Details of the Target

General Information of Target

Target ID LDTP01081
Target Name Sphingomyelin phosphodiesterase 2 (SMPD2)
Gene Name SMPD2
Gene ID 6610
Synonyms
Sphingomyelin phosphodiesterase 2; EC 3.1.4.12; Lyso-platelet-activating factor-phospholipase C; Lyso-PAF-PLC; Neutral sphingomyelinase; N-SMase; nSMase; nSMase1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLR
QKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGL
LVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLN
MHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYV
LYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERS
PLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTP
SVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRT
KEQ
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Neutral sphingomyelinase family
Subcellular location
Cell membrane
Function
Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo. Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine.
TTD ID
T57316
Uniprot ID
O60906
DrugMap ID
TTE5VI6
Ensemble ID
ENST00000258052.8
HGNC ID
HGNC:11121
ChEMBL ID
CHEMBL4712

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C304(2.22)  LDD0171  [2]
DBIA
 Probe Info  		C304(26.05)  LDD0209  [3]
IPM
 Probe Info  		C304(9.59)  LDD1701  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C304(2.22)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C16(0.76); C221(0.89); C304(1.22)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C304(0.97)  LDD0532  [8]
 LDCM0216  AC100 PaTu 8988t C16(0.93)  LDD1095  [8]
 LDCM0217  AC101 PaTu 8988t C16(0.95)  LDD1096  [8]
 LDCM0218  AC102 PaTu 8988t C16(1.25)  LDD1097  [8]
 LDCM0219  AC103 PaTu 8988t C16(0.94)  LDD1098  [8]
 LDCM0220  AC104 PaTu 8988t C16(0.97)  LDD1099  [8]
 LDCM0221  AC105 PaTu 8988t C16(1.03)  LDD1100  [8]
 LDCM0222  AC106 PaTu 8988t C16(0.91)  LDD1101  [8]
 LDCM0223  AC107 PaTu 8988t C16(1.14)  LDD1102  [8]
 LDCM0224  AC108 PaTu 8988t C16(1.07)  LDD1103  [8]
 LDCM0225  AC109 PaTu 8988t C16(0.91)  LDD1104  [8]
 LDCM0226  AC11 HCT 116 C304(1.21)  LDD0543  [8]
 LDCM0227  AC110 PaTu 8988t C16(1.10)  LDD1106  [8]
 LDCM0228  AC111 PaTu 8988t C16(0.82)  LDD1107  [8]
 LDCM0229  AC112 PaTu 8988t C16(1.00)  LDD1108  [8]
 LDCM0230  AC113 HCT 116 C16(0.79); C304(1.03)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C16(0.61); C304(1.01)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C16(0.66); C304(1.08)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C16(0.58); C304(1.15)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C16(0.74); C304(1.06)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C16(0.70); C304(1.11)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C16(0.72); C304(1.12)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C304(1.07)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C16(0.70); C304(0.87)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C16(0.81); C304(0.89)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C16(0.62); C304(0.99)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C16(0.72); C304(0.77)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C16(0.80); C304(0.90)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C16(0.90); C304(0.93)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C16(0.60); C304(0.95)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C16(0.67); C304(0.89)  LDD0562  [8]
 LDCM0246  AC128 PaTu 8988t C16(0.90)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C16(0.92)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C16(1.01)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C16(0.92)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C16(1.00)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C16(1.19)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C16(0.93)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C16(1.02)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C16(0.82)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C16(0.82)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C16(0.83)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C16(0.77)  LDD1137  [8]
 LDCM0259  AC14 HCT 116 C304(0.90)  LDD0576  [8]
 LDCM0260  AC140 PaTu 8988t C16(1.14)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C16(0.92)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C16(1.16)  LDD1141  [8]
 LDCM0263  AC143 HCT 116 C221(1.16); C304(1.25)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C221(1.07); C304(1.10)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C221(0.99); C304(1.16)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C304(1.16); C221(1.32)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C221(0.97); C304(0.98)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C304(1.21); C221(1.29)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C304(1.27); C221(1.36)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C304(1.07)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C304(1.09); C221(1.13)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C221(1.06); C304(1.15)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C221(1.15); C304(1.20)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C221(1.31); C304(1.62)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C221(1.26); C304(1.16)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C221(1.15); C304(1.19)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C221(1.01); C304(1.12)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C221(1.21); C304(1.20)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C221(0.72); C304(1.03)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C221(0.60); C304(1.00)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C221(0.62); C304(1.06)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C16(0.77); C304(1.19); C221(1.22)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C221(0.82); C304(0.99)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C221(0.69); C304(0.99)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C221(0.74); C304(1.05)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C221(0.72); C304(1.12)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C221(0.75); C304(1.02)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C304(0.94); C221(1.14)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C221(1.11); C304(1.18)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C304(1.26); C221(1.33)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C221(1.11); C304(1.25)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C304(1.26); C221(1.34)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C16(0.79); C304(1.13); C221(1.33)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C304(1.45); C221(1.45)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C221(1.13); C304(1.28)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C221(1.40); C304(1.54)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C304(1.12); C221(1.38)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C304(0.97); C221(1.50)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C221(0.73)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C221(0.68)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C221(0.71)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C221(0.76)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C221(0.61)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C16(0.68); C304(1.18); C221(1.29)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C221(0.75)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C221(0.84)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C221(1.16)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C221(1.07)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C221(1.25)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C221(1.18)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C16(0.69)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C16(0.76)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C16(0.77)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C16(0.88)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C16(0.76); C304(1.19); C221(1.28)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C16(1.10)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C16(0.67)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C16(0.62)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C16(0.87)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C16(0.72)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C16(0.71)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C16(0.82)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C221(0.91); C304(1.21)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C304(1.09); C221(1.43)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C221(1.02); C304(1.09)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C304(1.18)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C304(1.10); C221(1.19)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C221(0.95); C304(1.11)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C221(0.85); C304(1.22)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C221(1.02); C304(1.15)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C221(1.14); C304(1.20)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C221(0.93); C304(1.14)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C304(1.09); C221(1.46)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C221(0.86); C304(1.09)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C221(0.82); C304(0.87)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C221(0.96); C304(0.98)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C304(1.06)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C221(0.90); C304(1.03)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C221(0.95); C304(0.96)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C221(0.90); C304(1.05)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C221(0.82); C304(1.12)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C221(0.93); C304(0.98)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C221(0.91); C304(1.09)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C221(0.82); C304(1.09)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C221(0.90); C304(0.93)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C304(1.00); C221(1.01)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C221(0.97); C304(1.05)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C304(1.13)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C221(0.79); C304(1.15)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C221(0.90); C304(1.06)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C221(0.82); C304(1.14)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C221(0.71); C304(1.07)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C221(0.77); C304(0.84)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C221(0.73); C304(1.08)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C221(0.79); C304(1.10)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C221(0.74); C304(1.18)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C221(0.79); C304(1.11)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C221(0.61); C304(1.08)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C221(0.72); C304(1.22)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C221(0.55); C304(1.01)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C221(0.55); C304(1.08)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C221(0.73); C304(1.12)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C221(0.66); C304(1.15)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C221(0.67); C304(1.23)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C221(0.84); C304(1.14)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C221(0.75); C304(1.20)  LDD0681  [8]
 LDCM0365  AC98 PaTu 8988t C16(1.06)  LDD1244  [8]
 LDCM0366  AC99 PaTu 8988t C16(1.06)  LDD1245  [8]
 LDCM0248  AKOS034007472 HCT 116 C304(1.16)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C304(1.14)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C304(0.92)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.62  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C221(0.87)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C304(1.14); C16(1.15)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C16(0.78); C304(1.29)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C16(0.68); C221(1.01); C304(1.20)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C304(0.89)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C304(1.07)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C304(0.91)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C304(1.04)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C221(0.85); C304(1.11)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C221(0.67); C304(1.00)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C221(0.81); C304(0.95)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C221(0.79); C304(1.06)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C221(0.79); C304(1.09)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C16(0.96); C304(1.42)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C221(0.84); C304(1.10)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C221(0.72); C304(1.20)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C221(1.21); C304(1.25)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C221(1.12); C304(1.27)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C221(1.11); C304(1.35)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C304(1.27); C221(1.46)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C304(1.12); C221(1.29)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C221(1.42)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C221(1.03)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C221(0.75)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C16(0.88); C304(1.19)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C221(0.82)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C16(0.80)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C16(0.68)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C16(0.74)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C16(0.75)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C221(0.99); C304(1.15)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C304(1.16); C221(1.20)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C304(0.97); C221(1.10)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C221(0.89); C304(1.25)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C16(0.89); C304(1.14)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C16(0.99); C304(1.17)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C16(1.07); C304(1.38)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C221(1.00)  LDD0720  [8]
 LDCM0404  CL17 HEK-293T C16(1.07); C221(1.07)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C16(0.61); C221(0.61)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C16(0.54); C221(0.54)  LDD1004  [8]
 LDCM0407  CL2 HCT 116 C16(1.08); C304(1.08)  LDD0724  [8]
 LDCM0408  CL20 HEK-293T C16(0.85); C221(0.85)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C16(0.90); C221(0.90)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C16(0.64); C221(0.64)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C16(0.93); C221(0.93)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C16(1.02); C221(1.02)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C16(0.83); C221(0.83)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C16(0.95); C221(0.95)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C16(0.83); C221(0.83)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C16(1.26); C221(1.26)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C16(0.99); C221(0.99)  LDD1015  [8]
 LDCM0418  CL3 HCT 116 C16(0.94); C304(1.04)  LDD0735  [8]
 LDCM0419  CL30 HEK-293T C16(0.73); C221(0.73)  LDD1017  [8]
 LDCM0420  CL31 HCT 116 C16(0.80); C221(1.12); C304(1.22)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C16(0.95); C221(1.03); C304(1.05)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C16(0.81); C221(0.94); C304(1.10)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C16(0.79); C221(1.08); C304(1.09)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C16(0.91); C221(0.95); C304(1.19)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C16(0.98); C221(1.24); C304(1.22)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C16(0.86); C221(1.45); C304(1.09)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C16(0.96); C221(0.91); C304(0.98)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C16(0.92); C304(1.28)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C16(0.81); C221(0.90); C304(1.10)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C16(0.84); C221(1.04); C304(0.94)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C16(0.88); C221(0.87); C304(0.99)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C16(1.01); C221(1.23); C304(0.99)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C16(0.80); C221(1.03); C304(1.03)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C16(0.79); C221(1.27); C304(1.22)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C304(1.02)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C304(0.97)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C304(0.91)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C304(1.01)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C16(1.05); C304(1.03)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C304(1.00)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C304(1.07)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C304(1.01)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C304(0.80)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C304(0.93)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C304(0.84)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C304(0.94)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C304(0.96)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C304(0.92)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C304(0.95)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C16(0.89); C304(1.06)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C304(1.04)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C16(0.83); C221(1.09); C304(1.16)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C16(1.02); C221(1.30); C304(1.10)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C16(0.76); C221(1.06); C304(1.04)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C16(0.80); C221(1.12); C304(1.12)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C16(0.87); C221(1.39); C304(0.97)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C16(0.71); C221(1.10); C304(1.02)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C16(0.81); C221(1.46); C304(0.90)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C16(0.71); C221(1.94); C304(0.95)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C16(1.00); C221(1.27); C304(1.10)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C16(1.03); C304(1.19)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C16(0.76); C221(1.15); C304(1.04)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C16(0.71); C221(1.35); C304(1.02)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C16(0.95); C221(1.43); C304(1.08)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C16(1.12); C221(1.39); C304(1.08)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C16(0.86); C221(1.56); C304(1.02)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C304(1.14)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C304(1.19)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C304(1.21)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C304(1.44)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C16(0.93); C304(1.23)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C304(1.15)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C304(1.24)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C304(1.38)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C304(1.48)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C304(1.53)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C304(1.16)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C304(1.22)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C304(1.42)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C304(1.34)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C304(1.73)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C16(1.00); C304(1.07)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C304(1.61)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C16(0.77); C221(0.99); C304(1.21)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C16(0.82); C221(1.06); C304(1.24)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C16(0.90); C221(0.97); C304(1.04)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C16(0.75); C221(0.95); C304(1.28)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C16(0.69); C221(0.95); C304(1.48)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C16(0.71); C221(1.13); C304(1.19)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C16(0.79); C221(1.29); C304(1.12)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C16(0.68); C221(0.85); C304(1.30)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C16(0.74); C221(0.89); C304(1.34)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C16(0.90)  LDD1698  [9]
 LDCM0625  F8 Ramos C221(1.18)  LDD2187  [10]
 LDCM0575  Fragment13 Ramos C221(1.56)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C221(1.22)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C221(0.93)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C221(0.93)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C221(0.72)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C221(1.19)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C221(1.09)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C221(0.85)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C221(1.24)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C221(1.15)  LDD2201  [10]
 LDCM0468  Fragment33 HCT 116 C16(0.79); C221(1.25); C304(1.04)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C221(1.06)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C221(1.29)  LDD2184  [10]
 LDCM0427  Fragment51 HCT 116 C16(0.99); C221(1.00); C304(1.38)  LDD0744  [8]
 LDCM0022  KB02 22RV1 C252(1.24)  LDD2243  [11]
 LDCM0023  KB03 Jurkat C304(26.05)  LDD0209  [3]
 LDCM0024  KB05 HMCB C16(1.25)  LDD3312  [11]
 LDCM0109  NEM HeLa N.A.  LDD0227  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamate decarboxylase 2 (GAD2) Group II decarboxylase family Q05329
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large neutral amino acids transporter small subunit 2 (SLC7A8) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UHI5
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCN family member 1 (CCN1) CCN family O00622
Protein kish-B (TMEM167B) KISH family Q9NRX6
Arfaptin-1 (ARFIP1) . P53367
Steroidogenic acute regulatory protein, mitochondrial (STAR) . P49675

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840