Details of the Target

General Information of Target

Target ID LDTP06178
Target Name KN motif and ankyrin repeat domain-containing protein 1 (KANK1)
Gene Name KANK1
Gene ID 23189
Synonyms
ANKRD15; KANK; KIAA0172; KN motif and ankyrin repeat domain-containing protein 1; Ankyrin repeat domain-containing protein 15; Kidney ankyrin repeat-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKR
LNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISK
PPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFR
RPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIR
HSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQ
LVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQS
TQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSR
SCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETT
HDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGT
SVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVC
ETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEA
AVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVG
EGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIA
CGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTL
LAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITG
NYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQI
AAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSE
SDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIR
ERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYI
AAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPI
MLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADV
NIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL
YAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD
Target Bioclass
Other
Subcellular location
Cell projection, ruffle membrane; Cytoplasm
Function
Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways.
Uniprot ID
Q14678
Ensemble ID
ENST00000382293.7
HGNC ID
HGNC:19309

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.S1018Y DBIA    Probe Info 
A549 SNV: p.E1033K .
CAL148 SNV: p.P1199T DBIA    Probe Info 
CCK81 SNV: p.A402V; p.D941G DBIA    Probe Info 
CHL1 Deletion: p.V1280del DBIA    Probe Info 
HCT116 SNV: p.W86Ter DBIA    Probe Info 
HEC1 SNV: p.Q493H DBIA    Probe Info 
HEC1B SNV: p.A443V .
HT115 SNV: p.F106S DBIA    Probe Info 
JHH7 SNV: p.L1182V .
KMS27 SNV: p.G496V .
KURAMOCHI SNV: p.C398F .
KYM1 SNV: p.V799I .
MCC13 SNV: p.Q211E DBIA    Probe Info 
MCC26 SNV: p.P182L DBIA    Probe Info 
MEC1 SNV: p.L305V .
MKN1 SNV: p.R1082M .
MOLT4 SNV: p.E166K; p.A518V .
MONOMAC6 SNV: p.K1179N .
P31FUJ Deletion: p.N969TfsTer6 DBIA    Probe Info 
SHP77 SNV: p.V586A .
SNU1 SNV: p.N1156T DBIA    Probe Info 
SNU423 Insertion: p.D1040RfsTer20 .
TCCSUP SNV: p.M172I .
WM2664 Insertion: p.E809GfsTer20 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C317(2.21)  LDD0171  [1]
DBIA
 Probe Info  		C317(1.26); C630(0.87); C640(0.87)  LDD0078  [2]
IA-alkyne
 Probe Info  		C317(0.00); C1114(0.00)  LDD0162  [3]
IPM
 Probe Info  		C907(0.00); C73(0.00); C317(0.00)  LDD0147  [4]
TFBX
 Probe Info  		C781(0.00); C73(0.00); C317(0.00); C1093(0.00)  LDD0148  [4]
Phosphinate-6
 Probe Info  		C73(0.00); C581(0.00)  LDD0018  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]
AOyne
 Probe Info  		14.20  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C317(2.21)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C317(0.86); C630(0.54); C640(0.54)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C317(0.96); C907(1.04)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C317(0.85); C907(1.40)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C317(0.88); C907(1.51)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C317(0.89); C907(1.39)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C317(1.28); C907(1.44)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C317(0.82); C907(1.21)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C317(1.41); C907(1.71)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C317(1.63); C907(1.69)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C317(0.70); C907(1.49)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C317(0.58); C907(1.40)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C317(0.90); C907(1.25)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C317(1.08); C907(1.12)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C317(1.19); C907(1.53)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C317(1.48); C907(1.35)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C317(0.77); C907(1.32)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C1114(1.09); C317(0.94); C907(0.88)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C1114(1.02); C317(0.96); C907(1.22)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C1114(1.02); C317(1.07); C907(0.95)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C1114(1.21); C317(1.00); C907(1.34)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C1114(1.18); C317(0.92); C907(1.02)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C1114(1.01); C317(0.95); C907(1.30)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C1114(1.17); C317(1.40); C907(1.11)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C317(1.01); C907(1.00)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C1114(1.11); C317(0.83); C907(1.46)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C1114(1.04); C317(1.03); C907(0.94)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C1114(1.02); C317(1.01); C907(1.45)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C1114(0.97); C317(1.09); C907(0.69)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C1114(1.02); C317(1.03); C907(1.01)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C1114(0.97); C317(0.85); C907(1.48)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C1114(0.99); C317(1.01); C907(1.58)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C1114(1.05); C317(0.75); C907(1.36)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C907(0.64)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C907(0.65)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C907(0.76)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C907(0.72)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C907(0.78)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C907(0.77)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C907(0.86)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C907(0.71)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C907(0.74)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C907(0.82)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C907(1.09)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C907(0.83)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C317(1.00); C907(0.98)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C907(0.93)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C907(0.97)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C907(0.78)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C317(0.74); C907(1.00)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C317(0.78); C907(0.97)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C907(0.95); C317(1.09)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C317(0.83); C907(0.90)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C907(0.95); C317(0.97)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C907(0.96); C317(1.53)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C907(1.04); C317(1.58)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C317(0.93); C907(1.06)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C317(0.93); C907(1.22)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C317(0.71); C907(0.90)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C317(0.95); C907(1.09)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C907(1.00); C317(1.38)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C317(1.22); C907(0.92)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C317(1.08); C907(0.86)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C317(0.81); C907(1.00)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C317(0.58); C907(1.04)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C1072(0.91); C317(1.10); C907(1.00); C781(1.23)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C1072(0.90); C317(0.99); C907(0.88)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C1072(1.27); C317(1.10); C907(1.62)  LDD1517  [10]
 LDCM0279  AC2 HCT 116 C630(0.59); C640(0.59); C317(0.90)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C1072(1.00); C317(1.03); C907(1.06)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C317(0.93); C907(1.06)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C1072(1.03); C907(1.04)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C1072(1.41); C317(1.05); C907(0.89)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C1072(0.88); C317(0.99); C907(0.91)  LDD1523  [10]
 LDCM0285  AC25 HCT 116 C640(0.82); C907(1.16); C1114(1.46)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C1114(0.90); C640(1.08); C907(1.09)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C640(1.05); C1114(1.07); C907(1.38)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C907(1.06); C640(1.06); C1114(1.17)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C640(0.90); C907(1.12); C1114(1.17)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C630(0.53); C640(0.53); C317(0.83)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C1114(1.09); C640(1.14); C907(1.47)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C640(0.84); C907(0.97); C1114(1.03)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C907(1.13); C1114(1.16); C640(1.21)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C640(1.06); C1114(1.09); C907(1.57)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C640(0.96); C1114(1.04); C907(1.35)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C630(0.58); C640(0.62); C907(1.01)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C640(0.85); C907(1.07); C630(1.19)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C640(0.72); C630(0.92); C907(1.15)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C640(0.68); C630(0.71); C907(1.28)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C640(0.93); C630(1.00); C907(1.21)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C630(0.54); C640(0.54); C317(0.56)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C640(0.61); C630(0.80); C907(1.46)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C640(0.64); C630(0.80); C907(1.32)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C640(0.68); C630(0.80); C907(1.37)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C640(0.65); C630(0.79); C907(1.45)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C640(0.84); C630(0.94); C907(1.35)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C640(0.77); C630(1.03); C907(1.49)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C907(1.19)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C907(0.99)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C907(1.16)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C907(1.00)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C630(0.45); C640(0.45); C317(0.53)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C907(1.00)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C907(0.93)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C907(1.14)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C907(1.32)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C907(1.08)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C907(1.48)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C907(1.09)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C317(0.84)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C317(0.83)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C317(1.11)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C317(1.05); C907(1.06)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C317(0.85)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C317(0.82)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C317(0.95)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C317(0.79)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C317(0.85)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C317(0.76)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C317(0.74)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C317(0.77)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C317(1.21)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C317(0.83)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C907(0.92); C317(1.03)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C317(0.98)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C317(0.94)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C317(0.91)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C317(0.98)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C317(0.94)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C317(1.02)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C317(0.90)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C317(0.89)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C317(1.02)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C317(1.04)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C317(0.92); C907(0.98)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C317(1.02)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C317(0.98)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C317(1.09)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C1114(1.00); C317(1.40); C907(1.48)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C1114(1.05); C907(1.25); C317(1.56)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C1114(1.03); C907(1.27); C317(1.48)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C1114(0.94); C907(1.22); C317(1.28)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C1114(1.01); C317(1.25); C907(1.32)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C1114(0.92); C907(1.25); C317(1.31)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C1114(0.87); C907(1.29); C317(1.61)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C1114(0.93); C317(1.06); C907(1.22)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C1114(0.99); C907(1.14); C317(1.42)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C1114(0.99); C907(1.22); C317(1.25)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C1114(0.90); C317(1.10); C907(1.34)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C907(1.05); C1114(1.18); C317(1.36)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C1114(0.92); C317(1.15); C907(1.25)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C1114(0.87); C907(0.93); C317(1.32)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C1114(0.82); C907(1.42); C317(1.58)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C907(1.42); C317(1.81)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C317(0.93); C907(1.55)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C317(1.06); C907(0.97)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C907(1.14); C317(1.18)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C317(0.96); C907(1.14)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C317(1.26); C630(0.87); C640(0.87)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C1114(0.72); C907(0.92); C630(0.98); C640(0.98)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C1114(0.60); C907(0.86); C630(0.93); C640(0.93)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C630(0.57); C640(0.57); C317(0.90)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C317(0.84); C907(1.04)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C317(0.89); C907(1.01)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C317(0.85); C907(0.92)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C317(0.93); C907(1.05)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C1072(0.89); C317(0.85); C907(1.02); C781(1.05)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C1072(1.46); C317(0.95); C907(0.90)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C1072(0.96); C317(1.07); C907(1.03); C73(1.07)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C1072(1.00); C317(0.87); C907(0.99)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C1072(0.90); C317(0.97); C907(0.95); C781(1.15)  LDD1582  [10]
 LDCM0379  CL11 HCT 116 C1114(0.71); C907(0.77); C630(0.80); C640(0.80)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C1072(0.92); C317(0.93); C907(1.05)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C1072(0.89); C317(0.97); C907(1.00); C73(1.03)  LDD1585  [10]
 LDCM0382  CL112 HCT 116 C907(0.89); C640(1.00); C1114(1.17)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C640(1.00); C1114(1.08); C907(1.10)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C640(0.81); C1114(1.02); C907(1.31)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C1114(1.02); C640(1.28); C907(1.30)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C1114(1.12); C640(1.22); C907(1.94)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C640(0.85); C630(1.38); C907(1.51)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C907(0.96); C640(0.98); C630(1.10)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C640(0.93); C907(0.99); C630(1.02)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C907(0.65); C1114(0.85); C630(0.89); C640(0.89)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C640(0.69); C630(0.74); C907(1.16)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C907(1.32)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C907(1.07)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C907(1.24)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C907(1.35)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C317(0.91)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C317(0.86)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C317(0.76)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C317(0.93)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C1114(0.76); C630(0.79); C640(0.79); C317(0.80)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C1114(0.55); C630(0.79); C640(0.79); C907(0.90)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C630(0.59); C640(0.59); C907(0.83); C1114(0.96)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C907(1.05); C317(1.32)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C907(1.00); C317(1.20)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C907(0.93); C317(1.13)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C907(0.99); C317(1.00)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C1114(0.72); C630(0.80); C640(0.80); C907(0.82)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C907(0.92); C317(1.08)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C907(0.87); C317(1.06)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C317(0.93); C907(0.97)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C317(1.04); C907(1.10)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C907(0.88); C317(0.96)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C317(1.11); C907(0.97)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C317(1.18); C907(0.81)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C317(1.10); C907(0.94)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C317(1.18); C907(0.98)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C317(1.06); C907(0.86)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C1114(0.74); C317(0.96); C630(0.78); C640(0.78)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C317(1.05); C907(0.93)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C1114(1.05); C317(1.01); C907(0.95)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C1114(0.83); C317(1.09); C907(1.08)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C1114(0.83); C317(1.10); C907(1.09)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C1114(0.97); C317(1.00); C907(1.04)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C1114(1.18); C317(0.96); C907(1.07)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C1114(1.03); C317(0.99); C907(1.06)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C1114(1.04); C317(0.99); C907(1.01)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C1114(1.09); C317(0.81); C907(0.94)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C1114(0.72); C317(1.00); C630(0.90); C640(0.90)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C1114(0.85); C317(0.85); C907(0.99)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C1114(1.10); C317(0.89); C907(1.04)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C1114(1.36); C317(0.63); C907(1.01)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C1114(1.02); C317(1.00); C907(0.95)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C1114(0.99); C317(1.05); C907(1.05)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C1114(0.94); C317(1.15); C907(1.07)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C630(1.15); C640(1.15); C907(0.97)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C630(1.06); C640(1.06); C907(0.89)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C630(1.06); C640(1.06); C907(1.05)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C630(0.98); C640(0.98); C907(0.95)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C1114(0.76); C317(0.64); C630(0.99); C640(0.99)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C630(0.85); C640(0.85); C907(0.87)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C630(0.98); C640(0.98); C907(0.95)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C630(1.00); C640(1.00); C907(1.11)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C630(1.59); C640(1.59); C907(1.02)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C630(1.00); C640(1.00); C907(0.96)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C630(0.89); C640(0.89); C907(1.00)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C630(0.75); C640(0.75); C907(1.03)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C630(0.75); C640(0.75); C907(0.91)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C630(0.81); C640(0.81); C907(1.07)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C630(0.74); C640(0.74); C907(0.86)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C1114(0.66); C317(0.97); C630(0.89); C640(0.89)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C630(0.80); C640(0.80); C907(0.89)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C317(1.06); C630(1.21); C640(1.21); C907(1.04)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C317(1.11); C630(0.99); C640(0.99); C907(1.03)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C317(1.11); C630(1.19); C640(1.19); C907(1.07)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C317(0.94); C630(1.21); C640(1.21); C907(1.09)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C317(0.93); C630(1.18); C640(1.18); C907(1.01)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C317(0.99); C630(1.22); C640(1.22); C907(1.25)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C317(0.81); C630(1.01); C640(1.01); C907(1.23)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C317(0.92); C630(1.13); C640(1.13); C907(1.04)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C317(1.19); C630(1.30); C640(1.30); C907(1.01)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C1114(0.90); C317(0.89); C630(0.82); C640(0.82)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C317(1.01); C630(0.95); C640(0.95); C907(1.03)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C317(1.06); C630(0.98); C640(0.98); C907(0.96)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C317(1.10); C630(1.09); C640(1.09); C907(0.96)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C317(1.14); C630(0.97); C640(0.97); C907(1.14)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C317(1.12); C630(1.20); C640(1.20); C907(1.19)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C317(1.01)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C317(0.92)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C317(0.99)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C317(0.97)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C1114(0.73); C317(1.30); C630(0.85); C640(0.85)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C317(1.07)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C317(0.96)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C317(0.91)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C317(0.80)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C317(1.19)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C317(1.04)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C317(1.00)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C317(0.94)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C317(0.95)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C317(1.04)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C1114(0.60); C317(0.83); C630(1.01); C640(1.01)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C317(1.00)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C317(0.76); C630(0.55); C640(0.55)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C317(0.67); C630(0.80); C640(0.80)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C317(0.99); C630(0.73); C640(0.73)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C317(0.98); C630(0.73); C640(0.73)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C317(0.92); C630(0.55); C640(0.55)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C317(0.71); C630(0.63); C640(0.63)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C317(0.80); C630(0.44); C640(0.44)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C317(0.82); C630(0.58); C640(0.58)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C317(0.96); C630(0.42); C640(0.42)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C1072(1.29); C317(1.00); C907(1.03); C73(1.05)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C317(1.02); C630(1.22); C640(1.22); C907(1.08)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C1114(1.34); C317(0.67); C907(1.12)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C907(5.28); C386(1.62)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C907(2.28); C386(1.29)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C907(6.60); C386(1.11)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C630(1.18); C640(1.18); C907(1.02)  LDD2173  [2]
 LDCM0112  W16 Hep-G2 C317(0.56); C907(0.71)  LDD0239  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin-like protein KIF21A (KIF21A) Kinesin family Q7Z4S6
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
14-3-3 protein theta (YWHAQ) 14-3-3 family P27348
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein eta (YWHAH) 14-3-3 family Q04917
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) . Q9UQB8
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1) . Q9Y6D6

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402