Details of the Target

General Information of Target

Target ID LDTP01409
Target Name ATP-dependent DNA helicase Q5 (RECQL5)
Gene Name RECQL5
Gene ID 9400
Synonyms
RECQ5; ATP-dependent DNA helicase Q5; EC 5.6.2.4; DNA 3'-5' helicase RecQ5; DNA helicase, RecQ-like type 5; RecQ5; RecQ protein-like 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL
CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK
PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR
SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG
NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL
VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR
LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYF
GDALPACAKGCDHCQNPTAVRRRLEALERSSSWSKTCIGPSQGNGFDPELYEGGRKGYGD
FSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMQLRKGKDPKIEEFVPPDENCPLKEASSR
RIPRLTVKAREHCLRLLEEALSSNRQSTRTADEADLRAKAVELEHETFRNAKVANLYKAS
VLKKVADIHRASKDGQPYDMGGSAKSCSAQAEPPEPNEYDIPPASHVYSLKPKRVGAGFP
KGSCPFQTATELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGS
AHYGGPSPEKKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLAS
APEAEGACPSCEGVQGPPMAPEKYTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTP
EVQPTPAKDTWKGKRPRSQQENPESQPQKRPRPSAKPSVVAEVKGSVSASEQGTLNPTAQ
DPFQLSAPGVSLKEAANVVVKCLTPFYKEGKFASKELFKGFARHLSHLLTQKTSPGRSVK
EEAQNLIRHFFHGRARCESEADWHGLCGPQR
Target Bioclass
Enzyme
Family
Helicase family, RecQ subfamily
Subcellular location
Cytoplasm; Nucleus, nucleoplasm
Function
DNA helicase that plays an important role in DNA replication, transcription and repair. Probably unwinds DNA in a 3'-5' direction (Probable). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Associates also with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA.
Uniprot ID
O94762
Ensemble ID
ENST00000317905.10
HGNC ID
HGNC:9950

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.P694RfsTer60 .
CAL78 SNV: p.K579N .
JURKAT SNV: p.P634L Compound 10    Probe Info 
KMRC3 SNV: p.A315T .
MEWO Deletion: p.K731RfsTer23
SNV: p.S734R		 DBIA    Probe Info 
MFE319 SNV: p.L209P .
MOLT4 SNV: p.Y127F IA-alkyne    Probe Info 
NCIH2291 SNV: p.S318G DBIA    Probe Info 
NUGC3 SNV: p.K309N .
RKO SNV: p.C987S DBIA    Probe Info 
SBC5 Deletion: p.P840HfsTer38 DBIA    Probe Info 
SKMEL2 SNV: p.L207M DBIA    Probe Info 
SW1573 SNV: p.Q274K DBIA    Probe Info 
TF1 SNV: p.T395I .
TOV21G SNV: p.G656V .
WM793 SNV: p.S858F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K22(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y239(9.22)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C824(2.72); C791(2.28); C788(2.40); C664(3.31)  LDD0169  [4]
DBIA
 Probe Info  		C261(1.23); C266(1.14); C272(1.12); C281(1.12)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C281(0.00); C272(0.00); C427(0.00); C61(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
AOyne
 Probe Info  		12.30  LDD0443  [13]
NAIA_5
 Probe Info  		C161(0.00); C61(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C824(2.72); C791(2.28); C788(2.40); C664(3.31)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C977(0.73); C261(1.32); C431(1.11); C434(1.12)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C977(0.98); C272(1.07); C281(1.07); C431(1.09)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C977(0.68); C261(0.92); C266(0.90); C431(0.97)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C977(0.72); C261(1.02); C266(0.94); C431(1.00)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C977(0.69); C261(1.04); C266(1.07); C431(1.09)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C977(0.97); C261(1.15); C266(1.05); C431(1.30)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C977(0.68); C261(1.23); C266(0.96); C431(1.04)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C977(0.98); C261(1.03); C266(0.94); C431(1.11)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C977(0.80); C261(1.09); C266(0.91); C431(1.28)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C977(1.06); C261(0.98); C266(0.89); C431(1.20)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C977(0.82); C261(0.98); C266(0.92); C431(0.98)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C977(0.57); C261(0.96); C266(0.93); C431(0.90)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C977(1.05); C272(1.06); C281(1.06); C431(1.18)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C977(0.59); C261(1.07); C266(1.00); C431(1.05)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C977(0.66); C261(1.28); C266(0.98); C431(1.00)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C977(0.74); C261(1.26); C266(1.06); C431(1.06)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C977(0.96); C261(0.82); C266(0.82); C431(1.10)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C977(1.22); C261(1.06); C266(0.59); C431(1.21)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C977(1.50); C261(1.04); C266(0.53); C431(1.26)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C977(1.11); C261(0.91); C266(0.61); C431(1.25)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C977(1.01); C261(0.93); C266(0.88); C431(1.16)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C977(1.13); C261(0.83); C266(0.92); C431(1.09)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C977(1.04); C261(0.97); C266(0.63); C431(1.29)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C977(1.06); C272(0.89); C281(0.89); C431(1.01)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C977(0.62); C261(0.89); C266(0.69); C431(1.34)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C977(1.01); C261(0.92); C266(1.22); C431(1.17)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C977(0.82); C261(1.04); C266(0.54); C431(1.13)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C977(0.84); C261(0.90); C266(1.03); C431(1.20)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C977(0.89); C261(1.00); C266(0.90); C431(1.02)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C977(1.06); C261(0.99); C266(0.59); C431(1.11)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C977(1.10); C261(0.91); C266(0.56); C431(1.34)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C977(1.27); C261(0.86); C266(0.86); C431(1.24)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C977(1.64); C261(1.62); C266(1.28); C431(1.17)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C977(1.34); C261(1.43); C266(1.02); C431(0.75)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C977(1.29); C261(0.99); C266(0.88); C431(1.01)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C977(1.43); C261(1.39); C266(1.13); C431(0.76)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C977(1.05); C261(1.17); C266(1.20); C431(0.79)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C977(1.21); C261(1.12); C266(1.02); C431(0.96)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C977(1.28); C261(1.19); C266(1.16); C431(0.96)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C977(1.56); C261(0.95); C266(0.93); C431(0.97)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C977(0.88); C261(1.09); C266(1.06); C431(0.86)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C977(0.84); C261(1.13); C266(1.16); C431(1.00)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C977(1.17); C261(1.73); C266(1.70); C431(1.03)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C977(1.07); C261(1.00); C266(1.08); C431(0.94)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C977(1.06); C272(1.11); C281(1.11); C431(1.08)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C977(1.21); C261(1.43); C266(1.35); C431(1.05)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C977(1.37); C261(1.26); C266(1.55); C431(0.96)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C977(1.19); C261(0.98); C266(1.04); C431(0.79)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C977(0.92); C987(0.89); C261(0.98); C266(0.98)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C987(0.86); C664(0.95); C261(0.99); C266(0.99)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C664(0.86); C987(0.89); C261(0.93); C266(0.93)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C664(0.71); C987(0.84); C977(1.04); C261(1.19)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C977(0.88); C987(0.98); C261(1.12); C266(1.12)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C664(0.87); C987(0.89); C977(1.04); C261(1.05)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C664(0.78); C977(0.98); C987(1.04); C261(1.28)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C61(0.85); C431(1.06); C272(1.08); C281(1.08)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C987(0.94); C977(0.97); C431(1.09); C664(1.12)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C987(0.87); C261(0.93); C266(0.93); C977(0.95)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C987(0.80); C977(0.84); C664(0.98); C431(1.41)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C664(0.71); C987(0.88); C261(1.13); C266(1.13)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C977(1.00); C261(1.22); C266(1.22); C431(1.30)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C977(1.17); C261(0.91); C266(0.91); C431(1.27)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C977(0.88); C261(1.12); C266(1.12); C431(1.07)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C977(1.05); C261(1.31); C266(1.31); C431(0.95)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C261(0.42); C664(0.88); C977(0.90); C987(0.90)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C977(0.87); C987(0.87); C261(0.91); C664(0.93)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C261(0.43); C664(0.87); C431(0.96); C434(1.11)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C261(0.96); C431(1.04); C434(1.14); C977(1.26)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C261(0.51); C664(0.90); C272(0.93); C281(0.93)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C261(0.68); C664(0.87); C977(1.04); C987(1.04)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C261(0.67); C664(0.84); C434(0.98); C431(0.99)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C261(0.37); C664(0.82); C431(0.85); C977(0.87)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C261(0.34); C664(0.73); C434(0.92); C431(0.92)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C261(0.94); C977(0.94); C272(0.98); C281(0.98)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C261(0.75); C977(0.87); C272(1.07); C281(1.07)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C977(0.90); C987(1.13); C431(1.14); C272(1.14)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C261(0.82); C977(0.90); C987(1.08); C272(1.27)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C977(0.86); C261(0.99); C272(1.07); C281(1.07)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C977(0.80); C987(0.80); C431(0.95); C434(1.05)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C977(0.95); C261(1.07); C272(1.08); C281(1.08)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C977(0.92); C272(1.09); C281(1.09); C431(1.21)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C261(0.73); C977(0.92); C272(1.11); C281(1.11)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C977(0.99); C261(1.08); C272(1.20); C281(1.20)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C261(1.05); C977(1.08); C272(1.20); C281(1.20)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C987(0.78); C977(0.80); C272(0.82); C281(0.82)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C261(0.56); C272(0.89); C281(0.89); C987(0.98)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C977(0.85); C987(0.87); C431(0.96); C434(1.03)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C977(0.92); C434(0.97); C272(1.00); C281(1.00)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C261(0.58); C977(0.96); C987(0.96); C272(0.98)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C977(0.79); C987(0.79); C261(1.08); C431(1.09)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C261(1.05); C977(1.08); C987(1.10); C272(1.16)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C261(0.73); C272(0.92); C281(0.92); C977(0.92)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C261(0.86); C977(0.98); C272(0.99); C281(0.99)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C977(0.89); C272(0.90); C281(0.90); C987(1.03)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C261(0.71); C987(0.99); C977(1.02); C272(1.05)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C987(0.99); C977(1.03); C272(1.17); C281(1.17)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C261(0.99); C434(1.01); C977(1.06); C431(1.07)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C977(0.92); C261(0.94); C987(1.02); C434(1.11)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C261(0.72); C977(1.12); C434(1.14); C987(1.27)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C977(1.19); C987(1.24); C261(1.29); C431(1.43)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C977(0.82); C987(0.82); C431(1.21); C434(1.26)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C434(1.31); C977(1.32); C431(1.32); C987(1.38)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C261(0.79); C434(1.01); C431(1.10); C987(1.21)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C261(0.81); C434(1.05); C977(1.09); C987(1.14)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C261(0.97); C977(1.07); C987(1.11); C434(1.18)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C977(1.05); C987(1.09); C434(1.21); C431(1.26)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C261(1.14); C987(1.21); C977(1.30); C431(1.42)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C261(1.34); C987(1.69); C431(1.77); C434(1.81)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C61(0.86); C272(1.08); C281(1.08); C987(1.13)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C61(0.82); C272(1.02); C281(1.02); C987(1.14)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C61(0.78); C261(0.88); C987(0.97); C272(1.16)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C61(0.86); C272(1.04); C281(1.04); C431(1.07)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C61(0.77); C987(0.97); C272(1.02); C281(1.02)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C61(0.73); C261(0.79); C272(0.94); C281(0.94)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C61(0.86); C261(1.06); C987(1.11); C272(1.16)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C61(0.69); C987(0.90); C272(0.96); C281(0.96)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C61(0.83); C987(0.91); C261(1.07); C272(1.11)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C977(0.88); C987(0.88); C272(0.89); C281(0.89)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C977(0.71); C987(0.81); C272(0.88); C281(0.88)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C987(0.77); C61(0.78); C977(0.79); C272(1.01)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C977(0.95); C261(0.99); C272(1.02); C281(1.02)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C272(0.90); C281(0.90); C977(0.97); C987(1.02)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C61(0.86); C272(0.88); C281(0.88); C987(0.98)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C261(0.79); C266(0.85); C272(0.90); C281(0.90)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C272(0.79); C281(0.79); C977(0.82); C987(0.86)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C272(0.87); C281(0.87); C261(0.88); C266(0.98)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C272(1.30); C281(1.30); C987(1.31); C261(1.34)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C987(1.00); C977(1.03); C261(1.09); C272(1.20)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C261(1.17); C266(1.36); C987(1.46); C272(1.50)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C272(1.02); C281(1.02); C987(1.05); C977(1.07)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C272(1.00); C281(1.00); C261(1.12); C977(1.16)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C261(0.75); C272(0.82); C281(0.82); C266(0.87)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C272(0.84); C281(0.84); C977(0.84); C434(0.92)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C272(0.87); C281(0.87); C977(0.88); C987(0.91)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C987(0.98); C272(0.99); C281(0.99); C977(1.04)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C977(0.71); C272(0.73); C281(0.73); C266(0.80)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C266(1.04); C261(1.12); C977(1.15); C987(1.24)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C977(1.10); C987(1.13); C261(1.63); C434(1.79)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C977(0.94); C987(1.09); C261(1.51); C431(1.80)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C977(0.81); C987(1.02); C261(1.16); C434(1.42)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C977(0.93); C987(1.06); C261(1.15); C431(1.24)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C977(1.02); C987(1.04); C261(1.11); C431(1.13)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C977(0.99); C987(1.01); C261(1.10); C431(1.16)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C977(1.16); C987(1.25); C261(1.27); C431(1.35)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C261(1.03); C431(1.05); C434(1.12); C987(1.30)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C977(1.25); C987(1.29); C261(1.54); C431(1.66)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C977(1.21); C987(1.23); C261(1.40); C434(1.76)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C977(0.84); C987(0.97); C261(1.02); C431(1.31)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C977(0.92); C987(1.08); C261(1.16); C431(1.19)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C977(0.97); C987(1.18); C431(1.20); C434(1.30)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C977(1.15); C987(1.22); C261(1.34); C431(1.43)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C977(1.01); C987(1.22); C261(1.41); C431(1.45)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C266(0.86); C977(1.01); C987(1.01); C261(1.01)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C977(0.66); C987(0.66); C266(0.93); C261(0.93)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C977(1.06); C272(0.96); C281(0.96); C431(0.96)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C61(0.81); C272(1.01); C281(1.01); C987(1.03)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C61(0.72); C272(1.05); C281(1.05); C431(1.42)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.78  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C261(1.23); C266(1.14); C272(1.12); C281(1.12)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C457(0.94)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C977(0.92); C434(0.96); C987(1.01); C431(1.02)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C664(1.11); C987(1.26); C977(1.29); C431(1.31)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C977(1.00); C987(1.00); C431(1.09); C434(1.13)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C61(0.76); C272(0.97); C281(0.97); C431(1.17)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C61(0.81); C272(0.89); C281(0.89); C431(0.91)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C434(0.83); C431(0.91); C272(0.96); C281(0.96)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C272(0.91); C281(0.91); C61(0.93); C434(0.99)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C261(0.60); C664(0.89); C431(0.95); C272(1.03)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C261(0.38); C664(0.85); C61(1.02); C977(1.20)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C261(0.52); C664(0.86); C977(0.94); C987(0.94)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C261(0.56); C664(0.82); C61(1.02); C977(1.06)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C261(0.63); C664(0.96); C61(1.03); C272(1.04)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C987(1.24); C977(1.44); C434(1.46); C664(1.62)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C664(0.76); C261(0.83); C431(1.09); C272(1.16)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C261(0.42); C664(0.82); C431(0.95); C61(0.96)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C977(0.84); C272(0.92); C281(0.92); C431(0.98)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C261(0.66); C977(0.90); C272(0.98); C281(0.98)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C977(0.93); C261(0.95); C272(0.96); C281(0.96)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C977(0.87); C272(0.96); C281(0.96); C987(1.22)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C977(0.79); C272(1.01); C281(1.01); C261(1.03)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C987(1.30); C977(1.35); C272(1.43); C281(1.43)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C261(0.77); C987(0.92); C977(0.93); C272(0.96)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C977(1.00); C987(1.02); C272(1.04); C281(1.04)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C664(0.79); C987(1.42); C431(1.46); C434(1.48)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C261(0.83); C977(0.90); C272(0.95); C281(0.95)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C261(0.65); C987(2.15); C431(2.28); C434(2.79)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C977(0.97); C261(1.10); C987(1.20); C431(1.23)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C261(1.02); C977(1.11); C434(1.13); C431(1.22)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C261(0.94); C987(1.20); C977(1.21); C434(1.31)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C272(0.86); C281(0.86); C431(0.90); C987(0.92)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C61(0.77); C261(0.86); C987(0.93); C272(0.93)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C61(0.76); C272(0.92); C281(0.92); C987(0.95)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C61(0.79); C261(1.00); C272(1.19); C281(1.19)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C664(1.10); C431(1.29); C987(1.30); C434(1.39)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C987(1.03); C434(1.04); C431(1.05); C977(1.11)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C431(1.16); C434(1.24); C664(1.26); C987(1.29)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C261(0.95); C266(0.95); C664(1.07); C431(1.21)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C261(0.93); C266(1.01); C431(1.02); C977(1.10)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C261(0.94); C266(0.99); C431(1.35); C434(1.36)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C266(1.10); C261(1.11); C431(1.20); C434(1.29)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C977(0.88); C987(0.91); C434(1.04); C431(1.09)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C266(0.90); C261(0.95); C431(1.35); C434(1.41)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C266(0.75); C261(0.87); C431(1.46); C434(1.51)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C266(0.82); C261(0.98); C431(2.11); C434(2.11)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C261(0.98); C266(1.23); C977(1.25); C987(1.25)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C977(1.81); C261(0.89); C266(0.75); C431(1.58)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C977(1.61); C261(0.86); C266(0.81); C431(1.35)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C977(1.36); C261(0.89); C266(0.87); C431(1.35)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C977(1.29); C261(0.85); C266(0.71); C431(1.18)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C977(1.36); C261(0.85); C266(0.73); C431(1.42)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C977(1.82); C261(0.82); C266(0.66); C431(1.41)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C977(0.92); C431(1.11); C434(1.05); C664(1.03)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C977(1.15); C261(1.07); C266(0.71); C431(1.15)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C977(1.17); C261(0.82); C431(1.12); C434(1.26)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C977(1.22); C261(1.03); C266(1.03); C431(1.28)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C977(1.37); C261(1.30); C266(1.30); C431(1.05)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C977(1.65); C261(1.31); C266(1.31); C431(1.30)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C977(1.95); C261(0.90); C266(0.90); C431(1.30)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C977(1.60); C261(1.09); C266(1.09); C431(1.21)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C977(1.94); C261(1.04); C266(1.04); C431(1.36)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C977(1.28); C261(1.28); C266(1.28); C431(1.26)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C977(1.02); C431(1.13); C434(1.07); C664(0.85)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C977(1.59); C261(1.25); C266(1.25); C431(1.17)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C977(1.74); C261(0.94); C266(0.94); C431(1.08)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C977(2.37); C261(1.03); C266(1.03); C431(1.79)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C977(1.61); C261(1.09); C266(1.09); C431(1.42)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C977(1.70); C261(0.94); C266(0.94); C431(1.52)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C977(1.93); C261(1.05); C266(1.05); C431(1.44)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C977(0.77); C261(0.91); C431(0.79); C434(0.84)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C977(0.91); C261(1.00); C431(0.83); C434(0.84)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C977(0.79); C261(1.24); C431(0.76); C434(0.80)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C977(1.05); C261(1.19); C431(0.84); C434(0.89)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C977(1.01); C431(1.23); C434(1.15); C664(0.83)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C977(1.43); C261(1.22); C431(0.82); C434(0.83)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C977(0.76); C261(1.13); C431(0.79); C434(0.80)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C977(1.25); C261(1.26); C431(0.83); C434(0.84)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C977(1.19); C261(1.16); C431(0.74); C434(0.79)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C977(0.97); C261(1.09); C431(0.82); C434(0.86)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C977(1.29); C261(1.06); C431(0.80); C434(0.85)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C977(1.31); C261(1.21); C431(0.97); C434(0.99)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C977(0.95); C261(0.96); C431(0.73); C434(0.78)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C977(1.05); C261(1.34); C431(0.77); C434(0.77)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C977(0.98); C261(1.17); C431(0.80); C434(0.81)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C977(1.17); C431(1.14); C434(1.15); C664(1.13)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C977(0.77); C261(1.20); C431(0.82); C434(0.87)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C977(1.02); C261(0.54); C431(0.97); C434(1.07)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C977(0.98); C261(0.72); C431(1.03); C434(1.19)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C977(1.13); C261(0.65); C431(1.15); C434(1.40)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C977(1.23); C261(0.66); C431(1.24); C434(1.47)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C977(0.89); C261(0.48); C431(1.00); C434(1.09)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C977(1.31); C261(0.47); C431(1.16); C434(1.41)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C977(0.99); C261(0.62); C431(1.21); C434(1.39)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C977(1.08); C261(0.56); C431(1.20); C434(1.32)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C977(1.06); C261(1.01); C431(1.10); C434(1.24)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C977(1.23); C431(1.40); C434(1.42); C664(0.79)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C977(1.27); C261(0.42); C431(1.10); C434(1.18)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C977(1.11); C261(0.73); C431(1.05); C434(1.25)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C977(1.06); C261(0.68); C431(1.07); C434(1.14)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C977(1.07); C261(0.64); C431(1.06); C434(1.19)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C977(1.19); C261(0.78); C431(1.12); C434(1.21)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C261(1.00); C266(1.00); C272(0.95); C281(0.95)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C261(0.80); C266(0.80); C272(0.86); C281(0.86)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C261(0.77); C266(0.77); C272(0.86); C281(0.86)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C261(0.92); C266(0.92); C272(0.82); C281(0.82)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C977(1.61); C431(1.55); C434(1.45); C664(1.77)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C261(0.75); C266(0.75); C272(0.93); C281(0.93)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C261(0.68); C266(0.68); C272(0.86); C281(0.86)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C261(0.71); C266(0.71); C272(0.99); C281(0.99)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C261(1.03); C266(1.03); C272(0.90); C281(0.90)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C261(1.11); C266(1.11); C272(0.86); C281(0.86)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C261(0.98); C266(0.98); C272(0.87); C281(0.87)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C261(0.80); C266(0.80); C272(0.91); C281(0.91)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C261(0.71); C266(0.71); C272(0.90); C281(0.90)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C261(0.85); C266(0.85); C272(0.87); C281(0.87)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C261(0.90); C266(0.90); C272(0.86); C281(0.86)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C977(1.01); C431(1.23); C434(1.19); C664(0.99)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C261(0.72); C266(0.72); C272(0.94); C281(0.94)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C977(1.06); C261(1.09); C431(1.05); C434(1.13)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C977(0.92); C261(1.47); C431(1.08); C434(1.19)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C977(1.06); C261(1.46); C431(1.01); C434(1.05)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C977(0.91); C261(1.51); C431(1.08); C434(1.24)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C977(0.84); C261(2.21); C431(0.98); C434(1.10)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C977(0.87); C261(1.83); C431(1.12); C434(1.18)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C977(0.68); C261(2.29); C431(1.00); C434(1.03)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C977(1.04); C261(1.15); C431(1.07); C434(1.13)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C977(0.68); C261(1.76); C431(1.21); C434(1.19)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C698(1.03); C457(1.13); C664(1.31); C532(0.88)  LDD1698  [14]
 LDCM0625  F8 Ramos C664(0.85); C698(1.30)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C698(8.49)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C664(2.62)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C664(0.83)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C664(1.04); C698(0.78)  LDD2193  [15]
 LDCM0580  Fragment21 Ramos 1.30; C664(0.67)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C664(0.69)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos 1.24; C664(0.68)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos 1.44; C664(0.17); C698(1.18)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C664(1.17)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C664(0.91)  LDD2200  [15]
 LDCM0468  Fragment33 HCT 116 C977(1.10); C261(0.67); C431(1.10); C434(1.29)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos 1.14; C664(0.70)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C664(2.44); C698(0.95)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C977(1.89); C261(0.93); C266(0.93); C431(1.76)  LDD0744  [5]
 LDCM0614  Fragment56 Ramos C664(2.69)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C698(0.91)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C664(1.31)  LDD2188  [15]
 LDCM0107  IAA HeLa H89(0.00); H691(0.00)  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C977(2.70); C987(2.70); C434(3.33); C261(2.46)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C977(2.12); C987(2.12); C434(5.29); C261(3.01)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C977(9.26); C987(9.26); C434(2.51); C261(2.01)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0021  THZ1 HCT 116 C261(1.26); C266(1.26); C431(1.19); C434(1.19)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) RNA polymerase beta' chain family P24928

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578