Details of the Target

General Information of Target

Target ID LDTP05319
Target Name Cerebellar degeneration-related protein 2 (CDR2)
Gene Name CDR2
Gene ID 1039
Synonyms
PCD17; Cerebellar degeneration-related protein 2; Major Yo paraneoplastic antigen; Paraneoplastic cerebellar degeneration-associated antigen
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLAENLVEEFEMKEDEPWYDHQDLQQDLQLAAELGKTLLDRNTELEDSVQQMYTTNQEQL
QEIEYLTKQVELLRQMNEQHAKVYEQLDVTARELEETNQKLVADSKASQQKILSLTETIE
CLQTNIDHLQSQVEELKSSGQGRRSPGKCDQEKPAPSFACLKELYDLRQHFVYDHVFAEK
ITSLQGQPSPDEEENEHLKKTVTMLQAQLSLERQKRVTMEEEYGLVLKENSELEQQLGAT
GAYRARALELEAEVAEMRQMLQSEHPFVNGVEKLVPDSLYVPFKEPSQSLLEEMFLTVPE
SHRKPLKRSSSETILSSLAGSDIVKGHEETCIRRAKAVKQRGISLLHEVDTQYSALKVKY
EELLKKCQEEQDSLSHKAVQTSRAAAKDLTGVNAQSEPVASGWELASVNPEPVSSPTTPP
EYKALFKEIFSCIKKTKQEIDEQRTKYRSLSSHS
Target Bioclass
Other
Family
CDR2 family
Uniprot ID
Q01850
Ensemble ID
ENST00000268383.7
HGNC ID
HGNC:1799

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C121(2.05)  LDD0168  [1]
DBIA
 Probe Info  		C432(39.78)  LDD0209  [2]
IA-alkyne
 Probe Info  		C367(0.00); C121(0.00)  LDD0162  [3]
NAIA_4
 Probe Info  		C121(0.00); C367(0.00)  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		C331(0.00); C432(0.00); C367(0.00)  LDD0148  [6]
Phosphinate-6
 Probe Info  		C432(0.00); C331(0.00)  LDD0018  [7]
W1
 Probe Info  		C331(0.00); C160(0.00); C432(0.00)  LDD0236  [8]
AOyne
 Probe Info  		14.40  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C121(2.05)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C121(2.44)  LDD0169  [1]
 LDCM0214  AC1 HCT 116 C331(1.16); C432(0.83)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C331(0.99)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C160(0.74); C331(1.33); C432(1.20)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C160(0.89); C331(1.35); C432(1.48)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C160(0.84); C331(0.99); C432(1.23)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C160(0.97); C331(1.11); C432(1.45)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C160(0.90); C331(1.11); C432(1.01)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C160(0.81); C331(1.34); C432(1.44)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C160(0.89); C331(1.28); C432(1.51)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C160(1.02); C331(1.61); C432(1.26)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C160(0.79); C331(1.41); C432(1.34)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C160(0.83); C331(1.04); C432(1.00)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C331(0.98)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C160(0.85); C331(1.44); C432(1.35)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C160(0.89); C331(1.21); C432(1.34)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C160(1.01); C331(1.21); C432(1.36)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C160(0.87); C331(0.86); C432(0.92)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C160(1.08); C331(0.62); C432(0.98)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C160(1.03); C331(0.47); C432(1.02)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C160(0.88); C331(0.39); C432(1.19)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C160(0.91); C331(0.39); C432(1.04)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C160(1.06); C331(0.60); C432(1.02)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C160(0.95); C331(0.76); C432(1.11)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C331(0.94)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C160(1.20); C331(0.55); C432(1.13)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C160(0.90); C331(0.42); C432(0.88)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C160(0.96); C331(0.48); C432(1.27)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C160(0.95); C331(0.41); C432(1.16)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C160(1.05); C331(0.50); C432(1.25)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C160(1.10); C331(0.45); C432(1.36)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C160(1.02); C331(0.53); C432(1.07)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C160(0.99); C331(0.45); C432(0.84)  LDD0562  [10]
 LDCM0246  AC128 HEK-293T C160(1.14)  LDD0844  [10]
 LDCM0247  AC129 HEK-293T C160(1.14)  LDD0845  [10]
 LDCM0249  AC130 HEK-293T C160(1.15)  LDD0847  [10]
 LDCM0250  AC131 HEK-293T C160(1.29)  LDD0848  [10]
 LDCM0251  AC132 HEK-293T C160(1.26)  LDD0849  [10]
 LDCM0252  AC133 HEK-293T C160(1.17)  LDD0850  [10]
 LDCM0253  AC134 HEK-293T C160(1.04)  LDD0851  [10]
 LDCM0254  AC135 HEK-293T C160(1.13)  LDD0852  [10]
 LDCM0255  AC136 HEK-293T C160(0.93)  LDD0853  [10]
 LDCM0256  AC137 HEK-293T C160(1.14)  LDD0854  [10]
 LDCM0257  AC138 HEK-293T C160(1.10)  LDD0855  [10]
 LDCM0258  AC139 HEK-293T C160(1.14)  LDD0856  [10]
 LDCM0259  AC14 HCT 116 C331(0.84)  LDD0576  [10]
 LDCM0260  AC140 HEK-293T C160(1.12)  LDD0858  [10]
 LDCM0261  AC141 HEK-293T C160(1.07)  LDD0859  [10]
 LDCM0262  AC142 HEK-293T C160(1.13)  LDD0860  [10]
 LDCM0263  AC143 HCT 116 C331(1.51)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C331(1.59)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C331(1.30)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C331(1.64)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C331(1.46)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C331(1.93)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C331(1.75)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C331(0.91)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C331(1.22)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C331(1.40)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C331(1.91)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C331(3.27)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C331(1.88)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C331(2.03)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C331(1.47)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C331(1.36)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C432(0.55); C160(0.89)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C432(0.70); C160(0.93)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C432(0.65); C160(1.02)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C432(0.82); C331(0.87)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C432(0.66); C160(1.15)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C432(0.64); C160(1.00)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C432(0.68); C160(1.10)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C432(0.54); C160(1.02)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C432(0.49); C160(0.97)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C160(1.02); C331(1.34)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C160(1.06); C331(1.27)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C331(1.10); C160(1.19)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C331(0.81); C160(1.14)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C331(1.10); C160(1.29)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C432(0.71); C331(0.92)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C331(0.89); C160(1.40)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C331(0.60); C160(1.05)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C331(1.20); C160(1.23)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C331(0.93); C160(1.35)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C331(0.90); C160(1.39)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C160(0.90)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C160(1.11)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C160(0.72)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C160(1.19)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C160(1.03)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C432(0.72); C331(0.87)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C160(0.95)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C160(1.29)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C160(1.29)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C160(1.55)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C160(0.86)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C160(0.81)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C331(0.95); C160(1.20)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C160(1.00); C331(1.12)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C160(0.85); C331(1.14)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C160(1.13); C331(1.71)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C432(0.67); C331(0.90)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C160(1.14); C331(1.53)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C331(1.07); C160(1.14)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C160(0.84); C331(1.07)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C160(1.26); C331(1.52)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C160(0.85); C331(1.40)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C160(1.25); C331(1.38)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C160(0.99); C331(1.76)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C160(0.94); C331(1.11)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C331(0.97); C160(1.01)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C331(0.87); C160(1.02)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C331(1.15)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C331(0.98); C160(1.04)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C331(0.82); C160(1.00)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C160(1.02); C331(1.17)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C160(0.99); C331(1.62)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C160(0.96); C331(1.16)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C331(0.25); C160(1.01)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C331(0.27); C160(1.10)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C331(0.31); C160(0.99)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C331(0.94)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C331(1.49)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C331(1.12)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C331(1.49)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C331(0.92)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C331(1.59)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C331(2.31)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C331(1.96)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C331(3.54)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C331(1.51)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C331(1.55)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C331(1.22)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C331(1.39)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C331(1.17)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C331(1.32)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C331(1.15)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C331(3.01)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C331(1.45)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C331(1.32)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C331(1.11)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C331(1.36)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C331(1.07)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C331(1.17)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C331(1.08)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C331(1.12)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C331(1.20)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C331(1.07)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C331(0.91)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C331(0.95)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C331(1.05)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C331(0.81)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C331(1.12)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C160(1.09); C331(1.27); C432(1.48)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C160(0.87); C432(1.23); C331(1.24)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C331(0.98)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C331(1.31)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C331(1.30)  LDD0592  [10]
 LDCM0632  CL-Sc Hep-G2 C367(0.97)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C331(1.05); C160(1.50)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C331(0.62); C160(1.10)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C432(0.82); C331(1.06)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C331(1.24)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C331(0.98)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C331(1.01)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C331(1.04)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C432(0.59); C160(0.99)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C432(0.59); C160(0.89)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C432(0.70); C160(0.86)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C432(0.44); C160(0.96)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C432(0.71); C160(1.06)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C331(0.63); C160(1.46)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C432(0.49); C160(1.08)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C432(0.62); C160(1.04)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C331(0.87); C160(1.29)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C331(1.09); C160(1.34)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C331(0.75); C160(1.46)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C331(0.87); C160(1.23)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C331(1.07); C160(1.28)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C160(1.16)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C160(1.33)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C160(1.38)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C331(0.68); C160(1.03)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C160(1.63)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C331(0.77); C160(1.25)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C160(0.94); C331(0.98)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C160(1.31); C331(1.53)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C160(1.07); C331(1.44)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C331(0.59); C160(1.00)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C331(0.85); C160(1.13)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C331(0.65); C160(1.01)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C160(1.01); C331(1.05)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C331(0.66); C160(0.98)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C331(0.53); C160(1.12)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C331(0.45); C160(1.63)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C432(1.19); C160(1.23); C331(1.33)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C432(0.93); C331(1.04)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C432(1.03); C331(1.07)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C432(0.84); C331(1.56)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C331(1.01); C160(1.40)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C432(0.85); C331(1.60)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C432(0.89); C331(1.62)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C432(0.79); C331(1.05)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C432(1.15); C331(1.35)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C432(1.02); C331(1.26)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C331(1.87); C432(1.10)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C331(0.95); C432(1.50)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C331(1.06); C432(1.00)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C331(1.18); C432(1.03)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C331(1.53); C432(0.91)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C160(1.17); C331(1.00)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C331(1.35); C432(1.04)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C160(1.65)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C160(1.20); C331(0.81)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C160(1.68); C331(1.02)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C160(1.06); C331(1.11)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C160(0.90); C331(1.12)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C160(1.17); C331(0.79)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C160(0.87); C331(0.94)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C160(0.94); C331(0.76)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C160(2.22); C331(0.89)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C160(1.09); C331(0.60)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C160(1.23); C331(0.44)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C160(0.83); C331(0.49)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C160(0.88); C331(0.49)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C160(0.89); C331(0.62)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C160(0.92); C331(0.72)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C331(1.83)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C331(0.90)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C331(0.89)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C331(0.86)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C160(1.02); C331(0.67)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C331(0.75)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C331(0.71)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C331(0.81)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C331(1.05)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C331(0.64)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C331(0.63)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C331(0.53)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C331(0.55)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C331(0.73)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C331(0.77)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C160(1.20); C331(0.60)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C331(0.61)  LDD0769  [10]
 LDCM0453  CL61 HEK-293T C331(1.25); C367(0.85); C160(0.98)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C331(0.99); C367(1.02); C160(1.01); C432(1.00)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C331(1.00); C367(0.94); C160(1.02)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C331(1.03); C367(0.91)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C331(1.42); C367(1.11); C160(1.02)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C331(1.20); C367(1.05); C160(1.06)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C331(1.14); C160(1.09)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C331(1.13); C160(1.04)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C331(1.10); C367(1.07); C160(1.06); C432(0.93)  LDD1664  [11]
 LDCM0462  CL7 HCT 116 C160(0.93); C331(0.69)  LDD0779  [10]
 LDCM0463  CL70 HEK-293T C331(1.22); C367(1.22); C160(1.03); C432(1.05)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C331(1.17); C367(1.13); C160(1.08)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C331(1.07); C367(1.25); C160(1.10); C432(1.23)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C331(1.31); C367(0.99); C160(1.04)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C331(0.98); C367(1.02); C160(1.09); C432(1.02)  LDD1670  [11]
 LDCM0469  CL76 HCT 116 C331(1.76)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C331(0.89)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C331(1.20)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C331(1.08)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C160(2.61); C331(0.54)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C331(1.38)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C331(1.11)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C331(1.03)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C331(1.02)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C331(1.75)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C331(1.38)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C331(0.87)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C331(1.06)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C331(1.96)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C331(1.62)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C160(0.97); C331(0.56)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C331(1.09)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C331(1.41); C432(0.88)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C331(1.58); C432(0.88)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C331(0.91); C432(0.76)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C331(1.16); C432(0.89)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C331(1.33); C432(0.85)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C331(0.78); C432(0.74)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C331(0.79); C432(0.76)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C331(0.79); C432(0.91)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C331(0.96); C432(0.86)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C331(1.10); C367(0.99); C160(1.05)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C331(2.06)  LDD1702  [12]
 LDCM0468  Fragment33 HEK-293T C331(0.95); C367(0.96); C160(0.92)  LDD1671  [11]
 LDCM0427  Fragment51 HCT 116 C160(0.84); C331(0.69)  LDD0744  [10]
 LDCM0022  KB02 HEK-293T C331(0.99); C367(1.07); C160(1.02)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C432(39.78)  LDD0209  [2]
 LDCM0024  KB05 VMRC-RCW C331(5.67)  LDD3487  [13]
 LDCM0112  W16 Hep-G2 C160(0.96)  LDD0239  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 4 (HDAC4) Histone deacetylase family P56524
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
GTP-binding protein GEM (GEM) RGK family P55040
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Transthyretin (TTR) Transthyretin family P02766
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Kinesin-1 heavy chain (KIF5B) Kinesin family P33176
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
REST corepressor 3 (RCOR3) CoREST family Q9P2K3
Zinc finger protein 35 (ZNF35) Krueppel C2H2-type zinc-finger protein family P13682
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Transcriptional enhancer factor TEF-3 (TEAD4) . Q15561
Upstream-binding factor 1-like protein 1 (UBTFL1) . P0CB47
Other
Click To Hide/Show 43 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein bL28m (MRPL28) Bacterial ribosomal protein bL28 family Q13084
Protein BEX2 (BEX2) BEX family Q9BXY8
Coiled-coil domain-containing protein 87 (CCDC87) CCDC87 family Q9NVE4
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Eukaryotic translation initiation factor 4E type 2 (EIF4E2) Eukaryotic initiation factor 4E family O60573
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Radial spoke head 14 homolog (RSPH14) Flagellar radial spoke RSP14 family Q9UHP6
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Meiosis-specific nuclear structural protein 1 (MNS1) MNS1 family Q8NEH6
Ornithine decarboxylase antizyme 2 (OAZ2) ODC antizyme family O95190
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Alpha-taxilin (TXLNA) Taxilin family P40222
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
Molecular chaperone MKKS (MKKS) TCP-1 chaperonin family Q9NPJ1
Testis-specific protein TEX28 (TEX28; TEX28P1; TEX28P2) TEX28 family O15482
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Coiled-coil domain-containing protein 153 (CCDC153) UPF0610 family Q494R4
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
INO80 complex subunit B (INO80B) . Q9C086
KAT8 regulatory NSL complex subunit 1 (KANSL1) . Q7Z3B3
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
MICAL-like protein 2 (MICALL2) . Q8IY33
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Protein lin-37 homolog (LIN37) . Q96GY3
Putative ankyrin repeat domain-containing protein 26-like 1 (ANKRD36BP1) . Q96IX9
Renal cancer differentiation gene 1 protein (C4orf46) . Q504U0
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840