Details of the Target

General Information of Target

Target ID LDTP03978
Target Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)
Gene Name PIK3CA
Gene ID 5290
Synonyms
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
Target Type
Successful
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family
Function
Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others. Plays a role in the positive regulation of phagocytosis and pinocytosis.
TTD ID
T80276
Uniprot ID
P42336
DrugMap ID
TTEUNMR
Ensemble ID
ENST00000263967.4
HGNC ID
HGNC:8975
ChEMBL ID
CHEMBL4005

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K863(1.64)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C862(2.74)  LDD0171  [2]
DBIA
 Probe Info  		C255(0.41); C257(0.41); C301(0.98); C692(1.18)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C695(0.00); C971(0.00); C215(0.00); C147(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C695(0.00); C420(0.00); C301(0.00); C692(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C420(0.00); C215(0.00); C242(0.00); C147(0.00)  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C862(2.74)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C255(0.41); C257(0.41); C301(0.98); C692(1.18)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C255(0.84); C257(0.84); C301(1.17); C692(0.91)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C147(0.95); C255(1.16); C257(1.16); C301(0.91)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C147(1.11); C255(1.09); C257(1.09); C301(1.01)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C147(0.98); C255(0.94); C257(0.94); C301(1.05)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C147(1.02); C255(0.98); C257(0.98); C301(1.21)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C147(1.10); C255(1.02); C257(1.02); C301(1.18)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C147(1.00); C255(0.88); C257(0.88); C301(0.86)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C147(1.06); C255(0.77); C257(0.77); C301(1.02)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C147(1.06); C255(0.84); C257(0.84); C301(1.26)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C147(1.05); C255(1.01); C257(1.01); C301(0.87)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C147(1.13); C255(1.27); C257(1.27); C301(0.84)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C255(0.74); C257(0.74); C301(1.29); C692(0.97)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C147(1.12); C255(0.86); C257(0.86); C301(0.92)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C147(1.07); C255(0.95); C257(0.95); C301(0.91)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C147(1.11); C255(0.99); C257(0.99); C301(0.84)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C301(0.97); C692(1.04); C862(1.13)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C301(0.93); C692(1.29); C862(1.15)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C301(1.04); C692(1.11); C862(1.30)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C301(1.07); C692(1.12); C862(1.32)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C301(1.00); C692(1.22); C862(1.25)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C301(1.00); C692(0.99); C862(1.25)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C301(1.06); C692(1.11); C862(1.25)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C255(0.93); C257(0.93); C301(1.05); C692(1.11)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C301(1.10); C692(0.92); C862(1.31)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C301(1.03); C692(1.12); C862(1.02)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C301(0.89); C692(1.13); C862(1.14)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C301(2.61); C692(1.44); C862(1.10)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C301(1.04); C692(0.93); C862(1.12)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C301(1.01); C692(0.98); C862(1.08)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C301(0.95); C692(0.97); C862(1.24)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C301(1.01); C692(1.00); C862(1.19)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C255(1.08); C257(1.08); C301(1.01); C862(1.24)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C255(1.05); C257(1.05); C301(0.98); C862(0.98)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C255(0.87); C257(0.87); C301(1.00); C862(1.15)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C255(0.92); C257(0.92); C301(1.03); C862(1.10)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C255(1.08); C257(1.08); C301(0.88); C862(1.19)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C255(0.92); C257(0.92); C301(1.02); C862(1.33)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C255(0.90); C257(0.90); C301(1.11); C862(1.25)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C255(0.99); C257(0.99); C301(1.01); C862(1.42)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C255(1.03); C257(1.03); C301(1.00); C862(1.21)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C255(0.94); C257(0.94); C301(1.00); C862(1.11)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C255(0.98); C257(0.98); C301(1.19); C862(1.01)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C255(1.00); C257(1.00); C301(0.98); C862(1.28)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C255(0.71); C257(0.71); C301(1.46); C692(0.85)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C255(1.06); C257(1.06); C301(1.02); C862(1.26)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C255(1.04); C257(1.04); C301(1.10); C862(1.09)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C255(0.91); C257(0.91); C301(0.92); C862(1.11)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C301(0.91); C255(0.95); C257(0.95); C862(1.35)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C255(0.70); C257(0.70); C301(0.96); C862(1.15)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C255(0.77); C257(0.77); C301(1.03); C862(1.06)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C255(0.63); C257(0.63); C301(0.94); C862(1.17)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C255(0.86); C257(0.86); C862(1.05); C301(1.12)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C255(0.72); C257(0.72); C301(1.00); C862(1.07)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C255(0.69); C257(0.69); C301(0.86); C862(1.19)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C692(0.93); C255(0.98); C257(0.98); C862(1.02)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C255(0.89); C257(0.89); C301(0.93); C862(1.00)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C255(0.76); C257(0.76); C301(0.98); C862(1.10)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C255(0.72); C257(0.72); C301(1.02); C862(1.16)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C255(0.73); C257(0.73); C301(0.81); C862(1.35)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C255(0.72); C257(0.72); C301(0.98); C862(1.19)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C255(0.81); C257(0.81); C301(0.93); C862(1.36)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C255(0.94); C257(0.94); C301(0.96); C862(1.10)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C255(0.87); C257(0.87); C301(0.94); C862(1.53)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C255(0.88); C257(0.88); C301(0.90); C692(0.90)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C692(0.58); C255(0.73); C257(0.73); C301(0.93)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C255(0.83); C257(0.83); C692(0.86); C301(0.90)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C255(0.60); C257(0.60); C692(0.96); C301(1.18)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C255(0.86); C257(0.86); C692(0.95); C301(1.00)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C692(0.71); C255(0.90); C257(0.90); C301(0.95)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C255(0.91); C257(0.91); C692(0.93); C862(0.95)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C692(0.78); C255(0.81); C257(0.81); C301(0.98)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C692(0.96); C255(0.97); C257(0.97); C862(0.98)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C862(0.98); C692(1.01); C340(1.13); C255(1.17)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C692(0.89); C255(1.10); C257(1.10); C862(1.15)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C692(0.87); C255(0.99); C257(0.99); C862(1.27)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C692(0.93); C340(1.13); C255(1.22); C257(1.22)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C692(0.92); C255(1.15); C257(1.15); C340(1.22)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C255(0.71); C257(0.71); C862(1.14); C692(1.14)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C692(0.85); C255(1.00); C257(1.00); C862(1.24)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C692(0.77); C255(1.12); C257(1.12); C340(1.38)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C692(0.80); C255(1.30); C257(1.30); C862(1.48)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C692(0.79); C255(1.03); C257(1.03); C862(1.30)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C692(0.74); C255(0.83); C257(0.83); C862(1.42)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C862(0.89); C255(1.26); C257(1.26); C692(1.29)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C255(1.00); C257(1.00); C862(1.02); C692(1.20)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C862(1.07); C255(1.11); C257(1.11); C692(1.18)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C255(1.03); C257(1.03); C862(1.17); C692(1.22)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C255(1.06); C257(1.06); C692(1.06); C862(1.25)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C255(0.60); C257(0.60); C301(1.05); C692(1.21)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C255(1.00); C257(1.00); C692(1.05); C862(1.15)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C255(0.99); C257(0.99); C862(1.03); C692(1.15)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C255(1.14); C257(1.14); C862(1.21); C692(1.21)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C255(1.04); C257(1.04); C692(1.06); C862(1.16)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C255(1.07); C257(1.07); C862(1.18); C692(1.18)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C692(1.00); C255(1.01); C257(1.01); C862(1.25)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C692(0.90); C301(0.95); C862(1.06)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C301(0.90); C692(1.01); C862(1.15)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C692(0.78); C862(1.11); C301(1.12)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C692(0.86); C301(1.49); C862(1.63)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C255(0.57); C257(0.57); C301(1.11); C692(1.36)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C692(0.86); C301(1.05); C862(1.16)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C862(0.71); C692(1.12); C301(1.29)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C692(0.90); C862(1.06); C301(1.17)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C692(0.95); C301(1.04); C862(1.19)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C692(0.92); C301(1.10); C862(1.16)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C301(0.84); C692(0.84); C862(1.52)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C692(0.71); C301(1.02); C862(1.35)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C692(0.57); C301(0.76); C255(0.81); C257(0.81)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C692(0.49); C255(0.69); C257(0.69); C301(1.02)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C692(0.62); C255(0.75); C257(0.75); C301(0.89)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C692(0.76); C255(0.85); C257(0.85); C301(1.14)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C692(0.48); C255(0.59); C257(0.59); C301(1.00)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C692(0.50); C255(0.71); C257(0.71); C301(0.91)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C692(0.60); C255(0.72); C257(0.72); C301(0.88)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C692(0.48); C255(0.64); C257(0.64); C301(0.98)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C692(0.55); C255(0.70); C257(0.70); C301(1.01)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C692(0.72); C255(0.76); C257(0.76); C301(0.95)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C692(0.65); C255(0.80); C257(0.80); C301(0.97)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C692(0.46); C255(0.68); C257(0.68); C301(0.76)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C255(0.71); C257(0.71); C692(0.77); C301(0.87)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C255(0.64); C257(0.64); C301(0.68); C692(0.71)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C692(0.79); C255(0.89); C257(0.89); C862(1.00)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C255(0.64); C257(0.64); C301(0.68); C692(0.74)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C301(0.67); C255(0.86); C257(0.86); C692(0.98)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C301(0.69); C255(0.79); C257(0.79); C692(0.81)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C255(0.66); C257(0.66); C301(0.69); C692(0.72)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C255(0.65); C257(0.65); C692(0.66); C301(0.76)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C255(0.61); C257(0.61); C692(0.62); C301(0.66)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C255(0.82); C257(0.82); C692(0.83); C301(0.86)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C255(0.83); C257(0.83); C692(0.88); C301(0.91)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C255(0.59); C257(0.59); C692(0.83); C301(0.88)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C301(0.73); C255(0.84); C257(0.84); C692(0.93)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C255(0.81); C257(0.81); C692(0.94); C862(1.17)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C692(0.82); C255(0.88); C257(0.88); C301(0.94)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C255(0.73); C257(0.73); C301(0.74); C692(0.76)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C255(0.51); C257(0.51); C692(0.67); C301(0.76)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C147(0.72); C862(0.92); C301(0.95)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C147(0.67); C862(1.01); C301(1.27)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C147(0.67); C301(0.95); C862(1.07)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C147(0.81); C301(0.89); C862(1.12)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C147(0.82); C862(0.96); C301(1.18)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C147(0.79); C862(0.86); C301(1.15)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C147(0.79); C862(0.98); C301(1.18)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C147(0.76); C862(0.96); C301(1.05)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C147(0.72); C301(0.93); C862(1.14)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C147(0.73); C301(0.81); C862(0.97)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C147(0.73); C301(0.77); C862(0.96)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C147(0.75); C862(1.10); C301(1.22)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C147(0.75); C862(0.95); C301(1.05)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C147(0.74); C301(1.00); C862(1.08)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C147(0.77); C301(0.90); C862(1.10)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C692(0.16); C301(0.97); C255(1.03); C257(1.03)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C692(0.80); C301(0.91); C255(0.94); C257(0.94)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C255(1.09); C257(1.09); C301(1.24); C692(1.11)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C255(0.78); C257(0.78); C692(0.99); C862(1.00)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C692(0.70); C255(0.81); C257(0.81); C301(1.15)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C255(0.86); C257(0.86); C862(0.89); C147(0.92)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C692(0.60); C301(0.83); C255(0.84); C257(0.84)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C255(0.60); C257(0.60); C301(1.00); C692(1.22)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C692(0.85); C255(0.91); C257(0.91); C862(1.21)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C255(0.79); C257(0.79); C862(0.98); C692(1.08)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C255(0.75); C257(0.75); C862(1.00); C692(1.10)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C255(0.79); C257(0.79); C692(0.90); C862(0.92)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C692(0.73); C255(0.84); C257(0.84); C301(0.94)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C692(0.47); C255(0.54); C257(0.54); C301(0.90)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C255(0.71); C257(0.71); C692(0.73); C301(0.93)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C692(0.64); C255(0.83); C257(0.83); C301(1.03)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C692(0.73); C255(0.77); C257(0.77); C301(0.99)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C692(0.57); C862(0.72); C255(0.78); C257(0.78)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C692(0.56); C255(0.77); C257(0.77); C301(1.07)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C692(0.71); C255(0.74); C257(0.74); C301(1.02)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C340(0.86); C692(1.01); C255(1.03); C257(1.03)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C692(0.78); C255(0.89); C257(0.89); C862(1.18)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C692(0.76); C255(0.81); C257(0.81); C340(0.99)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C692(0.86); C255(0.93); C257(0.93); C340(1.20)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C255(0.90); C257(0.90); C692(0.91); C340(1.16)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C692(0.97); C255(1.00); C257(1.00); C862(1.28)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C255(1.09); C257(1.09); C862(1.10); C692(1.12)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C692(1.06); C255(1.11); C257(1.11); C862(1.13)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C692(0.76); C255(0.88); C257(0.88); C862(0.96)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C255(1.07); C257(1.07); C692(1.14); C862(1.21)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C692(0.80); C862(1.05); C301(1.11)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C692(0.77); C862(1.10); C301(1.31)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C692(0.78); C301(0.87); C862(1.11)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C692(0.89); C301(1.02); C862(1.23)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C301(0.69); C255(0.88); C257(0.88); C692(0.88)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C255(0.76); C257(0.76); C692(0.84); C301(0.91)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C255(0.80); C257(0.80); C301(0.89); C692(0.90)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C692(0.64); C301(0.79); C255(0.92); C257(0.92)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C692(0.53); C255(0.69); C257(0.69); C862(0.86)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C692(0.77); C255(0.87); C257(0.87); C862(0.87)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C692(0.66); C301(0.72); C255(0.73); C257(0.73)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C255(0.76); C257(0.76); C862(1.03); C147(1.05)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C255(0.66); C257(0.66); C301(0.98); C862(1.15)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C255(0.50); C257(0.50); C301(0.69); C862(1.04)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C255(0.71); C257(0.71); C301(0.98); C862(1.08)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C255(0.82); C257(0.82); C692(0.87); C301(0.96)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C255(0.76); C257(0.76); C301(0.84); C862(1.21)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C255(0.73); C257(0.73); C301(0.77); C862(1.30)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C255(0.72); C257(0.72); C301(1.10); C862(1.42)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C255(0.77); C257(0.77); C301(0.92); C862(1.14)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C301(0.74); C255(0.83); C257(0.83); C862(1.31)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C255(0.71); C257(0.71); C301(0.90); C862(1.18)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C255(0.71); C257(0.71); C301(0.96); C862(1.11)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C255(0.80); C257(0.80); C301(1.00); C862(1.21)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C255(0.68); C257(0.68); C301(0.70); C862(1.08)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C255(0.84); C257(0.84); C301(1.05); C862(1.23)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C147(0.95); C255(0.94); C257(0.94); C301(1.16)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C255(0.75); C257(0.75); C301(0.86); C862(1.08)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C255(0.77); C257(0.77); C301(1.31); C340(1.06)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C147(1.02); C255(0.60); C257(0.60); C301(1.23)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C147(1.16); C255(0.62); C257(0.62); C301(1.48)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C147(1.27); C255(0.72); C257(0.72); C301(1.69)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C147(1.05); C255(0.78); C257(0.78); C301(1.60)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C147(1.14); C255(0.83); C257(0.83); C301(1.78)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C147(1.11); C255(0.84); C257(0.84); C301(1.78)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C147(1.03); C255(0.90); C257(0.90); C301(1.58)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C147(1.05); C255(0.86); C257(0.86); C301(0.89)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C147(0.95); C255(0.81); C257(0.81); C301(1.52)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C147(1.10); C255(0.74); C257(0.74); C301(1.59)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C147(1.17); C255(0.83); C257(0.83); C301(1.83)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C147(1.16); C255(0.72); C257(0.72); C301(1.72)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C147(1.30); C255(0.68); C257(0.68); C301(1.59)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C147(1.27); C255(0.77); C257(0.77); C301(1.58)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C255(1.02); C257(1.02); C301(0.88); C340(1.13)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C255(1.18); C257(1.18); C301(0.88); C340(1.25)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C255(0.78); C257(0.78); C301(0.82); C340(1.01)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C255(1.04); C257(1.04); C301(0.89); C340(1.00)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C147(1.02); C255(0.96); C257(0.96); C301(0.75)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C255(0.91); C257(0.91); C301(0.87); C340(1.02)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C255(0.98); C257(0.98); C301(0.92); C340(0.97)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C255(0.90); C257(0.90); C301(1.05); C340(1.09)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C255(1.10); C257(1.10); C301(1.25); C340(1.16)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C255(0.89); C257(0.89); C301(0.89); C340(1.01)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C255(1.02); C257(1.02); C301(0.78); C340(1.09)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C255(1.14); C257(1.14); C301(1.16); C340(0.99)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C255(1.17); C257(1.17); C301(1.02); C340(1.28)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C255(1.00); C257(1.00); C301(1.13); C340(1.06)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C255(1.14); C257(1.14); C301(1.08); C340(1.13)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C147(0.99); C255(0.85); C257(0.85); C301(0.67)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C255(0.91); C257(0.91); C301(0.89); C340(1.15)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C255(0.80); C257(0.80); C692(1.02); C862(1.04)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C255(0.81); C257(0.81); C692(0.95); C862(1.04)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C255(0.76); C257(0.76); C692(0.90); C862(1.10)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C255(0.82); C257(0.82); C692(0.87); C862(1.14)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C255(0.91); C257(0.91); C692(1.01); C862(1.02)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C255(0.89); C257(0.89); C692(0.83); C862(1.34)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C255(0.82); C257(0.82); C692(0.93); C862(1.12)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C255(0.67); C257(0.67); C692(0.77); C862(1.16)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C255(0.60); C257(0.60); C692(0.80); C862(0.99)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C147(1.23); C255(0.86); C257(0.86); C301(0.72)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C255(0.74); C257(0.74); C692(0.84); C862(1.09)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C255(0.75); C257(0.75); C692(0.88); C862(1.22)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C255(0.87); C257(0.87); C692(1.00); C862(1.04)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C255(0.79); C257(0.79); C692(0.88); C862(1.01)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C255(0.87); C257(0.87); C692(0.97); C862(0.98)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C255(1.20); C257(1.20); C692(0.62); C862(1.16)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C255(1.23); C257(1.23); C692(0.65); C862(1.04)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C255(1.07); C257(1.07); C692(0.69); C862(1.06)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C255(1.19); C257(1.19); C692(0.58); C862(1.06)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C147(1.06); C255(0.81); C257(0.81); C301(0.77)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C255(1.12); C257(1.12); C692(0.58); C862(1.03)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C255(1.76); C257(1.76); C692(0.55); C862(1.22)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C255(1.87); C257(1.87); C692(0.51); C862(1.06)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C255(1.33); C257(1.33); C692(0.48); C862(1.07)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C255(1.01); C257(1.01); C692(0.48); C862(1.29)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C255(1.24); C257(1.24); C692(0.84); C862(1.22)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C255(1.20); C257(1.20); C692(0.94); C862(1.16)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C255(2.13); C257(2.13); C692(0.77); C862(1.04)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C255(1.88); C257(1.88); C692(0.59); C862(0.96)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C255(1.09); C257(1.09); C692(0.43); C862(1.04)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C147(1.16); C255(0.75); C257(0.75); C301(0.68)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C255(1.59); C257(1.59); C692(1.16); C862(1.05)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C255(0.71); C257(0.71); C301(1.09); C692(0.94)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C255(0.66); C257(0.66); C301(1.04); C692(0.78)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C255(0.61); C257(0.61); C301(0.96); C692(1.00)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C255(0.58); C257(0.58); C301(1.28); C692(1.24)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C255(0.60); C257(0.60); C301(1.17); C692(0.88)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C255(0.76); C257(0.76); C301(0.80); C692(0.97)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C255(0.70); C257(0.70); C301(1.19); C692(0.99)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C255(0.60); C257(0.60); C301(1.19); C692(0.97)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C255(0.66); C257(0.66); C301(1.34); C692(1.10)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C862(1.07); C242(1.08); C378(0.89)  LDD1698  [6]
 LDCM0625  F8 Ramos C971(1.01); C242(1.04)  LDD2187  [7]
 LDCM0572  Fragment10 Ramos C242(0.70)  LDD2189  [7]
 LDCM0573  Fragment11 Ramos C242(20.00)  LDD2190  [7]
 LDCM0574  Fragment12 Ramos C242(0.79)  LDD2191  [7]
 LDCM0576  Fragment14 Ramos C971(0.61); C242(0.98)  LDD2193  [7]
 LDCM0580  Fragment21 Ramos C242(0.92)  LDD2195  [7]
 LDCM0586  Fragment28 Ramos C242(1.13)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C242(0.94)  LDD2199  [7]
 LDCM0468  Fragment33 HCT 116 C255(0.72); C257(0.72); C692(0.82); C862(1.05)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C242(1.02)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C971(0.36); C242(1.17)  LDD2184  [7]
 LDCM0427  Fragment51 HCT 116 C147(0.97); C255(0.84); C257(0.84); C301(1.78)  LDD0744  [3]
 LDCM0614  Fragment56 Ramos C242(0.87)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C971(0.37); C242(1.00)  LDD2186  [7]
 LDCM0022  KB02 Ramos C971(1.12); C242(1.87)  LDD2182  [7]
 LDCM0023  KB03 Ramos C971(0.64); C242(1.15)  LDD2183  [7]
 LDCM0024  KB05 COLO792 C242(4.31)  LDD3310  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein c-Fos (FOS) BZIP family P01100
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) PI3K p85 subunit family O00459
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Insulin receptor substrate 1 (IRS1) . P35568

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpelisib Small molecular drug D0W7HE
Bay 80-6946 Small molecular drug D0S5LD
Caffeine Small molecular drug DB00201
Copanlisib . DB12483
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Buparlisib Small molecular drug D01QSO
Gdc-0032 Small molecular drug D0UP1Z
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pa-799 Small molecular drug D05CBJ
Ly3023414 . D0H1WC
Mln1117 . D0Y2NS
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hhcyh33 Small molecular drug DYF2N4
Bly719 . D01LMM
Pwt-33597 . D0Y0FE
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atp Small molecular drug DB00171
Etp-46321 Small molecular drug DOR1I0
Wortmannin Small molecular drug DB08059
Pilaralisib . DB11772
Xl765 . DB05241

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840