Details of the Target

General Information of Target

Target ID LDTP03851
Target Name Breast cancer type 1 susceptibility protein (BRCA1)
Gene Name BRCA1
Gene ID 672
Synonyms
RNF53; Breast cancer type 1 susceptibility protein; EC 2.3.2.27; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQ
CPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKD
EVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYI
ELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQ
PSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVE
KAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPC
SENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVD
EYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTEN
LIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTE
QNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNI
HNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPV
RHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKE
FVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQ
ESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHS
RETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVT
FECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRG
NETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIP
STVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKL
NAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSS
HASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQ
GYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENL
LSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGS
SKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSE
DCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALE
DLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSK
CPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEG
TPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTT
DTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLI
TEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDV
VNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTL
GTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPH
SHY
Target Bioclass
Enzyme
Subcellular location
Cytoplasm; Nucleus
Function
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
Uniprot ID
P38398
Ensemble ID
ENST00000352993.7
HGNC ID
HGNC:1100
ChEMBL ID
CHEMBL5990

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.N976S DBIA    Probe Info 
GAMG SNV: p.H619N DBIA    Probe Info 
HCC1395 SNV: p.R1751Ter .
HCC1937 Insertion: p.Q1756PfsTer74 .
HCT15 SNV: p.S663N; p.P1190H .
HT115 SNV: p.E577Ter; p.S763F; p.K1711R .
IGROV1 Deletion: p.K654SfsTer47 .
J82 SNV: p.S114T .
JEKO1 SNV: p.N742S .
JHH7 SNV: p.L137I .
JURKAT SNV: p.C1270Y; p.D1505N .
LS180 SNV: p.N810T DBIA    Probe Info 
MCC13 Insertion: p.K527delinsRIDVSQ
SNV: p.P529H		 .
MOLT4 SNV: p.P832S; p.D1123Y; p.T1548M .
NCIH1993 SNV: p.C226F .
NCIH2172 SNV: p.Q1299H .
RKO SNV: p.D435Y DBIA    Probe Info 
SUPT1 SNV: p.R1762K DBIA    Probe Info 
SW1271 SNV: p.K1233I .
UACC62 SNV: p.P832S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C903(5.67); C442(2.13); C1251(2.18)  LDD0168  [2]
DBIA
 Probe Info  		C636(3.67); C644(3.67); C801(4.42); C805(4.42)  LDD0080  [3]
ATP probe
 Probe Info  		K672(0.00); K679(0.00); K680(0.00)  LDD0199  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
NAIA_5
 Probe Info  		C712(0.00); C348(0.00); C1270(0.00)  LDD2224  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
IPM
 Probe Info  		C1251(0.00); C712(0.00); C953(0.00)  LDD0005  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Phosphinate-6
 Probe Info  		C328(0.00); C805(0.00); C1103(0.00); C944(0.00)  LDD0018  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C206
 Probe Info  		18.38  LDD1881  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C903(5.67); C442(2.13); C1251(2.18)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C903(3.90)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C1103(0.79); C39(0.84); C44(0.84); C61(0.87)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C24(1.23); C27(1.23); C61(1.01); C64(1.01)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C61(0.96); C64(0.96); C818(0.89); C953(0.61)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C61(1.04); C64(1.04); C818(0.83); C953(0.67)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C61(1.00); C64(1.00); C818(0.97); C953(0.83)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C61(0.98); C64(0.98); C818(1.26); C953(0.90)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C61(1.22); C64(1.22); C818(1.06); C953(1.08)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C61(1.03); C64(1.03); C818(1.02); C953(0.87)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C61(1.19); C64(1.19); C818(1.07); C953(0.71)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C61(1.20); C64(1.20); C818(0.47); C953(0.90)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C61(1.00); C64(1.00); C818(0.51); C953(0.71)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C61(1.23); C64(1.23); C818(0.47); C953(0.60)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C24(1.06); C27(1.06); C61(0.95); C64(0.95)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C61(1.12); C64(1.12); C818(0.47); C953(0.55)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C61(1.11); C64(1.11); C818(0.53); C953(1.01)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C61(1.26); C64(1.26); C818(0.43); C953(0.79)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C24(0.90); C27(0.90); C61(0.91); C64(0.91)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C24(0.93); C27(0.93); C61(1.00); C64(1.00)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C24(1.17); C27(1.17); C61(0.98); C64(0.98)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C24(1.24); C27(1.24); C61(1.01); C64(1.01)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C24(1.15); C27(1.15); C61(0.98); C64(0.98)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C24(0.97); C27(0.97); C61(0.90); C64(0.90)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C24(1.04); C27(1.04); C61(0.94); C64(0.94)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C24(0.99); C27(0.99); C61(0.89); C64(0.89)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C24(1.04); C27(1.04); C61(1.24); C64(1.24)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C24(1.02); C27(1.02); C61(0.93); C64(0.93)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C24(0.92); C27(0.92); C61(1.01); C64(1.01)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C24(0.93); C27(0.93); C61(0.91); C64(0.91)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C24(0.96); C27(0.96); C61(0.96); C64(0.96)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C24(1.08); C27(1.08); C61(1.02); C64(1.02)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C24(1.20); C27(1.20); C61(1.04); C64(1.04)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C24(1.10); C27(1.10); C61(0.94); C64(0.94)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C61(0.89); C64(0.89)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C61(0.66); C64(0.66)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C61(0.77); C64(0.77)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C61(0.72); C64(0.72)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C61(0.69); C64(0.69)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C61(0.87); C64(0.87)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C61(0.90); C64(0.90)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C61(0.94); C64(0.94)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C61(0.91); C64(0.91)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C61(0.88); C64(0.88)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C61(0.88); C64(0.88)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C61(0.98); C64(0.98)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C24(1.20); C27(1.20); C61(0.97); C64(0.97)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C61(1.05); C64(1.05)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C61(0.95); C64(0.95)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C61(0.80); C64(0.80)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C1103(0.99); C24(1.09); C27(1.09); C39(0.97)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C801(0.90); C805(0.99); C1103(1.02); C39(1.18)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C39(0.95); C44(0.95); C805(1.03); C1103(1.06)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C1103(0.89); C805(1.09); C39(1.09); C44(1.09)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C1103(0.91); C801(0.99); C805(1.01); C39(1.11)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C1103(0.94); C805(0.98); C801(1.02); C39(1.43)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C805(0.96); C801(1.00); C1103(1.06); C39(1.15)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C61(0.98); C64(0.98); C24(1.11); C27(1.11)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C801(0.97); C805(1.01); C39(1.10); C44(1.10)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C801(0.96); C39(1.02); C44(1.02); C24(1.07)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C801(0.97); C805(1.10); C1103(1.11); C39(1.15)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C1103(1.06); C801(1.08); C805(1.39); C39(1.51)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1103(0.94); C24(1.40); C27(1.40); C39(1.23)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1103(0.99); C24(1.39); C27(1.39); C39(1.09)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1103(0.98); C24(1.10); C27(1.10); C39(1.00)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1103(0.95); C24(1.10); C27(1.10); C39(1.03)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C39(0.89); C44(0.89); C24(1.02); C27(1.02)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C953(0.84); C39(0.92); C44(0.92); C24(1.28)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C24(1.05); C27(1.05); C61(1.06); C64(1.06)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C1103(0.75); C818(0.80); C61(0.88); C64(0.88)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C953(0.81); C39(1.10); C44(1.10); C24(1.10)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C953(0.91); C39(1.09); C44(1.09); C61(1.26)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C953(0.87); C24(0.99); C27(0.99); C39(1.05)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C24(0.91); C27(0.91); C39(0.93); C44(0.93)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C953(1.00); C24(1.01); C27(1.01); C39(1.02)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C61(0.92); C64(0.92); C24(1.12); C27(1.12)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C61(1.00); C64(1.00); C39(1.11); C44(1.11)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C61(1.30); C64(1.30); C24(1.33); C27(1.33)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C61(1.17); C64(1.17); C24(1.21); C27(1.21)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C24(1.18); C27(1.18); C61(1.35); C64(1.35)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C818(0.74); C39(0.84); C44(0.84); C1103(0.88)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C61(1.21); C64(1.21); C24(1.24); C27(1.24)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C39(0.90); C44(0.90); C61(1.00); C64(1.00)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C39(1.13); C44(1.13); C61(1.29); C64(1.29)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C24(1.34); C27(1.34); C61(1.40); C64(1.40)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C61(1.35); C64(1.35); C39(1.44); C44(1.44)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C24(0.80); C27(0.80); C61(0.89); C64(0.89)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C24(0.76); C27(0.76); C61(0.86); C64(0.86)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C61(0.88); C64(0.88); C24(0.91); C27(0.91)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C24(0.92); C27(0.92); C61(1.07); C64(1.07)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C24(0.93); C27(0.93); C61(1.03); C64(1.03)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C818(0.68); C1103(0.82); C39(0.82); C44(0.82)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C24(0.89); C27(0.89); C61(1.09); C64(1.09)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C61(0.82); C64(0.82); C24(0.90); C27(0.90)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C39(0.88); C44(0.88); C61(0.96); C64(0.96)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C61(0.83); C64(0.83); C39(1.05); C44(1.05)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C24(0.86); C27(0.86); C61(0.96); C64(0.96)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C39(0.94); C44(0.94); C61(0.99); C64(0.99)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C39(1.28); C44(1.28)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C39(1.18); C44(1.18)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C39(1.06); C44(1.06)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C39(1.11); C44(1.11)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C818(0.67); C1103(0.73); C39(0.84); C44(0.84)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C39(1.06); C44(1.06)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C39(0.99); C44(0.99)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C39(0.99); C44(0.99)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C39(0.83); C44(0.83)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C39(0.96); C44(0.96)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C39(1.12); C44(1.12)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C39(1.20); C44(1.20)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C24(0.89); C44(1.00); C61(1.33); C64(1.33)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C24(0.87); C44(0.83); C61(1.09); C64(1.09)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C24(0.92); C44(0.94); C61(1.23); C64(1.23)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C61(1.08); C64(1.08); C24(1.20); C27(1.20)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C24(0.82); C44(1.00); C61(1.20); C64(1.20)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C24(0.89); C44(1.29); C61(1.04); C64(1.04)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C24(0.87); C44(0.84); C61(0.94); C64(0.94)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C24(0.83); C44(0.85); C61(0.90); C64(0.90)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C24(0.83); C44(0.83); C61(1.06); C64(1.06)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C24(0.85); C44(1.22); C61(1.05); C64(1.05)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C24(0.86); C44(0.89); C61(0.85); C64(0.85)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C24(0.82); C44(1.01); C61(0.96); C64(0.96)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C801(0.79); C805(0.79); C1103(0.84); C39(0.93)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1103(0.88); C39(0.90); C44(0.90); C801(0.91)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C24(1.03); C27(1.03); C61(1.11); C64(1.11)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C24(0.89); C27(0.89); C801(0.97); C805(0.97)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C801(0.76); C805(0.76); C24(0.90); C27(0.90)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1103(0.93); C24(0.95); C27(0.95); C801(0.96)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1103(1.09); C24(1.33); C27(1.33); C801(1.38)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C1103(1.13); C801(1.16); C805(1.16); C39(1.31)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1103(1.04); C24(1.41); C27(1.41); C801(1.74)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C24(1.01); C27(1.01); C1103(1.06); C801(1.11)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1103(0.84); C24(1.04); C27(1.04); C801(1.17)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C801(0.86); C805(0.86); C24(0.88); C27(0.88)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C801(0.78); C805(0.78); C24(0.88); C27(0.88)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C61(1.03); C64(1.03); C24(1.04); C27(1.04)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C24(1.02); C27(1.02); C801(1.11); C805(1.11)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C39(0.65); C44(0.65); C24(0.76); C27(0.76)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1103(1.21); C24(1.49); C27(1.49); C801(1.50)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C39(1.12); C44(1.12); C61(1.38); C64(1.38)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C39(1.09); C44(1.09); C61(1.29); C64(1.29)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C39(1.07); C44(1.07); C61(1.15); C64(1.15)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C61(1.11); C64(1.11); C818(1.23); C39(1.29)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C61(1.06); C64(1.06); C39(1.30); C44(1.30)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C61(1.11); C64(1.11); C818(1.26); C39(1.47)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C818(1.15); C61(1.23); C64(1.23); C39(1.26)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C818(0.90); C61(1.12); C64(1.12); C39(1.26)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C39(1.03); C44(1.03); C61(1.28); C64(1.28)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C39(0.87); C44(0.87); C61(1.30); C64(1.30)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C39(0.97); C44(0.97); C61(1.20); C64(1.20)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C39(0.72); C44(0.72); C61(1.03); C64(1.03)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C61(1.11); C64(1.11); C39(1.11); C44(1.11)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C39(0.86); C44(0.86); C61(1.17); C64(1.17)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C39(1.14); C44(1.14); C61(1.25); C64(1.25)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C953(0.92); C61(1.04); C64(1.04); C818(1.65)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C953(0.70); C818(0.84); C61(0.89); C64(0.89)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C24(1.05); C27(1.05); C61(0.94); C64(0.94)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C61(1.11); C64(1.11); C24(1.17); C27(1.17)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C61(1.09); C64(1.09); C24(1.63); C27(1.63)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.65  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1291(1.13); C1300(1.13); C801(1.08); C805(1.08)  LDD2171  [3]
 LDCM0632  CL-Sc Hep-G2 C712(0.28)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C801(0.77); C805(0.77); C61(0.80); C64(0.80)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C818(0.99); C61(1.01); C64(1.01); C801(1.40)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C61(0.79); C64(0.79); C39(0.82); C44(0.82)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C61(1.18); C64(1.18); C24(1.32); C27(1.32)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C61(0.85); C64(0.85); C24(1.22); C27(1.22)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C61(0.93); C64(0.93); C24(1.02); C27(1.02)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C61(0.91); C64(0.91); C24(1.11); C27(1.11)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C61(1.04); C64(1.04); C39(1.09); C44(1.09)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C953(0.94); C24(1.16); C27(1.16); C61(1.16)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C953(0.96); C24(1.04); C27(1.04); C61(1.12)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C953(1.11); C61(1.21); C64(1.21); C24(1.29)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C61(1.02); C64(1.02); C24(1.04); C27(1.04)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C818(0.85); C61(1.12); C64(1.12); C801(1.35)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C61(1.04); C64(1.04); C953(1.08); C24(1.11)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C39(0.84); C44(0.84); C24(1.01); C27(1.01)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C39(0.97); C44(0.97); C61(0.99); C64(0.99)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C39(1.06); C44(1.06); C61(1.20); C64(1.20)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C24(0.88); C27(0.88); C61(0.90); C64(0.90)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C61(1.09); C64(1.09); C24(1.16); C27(1.16)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C61(0.97); C64(0.97); C24(1.14); C27(1.14)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C39(1.02); C44(1.02); C24(1.22); C27(1.22)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C61(0.89); C64(0.89); C24(0.97); C27(0.97)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C39(0.90); C44(0.90); C24(0.94); C27(0.94)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C818(0.87); C61(1.47); C64(1.47); C801(1.90)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C24(0.75); C27(0.75); C61(0.85); C64(0.85)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C39(1.07); C44(1.07)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C39(1.03); C44(1.03)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C39(1.18); C44(1.18)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C39(1.23); C44(1.23)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C24(0.93); C44(0.75); C61(1.24); C64(1.24)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C24(0.84); C44(1.00); C61(1.51); C64(1.51)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C24(0.81); C44(0.92); C61(1.12); C64(1.12)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C24(0.95); C44(0.90); C61(1.37); C64(1.37)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C818(0.82); C801(0.98); C805(0.98); C61(1.16)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C818(0.91); C801(0.97); C805(0.97); C61(1.07)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C818(0.79); C61(1.12); C64(1.12); C801(1.32)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C39(0.75); C44(0.75); C61(0.86); C64(0.86)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C61(0.79); C64(0.79); C24(0.89); C27(0.89)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C61(0.89); C64(0.89); C1103(0.99); C24(1.23)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1103(0.89); C61(1.03); C64(1.03); C24(1.25)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C801(0.71); C805(0.71); C61(0.77); C64(0.77)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C1103(0.96); C61(0.96); C64(0.96); C24(1.24)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C61(1.10); C64(1.10); C1103(1.14); C953(1.21)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1103(0.85); C61(1.25); C64(1.25); C953(1.31)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C61(0.92); C64(0.92); C1103(0.95); C24(1.22)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1103(0.95); C61(1.21); C64(1.21); C24(1.49)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1103(1.14); C24(1.23); C27(1.23); C61(1.00)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1103(1.00); C24(1.12); C27(1.12); C61(0.97)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1103(0.90); C24(1.15); C27(1.15); C61(0.95)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1103(1.01); C24(1.14); C27(1.14); C61(0.96)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1103(0.87); C24(1.33); C27(1.33); C61(0.99)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C61(0.90); C64(0.90); C801(0.97); C805(0.97)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C1103(0.85); C24(1.23); C27(1.23); C61(0.82)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C1103(0.92); C24(0.94); C27(0.94); C61(1.30)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C24(1.06); C27(1.06); C39(0.77); C44(0.77)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C24(1.00); C27(1.00); C39(0.72); C44(0.72)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C24(1.32); C27(1.32); C39(0.73); C44(0.73)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C24(1.30); C27(1.30); C39(0.80); C44(0.80)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C24(1.10); C27(1.10); C39(0.70); C44(0.70)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C24(1.42); C27(1.42); C39(0.75); C44(0.75)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C24(1.14); C27(1.14); C39(0.82); C44(0.82)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C61(1.01); C64(1.01); C801(1.21); C805(1.21)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C24(1.17); C27(1.17); C39(0.90); C44(0.90)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C24(1.10); C27(1.10); C39(0.76); C44(0.76)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C24(1.79); C27(1.79); C39(0.74); C44(0.74)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C24(1.42); C27(1.42); C39(0.83); C44(0.83)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C24(1.28); C27(1.28); C39(0.78); C44(0.78)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C24(1.47); C27(1.47); C39(0.79); C44(0.79)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C39(0.95); C44(0.95); C61(0.89); C64(0.89)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C39(0.90); C44(0.90); C61(0.88); C64(0.88)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C39(0.95); C44(0.95); C61(0.94); C64(0.94)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C39(1.00); C44(1.00); C61(0.99); C64(0.99)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C61(0.95); C64(0.95); C801(1.23); C805(1.23)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C39(1.05); C44(1.05); C61(0.93); C64(0.93)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C39(1.16); C44(1.16); C61(0.90); C64(0.90)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C39(1.22); C44(1.22); C61(1.00); C64(1.00)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C39(1.00); C44(1.00); C61(1.06); C64(1.06)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C39(0.97); C44(0.97); C61(0.87); C64(0.87)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C39(0.81); C44(0.81); C61(0.88); C64(0.88)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C39(1.13); C44(1.13); C61(0.85); C64(0.85)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C39(1.14); C44(1.14); C61(0.95); C64(0.95)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C39(1.09); C44(1.09); C61(0.87); C64(0.87)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C39(0.95); C44(0.95); C61(0.91); C64(0.91)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C61(0.95); C64(0.95); C801(1.20); C805(1.20)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C39(0.93); C44(0.93); C61(0.93); C64(0.93)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C61(0.82); C64(0.82)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C61(0.87); C64(0.87)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C61(1.04); C64(1.04)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C61(0.95); C64(0.95)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C61(0.88); C64(0.88)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C61(1.00); C64(1.00)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C61(1.01); C64(1.01)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C61(1.00); C64(1.00)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C61(0.96); C64(0.96)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C61(1.23); C64(1.23); C801(1.39); C805(1.39)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C61(0.92); C64(0.92)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C61(0.89); C64(0.89)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C61(0.98); C64(0.98)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C61(0.92); C64(0.92)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C61(1.02); C64(1.02)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C1103(1.05); C39(0.75); C44(0.75)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C1103(0.96); C39(0.78); C44(0.78)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C1103(1.37); C39(0.82); C44(0.82)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C1103(0.91); C39(0.74); C44(0.74)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C61(1.46); C64(1.46); C801(1.48); C805(1.48)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C1103(0.96); C39(0.87); C44(0.87)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C1103(0.85); C39(0.78); C44(0.78)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C1103(0.90); C39(0.72); C44(0.72)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C1103(1.07); C39(0.90); C44(0.90)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C1103(1.30); C39(0.88); C44(0.88)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C1103(1.06); C39(0.96); C44(0.96)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C1103(1.08); C39(0.83); C44(0.83)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C1103(0.94); C39(0.74); C44(0.74)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C1103(0.97); C39(0.79); C44(0.79)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C1103(0.91); C39(0.86); C44(0.86)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C61(1.05); C64(1.05); C801(1.11); C805(1.11)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C1103(1.42); C39(0.72); C44(0.72)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C1103(0.71); C39(0.92); C44(0.92); C61(1.06)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C1103(0.79); C39(0.87); C44(0.87); C61(0.80)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C1103(0.74); C39(0.81); C44(0.81); C61(0.90)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C1103(0.86); C39(1.06); C44(1.06); C61(1.09)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C1103(0.69); C39(0.83); C44(0.83); C61(1.15)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C1103(0.76); C39(0.94); C44(0.94); C61(1.03)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C1103(0.08); C39(0.85); C44(0.85); C61(0.92)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C1103(0.58); C39(0.83); C44(0.83); C61(0.81)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C1103(1.04); C39(0.89); C44(0.89); C61(0.95)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C712(1.09); C818(1.08); C903(1.01); C348(1.00)  LDD1698  [12]
 LDCM0468  Fragment33 HCT 116 C61(1.10); C64(1.10)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C24(1.56); C27(1.56); C39(0.77); C44(0.77)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C636(3.67); C644(3.67); C801(4.42); C805(4.42)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C636(2.45); C644(2.45); C801(1.99); C805(1.99)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C636(3.56); C644(3.56); C801(3.42); C805(3.42)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C1291(1.13); C1300(1.13); C801(1.08); C805(1.08)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
60 kDa heat shock protein, mitochondrial (HSPD1) Chaperonin (HSP60) family P10809
DNA endonuclease RBBP8 (RBBP8) COM1/SAE2/CtIP family Q99708
Fanconi anemia group J protein (BRIP1) DEAD box helicase family Q9BX63
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1) Peptidase C12 family Q92560
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) PPP phosphatase family P62140
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) PPP phosphatase family P36873
Serine/threonine-protein kinase Chk1 (CHEK1) CAMK Ser/Thr protein kinase family O14757
DNA topoisomerase 2-alpha (TOP2A) Type II topoisomerase family P11388
Acetyl-CoA carboxylase 1 (ACACA) . Q13085
BRCA1-associated protein (BRAP) . Q7Z569
BRCA1-associated RING domain protein 1 (BARD1) . Q99728
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
G1/S-specific cyclin-D1 (CCND1) Cyclin family P24385
Huntingtin (HTT) Huntingtin family P42858
Importin subunit alpha-1 (KPNA2) Importin alpha family P52292
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-interferon-inducible protein 16 (IFI16) HIN-200 family Q16666
Zinc finger protein 350 (ZNF350) Krueppel C2H2-type zinc-finger protein family Q9GZX5
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Estrogen receptor beta (ESR2) Nuclear hormone receptor family Q92731
General transcription factor II-I (GTF2I) TFII-I family P78347
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G1/S-specific cyclin-E1 (CCNE1) Cyclin family P24864
BRCA1-A complex subunit Abraxas 1 (ABRAXAS1) FAM175 family Q6UWZ7
Histone H2AX (H2AX) Histone H2A family P16104
Negative elongation factor B (NELFB) NELF-B family Q8WX92
BRCA1-A complex subunit RAP80 (UIMC1) RAP80 family Q96RL1
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Small ubiquitin-related modifier 2 (SUMO2) Ubiquitin family P61956
Zinc finger CCHC domain-containing protein 8 (ZCCHC8) ZCCHC8 family Q6NZY4
BRCA1-associated ATM activator 1 (BRAT1) . Q6PJG6
Four and a half LIM domains protein 2 (FHL2) . Q14192
Hyaluronan mediated motility receptor (HMMR) . O75330
Mediator of DNA damage checkpoint protein 1 (MDC1) . Q14676
Neurabin-2 (PPP1R9B) . Q96SB3
Partner and localizer of BRCA2 (PALB2) . Q86YC2
TP53-binding protein 1 (TP53BP1) . Q12888

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402