Details of the Target

General Information of Target

Target ID LDTP00870
Target Name Unconventional myosin-Ib (MYO1B)
Gene Name MYO1B
Gene ID 4430
Synonyms
Unconventional myosin-Ib; MYH-1c; Myosin I alpha; MMI-alpha; MMIa
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRS
LPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKL
VMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDP
LGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSA
KVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKI
KDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRL
FSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTL
KEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLN
QVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQ
AMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPND
KKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPA
RSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKC
RTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCK
EAVTTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHA
VAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWP
SRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVG
QPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQ
KSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRT
TLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Function Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.
Uniprot ID
O43795
Ensemble ID
ENST00000304164.8
HGNC ID
HGNC:7596

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.L831F DBIA    Probe Info 
CCK81 Deletion: p.S730AfsTer4 DBIA    Probe Info 
HT SNV: p.F918S .
IGROV1 Deletion: p.K925NfsTer18
Insertion: p.S730KfsTer51		 DBIA    Probe Info 
J82 SNV: p.Q615H DBIA    Probe Info 
KMCH1 SNV: p.R1125G DBIA    Probe Info 
NCIH2122 SNV: p.E269D DBIA    Probe Info 
NCIH358 SNV: p.E330K DBIA    Probe Info 
OCIAML2 SNV: p.N146H .
PEO1 SNV: p.L295P DBIA    Probe Info 
SNGM SNV: p.R854H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.62  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
C-Sul
 Probe Info  		3.11  LDD0066  [3]
STPyne
 Probe Info  		K287(10.00); K495(10.00); K551(5.88); K565(10.00)  LDD0277  [4]
Probe 1
 Probe Info  		Y64(12.32); Y232(21.96); Y535(16.43); Y870(11.45)  LDD3495  [5]
BTD
 Probe Info  		C483(0.75)  LDD2091  [6]
AHL-Pu-1
 Probe Info  		C483(2.44)  LDD0169  [7]
DBIA
 Probe Info  		C103(1.06); C641(1.00); C613(0.99); C129(0.97)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C613(0.00); C310(0.00); C509(0.00); C641(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C613(0.00); C103(0.00); C310(0.00); C509(0.00)  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
WYneN
 Probe Info  		C103(0.00); C595(0.00); C509(0.00); C1123(0.00)  LDD0021  [14]
WYneO
 Probe Info  		C1123(0.00); C103(0.00); C641(0.00)  LDD0022  [14]
ENE
 Probe Info  		N.A.  LDD0006  [14]
IPM
 Probe Info  		C613(0.00); C129(0.00); C1123(0.00)  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
TFBX
 Probe Info  		C509(0.00); C1123(0.00); C613(0.00)  LDD0148  [15]
Acrolein
 Probe Info  		C103(0.00); C483(0.00); C310(0.00); C613(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C483(0.00); C641(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C483(0.00); C103(0.00); C509(0.00)  LDD0218  [16]
W1
 Probe Info  		C509(0.00); C310(0.00); C641(0.00); C613(0.00)  LDD0236  [17]
AOyne
 Probe Info  		11.40  LDD0443  [18]
NAIA_5
 Probe Info  		C613(0.00); C595(0.00); C779(0.00); C103(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [19]
STS-2
 Probe Info  		1.80  LDD0139  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C103(0.90); C595(0.65)  LDD2095  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C483(0.96); C1123(1.43)  LDD2117  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C483(0.85)  LDD2131  [6]
 LDCM0025  4SU-RNA DM93 C483(2.25)  LDD0170  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C483(2.44)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C103(1.86); C1123(1.47); C129(1.03); C483(1.36)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C129(1.06); C483(1.11); C613(1.09); C641(0.95)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C1123(1.07); C129(1.17); C509(0.98); C613(0.62)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C1123(1.34); C129(1.17); C509(0.86); C613(0.67)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C1123(0.99); C129(1.13); C509(0.96); C613(0.81)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C1123(0.97); C129(1.83); C509(0.82); C613(0.69)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C1123(0.97); C129(1.52); C509(1.17); C613(0.67)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C1123(0.97); C129(1.44); C509(0.78); C613(0.66)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C1123(1.01); C129(1.55); C509(0.86); C613(0.68)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C1123(1.06); C129(1.45); C509(0.90); C613(0.61)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C1123(1.05); C129(0.89); C509(0.84); C613(0.98)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C1123(1.02); C129(0.89); C509(0.85); C613(0.86)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C129(1.10); C483(1.18); C613(1.18); C641(1.08)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C1123(0.98); C129(1.03); C509(0.89); C613(0.96)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C1123(1.24); C129(1.03); C509(0.81); C613(0.91)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C1123(1.10); C129(1.20); C509(0.83); C613(0.60)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C1123(1.20); C129(1.10); C483(1.12); C509(1.27)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C1123(1.27); C129(1.36); C483(0.76); C509(0.91)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C1123(1.36); C129(1.60); C483(0.77); C509(0.96)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C1123(1.32); C129(1.51); C483(0.80); C509(1.05)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C1123(1.15); C129(1.26); C483(0.75); C509(1.00)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C1123(1.20); C129(1.12); C483(0.87); C509(0.97)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C1123(1.31); C129(1.16); C483(0.89); C509(0.93)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C129(0.93); C483(1.08); C613(1.06); C641(1.22)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C1123(1.38); C129(1.44); C483(0.88); C509(0.92)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C1123(1.13); C129(1.03); C483(1.00); C509(1.06)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C1123(1.33); C129(1.03); C483(1.08); C509(1.00)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C1123(0.93); C129(1.06); C483(1.04); C509(0.89)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C1123(1.17); C129(1.08); C483(0.88); C509(1.00)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C1123(1.42); C129(1.10); C483(0.93); C509(0.94)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C1123(1.33); C129(1.51); C483(0.81); C509(0.89)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C1123(1.30); C129(1.38); C483(0.76); C509(0.95)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C103(0.81); C1123(1.66); C129(1.32); C509(1.34)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C103(1.21); C1123(2.00); C129(0.95); C509(1.38)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C103(0.72); C1123(1.94); C129(1.24); C509(1.19)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C103(1.08); C1123(1.45); C129(1.02); C509(1.15)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C103(1.48); C1123(1.72); C129(0.90); C509(0.97)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C103(0.87); C1123(1.71); C129(1.05); C509(1.06)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C103(0.71); C1123(1.94); C129(1.33); C509(0.73)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C103(0.73); C1123(2.14); C129(1.10); C509(1.09)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C103(1.01); C1123(1.20); C129(1.15); C509(0.95)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C103(1.09); C1123(1.24); C129(1.02); C509(1.05)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C103(0.75); C1123(1.97); C129(1.30); C509(0.75)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C103(1.03); C1123(1.78); C129(1.14); C509(0.71)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C129(1.01); C483(1.16); C613(1.27); C641(1.02)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C103(0.83); C1123(1.91); C129(1.35); C509(0.65)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C103(0.92); C1123(1.78); C129(1.30); C509(0.62)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C103(1.77); C1123(2.16); C129(0.84); C509(0.97)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C613(0.91); C483(1.01); C1123(1.06); C129(1.15)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C483(0.33); C641(0.63); C613(1.02); C1123(1.14)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C483(0.55); C613(0.94); C1123(1.02); C641(1.12)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C483(0.48); C641(0.92); C613(1.06); C1123(1.14)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C483(0.33); C641(0.70); C613(0.97); C1123(1.29)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C483(0.40); C641(0.72); C613(1.15); C1123(1.26)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C483(0.33); C641(0.61); C613(1.03); C1123(1.10)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C641(0.85); C483(0.99); C613(1.13); C129(1.13)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C483(0.70); C641(0.91); C1123(1.04); C613(1.07)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C483(0.68); C613(1.08); C1123(1.19); C129(1.21)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C483(0.36); C641(0.64); C1123(0.95); C613(1.02)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C483(0.38); C641(0.91); C613(1.22); C1123(1.25)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C1123(1.30); C129(1.58); C483(0.39); C613(1.05)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C1123(1.02); C129(1.62); C483(0.35); C613(1.06)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C1123(1.11); C129(1.10); C483(0.76); C613(1.13)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C1123(1.19); C129(1.22); C483(0.81); C613(0.87)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C483(0.66); C103(0.82); C613(0.95); C641(1.17)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C483(0.39); C103(0.54); C641(0.69); C613(0.93)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C483(0.50); C103(0.75); C641(0.81); C613(1.00)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C641(0.79); C509(0.92); C129(1.04); C613(1.17)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C483(0.62); C103(0.91); C613(0.94); C1123(1.02)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C483(0.54); C103(0.68); C641(0.95); C613(0.96)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C483(0.77); C613(0.86); C641(0.98); C103(0.99)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C483(0.63); C103(0.70); C613(0.90); C1123(1.02)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C483(0.80); C641(0.94); C613(0.98); C103(1.07)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C641(0.78); C509(0.80); C103(0.83); C1123(0.92)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C641(0.69); C103(0.76); C509(0.78); C129(1.08)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C641(0.60); C509(0.63); C103(0.64); C1123(0.88)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C103(0.65); C641(0.66); C1123(0.71); C509(0.81)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C641(0.53); C509(0.65); C103(0.66); C1123(0.88)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C509(0.85); C641(0.95); C129(1.01); C613(1.11)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C641(0.54); C103(0.59); C509(0.67); C1123(0.96)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C509(0.68); C641(0.72); C103(0.73); C1123(1.01)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C103(0.45); C641(0.47); C509(0.85); C1123(1.05)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C509(0.52); C103(0.56); C641(0.61); C1123(0.87)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C103(0.48); C509(0.58); C641(0.62); C1123(0.79)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C129(0.89); C1123(0.97); C613(0.98); C310(1.33)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C1123(0.92); C129(0.92); C641(1.16); C613(1.18)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C129(0.86); C1123(0.89); C613(1.13); C103(1.35)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C129(0.92); C1123(1.06); C641(1.09); C613(1.12)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C1123(0.96); C129(0.99); C613(1.05); C310(1.10)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C509(0.61); C641(0.80); C483(0.92); C613(1.24)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C310(0.91); C103(1.00); C509(1.04); C613(1.28)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C1123(0.98); C103(1.07); C310(1.10); C509(1.16)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C103(0.95); C310(1.00); C509(1.03); C1123(1.09)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C641(0.91); C1123(0.92); C103(1.10); C129(1.13)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C310(1.02); C103(1.07); C1123(1.14); C509(1.19)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C310(0.94); C1123(0.96); C103(1.08); C509(1.16)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C483(0.56); C129(0.98); C509(1.01); C613(1.07)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C103(0.90); C483(0.92); C1123(0.92); C641(0.94)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C483(0.82); C129(0.87); C1123(0.94); C613(1.04)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C483(0.53); C641(0.69); C103(0.81); C509(0.95)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C509(0.64); C641(0.82); C483(0.93); C613(1.18)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C483(0.61); C641(0.62); C509(0.69); C103(0.80)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C483(0.54); C509(0.73); C129(0.82); C1123(0.95)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C483(0.65); C641(0.75); C1123(0.96); C103(1.03)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C641(0.63); C103(0.72); C483(0.73); C613(1.05)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C641(0.67); C483(0.76); C103(0.79); C1123(1.01)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C509(0.74); C641(0.75); C103(0.91); C483(0.96)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C483(0.66); C641(0.67); C1123(0.79); C103(0.83)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C641(0.33); C509(0.40); C483(0.45); C1123(0.85)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C641(0.31); C483(0.44); C509(0.55); C1123(0.94)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C641(0.28); C483(0.43); C509(0.47); C1123(0.79)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C641(0.67); C483(0.78); C613(1.04); C129(1.30)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C641(0.49); C483(0.53); C509(0.63); C1123(0.80)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C641(0.53); C483(0.70); C509(0.79); C613(1.20)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C641(0.29); C509(0.38); C483(0.40); C1123(1.07)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C641(0.41); C483(0.47); C509(0.47); C1123(1.02)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C641(0.25); C483(0.44); C509(0.45); C1123(0.85)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C641(0.35); C509(0.47); C483(0.57); C1123(1.14)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C641(0.47); C509(0.53); C483(0.58); C1123(0.98)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C641(0.32); C509(0.47); C483(0.51); C1123(1.00)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C641(0.75); C613(1.05); C103(1.08); C129(1.16)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C641(0.65); C103(1.00); C1123(1.06); C613(1.10)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C483(0.83); C641(0.92); C129(0.97); C613(1.06)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C641(0.53); C103(0.85); C1123(1.18); C613(1.29)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C641(0.96); C129(0.99); C613(1.00); C103(1.18)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C641(0.59); C103(0.87); C613(1.09); C1123(1.15)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C641(0.65); C103(1.07); C613(1.18); C1123(1.46)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C641(0.77); C103(1.16); C613(1.31); C1123(1.50)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C641(0.60); C103(0.86); C613(1.41); C1123(1.48)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C641(0.71); C103(0.93); C613(1.12); C1123(1.29)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C641(0.54); C103(0.81); C613(1.08); C1123(1.48)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C103(0.81); C641(0.90); C129(1.04); C613(1.12)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C641(0.67); C103(0.70); C613(1.15); C1123(1.29)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C483(0.77); C641(0.97); C129(1.13); C613(1.21)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C641(0.76); C613(1.04); C1123(1.10); C103(1.15)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C103(0.97); C129(1.03); C641(1.05); C1123(1.09)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C641(0.71); C103(1.03); C1123(1.39); C613(1.45)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C103(0.32); C310(0.59); C483(0.65); C1123(0.85)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C103(0.45); C1123(0.54); C310(0.54); C483(0.58)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C103(0.53); C1123(0.58); C310(0.75); C509(0.76)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C103(0.47); C1123(0.64); C509(0.64); C483(0.68)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C509(0.76); C641(0.80); C1123(0.88); C613(0.94)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C1123(0.52); C509(0.58); C641(0.65); C103(0.66)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C103(0.30); C483(0.56); C310(0.58); C1123(0.64)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C509(0.51); C641(0.75); C613(0.90); C129(0.92)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C103(0.25); C310(0.52); C483(0.57); C1123(0.80)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C103(0.35); C483(0.48); C310(0.57); C1123(0.74)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C103(0.47); C1123(0.47); C483(0.63); C310(0.65)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C1123(0.43); C103(0.51); C310(0.69); C613(0.88)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C509(0.57); C641(0.62); C103(0.80); C613(0.88)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C103(0.42); C1123(0.62); C483(0.65); C310(0.66)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C103(0.40); C509(0.53); C1123(0.54); C310(0.56)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C641(0.40); C509(0.79); C613(0.83); C1123(1.00)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C613(0.63); C509(0.84); C1123(0.94); C641(1.07)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C129(0.89); C483(1.12); C613(1.11); C641(1.10)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C129(1.03); C641(1.07); C613(1.10); C483(1.14)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C641(0.55); C483(0.69); C613(1.22); C129(1.55)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C103(1.06); C641(1.00); C613(0.99); C129(0.97)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C483(0.75)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C129(1.77)  LDD2214  [20]
 LDCM0108  Chloroacetamide HeLa C483(0.00); C310(0.00); C509(0.00); C641(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C129(20.00); C613(1.02)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C613(0.84); C129(0.86); C1123(1.09); C641(1.11)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C483(0.60); C103(0.66); C310(0.67); C509(0.74)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C509(0.68); C483(0.88); C641(0.89); C1123(0.98)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C641(0.67); C483(0.73); C129(1.10); C613(1.10)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C129(0.95); C641(1.01); C613(1.02); C483(1.23)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C129(0.86); C613(0.96); C641(1.05); C483(1.07)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C483(0.93); C129(1.01); C613(1.03); C641(1.19)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C483(0.46); C103(0.61); C641(0.63); C613(0.97)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C483(0.36); C103(0.47); C641(0.53); C613(0.87)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C483(0.34); C103(0.43); C641(0.61); C613(0.92)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C483(0.35); C103(0.42); C641(0.52); C613(1.17)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C483(0.41); C641(0.62); C103(0.64); C1123(1.05)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C103(0.61); C310(0.69); C483(0.70); C509(0.75)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C483(0.33); C641(0.47); C103(0.48); C613(1.00)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C483(0.47); C103(0.65); C641(0.77); C613(0.98)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C509(0.65); C103(0.76); C641(0.80); C1123(0.90)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C103(0.50); C641(0.58); C509(0.68); C1123(0.75)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C509(0.54); C103(0.66); C641(0.75); C1123(1.01)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C509(0.50); C103(0.59); C1123(0.67); C641(0.68)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C509(0.50); C641(0.69); C103(0.70); C1123(1.05)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C103(0.92); C1123(1.01); C310(1.06); C641(1.21)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C1123(0.96); C103(0.99); C509(1.06); C310(1.08)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C310(0.88); C103(0.90); C1123(1.05); C613(1.06)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C103(0.57); C483(0.75); C509(0.78); C641(0.86)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C1123(0.86); C129(0.92); C641(0.96); C103(1.04)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C641(0.62); C129(0.69); C509(0.97); C1123(0.98)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C641(0.77); C483(0.81); C1123(0.94); C509(1.07)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C641(0.57); C103(0.76); C483(0.78); C1123(0.82)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C641(0.78); C483(0.79); C103(0.80); C1123(0.83)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C483(0.77); C1123(0.82); C641(0.87); C509(0.89)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C641(0.57); C483(0.65); C509(0.68); C1123(0.72)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C641(0.52); C483(0.70); C509(0.72); C1123(0.79)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C641(0.22); C509(0.42); C483(0.44); C1123(0.74)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C103(0.67); C483(0.92); C641(0.93); C509(0.96)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C509(0.79); C103(0.83); C483(0.84); C641(0.92)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C641(0.94); C483(0.96); C129(1.05); C509(1.10)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C641(0.57); C103(0.72); C310(0.72); C1123(1.00)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C103(0.70); C641(0.77); C310(0.78); C1123(0.92)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C103(0.77); C310(0.79); C641(0.82); C613(1.11)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C641(0.55); C103(0.70); C310(0.79); C613(1.01)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C129(0.91); C613(1.00); C641(1.12); C483(1.18)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C641(0.30); C103(0.36); C310(0.52); C483(0.60)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C641(0.32); C103(0.39); C310(0.53); C483(0.63)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C641(0.35); C103(0.41); C310(0.69); C483(0.81)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C641(0.38); C103(0.39); C310(0.60); C483(0.63)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C641(0.36); C103(0.40); C310(0.52); C483(0.64)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C103(0.37); C1123(1.19); C129(1.51); C310(0.56)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C103(0.37); C1123(1.11); C129(1.33); C310(0.69)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C103(0.65); C1123(1.33); C129(1.08); C310(0.70)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C103(0.48); C1123(1.14); C129(1.35); C310(0.56)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C103(0.43); C1123(1.22); C129(1.38); C310(0.61)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C103(1.24); C1123(1.07); C129(0.95); C310(0.91)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C103(0.78); C1123(1.15); C129(1.08); C310(0.79)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C103(1.20); C1123(1.05); C129(1.28); C483(0.65)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C103(0.95); C1123(1.32); C129(1.30); C483(1.03)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C103(0.95); C1123(1.11); C129(1.31); C483(0.63)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C103(0.99); C1123(1.05); C129(2.19); C483(0.45)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C103(0.92); C1123(1.01); C129(2.52); C483(0.41)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C103(1.00); C1123(1.10); C129(2.08); C483(0.41)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C103(0.84); C1123(1.15); C129(2.34); C483(0.41)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C103(0.98); C1123(1.04); C129(2.17); C483(0.40)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C103(0.72); C1123(0.97); C129(0.95); C310(1.48)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C103(0.77); C1123(0.95); C129(2.03); C483(0.41)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C103(0.93); C1123(1.11); C129(1.96); C483(0.42)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C103(0.93); C1123(1.21); C129(3.24); C483(0.53)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C103(0.98); C1123(0.97); C129(2.52); C483(0.50)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C103(0.93); C1123(0.89); C129(1.92); C483(0.57)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C103(1.04); C1123(1.12); C129(2.23); C483(0.47)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C103(0.72); C1123(1.08); C129(0.73); C613(0.93)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C103(0.68); C1123(0.99); C129(0.81); C613(0.90)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C103(0.76); C1123(1.01); C129(0.83); C613(0.88)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C103(0.80); C1123(0.99); C129(1.01); C613(1.00)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C103(1.21); C1123(1.23); C129(1.03); C310(1.27)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C103(0.76); C1123(1.20); C129(0.80); C613(0.89)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C103(0.75); C1123(1.16); C129(0.77); C613(0.83)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C103(0.58); C1123(1.28); C129(0.73); C613(0.85)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C103(0.72); C1123(1.06); C129(0.94); C613(0.93)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C103(0.64); C1123(1.02); C129(0.71); C613(0.93)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C103(0.74); C1123(1.19); C129(0.81); C613(1.00)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C103(0.69); C1123(1.12); C129(1.01); C613(0.98)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C103(0.93); C1123(1.12); C129(0.73); C613(0.83)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C103(0.64); C1123(1.21); C129(0.78); C613(0.92)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C103(0.74); C1123(1.10); C129(0.93); C613(0.98)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C103(0.78); C1123(1.15); C129(1.00); C310(1.27)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C103(0.63); C1123(0.94); C129(1.18); C613(0.93)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C103(0.81); C1123(0.93); C129(1.22); C483(0.80)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C103(0.79); C1123(0.86); C129(1.29); C483(0.85)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C103(0.72); C1123(0.99); C129(1.36); C483(0.67)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C103(0.52); C1123(1.10); C129(1.56); C483(0.44)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C103(0.78); C1123(1.00); C129(1.29); C483(0.85)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C103(0.50); C1123(1.15); C129(1.94); C483(0.47)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C103(0.51); C1123(0.88); C129(1.77); C483(0.56)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C103(0.71); C1123(1.01); C129(1.49); C483(0.67)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C103(1.00); C1123(1.04); C129(1.17); C483(1.54)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C103(0.56); C1123(1.38); C129(1.42); C310(1.19)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C103(0.77); C1123(0.93); C129(1.42); C483(0.78)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C103(0.76); C1123(0.99); C129(1.61); C483(0.56)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C103(0.81); C1123(0.93); C129(1.23); C483(0.82)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C103(0.59); C1123(0.92); C129(1.57); C483(0.60)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C103(0.65); C1123(0.98); C129(1.62); C483(0.55)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C1123(1.24); C129(1.13); C509(1.23); C613(1.00)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C1123(0.72); C129(1.19); C509(1.05); C613(1.49)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C1123(1.07); C129(1.18); C509(0.86); C613(0.95)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C1123(0.95); C129(1.70); C509(1.24); C613(1.13)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C103(0.48); C1123(1.19); C129(1.77); C310(0.96)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C1123(0.94); C129(1.19); C509(1.07); C613(1.04)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C1123(0.77); C129(1.37); C509(1.17); C613(1.00)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C1123(0.98); C129(1.94); C509(1.50); C613(0.91)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C1123(1.00); C129(1.92); C509(1.15); C613(0.94)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C1123(1.04); C129(2.12); C509(0.91); C613(1.02)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C1123(1.08); C129(1.37); C509(1.03); C613(0.89)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C1123(0.69); C129(1.13); C509(1.07); C613(1.00)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C1123(0.87); C129(1.33); C509(1.29); C613(0.86)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C1123(1.04); C129(1.74); C509(1.24); C613(1.22)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C1123(1.14); C129(2.18); C509(1.11); C613(0.96)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C103(0.74); C1123(1.23); C129(1.25); C310(0.77)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C1123(0.99); C129(0.96); C509(1.15); C613(1.00)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C103(0.84); C1123(0.94); C129(1.01); C483(0.80)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C103(0.77); C1123(0.81); C129(1.02); C483(0.82)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C103(1.00); C1123(0.83); C129(0.98); C483(0.96)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C103(1.59); C1123(0.84); C129(1.06); C483(0.87)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C103(1.00); C1123(0.98); C129(0.99); C483(0.87)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C103(0.89); C1123(0.89); C129(0.94); C483(0.86)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C103(0.84); C1123(1.10); C129(1.04); C483(0.80)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C103(1.22); C1123(1.31); C129(1.19); C483(1.02)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C103(1.49); C1123(1.45); C129(1.14); C483(0.57)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C1123(0.98); C595(0.86); C641(0.98); C103(0.96)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C595(2.42); C613(2.35); C310(2.16); C1123(2.10)  LDD1702  [6]
 LDCM0468  Fragment33 HCT 116 C103(0.68); C1123(0.83); C129(1.47); C483(0.68)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C103(0.43); C1123(1.00); C129(2.81); C483(0.49)  LDD0744  [8]
 LDCM0107  IAA HeLa H488(0.00); H605(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C1123(2.49); C509(1.78); C129(1.03); C613(1.08)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C1123(1.23); C509(1.13); C129(1.31); C613(1.04)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C1123(1.90); C509(1.54); C129(1.11); C613(0.98)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0225  [16]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1107(0.97)  LDD2092  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C483(1.39)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1107(0.91); C1123(0.68)  LDD2096  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1107(1.38)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C483(1.60)  LDD2099  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1107(1.85)  LDD2105  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1107(1.01)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C483(0.59)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C483(1.17)  LDD2111  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1123(0.95)  LDD2118  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1107(0.95); C1123(1.10)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1123(1.12)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1123(1.06)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C641(0.91)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1123(0.91)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C483(0.88); C1123(1.03)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C483(1.08)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C483(1.04)  LDD2134  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C483(1.54); C641(1.23)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1107(1.95); C1123(1.07)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C103(0.91); C1107(0.40)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1107(0.75)  LDD2141  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C483(1.08); C1123(1.05)  LDD2146  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1123(1.00)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C483(0.55)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1107(1.52)  LDD2153  [6]
 LDCM0021  THZ1 HCT 116 C129(1.16); C613(1.07); C509(1.14)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402