Details of the Target

General Information of Target

Target ID LDTP04226
Target Name Paxillin (PXN)
Gene Name PXN
Gene ID 5829
Synonyms
Paxillin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNG
TILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSF
PNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPL
YGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQG
EMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKIQGLEQRADGERCWAAGWPRDGG
RSSPGGQDEGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGA
CKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYC
NGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCA
RAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQK
PITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
Target Bioclass
Other
Family
Paxillin family
Subcellular location
Cytoplasm, cytoskeleton
Function Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion.
Uniprot ID
P49023
Ensemble ID
ENST00000228307.11
HGNC ID
HGNC:9718
ChEMBL ID
CHEMBL5715

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.73  LDD0215  [2]
STPyne
 Probe Info  		K123(10.00); K199(10.00); K363(6.01); K466(5.88)  LDD0277  [3]
Probe 1
 Probe Info  		Y404(43.63)  LDD3495  [4]
AF-1
 Probe Info  		2.48  LDD0421  [5]
BTD
 Probe Info  		C538(0.87)  LDD1700  [6]
Sulforaphane-probe2
 Probe Info  		1.83  LDD0160  [7]
HHS-475
 Probe Info  		Y468(0.77); Y88(0.77); Y118(0.87); Y418(0.89)  LDD0264  [8]
HHS-465
 Probe Info  		Y418(4.61)  LDD2237  [9]
DBIA
 Probe Info  		C561(1.19); C564(1.19); C443(1.11); C446(1.11)  LDD0078  [10]
5E-2FA
 Probe Info  		H78(0.00); H116(0.00)  LDD2235  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C546(0.00); C405(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
ENE
 Probe Info  		N.A.  LDD0006  [15]
IPM
 Probe Info  		C582(0.00); C108(0.00); C290(0.00)  LDD0005  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		C108(0.00); C290(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
NAIA_5
 Probe Info  		C464(0.00); C546(0.00); C405(0.00)  LDD2223  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C108(0.91)  LDD2142  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C108(0.60)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C108(0.86)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C361(0.79); C538(0.62); C358(1.01); C585(0.76)  LDD2117  [6]
 LDCM0214  AC1 HCT 116 C290(0.99)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C290(0.70)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C290(0.99)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C290(0.98)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C290(0.86)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C290(1.27)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C290(1.00)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C290(1.35)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C290(1.30)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C290(0.99)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C290(0.96)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C290(0.77)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C290(1.17)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C290(0.88)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C290(0.83)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C290(0.89)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C290(0.89)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C290(1.40)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C290(1.31)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C290(1.59)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C290(1.41)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C290(1.30)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C290(1.52)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C290(0.80)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C290(1.04)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C290(1.48)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C290(1.22)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C290(1.81)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C290(1.31)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C290(1.26)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C290(1.42)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C290(1.76)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C290(1.42)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C290(1.15)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C290(1.57)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C290(1.40)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C290(1.18)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C290(1.26)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C290(1.96)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C290(1.36)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C290(1.05)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C290(0.89)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C290(1.23)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C290(1.51)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C290(0.62)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C290(1.34)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C290(1.41)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C290(1.38)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C290(1.00)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C290(1.96)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C290(1.23)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C290(1.34)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C290(1.49)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C290(2.73)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C290(1.90)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C290(0.75)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C290(1.02)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C290(1.12)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C290(1.23)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C290(2.95)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C290(1.70)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C290(1.38)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C290(1.13)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C290(1.16)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C290(0.91)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C290(0.95)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C290(0.97)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C290(0.78)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C290(0.88)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C290(1.00)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C290(1.01)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C290(1.05)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C290(0.74)  LDD0601  [10]
 LDCM0285  AC25 PaTu 8988t C290(0.59)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C290(0.82)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C290(0.93)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C290(1.14)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C290(0.99)  LDD1168  [10]
 LDCM0290  AC3 HCT 116 C290(1.04)  LDD0607  [10]
 LDCM0291  AC30 PaTu 8988t C290(0.62)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C290(0.79)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C290(1.10)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C290(0.93)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C290(0.90)  LDD1174  [10]
 LDCM0296  AC35 PaTu 8988t C290(1.15)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C290(1.24)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C290(1.50)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C290(1.44)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C290(1.66)  LDD1179  [10]
 LDCM0301  AC4 HCT 116 C290(1.11)  LDD0618  [10]
 LDCM0302  AC40 PaTu 8988t C290(1.60)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C290(1.20)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C290(1.42)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C290(1.34)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C290(1.98)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C290(1.40)  LDD1186  [10]
 LDCM0308  AC46 HCT 116 C290(0.87)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C290(0.90)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C290(0.85)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C290(1.37)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C290(1.33)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C290(1.67)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C290(0.84)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C290(1.16)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C290(1.16)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C290(1.20)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C290(1.30)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C290(1.63)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C290(1.16)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C290(1.08)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C290(1.40)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C290(0.93)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C290(1.23)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C290(1.22)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C290(1.32)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C290(1.07)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C290(1.42)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C290(0.95)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C290(0.86)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C290(1.01)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C290(1.17)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C290(1.36)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C290(0.70)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C290(1.29)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C290(0.99)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C290(1.41)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C290(1.87)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C290(1.69)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C290(2.29)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C290(1.71)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C290(1.67)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C290(1.38)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C290(1.24)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C290(0.92)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C290(1.46)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C290(1.04)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C290(1.96)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C290(1.62)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C290(1.23)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C290(0.86)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C290(1.38)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C290(1.04)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C290(0.99)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C290(1.48)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C290(0.93)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C290(2.15)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C290(1.71)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C290(0.95)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C290(0.90)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C290(1.36)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C290(1.63)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C290(1.38)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C290(1.76)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C290(0.94)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C108(1.04)  LDD2138  [6]
 LDCM0166  Afatinib A431 2.48  LDD0421  [5]
 LDCM0248  AKOS034007472 HCT 116 C290(0.71)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C290(0.81)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C290(0.74)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.38  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C561(1.19); C564(1.19); C443(1.11); C446(1.11)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C108(0.43)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C108(1.62)  LDD2214  [18]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0367  CL1 HCT 116 C290(0.86)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C290(1.17)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C290(1.09)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C290(0.62)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C290(0.71)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C290(0.64)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C290(0.70)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C290(1.15)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C290(1.09)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C290(1.37)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C290(1.08)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C290(1.24)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C290(1.10)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C290(1.18)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C290(1.00)  LDD0698  [10]
 LDCM0382  CL112 PaTu 8988t C290(1.06)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C290(0.76)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C290(0.75)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C290(0.75)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C290(0.65)  LDD1265  [10]
 LDCM0387  CL117 PaTu 8988t C290(1.24)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C290(1.22)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C290(1.30)  LDD1268  [10]
 LDCM0390  CL12 HCT 116 C290(1.15)  LDD0707  [10]
 LDCM0391  CL120 PaTu 8988t C290(1.40)  LDD1270  [10]
 LDCM0392  CL121 HCT 116 C290(1.10)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C290(0.87)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C290(1.34)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C290(1.09)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C290(0.99)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C290(1.11)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C290(1.27)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C290(1.36)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C290(1.03)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C290(1.32)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C290(1.01)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C290(1.20)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C290(0.86)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C290(1.14)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C290(1.12)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C290(0.94)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C290(1.13)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C290(1.21)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C290(0.96)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C290(1.15)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C290(1.10)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C290(1.10)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C290(1.29)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C290(1.15)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C290(1.32)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C290(1.37)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C290(1.29)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C290(1.18)  LDD0736  [10]
 LDCM0420  CL31 PaTu 8988t C290(0.94)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C290(0.97)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C290(0.95)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C290(1.15)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C290(1.03)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C290(0.87)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C290(1.01)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C290(0.93)  LDD1307  [10]
 LDCM0429  CL4 HCT 116 C290(0.85)  LDD0746  [10]
 LDCM0430  CL40 PaTu 8988t C290(0.76)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C290(0.98)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C290(0.95)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C290(0.87)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C290(1.13)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C290(1.11)  LDD1314  [10]
 LDCM0436  CL46 HCT 116 C290(1.01)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C290(0.91)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C290(0.94)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C290(0.90)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C290(1.00)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C290(1.01)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C290(0.81)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C290(0.93)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C290(0.95)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C290(1.00)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C290(0.94)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C290(0.78)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C290(0.98)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C290(1.08)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C290(1.01)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C290(1.17)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C290(0.98)  LDD0769  [10]
 LDCM0453  CL61 PaTu 8988t C290(1.09)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C290(1.05)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C290(1.10)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C290(1.24)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C290(0.96)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C290(0.98)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C290(1.15)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C290(1.68)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C290(1.79)  LDD1340  [10]
 LDCM0462  CL7 HCT 116 C290(0.89)  LDD0779  [10]
 LDCM0463  CL70 PaTu 8988t C290(1.33)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C290(1.05)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C290(1.12)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C290(1.39)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C290(1.19)  LDD1346  [10]
 LDCM0469  CL76 HCT 116 C290(0.85)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C290(0.95)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C290(1.05)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C290(0.80)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C290(1.80)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C290(1.00)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C290(0.85)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C290(0.93)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C290(1.05)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C290(1.04)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C290(0.71)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C290(0.84)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C290(1.30)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C290(0.95)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C290(0.99)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C290(0.87)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C290(1.00)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C290(1.15)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C290(1.04)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C290(1.12)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C290(0.78)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C290(1.05)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C290(0.95)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C290(0.90)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C290(0.99)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C290(1.08)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C405(1.03); C290(1.32); C582(1.10); C502(1.16)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C582(1.26); C290(1.26); C546(1.08); C108(0.85)  LDD1702  [6]
 LDCM0625  F8 Ramos C546(1.74); C108(0.85)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C546(1.09); C108(0.36)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C546(1.18); C108(6.34)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C546(1.21); C108(0.23)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C546(1.32)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C546(0.59); C108(0.17)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C546(1.03); C108(0.20)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C546(1.54); C108(1.45)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C108(0.79)  LDD2196  [20]
 LDCM0586  Fragment28 Ramos C546(0.50)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C546(2.78); C108(4.29)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C546(1.80)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C546(1.21); C108(0.54)  LDD2201  [20]
 LDCM0468  Fragment33 PaTu 8988t C290(1.19)  LDD1347  [10]
 LDCM0596  Fragment38 Ramos C546(2.57)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C108(0.42)  LDD2184  [20]
 LDCM0427  Fragment51 PaTu 8988t C290(1.08)  LDD1306  [10]
 LDCM0569  Fragment7 Ramos C546(0.64); C108(0.29)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C546(1.31); C108(0.28)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y468(0.77); Y88(0.77); Y118(0.87); Y418(0.89)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y118(0.56); Y88(0.74); Y418(0.75); Y468(1.54)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y118(0.61); Y88(0.68); Y418(0.77); Y468(1.39)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y418(0.86); Y88(0.90); Y118(1.10); Y468(1.38)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y418(0.85); Y468(1.60); Y118(1.83); Y88(1.99)  LDD0268  [8]
 LDCM0022  KB02 HEK-293T C405(0.93); C582(1.04); C585(1.04); C535(1.19)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C405(0.96); C582(1.05); C585(1.05); C535(1.19)  LDD1497  [19]
 LDCM0024  KB05 COLO792 C290(3.06); C108(1.34)  LDD3310  [21]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C108(0.96)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C108(0.51); C538(0.53)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C108(0.75)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C108(1.13)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C361(1.03); C538(0.63)  LDD2093  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C538(0.64)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C290(0.96)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C108(0.72); C538(0.66)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C108(0.82)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C538(1.07)  LDD2101  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C108(1.56)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C108(0.93)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C108(0.89); C361(0.96); C535(0.89)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C361(0.65); C538(0.45); C358(0.52)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C108(0.90); C538(0.86); C535(0.79)  LDD2111  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C361(1.19)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C535(0.59)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C361(0.51)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C535(0.85); C358(0.84)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C361(0.58)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C108(0.90); C361(0.78); C538(0.72)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C361(0.74); C538(0.72); C358(0.88)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C361(1.01)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C361(1.28)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C538(0.47)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C358(0.98)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C108(0.72); C538(0.45)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C538(0.59); C358(1.23)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C538(0.82); C358(0.83)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C538(0.87)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C535(0.85)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C108(0.61)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C361(0.66)  LDD2143  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C361(0.93); C538(0.44); C358(1.08)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C358(0.94)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C108(0.33); C538(0.86); C546(0.86)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C108(1.58)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C108(0.47)  LDD2206  [22]
 LDCM0003  Sulforaphane MDA-MB-231 1.83  LDD0160  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase CSK (CSK) Tyr protein kinase family P41240
Focal adhesion kinase 1 (PTK2) Tyr protein kinase family Q05397
Tyrosine-protein kinase Blk (BLK) Tyr protein kinase family P51451
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) Protein-tyrosine phosphatase family Q06124
Tyrosine-protein phosphatase non-receptor type 12 (PTPN12) Protein-tyrosine phosphatase family Q05209
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Protein dpy-30 homolog (DPY30) Dpy-30 family Q9C005
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
Integrin alpha-4 (ITGA4) Integrin alpha chain family P13612
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
ARF GTPase-activating protein GIT1 (GIT1) . Q9Y2X7
ARF GTPase-activating protein GIT2 (GIT2) . Q14161
Rhombotin-1 (LMO1) . P25800
Whirlin (WHRN) . Q9P202

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.