Details of the Target

General Information of Target

Target ID LDTP06053
Target Name MORC family CW-type zinc finger protein 3 (MORC3)
Gene Name MORC3
Gene ID 23515
Synonyms
KIAA0136; NXP2; ZCWCC3; MORC family CW-type zinc finger protein 3; Nuclear matrix protein 2; Zinc finger CW-type coiled-coil domain protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDH
ICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTK
NGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERM
DQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVR
ITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQD
FDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWR
KLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPE
MIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNS
LKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQ
SHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEID
VRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMF
TDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEI
ERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELL
EMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVG
QLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST
Target Bioclass
Other
Subcellular location
Nucleus, nucleoplasm
Function
Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.; (Microbial infection) May be required for influenza A transcription during viral infection.
Uniprot ID
Q14149
Ensemble ID
ENST00000400485.6
HGNC ID
HGNC:23572

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y290(13.11)  LDD3495  [2]
BTD
 Probe Info  		C15(1.03)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C619(2.07); C694(6.06)  LDD0168  [4]
HHS-475
 Probe Info  		Y738(0.46)  LDD0264  [5]
DBIA
 Probe Info  		C694(0.94)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C15(0.00); C446(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C307(0.00); C15(0.00); C717(0.00); C694(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C307(0.00); C15(0.00); C671(0.00); C694(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C632(0.00); C671(0.00); C694(0.00)  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
VSF
 Probe Info  		C694(0.00); C632(0.00)  LDD0007  [11]
W1
 Probe Info  		C671(0.00); C15(0.00)  LDD0236  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C632(0.00); C851(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C787(0.58)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C787(0.50)  LDD2095  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C15(0.98); C332(0.70)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C15(1.04)  LDD2152  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C787(0.63)  LDD2131  [3]
 LDCM0025  4SU-RNA HEK-293T C619(2.07); C694(6.06)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C619(3.11); C694(4.86)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C413(0.96); C416(0.96); C307(1.09); C632(0.96)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C307(1.05); C632(1.34); C671(1.04); C694(1.20)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C15(0.91); C413(0.75); C416(0.75); C255(0.65)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C15(1.03); C413(0.71); C416(0.71); C255(0.62)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C15(0.97); C413(0.80); C416(0.80); C255(0.70)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C15(1.09); C413(0.69); C416(0.69); C255(0.57)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C15(0.91); C413(0.88); C416(0.88); C255(0.70)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C15(0.95); C413(0.88); C416(0.88); C255(0.61)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C15(0.92); C413(0.79); C416(0.79); C255(0.61)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C15(0.94); C413(0.77); C416(0.77); C255(0.59)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C15(0.96); C413(0.80); C416(0.80); C255(0.70)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C15(0.91); C413(0.90); C416(0.90); C255(0.95)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C307(1.07); C632(1.31); C671(1.33); C694(1.32)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C15(0.90); C413(0.84); C416(0.84); C255(0.82)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C15(1.01); C413(0.72); C416(0.72); C255(0.80)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C15(1.02); C413(0.82); C416(0.82); C255(0.65)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C15(1.09); C413(1.10); C416(1.10); C307(1.02)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C15(1.01); C413(1.46); C416(1.46); C307(1.04)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C15(0.95); C413(1.06); C416(1.06); C307(1.04)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C15(1.35); C413(0.94); C416(0.94); C307(1.00)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C15(1.00); C413(0.94); C416(0.94); C307(1.06)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C15(0.87); C413(0.97); C416(0.97); C307(1.02)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C15(1.10); C413(1.24); C416(1.24); C307(1.00)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C307(1.10); C632(1.01); C671(0.93); C694(1.08)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C15(1.17); C413(1.03); C416(1.03); C307(0.97)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C15(0.87); C413(1.35); C416(1.35); C307(1.04)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C15(1.06); C413(1.36); C416(1.36); C307(0.96)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C15(0.80); C413(1.23); C416(1.23); C307(0.93)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C15(0.87); C413(1.25); C416(1.25); C307(1.02)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C15(0.89); C413(1.49); C416(1.49); C307(1.01)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C15(1.06); C413(1.10); C416(1.10); C307(1.03)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C15(0.81); C413(1.04); C416(1.04); C307(1.08)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C413(0.92); C416(0.92); C632(1.27); C694(2.17)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C413(0.75); C416(0.75); C632(1.12); C694(0.69)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C413(0.83); C416(0.83); C632(1.30); C694(1.08)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C413(0.81); C416(0.81); C632(1.12); C694(0.90)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C413(0.96); C416(0.96); C632(1.03); C694(0.85)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C413(0.88); C416(0.88); C632(1.07); C694(1.20)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C413(0.73); C416(0.73); C632(1.19); C694(1.35)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C413(0.79); C416(0.79); C632(1.18); C694(1.06)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C413(0.81); C416(0.81); C632(0.99); C694(1.00)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C413(0.88); C416(0.88); C632(1.05); C694(1.05)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C413(0.71); C416(0.71); C632(1.14); C694(1.17)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C413(0.86); C416(0.86); C632(1.08); C694(1.13)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C307(1.06); C632(1.16); C671(0.90); C694(1.16)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C413(0.79); C416(0.79); C632(1.28); C694(1.16)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C413(0.78); C416(0.78); C632(1.14); C694(1.39)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C413(0.92); C416(0.92); C632(0.99); C694(0.92)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C15(1.10); C413(0.87); C416(0.87); C307(1.04)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C413(0.89); C416(0.89); C307(1.05); C435(1.10)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C413(0.83); C416(0.83); C307(1.02); C435(1.02)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C413(0.92); C416(0.92); C15(0.96); C307(1.11)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C413(0.84); C416(0.84); C435(0.94); C15(1.04)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C15(0.92); C413(1.06); C416(1.06); C435(1.10)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C413(0.87); C416(0.87); C15(1.20); C307(1.23)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C671(0.95); C307(1.11); C800(1.12); C797(1.14)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C413(0.83); C416(0.83); C307(1.02); C800(1.11)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C307(0.70); C413(0.82); C416(0.82); C15(0.87)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C307(0.87); C413(0.88); C416(0.88); C15(1.10)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C413(0.85); C416(0.85); C15(1.05); C307(1.63)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C15(1.03); C413(0.89); C416(0.89); C307(1.08)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C15(1.06); C413(0.79); C416(0.79); C307(0.91)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C15(1.22); C413(0.91); C416(0.91); C307(0.91)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C15(0.92); C413(0.87); C416(0.87); C307(1.01)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C435(0.83); C413(0.85); C416(0.85); C797(0.97)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C717(0.84); C255(0.89); C413(0.89); C416(0.89)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C717(0.79); C413(0.91); C416(0.91); C435(0.93)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C413(0.97); C416(0.97); C797(1.03); C800(1.03)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C15(0.96); C413(0.99); C416(0.99); C435(1.02)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C435(0.84); C255(0.88); C15(0.96); C307(0.98)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C435(0.78); C15(0.82); C413(0.93); C416(0.93)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C435(0.75); C413(0.80); C416(0.80); C15(0.86)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C413(0.89); C416(0.89); C307(0.91); C797(0.92)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C15(0.86); C435(0.93); C632(0.97); C413(1.03)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C255(0.85); C15(0.92); C413(0.95); C416(0.95)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C255(0.81); C15(0.94); C413(0.98); C416(0.98)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C255(0.83); C435(0.92); C15(0.93); C413(0.94)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C255(0.70); C307(0.88); C435(0.92); C413(0.95)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C632(0.98); C413(0.98); C416(0.98); C797(1.01)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C255(0.68); C435(0.83); C413(1.00); C416(1.00)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C255(0.82); C15(0.82); C413(0.95); C416(0.95)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C255(0.69); C15(0.79); C413(0.90); C416(0.90)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C255(0.84); C413(0.96); C416(0.96); C435(0.99)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C413(0.79); C416(0.79); C435(0.90); C255(0.91)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C694(0.79); C632(0.90); C800(0.91); C797(0.91)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C632(0.85); C694(0.88); C800(0.94); C307(0.98)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C694(0.79); C307(0.80); C632(0.82); C800(0.98)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C307(0.92); C797(0.93); C800(0.93); C694(0.95)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C632(0.97); C307(1.02); C800(1.02); C797(1.03)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C413(0.96); C416(0.96); C632(1.06); C307(1.18)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C632(0.86); C307(0.97); C694(1.04); C800(1.11)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C694(0.96); C307(0.99); C800(1.08); C797(1.14)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C800(0.99); C797(1.00); C307(1.07); C694(1.07)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C307(1.01); C800(1.04); C797(1.05); C694(1.07)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C632(0.85); C694(0.90); C307(0.91); C797(1.02)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C632(0.98); C307(1.04); C694(1.05); C797(1.23)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C413(0.87); C416(0.87); C307(0.87); C632(0.97)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C671(0.95); C632(0.98); C413(1.00); C416(1.00)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C632(0.95); C307(1.00); C797(1.05); C694(1.08)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C307(0.90); C413(1.00); C416(1.00); C671(1.24)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C413(1.02); C416(1.02); C671(1.15); C632(1.19)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C413(0.94); C416(0.94); C307(0.99); C632(1.28)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C632(0.71); C694(0.89); C307(1.01); C671(1.02)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C413(0.90); C416(0.90); C694(1.01); C632(1.06)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C413(0.96); C416(0.96); C307(0.97); C797(1.06)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C307(1.03); C632(1.10); C413(1.11); C416(1.11)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C671(0.98); C413(0.98); C416(0.98); C307(1.00)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C413(0.93); C416(0.93); C307(0.99); C671(1.26)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C413(1.05); C416(1.05); C255(1.06); C307(1.08)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C307(0.83); C413(0.83); C416(0.83); C255(1.07)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C307(0.86); C255(0.86); C413(0.97); C416(0.97)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C671(0.99); C307(1.04); C632(1.14); C800(1.24)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C255(0.82); C307(0.99); C413(1.20); C416(1.20)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C255(0.99); C413(1.00); C416(1.00); C15(1.02)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C255(0.78); C307(0.96); C413(1.02); C416(1.02)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C255(0.79); C307(0.90); C413(0.91); C416(0.91)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C255(0.83); C413(1.07); C416(1.07); C307(1.10)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C255(0.88); C413(0.95); C416(0.95); C307(1.05)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C307(0.97); C255(1.04); C413(1.05); C416(1.05)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C255(0.80); C413(0.82); C416(0.82); C307(0.97)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C797(0.97); C800(0.97); C717(1.01); C632(1.02)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C413(0.79); C416(0.79); C797(0.90); C800(0.90)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C632(0.98); C671(1.05); C797(1.05); C800(1.05)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C413(0.62); C416(0.62); C797(0.91); C800(0.91)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C797(0.82); C800(0.82); C413(0.89); C416(0.89)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C797(0.85); C800(0.85); C413(0.91); C416(0.91)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C413(0.72); C416(0.72); C717(1.11); C797(1.14)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C413(0.77); C416(0.77); C797(1.03); C800(1.03)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C413(0.78); C416(0.78); C797(1.14); C800(1.14)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C413(0.73); C416(0.73); C797(0.91); C800(0.91)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C413(0.77); C416(0.77); C797(1.05); C800(1.05)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C413(0.79); C416(0.79); C797(0.93); C800(0.93)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C413(0.75); C416(0.75); C797(0.83); C800(0.83)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C671(0.86); C307(1.10); C797(1.20); C800(1.24)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C413(0.82); C416(0.82); C797(0.95); C800(0.95)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C797(0.88); C800(0.88); C694(1.03); C717(1.03)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C413(0.66); C416(0.66); C797(1.10); C800(1.10)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C255(0.35); C413(0.81); C416(0.81); C307(0.96)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C255(0.37); C413(0.78); C416(0.78); C435(0.89)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C255(0.34); C413(0.72); C416(0.72); C717(0.88)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C255(0.37); C413(0.78); C416(0.78); C717(0.81)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C255(0.33); C413(0.93); C416(0.93); C632(0.93)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C255(0.33); C307(0.94); C413(0.98); C416(0.98)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C255(0.35); C413(0.75); C416(0.75); C717(0.90)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C255(0.34); C717(0.74); C413(0.84); C416(0.84)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C255(0.37); C413(0.78); C416(0.78); C307(0.95)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C255(0.35); C413(0.79); C416(0.79); C435(0.98)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C255(0.37); C413(0.90); C416(0.90); C717(0.91)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C255(0.69); C413(0.87); C416(0.87); C307(1.00)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C255(0.34); C307(0.88); C413(0.96); C416(0.96)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C255(0.54); C413(0.81); C416(0.81); C435(0.97)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C255(0.31); C717(0.88); C435(0.88); C413(0.90)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C255(0.57); C413(0.66); C416(0.66); C307(0.88)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C413(0.65); C416(0.65); C255(0.66); C307(0.87)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C307(1.08); C632(1.06); C671(1.07); C694(1.06)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C307(1.09); C671(1.11); C797(1.15); C800(1.16)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C671(1.11); C307(1.15); C797(1.64); C800(1.69)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 10.59  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C694(0.94)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C15(0.43)  LDD2091  [3]
 LDCM0632  CL-Sc Hep-G2 C632(0.97)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C255(0.84); C632(0.90); C307(0.95); C797(0.96)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C435(0.98); C307(0.99); C255(1.06); C413(1.16)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C413(0.92); C416(0.92); C632(1.04); C307(1.08)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C307(1.00); C671(1.03); C632(1.25); C800(1.25)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C632(0.94); C671(0.98); C307(1.00); C800(1.07)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C632(0.89); C671(0.96); C307(1.02); C797(1.02)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C797(0.96); C800(0.97); C671(0.98); C632(1.05)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C413(0.83); C416(0.83); C435(0.96); C255(0.98)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C255(0.79); C413(0.87); C416(0.87); C435(1.06)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C413(0.74); C416(0.74); C255(0.84); C435(0.90)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C413(0.78); C416(0.78); C435(0.89); C255(1.04)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C413(0.78); C416(0.78); C255(0.84); C307(0.85)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C255(0.96); C413(0.99); C416(0.99); C435(1.01)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C413(0.70); C416(0.70); C435(0.78); C255(1.06)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C413(0.73); C416(0.73); C435(0.78); C717(0.86)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C435(0.81); C632(0.88); C413(0.88); C416(0.88)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C255(0.70); C413(0.87); C416(0.87); C15(0.87)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C413(0.68); C416(0.68); C255(0.70); C435(0.88)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C255(0.74); C413(0.88); C416(0.88); C307(1.09)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C435(0.85); C255(0.87); C413(1.00); C416(1.00)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C307(0.99); C632(1.19); C797(1.46); C800(1.48)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C694(0.97); C307(0.98); C632(1.01); C800(1.03)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C632(1.12); C694(1.12); C800(1.14); C797(1.17)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C307(0.93); C435(1.04); C15(1.05); C255(1.08)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C307(0.93); C694(0.96); C800(1.07); C797(1.13)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C632(0.89); C307(0.94); C671(1.07); C694(1.33)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C413(0.87); C416(0.87); C797(0.96); C307(1.00)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C413(0.89); C416(0.89); C307(0.96); C671(1.03)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C413(0.91); C416(0.91); C307(1.00); C797(1.11)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C255(0.87); C413(0.94); C416(0.94); C694(0.98)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C255(0.83); C632(0.83); C307(1.01); C413(1.03)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C307(0.73); C255(0.78); C632(1.04); C413(1.09)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C307(0.92); C15(0.99); C413(1.08); C416(1.08)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C307(0.87); C255(0.97); C632(1.01); C15(1.06)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C632(0.89); C307(0.94); C797(1.00); C800(1.00)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C255(0.90); C307(0.98); C15(1.07); C632(1.13)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C255(0.90); C694(0.94); C307(1.03); C435(1.11)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C255(0.92); C632(1.04); C671(1.05); C307(1.06)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C671(1.03); C307(1.05); C255(1.31); C694(1.32)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C255(0.88); C694(0.96); C307(0.99); C671(1.07)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C632(0.81); C255(0.91); C307(0.93); C797(0.98)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C255(0.43); C694(0.92); C307(1.00); C632(1.06)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C255(0.39); C413(0.99); C416(0.99); C307(1.02)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C255(0.56); C694(0.64); C307(0.82); C671(0.93)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C255(0.63); C671(0.80); C694(0.88); C307(1.04)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C255(0.42); C307(0.98); C671(1.06); C413(1.19)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C413(1.12); C416(1.12); C255(0.41); C307(0.96)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C413(1.47); C416(1.47); C255(0.63); C307(1.02)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C413(1.17); C416(1.17); C255(0.76); C307(1.04)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C413(1.19); C416(1.19); C255(0.58); C307(0.95)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C413(1.32); C416(1.32); C255(0.59); C307(1.04)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C15(2.73); C413(1.53); C416(1.53); C255(1.09)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C413(1.30); C416(1.30); C255(0.90); C307(1.10)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C15(1.32); C413(0.82); C416(0.82); C307(1.17)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C15(1.15); C413(0.74); C416(0.74); C307(1.20)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C15(1.55); C413(0.70); C416(0.70); C307(1.38)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C15(9.06); C413(0.69); C416(0.69); C307(1.30)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C15(1.14); C413(0.74); C416(0.74); C307(1.13)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C15(1.25); C413(0.80); C416(0.80); C307(1.13)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C15(1.13); C413(0.71); C416(0.71); C307(1.20)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C15(1.46); C413(0.63); C416(0.63); C307(1.14)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C15(1.11); C413(1.58); C416(1.58); C255(0.72)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C15(2.22); C413(0.88); C416(0.88); C307(1.02)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C15(1.04); C413(0.69); C416(0.69); C307(1.12)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C15(1.42); C413(0.76); C416(0.76); C307(1.34)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C15(1.27); C413(0.67); C416(0.67); C307(1.41)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C15(1.34); C413(0.80); C416(0.80); C307(1.14)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C15(1.36); C413(0.78); C416(0.78); C307(1.15)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C15(1.22); C413(1.04); C416(1.04); C255(0.81)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C15(1.13); C413(0.96); C416(0.96); C255(0.98)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C15(1.11); C413(0.73); C416(0.73); C255(0.81)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C15(1.15); C413(0.98); C416(0.98); C255(1.16)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C15(0.78); C413(1.26); C416(1.26); C255(1.04)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C15(1.19); C413(1.04); C416(1.04); C255(0.94)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C15(1.12); C413(0.94); C416(0.94); C255(0.95)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C15(1.35); C413(0.99); C416(0.99); C255(0.76)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C15(1.01); C413(0.93); C416(0.93); C255(0.99)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C15(1.06); C413(1.11); C416(1.11); C255(0.81)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C15(1.02); C413(1.13); C416(1.13); C255(1.06)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C15(1.34); C413(0.81); C416(0.81); C255(1.18)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C15(1.07); C413(1.00); C416(1.00); C255(1.07)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C15(1.02); C413(1.13); C416(1.13); C255(1.00)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C15(1.33); C413(0.94); C416(0.94); C255(1.13)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C15(0.94); C413(1.34); C416(1.34); C255(0.91)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C15(1.22); C413(0.79); C416(0.79); C255(0.91)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C15(1.14); C413(1.42); C416(1.42); C255(0.86)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C15(1.11); C413(1.18); C416(1.18); C255(0.80)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C15(1.48); C413(1.05); C416(1.05); C255(0.75)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C15(1.07); C413(1.29); C416(1.29); C255(0.92)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C15(1.05); C413(1.21); C416(1.21); C255(1.06)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C15(1.16); C413(1.08); C416(1.08); C255(0.89)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C15(1.13); C413(1.21); C416(1.21); C255(1.07)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C15(1.19); C413(1.25); C416(1.25); C255(0.80)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C15(1.22); C413(1.26); C416(1.26); C255(0.69)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C15(0.93); C413(1.28); C416(1.28); C255(1.04)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C15(1.15); C413(1.08); C416(1.08); C255(0.90)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C15(1.23); C413(1.18); C416(1.18); C255(0.77)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C15(1.28); C413(1.39); C416(1.39); C255(0.71)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C15(1.32); C413(1.13); C416(1.13); C255(0.79)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C15(1.21); C413(1.24); C416(1.24); C255(0.85)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C15(0.95); C413(0.77); C416(0.77); C307(1.00)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C15(0.94); C413(0.67); C416(0.67); C307(1.03)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C15(1.07); C413(0.90); C416(0.90); C307(1.04)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C15(0.99); C413(0.82); C416(0.82); C307(1.02)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C15(3.36); C413(1.28); C416(1.28); C255(0.88)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C15(0.95); C413(0.92); C416(0.92); C307(1.04)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C15(0.88); C413(0.82); C416(0.82); C307(1.06)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C15(0.90); C413(0.90); C416(0.90); C307(1.17)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C15(0.89); C413(0.71); C416(0.71); C307(1.07)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C15(1.06); C413(0.78); C416(0.78); C307(1.20)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C15(1.01); C413(0.72); C416(0.72); C307(1.05)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C15(0.88); C413(0.78); C416(0.78); C307(1.09)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C15(1.11); C413(0.83); C416(0.83); C307(1.04)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C15(0.84); C413(0.73); C416(0.73); C307(1.11)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C15(0.97); C413(0.79); C416(0.79); C307(1.33)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C15(1.58); C413(1.14); C416(1.14); C255(0.82)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C15(1.09); C413(0.68); C416(0.68); C307(1.10)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C413(0.80); C416(0.80); C307(1.02); C632(0.97)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C413(0.87); C416(0.87); C307(0.90); C632(0.81)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C413(1.07); C416(1.07); C307(1.03); C632(0.86)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C413(0.82); C416(0.82); C307(1.03); C632(1.02)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C413(0.68); C416(0.68); C307(1.05); C632(0.99)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C413(1.08); C416(1.08); C307(1.01); C632(0.97)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C413(0.83); C416(0.83); C307(1.07); C632(1.10)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C413(0.89); C416(0.89); C307(1.06); C632(1.07)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C413(1.27); C416(1.27); C307(1.13); C632(0.98)  LDD0811  [6]
 LDCM0634  CY-0357 Hep-G2 C694(1.07); C632(0.50)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C694(1.01); C632(0.94); C671(1.03); C255(1.00)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C15(6.81)  LDD1702  [3]
 LDCM0625  F8 Ramos C694(1.47); C15(1.47)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C694(1.73)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C694(19.60); C15(3.40)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C694(0.95); C15(5.05)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C694(1.05); C15(1.46)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C694(1.41); C15(1.25)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C694(0.92); C15(6.15)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C694(1.30); C15(1.44)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C694(1.80); C15(1.19)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C694(1.53); C15(0.81)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C694(1.05); C15(1.38)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C694(1.58); C15(1.87)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C694(1.39); C15(0.77)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C694(1.95); C15(10.85)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C15(1.24); C413(1.11); C416(1.11); C255(0.81)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C694(2.52); C15(0.83)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C694(1.52); C15(2.10)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C15(3.89); C413(0.78); C416(0.78); C307(1.22)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C694(1.80); C15(1.11)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C694(1.30); C15(0.94)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C694(1.46); C15(4.67)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C694(1.10); C15(9.32)  LDD2188  [16]
 LDCM0116  HHS-0101 DM93 Y738(0.46)  LDD0264  [5]
 LDCM0118  HHS-0301 DM93 Y738(0.77)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y738(1.23)  LDD0267  [5]
 LDCM0022  KB02 HCT 116 C797(1.86); C800(1.86); C307(1.35); C632(1.58)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C797(1.55); C800(1.55); C307(1.37); C632(1.16)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C797(1.72); C800(1.72); C307(1.52); C632(1.30)  LDD0082  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C15(1.03)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C15(1.01)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C787(0.62)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C15(0.68); C332(0.52)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C15(0.81)  LDD2111  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C15(1.02); C332(0.67)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C15(0.61)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C15(0.80)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C15(1.04)  LDD2129  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C15(0.91)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C15(1.03)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C15(0.82)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C15(0.84); C332(0.94)  LDD2146  [3]
 LDCM0021  THZ1 HCT 116 C307(0.97); C435(1.10); C413(1.56); C416(1.56)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RNF216 (RNF216) . Q9NWF9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578