Details of the Target

General Information of Target

Target ID LDTP00465
Target Name Gem-associated protein 2 (GEMIN2)
Gene Name GEMIN2
Gene ID 8487
Synonyms
SIP1; Gem-associated protein 2; Gemin-2; Component of gems 2; Survival of motor neuron protein-interacting protein 1; SMN-interacting protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRRAELAGLKTMAWVPAESAVEELMPRLLPVEPCDLTEGFDPSVPPRTPQEYLRRVQIEA
AQCPDVVVAQIDPKKLKRKQSVNISLSGCQPAPEGYSPTLQWQQQQVAQFSTVRQNVNKH
RSHWKSQQLDSNVTMPKSEDEEGWKKFCLGEKLCADGAVGPATNESPGIDYVQIGFPPLL
SIVSRMNQATVTSVLEYLSNWFGERDFTPELGRWLYALLACLEKPLLPEAHSLIRQLARR
CSEVRLLVDSKDDERVPALNLLICLVSRYFDQRDLADEPS
Target Bioclass
Other
Family
Gemin-2 family
Subcellular location
Nucleus, gem
Function
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound.
Uniprot ID
O14893
Ensemble ID
ENST00000308317.12
HGNC ID
HGNC:10884

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K119(0.57)  LDD0277  [1]
m-APA
 Probe Info  		9.86  LDD0403  [2]
BTD
 Probe Info  		C241(2.35)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C63(3.74)  LDD0168  [4]
DBIA
 Probe Info  		C63(57.73)  LDD0209  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C63(0.00); C34(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C154(0.00); C63(0.00)  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C63(0.00); C34(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		C34(0.00); C63(0.00); C89(0.00)  LDD2226  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
PPMS
 Probe Info  		N.A.  LDD0008  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C154(0.00); C63(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
W1
 Probe Info  		C63(0.00); C34(0.00)  LDD0236  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C264(0.00); C34(0.00); C148(0.00); C63(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C241(1.05); C148(0.62)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C241(0.95); C148(1.23)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C241(1.02)  LDD2152  [3]
 LDCM0025  4SU-RNA HEK-293T C63(3.74)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C63(6.68); C154(4.55)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C264(0.69); C89(0.80)  LDD0812  [15]
 LDCM0215  AC10 HEK-293T C264(0.99); C89(0.86)  LDD0813  [15]
 LDCM0216  AC100 HCT 116 C89(0.55)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C89(0.63)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C89(0.76)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C89(0.79)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C89(0.72)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C89(0.53)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C89(0.64)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C89(0.66)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C89(0.73)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C89(0.83)  LDD0542  [15]
 LDCM0226  AC11 HEK-293T C264(0.72); C89(1.08)  LDD0824  [15]
 LDCM0227  AC110 HCT 116 C89(0.70)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C89(0.60)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C89(0.66)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C89(0.68)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C89(0.83)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C89(0.65)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C89(0.84)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C89(0.73)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C89(0.81)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C89(0.64)  LDD0553  [15]
 LDCM0237  AC12 HEK-293T C264(0.76); C89(0.87)  LDD0835  [15]
 LDCM0238  AC120 HCT 116 C89(1.02)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C89(0.66)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C89(0.73)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C89(0.87)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C89(1.44)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C89(1.21)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C89(0.87)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C89(0.91)  LDD0562  [15]
 LDCM0246  AC128 HEK-293T C89(1.20)  LDD0844  [15]
 LDCM0247  AC129 HEK-293T C89(1.00)  LDD0845  [15]
 LDCM0249  AC130 HEK-293T C89(1.06)  LDD0847  [15]
 LDCM0250  AC131 HEK-293T C89(1.09)  LDD0848  [15]
 LDCM0251  AC132 HEK-293T C89(0.97)  LDD0849  [15]
 LDCM0252  AC133 HEK-293T C89(1.17)  LDD0850  [15]
 LDCM0253  AC134 HEK-293T C89(1.03)  LDD0851  [15]
 LDCM0254  AC135 HEK-293T C89(1.19)  LDD0852  [15]
 LDCM0255  AC136 HEK-293T C89(1.15)  LDD0853  [15]
 LDCM0256  AC137 HEK-293T C89(1.39)  LDD0854  [15]
 LDCM0257  AC138 HEK-293T C89(1.52)  LDD0855  [15]
 LDCM0258  AC139 HEK-293T C89(1.40)  LDD0856  [15]
 LDCM0259  AC14 HEK-293T C264(0.86); C89(0.89)  LDD0857  [15]
 LDCM0260  AC140 HEK-293T C89(1.14)  LDD0858  [15]
 LDCM0261  AC141 HEK-293T C89(1.28)  LDD0859  [15]
 LDCM0262  AC142 HEK-293T C89(1.06)  LDD0860  [15]
 LDCM0263  AC143 HCT 116 C89(0.73)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C89(1.11)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C89(1.12)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C89(0.91)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C89(0.92)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C89(0.92)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C89(0.92)  LDD0586  [15]
 LDCM0270  AC15 HEK-293T C264(0.92); C89(1.50)  LDD0868  [15]
 LDCM0271  AC150 HCT 116 C89(0.98)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C89(1.18)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C89(1.05)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C89(1.07)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C89(0.87)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C89(1.32)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C89(1.02)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C89(1.34)  LDD2161  [15]
 LDCM0276  AC17 HEK-293T C264(0.82); C89(0.71)  LDD0874  [15]
 LDCM0277  AC18 HEK-293T C264(0.88); C89(0.77)  LDD0875  [15]
 LDCM0278  AC19 HEK-293T C264(0.88); C89(0.83)  LDD0876  [15]
 LDCM0279  AC2 HEK-293T C264(0.77); C89(0.88)  LDD0877  [15]
 LDCM0280  AC20 HEK-293T C264(0.97); C89(0.80)  LDD0878  [15]
 LDCM0281  AC21 HEK-293T C264(0.67); C89(0.71)  LDD0879  [15]
 LDCM0282  AC22 HEK-293T C264(0.86); C89(0.88)  LDD0880  [15]
 LDCM0283  AC23 HEK-293T C264(0.84); C89(0.76)  LDD0881  [15]
 LDCM0284  AC24 HEK-293T C264(0.97); C89(0.86)  LDD0882  [15]
 LDCM0285  AC25 HEK-293T C89(0.99)  LDD0883  [15]
 LDCM0286  AC26 HEK-293T C89(0.91)  LDD0884  [15]
 LDCM0287  AC27 HEK-293T C89(0.80)  LDD0885  [15]
 LDCM0288  AC28 HEK-293T C89(0.67)  LDD0886  [15]
 LDCM0289  AC29 HEK-293T C89(0.73)  LDD0887  [15]
 LDCM0290  AC3 HEK-293T C264(0.79); C89(1.04)  LDD0888  [15]
 LDCM0291  AC30 HEK-293T C89(0.76)  LDD0889  [15]
 LDCM0292  AC31 HEK-293T C89(0.79)  LDD0890  [15]
 LDCM0293  AC32 HEK-293T C89(0.82)  LDD0891  [15]
 LDCM0294  AC33 HEK-293T C89(0.73)  LDD0892  [15]
 LDCM0295  AC34 HEK-293T C89(0.79)  LDD0893  [15]
 LDCM0296  AC35 HEK-293T C89(1.06)  LDD0894  [15]
 LDCM0297  AC36 HEK-293T C89(0.82)  LDD0895  [15]
 LDCM0298  AC37 HEK-293T C89(0.90)  LDD0896  [15]
 LDCM0299  AC38 HEK-293T C89(0.86)  LDD0897  [15]
 LDCM0300  AC39 HEK-293T C89(0.90)  LDD0898  [15]
 LDCM0301  AC4 HEK-293T C264(0.83); C89(1.12)  LDD0899  [15]
 LDCM0302  AC40 HEK-293T C89(0.86)  LDD0900  [15]
 LDCM0303  AC41 HEK-293T C89(0.94)  LDD0901  [15]
 LDCM0304  AC42 HEK-293T C89(0.86)  LDD0902  [15]
 LDCM0305  AC43 HEK-293T C89(0.97)  LDD0903  [15]
 LDCM0306  AC44 HEK-293T C89(0.82)  LDD0904  [15]
 LDCM0307  AC45 HEK-293T C89(0.86)  LDD0905  [15]
 LDCM0308  AC46 HEK-293T C89(0.62)  LDD0906  [15]
 LDCM0309  AC47 HEK-293T C89(0.69)  LDD0907  [15]
 LDCM0310  AC48 HEK-293T C89(0.66)  LDD0908  [15]
 LDCM0311  AC49 HEK-293T C89(1.00)  LDD0909  [15]
 LDCM0312  AC5 HEK-293T C264(0.69); C89(0.81)  LDD0910  [15]
 LDCM0313  AC50 HEK-293T C89(0.65)  LDD0911  [15]
 LDCM0314  AC51 HEK-293T C89(1.02)  LDD0912  [15]
 LDCM0315  AC52 HEK-293T C89(0.55)  LDD0913  [15]
 LDCM0316  AC53 HEK-293T C89(0.75)  LDD0914  [15]
 LDCM0317  AC54 HEK-293T C89(0.73)  LDD0915  [15]
 LDCM0318  AC55 HEK-293T C89(0.71)  LDD0916  [15]
 LDCM0319  AC56 HEK-293T C89(1.00)  LDD0917  [15]
 LDCM0320  AC57 HEK-293T C89(1.19)  LDD0918  [15]
 LDCM0321  AC58 HEK-293T C89(0.98)  LDD0919  [15]
 LDCM0322  AC59 HEK-293T C89(1.08)  LDD0920  [15]
 LDCM0323  AC6 HEK-293T C264(0.94); C89(0.76)  LDD0921  [15]
 LDCM0324  AC60 HEK-293T C89(0.90)  LDD0922  [15]
 LDCM0325  AC61 HEK-293T C89(0.87)  LDD0923  [15]
 LDCM0326  AC62 HEK-293T C89(0.88)  LDD0924  [15]
 LDCM0327  AC63 HEK-293T C89(0.91)  LDD0925  [15]
 LDCM0328  AC64 HEK-293T C89(0.88)  LDD0926  [15]
 LDCM0329  AC65 HEK-293T C89(0.86)  LDD0927  [15]
 LDCM0330  AC66 HEK-293T C89(0.93)  LDD0928  [15]
 LDCM0331  AC67 HEK-293T C89(0.86)  LDD0929  [15]
 LDCM0332  AC68 HCT 116 C89(1.36)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C89(1.21)  LDD0650  [15]
 LDCM0334  AC7 HEK-293T C264(0.66); C89(0.61)  LDD0932  [15]
 LDCM0335  AC70 HCT 116 C89(1.03)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C89(1.98)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C89(2.82)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C89(1.23)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C89(1.41)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C89(1.29)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C89(1.78)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C89(1.83)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C89(0.94)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C89(1.89)  LDD0661  [15]
 LDCM0345  AC8 HEK-293T C264(0.78); C89(0.63)  LDD0943  [15]
 LDCM0346  AC80 HCT 116 C89(3.16)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C89(0.89)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C89(1.05)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C89(1.40)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C89(1.29)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C89(1.18)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C89(1.14)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C89(1.33)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C89(1.61)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C89(1.29)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C89(1.23)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C89(1.39)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C89(1.49)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C89(1.26)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C89(1.21)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C89(1.51)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C89(1.22)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C89(1.61)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C89(0.54)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C89(0.61)  LDD0683  [15]
 LDCM0248  AKOS034007472 HEK-293T C264(0.88); C89(1.07)  LDD0846  [15]
 LDCM0356  AKOS034007680 HEK-293T C264(0.79); C89(1.12)  LDD0954  [15]
 LDCM0275  AKOS034007705 HEK-293T C264(0.82); C89(0.71)  LDD0873  [15]
 LDCM0156  Aniline NCI-H1299 9.86  LDD0403  [2]
 LDCM0498  BS-3668 MDA-MB-231 C241(0.72)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C34(0.81)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C89(0.91)  LDD0965  [15]
 LDCM0368  CL10 HEK-293T C89(1.32)  LDD0966  [15]
 LDCM0369  CL100 HEK-293T C264(0.83); C89(0.99)  LDD0967  [15]
 LDCM0370  CL101 HEK-293T C264(0.81); C89(0.74)  LDD0968  [15]
 LDCM0371  CL102 HEK-293T C264(0.88); C89(0.75)  LDD0969  [15]
 LDCM0372  CL103 HEK-293T C264(0.71); C89(0.77)  LDD0970  [15]
 LDCM0373  CL104 HEK-293T C264(0.90); C89(1.15)  LDD0971  [15]
 LDCM0374  CL105 HEK-293T C264(1.13); C89(1.00)  LDD0972  [15]
 LDCM0375  CL106 HEK-293T C264(1.18); C89(0.97)  LDD0973  [15]
 LDCM0376  CL107 HEK-293T C264(0.97); C89(0.86)  LDD0974  [15]
 LDCM0377  CL108 HEK-293T C264(0.88); C89(0.93)  LDD0975  [15]
 LDCM0378  CL109 HEK-293T C264(0.92); C89(0.83)  LDD0976  [15]
 LDCM0379  CL11 HEK-293T C89(1.20)  LDD0977  [15]
 LDCM0380  CL110 HEK-293T C264(0.87); C89(0.80)  LDD0978  [15]
 LDCM0381  CL111 HEK-293T C264(0.97); C89(0.76)  LDD0979  [15]
 LDCM0382  CL112 HEK-293T C89(0.76)  LDD0980  [15]
 LDCM0383  CL113 HEK-293T C89(0.83)  LDD0981  [15]
 LDCM0384  CL114 HEK-293T C89(0.83)  LDD0982  [15]
 LDCM0385  CL115 HEK-293T C89(0.76)  LDD0983  [15]
 LDCM0386  CL116 HEK-293T C89(0.79)  LDD0984  [15]
 LDCM0387  CL117 HEK-293T C89(0.90)  LDD0985  [15]
 LDCM0388  CL118 HEK-293T C89(0.87)  LDD0986  [15]
 LDCM0389  CL119 HEK-293T C89(0.86)  LDD0987  [15]
 LDCM0390  CL12 HEK-293T C89(0.79)  LDD0988  [15]
 LDCM0391  CL120 HEK-293T C89(0.97)  LDD0989  [15]
 LDCM0392  CL121 HEK-293T C89(0.91)  LDD0990  [15]
 LDCM0393  CL122 HEK-293T C89(1.11)  LDD0991  [15]
 LDCM0394  CL123 HEK-293T C89(0.65)  LDD0992  [15]
 LDCM0395  CL124 HEK-293T C89(1.33)  LDD0993  [15]
 LDCM0396  CL125 HEK-293T C89(1.01)  LDD0994  [15]
 LDCM0397  CL126 HEK-293T C89(0.97)  LDD0995  [15]
 LDCM0398  CL127 HEK-293T C89(1.16)  LDD0996  [15]
 LDCM0399  CL128 HEK-293T C89(1.26)  LDD0997  [15]
 LDCM0400  CL13 HEK-293T C89(0.91)  LDD0998  [15]
 LDCM0401  CL14 HEK-293T C89(0.68)  LDD0999  [15]
 LDCM0402  CL15 HEK-293T C89(0.84)  LDD1000  [15]
 LDCM0403  CL16 HEK-293T C89(0.86)  LDD1001  [15]
 LDCM0404  CL17 HEK-293T C89(0.93)  LDD1002  [15]
 LDCM0405  CL18 HEK-293T C89(0.88)  LDD1003  [15]
 LDCM0406  CL19 HEK-293T C89(1.06)  LDD1004  [15]
 LDCM0407  CL2 HEK-293T C89(0.93)  LDD1005  [15]
 LDCM0408  CL20 HEK-293T C89(0.91)  LDD1006  [15]
 LDCM0409  CL21 HEK-293T C89(1.06)  LDD1007  [15]
 LDCM0410  CL22 HEK-293T C89(0.90)  LDD1008  [15]
 LDCM0411  CL23 HEK-293T C89(0.90)  LDD1009  [15]
 LDCM0412  CL24 HEK-293T C89(0.80)  LDD1010  [15]
 LDCM0413  CL25 HEK-293T C89(0.95)  LDD1011  [15]
 LDCM0414  CL26 HEK-293T C89(0.92)  LDD1012  [15]
 LDCM0415  CL27 HEK-293T C89(0.96)  LDD1013  [15]
 LDCM0416  CL28 HEK-293T C89(0.93)  LDD1014  [15]
 LDCM0417  CL29 HEK-293T C89(0.97)  LDD1015  [15]
 LDCM0418  CL3 HEK-293T C89(0.80)  LDD1016  [15]
 LDCM0419  CL30 HEK-293T C89(1.05)  LDD1017  [15]
 LDCM0420  CL31 HCT 116 C89(0.91)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C89(0.75)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C89(0.81)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C89(0.84)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C89(0.98)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C89(0.78)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C89(0.93)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C89(0.72)  LDD0745  [15]
 LDCM0429  CL4 HEK-293T C89(0.75)  LDD1027  [15]
 LDCM0430  CL40 HCT 116 C89(0.79)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C89(0.99)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C89(0.77)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C89(0.78)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C89(0.76)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C89(0.69)  LDD0752  [15]
 LDCM0436  CL46 HEK-293T C89(0.80)  LDD1034  [15]
 LDCM0437  CL47 HEK-293T C89(0.79)  LDD1035  [15]
 LDCM0438  CL48 HEK-293T C89(0.78)  LDD1036  [15]
 LDCM0439  CL49 HEK-293T C89(0.97)  LDD1037  [15]
 LDCM0440  CL5 HEK-293T C89(1.02)  LDD1038  [15]
 LDCM0441  CL50 HEK-293T C89(1.13)  LDD1039  [15]
 LDCM0442  CL51 HEK-293T C89(0.96)  LDD1040  [15]
 LDCM0443  CL52 HEK-293T C89(1.14)  LDD1041  [15]
 LDCM0444  CL53 HEK-293T C89(1.07)  LDD1042  [15]
 LDCM0445  CL54 HEK-293T C89(0.90)  LDD1043  [15]
 LDCM0446  CL55 HEK-293T C89(0.92)  LDD1044  [15]
 LDCM0447  CL56 HEK-293T C89(0.91)  LDD1045  [15]
 LDCM0448  CL57 HEK-293T C89(0.99)  LDD1046  [15]
 LDCM0449  CL58 HEK-293T C89(1.04)  LDD1047  [15]
 LDCM0450  CL59 HEK-293T C89(0.92)  LDD1048  [15]
 LDCM0451  CL6 HEK-293T C89(0.87)  LDD1049  [15]
 LDCM0452  CL60 HEK-293T C89(0.93)  LDD1050  [15]
 LDCM0453  CL61 HEK-293T C89(0.80)  LDD1051  [15]
 LDCM0454  CL62 HEK-293T C89(0.83)  LDD1052  [15]
 LDCM0455  CL63 HEK-293T C89(0.84)  LDD1053  [15]
 LDCM0456  CL64 HEK-293T C89(0.90)  LDD1054  [15]
 LDCM0457  CL65 HEK-293T C89(1.07)  LDD1055  [15]
 LDCM0458  CL66 HEK-293T C89(1.10)  LDD1056  [15]
 LDCM0459  CL67 HEK-293T C89(1.16)  LDD1057  [15]
 LDCM0460  CL68 HEK-293T C89(0.99)  LDD1058  [15]
 LDCM0461  CL69 HEK-293T C89(1.33)  LDD1059  [15]
 LDCM0462  CL7 HEK-293T C89(0.90)  LDD1060  [15]
 LDCM0463  CL70 HEK-293T C89(1.04)  LDD1061  [15]
 LDCM0464  CL71 HEK-293T C89(0.94)  LDD1062  [15]
 LDCM0465  CL72 HEK-293T C89(0.98)  LDD1063  [15]
 LDCM0466  CL73 HEK-293T C89(1.03)  LDD1064  [15]
 LDCM0467  CL74 HEK-293T C89(1.10)  LDD1065  [15]
 LDCM0469  CL76 HCT 116 C89(1.29)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C89(1.37)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C89(1.08)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C89(1.18)  LDD0789  [15]
 LDCM0473  CL8 HEK-293T C89(1.05)  LDD1071  [15]
 LDCM0474  CL80 HCT 116 C89(0.99)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C89(0.96)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C89(1.22)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C89(1.24)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C89(1.07)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C89(1.20)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C89(1.53)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C89(1.19)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C89(1.44)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C89(1.23)  LDD0800  [15]
 LDCM0484  CL9 HEK-293T C89(1.19)  LDD1082  [15]
 LDCM0485  CL90 HCT 116 C89(1.29)  LDD0802  [15]
 LDCM0486  CL91 HEK-293T C264(0.65); C89(0.98)  LDD1084  [15]
 LDCM0487  CL92 HEK-293T C264(0.83); C89(1.01)  LDD1085  [15]
 LDCM0488  CL93 HEK-293T C264(0.89); C89(0.97)  LDD1086  [15]
 LDCM0489  CL94 HEK-293T C264(1.13); C89(0.93)  LDD1087  [15]
 LDCM0490  CL95 HEK-293T C264(0.67); C89(0.97)  LDD1088  [15]
 LDCM0491  CL96 HEK-293T C264(0.75); C89(0.92)  LDD1089  [15]
 LDCM0492  CL97 HEK-293T C264(0.84); C89(0.94)  LDD1090  [15]
 LDCM0493  CL98 HEK-293T C264(0.81); C89(1.01)  LDD1091  [15]
 LDCM0494  CL99 HEK-293T C264(0.95); C89(1.04)  LDD1092  [15]
 LDCM0495  E2913 HEK-293T C89(0.80); C34(1.16); C264(0.92); C154(1.05)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C148(2.39)  LDD1702  [3]
 LDCM0625  F8 Ramos C63(0.83)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C63(0.92)  LDD2189  [17]
 LDCM0574  Fragment12 Ramos C63(0.82)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C63(0.86)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C63(0.78)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C63(0.66)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C63(0.80)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C63(0.97)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C63(1.01)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C63(0.48)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C63(1.04)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C63(1.01)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C63(1.14)  LDD2201  [17]
 LDCM0468  Fragment33 HEK-293T C89(1.00)  LDD1066  [15]
 LDCM0596  Fragment38 Ramos C63(0.97)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C63(1.13)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C89(1.30)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C63(1.04)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C63(1.14)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C63(1.04)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C63(1.04)  LDD2188  [17]
 LDCM0022  KB02 HEK-293T C34(1.11); C264(1.19); C154(1.18); C63(1.09)  LDD1492  [16]
 LDCM0023  KB03 Jurkat C63(57.73)  LDD0209  [5]
 LDCM0024  KB05 G361 C154(1.54)  LDD3311  [18]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C241(1.03)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C241(1.03)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C241(1.48)  LDD2094  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C241(0.85)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C241(1.02)  LDD2099  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C241(1.31)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C241(0.67)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C241(0.77)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C241(0.88)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C241(0.86); C148(0.79)  LDD2111  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C241(0.66)  LDD2116  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C241(0.60)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C241(0.74)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C241(0.54); C148(1.48)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C241(0.97)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C241(0.89)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C148(0.45)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C264(0.88)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C241(1.17)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C241(1.01); C148(1.33)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C241(0.85); C148(0.75)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C241(2.35)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C241(0.77)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C241(1.79)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C241(0.71)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C148(0.53)  LDD2148  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C241(0.74)  LDD2149  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C241(0.59)  LDD2150  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Ribonuclease P protein subunit p14 (RPP14) Eukaryotic/archaeal RNase P protein component 2 family O95059
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-7 (KPNA6) Importin alpha family O60684
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-D10 (HOXD10) Abd-B homeobox family P28358
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Homeobox protein MOX-1 (MEOX1) . P50221
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Small nuclear ribonucleoprotein F (SNRPF) SnRNP Sm proteins family P62306

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840