Details of the Target

General Information of Target

Target ID LDTP06077
Target Name Four and a half LIM domains protein 2 (FHL2)
Gene Name FHL2
Gene ID 2274
Synonyms
DRAL; SLIM3; Four and a half LIM domains protein 2; FHL-2; LIM domain protein DRAL; Skeletal muscle LIM-protein 3; SLIM-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRH
WHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGS
SWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQP
WHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFE
ERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes.
Uniprot ID
Q14192
Ensemble ID
ENST00000322142.13
HGNC ID
HGNC:3703

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO829 Insertion: p.C272WfsTer20 DBIA    Probe Info 
DU145 SNV: p.Y97Ter DBIA    Probe Info 
NCIH1792 SNV: p.P227H DBIA    Probe Info 
NCIH1975 SNV: p.S99C DBIA    Probe Info 
SKES1 SNV: p.I270V .
T24 SNV: p.R242W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K144(2.95); K167(2.04); K193(4.55); K220(10.00)  LDD0277  [2]
BTD
 Probe Info  		C254(1.56)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C126(5.18)  LDD0170  [4]
HHS-475
 Probe Info  		Y56(0.40); Y93(0.49); Y236(0.81)  LDD0264  [5]
DBIA
 Probe Info  		C209(3.10); C212(2.21); C214(2.06); C251(1.99)  LDD0080  [6]
5E-2FA
 Probe Info  		H8(0.00); H67(0.00)  LDD2235  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
IPM
 Probe Info  		N.A.  LDD0005  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		C7(0.00); C153(0.00); C191(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		C150(0.00); C153(0.00); C191(0.00); C185(0.00)  LDD0218  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C132(0.00); C10(0.00); C7(0.00)  LDD2223  [14]
HHS-465
 Probe Info  		Y56(0.00); Y93(0.00); K100(0.00); K57(0.00)  LDD2240  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C254(0.48)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C254(0.59)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C254(0.99)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C254(1.10)  LDD2152  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C254(0.49)  LDD2132  [3]
 LDCM0025  4SU-RNA DM93 C126(5.18)  LDD0170  [4]
 LDCM0214  AC1 HCT 116 C10(0.89); C248(0.94); C7(1.03); C132(0.93)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C10(1.27); C248(1.07); C7(1.28); C132(1.44)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C10(0.96); C248(0.93); C7(0.96); C132(0.92)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C10(0.93); C248(0.90); C7(0.93); C132(1.18)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C10(1.02); C248(1.16); C7(1.02); C132(1.19)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C10(1.17); C248(1.16); C7(1.17); C132(1.29)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C10(0.97); C248(1.03); C7(0.97); C132(1.07)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C10(1.12); C248(1.25); C7(1.12); C132(1.46)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C10(1.15); C248(1.08); C7(1.15); C132(1.32)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C10(1.05); C248(1.12); C7(0.95); C132(1.22)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C10(0.97); C248(1.01); C7(1.02); C132(1.00)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C10(0.86); C248(0.91); C7(0.84); C132(0.92)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C10(1.35); C248(1.06); C7(1.35); C132(1.27)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C10(1.03); C248(1.06); C7(0.98); C132(1.04)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C10(1.07); C248(0.88); C7(1.03); C132(1.19)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C10(1.14); C248(1.03); C7(1.05); C132(1.23)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C10(0.89); C248(0.95); C7(0.90); C132(0.98)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C10(1.19); C248(1.00); C7(1.16); C132(1.16)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C10(1.27); C248(1.37); C7(1.23); C132(0.96)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C10(1.24); C248(1.29); C7(1.20); C132(1.04)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C10(1.03); C248(1.02); C7(1.06); C132(0.92)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C10(1.16); C248(1.07); C7(1.15); C132(0.97)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C10(1.08); C248(1.02); C7(1.07); C132(1.07)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C10(1.15); C248(1.00); C7(1.16); C132(1.26)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C10(1.15); C248(1.08); C7(1.08); C132(0.94)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C10(0.94); C248(0.93); C7(0.96); C132(0.78)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C10(1.06); C248(1.09); C7(1.08); C132(0.97)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C10(0.94); C248(0.92); C7(0.98); C132(0.88)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C10(0.95); C248(0.92); C7(0.98); C132(0.88)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C10(1.09); C248(0.94); C7(1.06); C132(0.93)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C10(1.12); C248(1.10); C7(1.12); C132(0.96)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C10(1.12); C248(1.08); C7(1.14); C132(0.87)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C10(1.13); C248(1.11); C7(1.15); C132(0.97)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C10(0.69); C248(0.70); C7(0.66); C132(0.69)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C10(0.89); C248(0.85); C7(0.89); C132(0.95)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C10(0.72); C248(0.65); C7(0.67); C132(0.65)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C10(0.71); C248(0.66); C7(0.68); C132(0.80)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C10(0.85); C248(0.84); C7(0.84); C132(0.76)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C10(0.91); C248(0.81); C7(0.89); C132(0.86)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C10(0.92); C248(0.93); C7(0.90); C132(0.91)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C10(0.84); C248(0.84); C7(0.82); C132(1.01)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C10(0.85); C248(0.81); C7(0.86); C132(0.75)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C10(0.94); C248(0.86); C7(0.99); C132(1.04)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C10(0.89); C248(0.77); C7(0.85); C132(0.74)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C10(1.36); C248(1.05); C7(1.36); C132(1.30)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C10(0.90); C248(0.85); C7(0.90); C132(0.93)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C10(0.87); C248(0.78); C7(0.85); C132(0.90)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C10(0.76); C248(0.65); C7(0.75); C132(0.78)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C10(0.95); C248(0.95); C7(0.96); C132(0.89)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C49(0.78); C92(0.84); C51(0.90); C153(0.93)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C272(0.65); C275(0.65); C49(0.72); C185(0.85)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C49(0.59); C51(0.71); C272(0.82); C275(0.82)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C49(0.82); C153(0.84); C92(0.86); C272(0.94)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C49(0.56); C51(0.71); C254(0.93); C153(0.95)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C49(0.58); C51(0.70); C153(1.06); C221(1.12)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C51(0.62); C153(0.72); C209(0.96); C49(0.97)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C272(0.75); C275(0.75); C49(0.75); C51(0.82)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C272(0.66); C275(0.66); C49(0.71); C89(0.85)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C49(0.65); C51(0.75); C153(0.95); C92(1.04)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C49(0.58); C51(0.59); C272(0.69); C275(0.69)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C10(1.24); C248(1.11); C7(1.24); C132(1.12)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C10(1.37); C248(1.23); C7(1.35); C132(1.22)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C10(1.03); C248(0.91); C7(1.03); C132(0.91)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C10(1.00); C248(0.99); C7(0.99); C132(0.97)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C272(0.38); C275(0.38); C10(0.89); C132(0.91)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C272(0.41); C275(0.41); C49(0.87); C248(0.90)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C272(0.40); C275(0.40); C254(0.93); C49(0.96)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C209(0.68); C212(0.68); C272(0.73); C275(0.73)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C272(0.47); C275(0.47); C51(0.97); C254(0.97)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C272(0.42); C275(0.42); C51(0.80); C49(0.83)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C272(0.33); C275(0.33); C162(0.90); C153(0.95)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C272(0.31); C275(0.31); C254(0.77); C49(0.78)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C272(0.40); C275(0.40); C49(0.75); C51(0.83)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C248(0.83); C209(0.87); C212(0.90); C214(0.91)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C212(0.72); C209(0.98); C214(1.02); C162(1.07)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C248(1.02); C188(1.02); C89(1.03); C212(1.05)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C248(0.94); C185(1.05); C188(1.06); C191(1.09)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C212(0.79); C185(0.90); C188(0.95); C209(1.01)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C272(0.70); C275(0.70); C209(0.72); C212(0.72)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C212(0.97); C209(1.06); C188(1.13); C248(1.18)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C248(1.02); C251(1.06); C185(1.07); C188(1.09)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C212(0.85); C209(1.10); C185(1.15); C188(1.19)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C248(1.05); C188(1.13); C185(1.15); C191(1.17)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C212(0.88); C248(1.09); C89(1.11); C49(1.15)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C272(0.81); C275(0.81); C224(0.82); C254(0.83)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C272(0.86); C275(0.86); C251(0.88); C7(0.88)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C209(0.68); C214(0.74); C7(0.88); C272(0.89)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C272(0.79); C275(0.79); C153(0.92); C251(0.94)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C214(0.80); C209(0.85); C254(0.93); C188(0.93)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C272(0.70); C275(0.70); C150(0.86); C209(0.87)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C254(0.84); C272(0.93); C275(0.93); C51(1.00)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C272(0.88); C275(0.88); C10(0.89); C7(0.90)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C272(0.89); C275(0.89); C254(0.89); C51(0.92)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C272(0.88); C275(0.88); C254(0.95); C10(0.97)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C272(0.93); C275(0.93); C254(0.96); C224(0.97)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C254(0.87); C7(1.07); C10(1.08); C251(1.10)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C254(0.90); C162(0.96); C165(0.96); C221(0.96)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C254(0.83); C191(0.91); C214(0.95); C248(1.01)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C214(0.80); C191(0.91); C162(0.95); C165(0.95)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C254(1.20); C248(1.21); C162(1.26); C165(1.26)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C209(0.67); C212(0.67); C272(0.82); C275(0.82)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C254(1.16); C248(1.21); C162(1.23); C165(1.23)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C248(0.82); C191(0.82); C214(0.86); C251(0.87)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C248(0.92); C254(0.93); C251(1.04); C214(1.07)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C254(0.84); C248(0.90); C251(1.01); C221(1.04)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C254(0.81); C185(1.12); C248(1.13); C191(1.14)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C248(1.11); C254(1.12); C89(1.23); C162(1.26)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C254(1.12); C185(1.17); C248(1.32); C162(1.48)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C49(0.93); C132(0.94); C209(1.05); C214(1.11)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C49(0.70); C254(1.13); C89(1.14); C132(1.16)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C49(0.87); C51(1.19); C209(1.20); C248(1.25)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C49(0.69); C188(0.74); C191(0.79); C51(0.91)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C49(0.89); C209(1.01); C214(1.17); C132(1.17)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C49(1.03); C7(1.06); C214(1.07); C209(1.07)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C49(1.15); C191(1.18); C209(1.23); C7(1.29)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C49(0.93); C209(0.95); C214(1.06); C191(1.16)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C209(0.99); C214(1.12); C49(1.15); C132(1.17)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C212(0.78); C209(0.91); C214(0.92); C7(1.06)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C212(0.79); C209(0.84); C214(0.93); C7(1.00)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C209(0.95); C212(0.98); C214(1.01); C49(1.05)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C272(0.81); C275(0.81); C254(0.93); C51(0.97)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C272(0.83); C275(0.83); C254(0.86); C49(0.92)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C188(0.64); C191(0.70); C153(0.86); C254(0.90)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C272(0.65); C275(0.65); C162(0.71); C165(0.71)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C272(0.68); C275(0.68); C185(0.77); C162(0.78)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C272(0.86); C275(0.86); C185(0.87); C162(0.89)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C272(0.70); C275(0.70); C185(0.93); C162(1.01)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C272(0.87); C275(0.87); C185(0.95); C162(1.05)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C272(0.95); C275(0.95); C254(1.03); C162(1.16)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C272(0.75); C275(0.75); C185(0.84); C162(0.86)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C272(0.74); C275(0.74); C185(0.93); C162(1.03)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C272(0.68); C275(0.68); C162(0.75); C165(0.75)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C272(0.52); C275(0.52); C185(0.73); C162(0.80)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C49(0.70); C51(0.91); C153(0.94); C209(0.98)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C272(0.72); C275(0.72); C162(0.91); C165(0.91)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C162(0.72); C165(0.72); C185(0.76); C51(0.78)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C272(0.78); C275(0.78); C162(0.96); C165(0.96)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C272(0.85); C275(0.85); C254(0.90); C49(1.07)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C272(0.78); C275(0.78); C89(0.94); C49(0.99)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C272(0.64); C275(0.64); C89(0.82); C92(0.92)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C272(0.76); C275(0.76); C89(0.91); C162(0.93)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C162(0.78); C89(0.80); C272(0.81); C275(0.81)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C272(0.64); C275(0.64); C165(0.93); C162(0.97)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C272(0.75); C275(0.75); C89(1.01); C162(1.02)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C209(0.66); C191(0.74); C188(0.79); C212(0.82)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C272(0.84); C275(0.84); C212(1.07); C165(1.16)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C272(0.70); C275(0.70); C212(1.04); C254(1.09)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C272(0.87); C275(0.87); C165(1.01); C89(1.02)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C272(0.81); C275(0.81); C89(0.89); C254(0.93)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C272(0.83); C275(0.83); C89(0.88); C162(0.88)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C272(0.81); C275(0.81); C89(0.90); C254(0.96)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C272(0.87); C275(0.87); C89(1.12); C165(1.16)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C254(1.02); C272(1.07); C275(1.07); C162(1.09)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C162(0.73); C165(0.73); C209(0.80); C89(0.81)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C254(0.58)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C10(1.09); C248(0.94); C7(1.09); C132(1.17)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C153(0.87); C209(0.89); C272(0.89); C275(0.89)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C51(0.60); C272(0.78); C275(0.78); C49(0.80)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 13.73  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C209(1.50); C212(1.50); C214(1.50); C150(1.31)  LDD2171  [6]
 LDCM0498  BS-3668 MDA-MB-231 C254(0.76)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C150(0.00); C10(0.00); C153(0.00); C191(0.00)  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C272(0.64); C275(0.64); C188(0.86); C191(0.86)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C272(0.62); C275(0.62); C51(0.88); C185(0.92)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C209(0.78); C212(0.78); C272(0.88); C275(0.88)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C49(0.66); C51(0.82); C188(0.88); C191(0.90)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C49(0.48); C188(0.71); C153(0.75); C191(0.77)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C49(0.59); C153(0.76); C150(0.83); C188(0.84)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C49(0.67); C51(0.76); C153(0.86); C251(0.87)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C272(0.34); C275(0.34); C165(0.88); C132(0.89)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C272(0.30); C275(0.30); C254(0.86); C51(0.99)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C272(0.33); C275(0.33); C254(0.88); C248(1.02)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C272(0.25); C275(0.25); C254(0.91); C132(0.99)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C272(0.32); C275(0.32); C185(0.96); C162(0.99)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C185(0.75); C272(0.77); C275(0.77); C51(0.85)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C272(0.33); C275(0.33); C248(0.83); C254(0.84)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C272(0.40); C275(0.40); C254(0.80); C224(0.89)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C185(0.70); C188(0.81); C212(0.84); C191(0.85)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C212(0.90); C209(1.08); C185(1.11); C248(1.17)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C212(0.63); C185(0.87); C209(0.89); C188(0.95)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C89(0.98); C185(1.01); C248(1.13); C209(1.15)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C212(0.76); C209(0.88); C185(0.90); C188(0.96)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C254(0.66); C132(1.12); C51(1.16); C49(1.20)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C251(0.99); C272(1.02); C275(1.02); C248(1.03)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C209(0.95); C214(1.00); C7(1.02); C251(1.02)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C272(0.99); C275(0.99); C51(1.02); C185(1.06)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C214(0.80); C209(0.82); C10(0.96); C7(0.96)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C254(0.86); C214(0.95); C51(1.40); C185(1.50)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C248(0.92); C254(0.95); C224(0.96); C221(0.96)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C254(0.68); C248(0.80); C221(0.90); C251(0.90)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C248(0.91); C254(0.92); C162(1.08); C165(1.08)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C212(0.82); C209(0.84); C214(0.88); C132(0.88)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C49(0.92); C209(0.94); C165(0.97); C51(0.99)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C209(0.90); C212(0.92); C49(0.95); C214(0.98)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C254(1.05); C49(1.07); C214(1.17); C209(1.18)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C185(0.80); C51(0.83); C272(1.04); C275(1.04)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C185(0.78); C272(0.79); C275(0.79); C51(0.82)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C51(0.84); C185(0.84); C272(0.90); C275(0.90)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C254(1.10); C150(1.14); C191(1.15); C214(1.16)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C10(0.73); C188(0.82); C191(0.83); C254(0.90)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C191(0.85); C185(0.97); C188(1.06); C10(1.13)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C272(0.87); C275(0.87); C191(0.98); C185(1.01)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C191(0.88); C272(0.91); C275(0.91); C214(0.92)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C254(1.10); C272(1.12); C275(1.12); C185(1.13)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C185(0.82); C191(0.85); C272(0.92); C275(0.92)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C49(0.86); C51(0.86); C191(1.12); C185(1.24)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C191(0.90); C272(0.95); C275(0.95); C188(1.01)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C191(0.90); C185(1.03); C272(1.06); C275(1.06)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C10(1.47); C248(1.82); C7(1.55); C132(1.79)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C10(1.26); C248(1.70); C7(1.37); C132(1.55)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C10(1.40); C248(1.54); C7(1.33); C132(1.49)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C10(1.39); C248(1.97); C7(1.63); C132(1.65)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C10(1.66); C248(1.86); C7(1.57); C132(1.85)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C10(1.02); C248(1.38); C7(1.02); C132(1.14)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C10(0.94); C248(1.49); C7(1.24); C132(1.42)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C10(0.66); C248(0.99); C7(0.80); C132(0.99)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C10(1.14); C248(1.05); C7(1.18); C132(1.20)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C10(0.99); C248(0.93); C7(1.17); C132(1.03)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C10(0.96); C248(1.25); C7(1.01); C132(1.30)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C10(0.96); C248(1.23); C7(1.02); C132(1.42)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C10(0.93); C248(1.05); C7(0.96); C132(1.33)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C10(1.01); C248(1.23); C7(1.14); C132(1.62)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C10(0.97); C248(1.22); C7(1.04); C132(1.49)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C10(1.03); C248(1.20); C7(1.03); C132(1.03)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C10(0.95); C248(1.43); C7(0.97); C132(1.48)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C10(1.00); C248(1.18); C7(1.05); C132(1.22)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C10(1.05); C248(1.22); C7(1.05); C132(2.11)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C10(0.95); C248(1.25); C7(1.06); C132(1.67)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C10(1.01); C248(1.12); C7(1.06); C132(1.41)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C10(0.94); C248(1.45); C7(0.97); C132(1.86)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C10(0.88); C248(0.93); C7(0.86); C132(1.21)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C10(0.92); C248(0.90); C7(0.89); C132(0.99)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C10(0.89); C248(0.99); C7(0.86); C132(1.05)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C10(0.84); C248(1.02); C7(0.80); C132(0.88)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C10(1.10); C248(1.17); C7(1.10); C132(1.05)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C10(0.82); C248(0.93); C7(0.84); C132(1.00)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C10(0.88); C248(0.96); C7(0.90); C132(0.92)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C10(0.93); C248(1.08); C7(0.92); C132(1.01)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C10(0.96); C248(0.97); C7(0.94); C132(1.02)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C10(0.91); C248(0.97); C7(0.89); C132(1.11)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C10(0.94); C248(1.10); C7(0.91); C132(1.02)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C10(1.04); C248(1.10); C7(1.01); C132(1.04)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C10(0.91); C248(0.88); C7(0.90); C132(0.90)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C10(0.87); C248(1.04); C7(0.85); C132(1.04)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C10(0.97); C248(1.08); C7(0.96); C132(1.05)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C10(1.17); C248(1.26); C7(1.17); C132(1.11)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C10(0.87); C248(0.98); C7(0.86); C132(1.10)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C10(1.00); C248(0.95); C7(1.01); C132(0.98)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C10(0.97); C248(1.02); C7(0.98); C132(0.99)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C10(1.00); C248(1.06); C7(1.02); C132(1.13)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C10(1.33); C248(1.11); C7(1.32); C132(1.12)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C10(0.89); C248(0.90); C7(0.90); C132(0.91)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C10(1.49); C248(1.19); C7(1.49); C132(1.41)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C10(1.50); C248(1.15); C7(1.47); C132(1.23)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C10(1.37); C248(1.01); C7(1.32); C132(1.19)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C10(1.13); C248(0.99); C7(1.06); C132(1.08)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C10(1.36); C248(1.44); C7(1.36); C132(1.30)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C10(1.17); C248(1.06); C7(1.12); C132(1.11)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C10(1.19); C248(0.99); C7(1.22); C132(1.15)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C10(1.11); C248(0.96); C7(1.03); C132(1.09)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C10(1.03); C248(0.93); C7(1.04); C132(1.05)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C10(1.16); C248(0.99); C7(1.14); C132(1.24)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C10(1.13); C248(1.03); C7(1.13); C132(1.16)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C10(0.94); C248(0.72); C7(0.93); C132(0.98)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C10(1.21); C248(1.07); C7(1.20); C132(1.42)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C10(1.32); C248(1.17); C7(1.32); C132(1.60)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C10(1.50); C248(1.34); C7(1.50); C132(1.38)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C10(1.00); C248(0.94); C7(1.01); C132(1.09)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C10(1.15); C248(0.97); C7(1.15); C132(1.33)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C10(1.66); C248(1.17); C7(1.61); C132(1.71)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C10(1.31); C248(1.02); C7(1.28); C132(1.44)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C10(1.62); C248(1.20); C7(1.58); C132(1.66)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C10(1.20); C248(1.04); C7(1.11); C132(1.15)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C10(1.07); C248(0.91); C7(0.96); C132(0.90)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C10(1.20); C248(0.91); C7(1.11); C132(1.08)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C10(1.47); C248(1.16); C7(1.38); C132(1.56)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C10(2.07); C248(1.44); C7(2.00); C132(2.19)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C10(1.13); C248(1.21); C7(1.13); C132(1.24)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C10(0.79); C248(0.54); C7(0.73); C132(0.66)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C10(1.12); C248(0.93); C7(1.24); C132(1.11)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C10(1.09); C248(0.83); C7(1.21); C132(0.95)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C10(0.89); C248(0.79); C7(0.96); C132(0.97)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C10(0.90); C248(0.90); C7(1.04); C132(0.97)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C10(1.03); C248(0.82); C7(1.13); C132(1.02)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C10(1.08); C248(0.94); C7(1.15); C132(1.13)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C10(0.97); C248(0.97); C7(1.03); C132(1.05)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C10(0.98); C248(0.87); C7(1.06); C132(0.98)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C10(1.02); C248(1.04); C7(1.08); C132(1.10)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C132(0.87); C251(0.90); C221(0.96); C10(0.78)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C251(1.27); C224(1.25); C254(1.18); C132(1.14)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C10(1.23); C248(1.15); C7(1.22); C132(1.28)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C10(0.98); C248(1.58); C7(1.00); C132(2.38)  LDD0744  [6]
 LDCM0116  HHS-0101 DM93 Y56(0.40); Y93(0.49); Y236(0.81)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y56(0.64); Y236(0.71); Y93(0.83)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y56(0.47); Y93(0.90); Y236(1.01)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y93(0.84); Y236(1.09); Y56(1.13)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y93(0.55); Y56(0.72); Y236(1.03)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C209(3.10); C212(2.21); C214(2.06); C251(1.99)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C209(2.88); C212(2.52); C214(1.88); C251(1.94)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C209(10.91); C212(5.75); C214(5.62); C251(2.23)  LDD0082  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C254(1.17); C221(0.62)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C254(1.02); C7(1.25)  LDD2099  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C254(1.44)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C254(1.01); C7(1.09)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C254(0.72)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C254(0.89)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C254(0.84)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C254(1.28)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C254(0.81)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C254(0.89)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C254(1.04)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C254(1.28); C221(0.51)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C7(0.89)  LDD2135  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C254(0.86); C7(0.97)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C254(1.56)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C254(0.94); C221(0.61)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C254(0.68)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C254(1.29)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C254(0.95)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C254(0.55)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C254(0.67)  LDD2150  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C254(0.89)  LDD2207  [17]
 LDCM0021  THZ1 HCT 116 C209(1.50); C212(1.50); C214(1.50); C150(1.31)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-casein (CSN2) Beta-casein family P05814
Cullin-associated NEDD8-dissociated protein 2 (CAND2) CAND family O75155
PR domain-containing protein 11 (PRDM11) Class V-like SAM-binding methyltransferase superfamily Q9NQV5
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
mRNA-decapping enzyme 1A (DCP1A) DCP1 family Q9NPI6
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Cytokine-like nuclear factor N-PAC (GLYR1) HIBADH-related family Q49A26
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
Ras-like protein family member 12 (RASL12) Ras family Q9NYN1
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Sphingosine kinase 1 (SPHK1) . Q9NYA1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin-1 heavy chain (KIF5B) Kinesin family P33176
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 34 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein BarH-like 2 (BARX2) BAR homeobox family Q9UMQ3
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) BZIP family P18847
Zinc finger protein 143 (ZNF143) GLI C2H2-type zinc-finger protein family P52747
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein 23 (ZNF23) Krueppel C2H2-type zinc-finger protein family P17027
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 64 (ZFP64) Krueppel C2H2-type zinc-finger protein family Q9NTW7
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Nuclear respiratory factor 1 (NRF1) NRF1/Ewg family Q16656
PHD finger protein 1 (PHF1) Polycomblike family O43189
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Transcription factor RFX3 (RFX3) RFX family P48380
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
Krueppel-like factor 12 (KLF12) Sp1 C2H2-type zinc-finger protein family Q9Y4X4
Transcription factor Sp2 (SP2) Sp1 C2H2-type zinc-finger protein family Q02086
Sterol regulatory element-binding protein 2 (SREBF2) SREBP family Q12772
Homeobox protein PKNOX1 (PKNOX1) TALE/MEIS homeobox family P55347
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) . O75398
DNA-binding protein inhibitor ID-3 (ID3) . Q02535
Forkhead box protein O1 (FOXO1) . Q12778
Glucocorticoid modulatory element-binding protein 2 (GMEB2) . Q9UKD1
Golgin-45 (BLZF1) . Q9H2G9
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor SOX-30 (SOX30) . O94993
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Transcriptional repressor p66-beta (GATAD2B) . Q8WXI9
Zinc finger MYM-type protein 4 (ZMYM4) . Q5VZL5
Zinc finger protein 200 (ZNF200) . P98182
Zinc finger protein 408 (ZNF408) . Q9H9D4
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sialic acid-binding Ig-like lectin 6 (SIGLEC6) SIGLEC (sialic acid binding Ig-like lectin) family O43699
Other
Click To Hide/Show 43 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Junction plakoglobin (JUP) Beta-catenin family P14923
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Stabilizer of axonemal microtubules 2 (SAXO2) FAM154 family Q658L1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12) G protein gamma family Q9UBI6
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4) G protein gamma family P50150
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Protein INCA1 (INCA1) INCA family Q0VD86
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) LRIF1 family Q5T3J3
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Protein Niban 1 (NIBAN1) Niban family Q9BZQ8
Phosphatidylinositol-binding clathrin assembly protein (PICALM) PICALM/SNAP91 family Q13492
Proline-rich protein 5-like (PRR5L) PROTOR family Q6MZQ0
Protein ripply1 (RIPPLY1) Ripply family Q0D2K3
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
T-complex protein 10A homolog 1 (TCP10L) TCP10 family Q8TDR4
General transcription factor IIH subunit 1 (GTF2H1) TFB1 family P32780
General transcription factor IIF subunit 2 (GTF2F2) TFIIF beta subunit family P13984
Vexin (VXN) Vexin family Q8TAG6
182 kDa tankyrase-1-binding protein (TNKS1BP1) . Q9C0C2
A-kinase-interacting protein 1 (AKIP1) . Q9NQ31
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
APOBEC1 complementation factor (A1CF) . Q9NQ94
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Ciliary microtubule inner protein 1 (CIMIP1) . Q9H1P6
Coiled-coil domain-containing protein 92 (CCDC92) . Q53HC0
Death-associated protein-like 1 (DAPL1) . A0PJW8
Four and a half LIM domains protein 2 (FHL2) . Q14192
Heat shock factor 2-binding protein (HSF2BP) . O75031
Keratinocyte proline-rich protein (KPRP) . Q5T749
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Low density lipoprotein receptor adapter protein 1 (LDLRAP1) . Q5SW96
MAGE-like protein 2 (MAGEL2) . Q9UJ55
PHD finger protein 21A (PHF21A) . Q96BD5
Protein FAM204A (FAM204A) . Q9H8W3
Putative uncharacterized protein TXNRD3NB (TXNRD3NB) . Q6F5E7
Retinoic acid-induced protein 2 (RAI2) . Q9Y5P3
Rho GTPase-activating protein 9 (ARHGAP9) . Q9BRR9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.