)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C165(0.93)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C165(0.87)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C165(0.78)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C165(0.82)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C165(0.93)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C165(0.94)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C165(0.84)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C165(0.92)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C165(0.94)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C165(0.77)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C165(1.10)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C165(1.05)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C165(1.15)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C165(1.16)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C165(1.04)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C165(1.18)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C165(1.15)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C165(0.96)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C165(0.92)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C165(1.16)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C165(1.13)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C165(1.19)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C165(1.13)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C165(1.03)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C165(1.09)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C165(1.18)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C165(1.07)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C165(1.10)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C165(1.20)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C165(1.59)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C165(1.23)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C165(1.16)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C165(1.36)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C165(1.18)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C165(1.40)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C165(1.17)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C165(1.11)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C165(1.04)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C165(1.29)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C165(1.45)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C165(1.00)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C165(0.90)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C165(1.13)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C165(1.01)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C165(0.94)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C165(1.12)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C165(1.26)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C165(1.14)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C165(1.10)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C165(1.16)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C165(1.10)  LDD0811  [3]
 LDCM0634  CY-0357 Hep-G2 C165(0.72)  LDD2228  [5]
 LDCM0495  E2913 HEK-293T C165(0.90)  LDD1698  [10]
 LDCM0625  F8 Ramos C165(0.83)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C165(0.89)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C165(0.85)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C165(0.74)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C165(0.91)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C165(0.77)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C165(0.68)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C165(0.86)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C165(0.87)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C165(1.20)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C165(2.01)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C165(0.53)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C165(0.84)  LDD2200  [11]
 LDCM0468  Fragment33 HCT 116 C165(1.01)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C165(0.96)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C165(0.77)  LDD2184  [11]
 LDCM0427  Fragment51 HCT 116 C165(1.33)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C165(0.66)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C165(0.56)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C165(0.66)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C165(0.56)  LDD2188  [11]
 LDCM0149  GA MCF-7 C165(3.43)  LDD0379  [12]
 LDCM0022  KB02 HCT 116 C165(1.94)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C165(1.24)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C165(1.66)  LDD0082  [3]
 LDCM0131  RA190 MM1.R C165(1.48)  LDD0304  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Translin (TSN) Translin family Q15631
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger and BTB domain-containing protein 43 (ZBTB43) Krueppel C2H2-type zinc-finger protein family O43298
Zinc finger protein 48 (ZNF48) Krueppel C2H2-type zinc-finger protein family Q96MX3
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
AT-rich interactive domain-containing protein 3A (ARID3A) . Q99856
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 7B (ZBTB7B) . O15156
Other
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Large ribosomal subunit protein bL12m (MRPL12) Bacterial ribosomal protein bL12 family P52815
Protein BEX5 (BEX5) BEX family Q5H9J7
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
MRG/MORF4L-binding protein (MRGBP) EAF7 family Q9NV56
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
Troponin T, cardiac muscle (TNNT2) Troponin T family P45379
Vasculin (GPBP1) Vasculin family Q86WP2
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
BTB/POZ domain-containing protein KCTD1 (KCTD1) . Q719H9
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Ecotropic viral integration site 5 protein homolog (EVI5) . O60447
F-box only protein 16 (FBXO16) . Q8IX29
GRAM domain-containing protein 2B (GRAMD2B) . Q96HH9
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) . Q96JM7
Leucine zipper protein 4 (LUZP4) . Q9P127
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
PRKCA-binding protein (PICK1) . Q9NRD5
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Zinc finger and BTB domain-containing protein 10 (ZBTB10) . Q96DT7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.