Details of the Target

General Information of Target

Target ID LDTP00448
Target Name Tetraspanin-4 (TSPAN4)
Gene Name TSPAN4
Gene ID 7106
Synonyms
NAG2; TM4SF7; Tetraspanin-4; Tspan-4; Novel antigen 2; NAG-2; Transmembrane 4 superfamily member 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATLSSSFPSLSAANLLIIT
GAFVMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKIDRYAQQDLK
KGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSESCGLH
APGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQVVKADTYCA
Target Bioclass
Other
Family
Tetraspanin (TM4SF) family
Subcellular location
Membrane
Uniprot ID
O14817
Ensemble ID
ENST00000397397.7
HGNC ID
HGNC:11859

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C190(0.70)  LDD2089  [1]
IA-alkyne
 Probe Info  		C5(2.36)  LDD2183  [2]
IPM
 Probe Info  		C190(19.55)  LDD1701  [1]
DBIA
 Probe Info  		C190(1.23)  LDD0531  [3]
WYneO
 Probe Info  		N.A.  LDD0022  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C190(1.86)  LDD2112  [1]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C190(0.63)  LDD2117  [1]
 LDCM0214  AC1 HCT 116 C190(1.23)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C190(1.17)  LDD0532  [3]
 LDCM0216  AC100 PaTu 8988t C190(1.03)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C190(1.02)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C190(0.97)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C190(1.35)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C190(1.20)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C190(1.00)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C190(1.17)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C190(0.98)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C190(1.78)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C190(1.13)  LDD1104  [3]
 LDCM0226  AC11 HCT 116 C190(1.22)  LDD0543  [3]
 LDCM0227  AC110 PaTu 8988t C190(1.12)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C190(1.09)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C190(0.99)  LDD1108  [3]
 LDCM0230  AC113 PaTu 8988t C170(0.92); C177(0.92); C190(0.93)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C170(0.95); C177(0.95); C190(1.03)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C170(1.09); C177(1.09); C190(1.08)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C170(0.90); C177(0.90); C190(1.14)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C170(0.94); C177(0.94); C190(1.39)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C170(0.97); C177(0.97); C190(1.05)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C170(1.05); C177(1.05); C190(1.09)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C190(1.07)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C170(1.02); C177(1.02); C190(0.95)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C170(0.97); C177(0.97); C190(1.25)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C170(0.92); C177(0.92); C190(0.92)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C170(1.01); C177(1.01); C190(0.83)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C170(0.97); C177(0.97); C190(1.02)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C170(0.90); C177(0.90); C190(0.92)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C170(0.91); C177(0.91); C190(0.96)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C170(1.06); C177(1.06); C190(1.11)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C169(1.05); C177(1.05); C190(1.32)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C169(0.87); C177(0.87); C190(1.25)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C169(1.02); C177(1.02); C190(1.30)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C169(0.98); C177(0.98); C190(0.92)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C169(0.93); C177(0.93); C190(0.89)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C169(1.01); C177(1.01); C190(1.00)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C169(1.02); C177(1.02); C190(1.03)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C169(1.20); C177(1.20); C190(1.10)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C169(1.03); C177(1.03); C190(1.25)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C169(0.91); C177(0.91); C190(1.15)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C169(1.09); C177(1.09); C190(1.34)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C169(1.03); C177(1.03); C190(1.19)  LDD1137  [3]
 LDCM0259  AC14 HCT 116 C190(1.22)  LDD0576  [3]
 LDCM0260  AC140 PaTu 8988t C169(1.00); C177(1.00); C190(1.13)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C169(0.87); C177(0.87); C190(1.09)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C169(0.94); C177(0.94); C190(1.20)  LDD1141  [3]
 LDCM0263  AC143 PaTu 8988t C170(1.21); C169(1.11); C177(1.16); C190(1.08)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C170(0.98); C169(1.11); C177(1.04); C190(0.89)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C170(1.31); C169(1.13); C177(1.22); C190(1.11)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C170(0.91); C169(1.12); C177(1.02); C190(1.00)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C170(1.12); C169(1.11); C177(1.11); C190(1.11)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C170(1.36); C169(1.23); C177(1.30); C190(1.13)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C170(1.23); C169(1.23); C177(1.23); C190(1.37)  LDD1148  [3]
 LDCM0270  AC15 HCT 116 C190(1.08)  LDD0587  [3]
 LDCM0271  AC150 PaTu 8988t C170(0.97); C169(1.06); C177(1.02); C190(1.09)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C170(0.96); C169(0.81); C177(0.88); C190(1.22)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C170(0.99); C169(0.93); C177(0.96); C190(1.09)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C170(1.21); C169(1.03); C177(1.12); C190(1.25)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C170(1.25); C169(1.17); C177(1.21); C190(1.29)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C170(1.03); C169(1.04); C177(1.04); C190(1.08)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C170(1.07); C169(0.86); C177(0.96); C190(1.20)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C170(1.03); C169(1.01); C177(1.02); C190(1.16)  LDD2169  [3]
 LDCM0276  AC17 HCT 116 C190(1.09)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C190(1.28)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C190(1.05)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C190(1.21)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C190(1.07)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C190(1.05)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C190(1.12)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C190(1.42)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C190(1.00)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C190(1.21)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C190(1.19)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C190(1.35)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C190(1.38)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C190(1.27)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C190(1.28)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C190(1.29)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C190(1.31)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C190(1.32)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C190(1.19)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C190(1.28)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C190(0.90)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C190(0.89)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C190(0.78)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C190(1.02)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C190(1.00)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C190(1.19)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C190(1.46)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C190(0.90)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C190(1.15)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C190(1.04)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C190(1.15)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C190(1.13)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C190(1.13)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C190(1.56)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C190(0.95)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C190(1.45)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C190(1.34)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C190(1.27)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C190(1.01)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C190(1.14)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C190(1.11)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C190(1.19)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C190(1.08)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C190(1.15)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C190(0.93)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C190(0.88)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C190(1.06)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C190(1.11)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C190(1.08)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C190(1.02)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C190(1.20)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C190(1.01)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C190(1.18)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C190(1.58)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C190(1.47)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C190(1.31)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C190(1.37)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C190(1.19)  LDD0662  [3]
 LDCM0349  AC83 PaTu 8988t C190(1.08)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C190(1.02)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C190(0.93)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C190(1.10)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C190(1.14)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C190(0.92)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C190(1.08)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C190(0.95)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C190(1.01)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C190(1.04)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C190(1.08)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C190(0.97)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C190(0.92)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C190(0.99)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C190(1.10)  LDD1243  [3]
 LDCM0365  AC98 PaTu 8988t C190(1.18)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C190(1.05)  LDD1245  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C190(1.18)  LDD2113  [1]
 LDCM0248  AKOS034007472 HCT 116 C190(1.27)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C190(1.12)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C190(1.40)  LDD0592  [3]
 LDCM0367  CL1 PaTu 8988t C169(0.87); C177(0.87)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C169(0.82); C177(0.82)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C190(1.45)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C190(1.34)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C190(1.20)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C190(1.51)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C190(1.33)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C190(1.31)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C190(1.33)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C190(1.36)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C190(1.77)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C190(1.38)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C169(1.01); C177(1.01)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C190(1.65)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C190(1.54)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C190(1.32)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C190(1.26)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C190(1.50)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C190(1.45)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C190(1.24)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C190(1.56)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C190(1.10)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C190(0.98)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C169(0.98); C177(0.98)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C190(0.95)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C190(1.09)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C190(1.16)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C190(1.80)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C190(1.50)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C190(0.98)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C190(1.12)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C190(1.08)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C190(1.18)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C169(0.72); C177(0.72)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C169(0.78); C177(0.78)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C169(1.20); C177(1.20)  LDD1281  [3]
 LDCM0403  CL16 HCT 116 C190(1.15)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C190(1.20)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C190(1.00)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C190(1.06)  LDD0723  [3]
 LDCM0407  CL2 PaTu 8988t C169(0.86); C177(0.86)  LDD1286  [3]
 LDCM0408  CL20 HCT 116 C190(1.03)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C190(1.24)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C190(1.31)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C190(0.94)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C190(1.09)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C190(1.35)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C190(1.03)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C190(1.06)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C190(1.07)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C190(1.02)  LDD0734  [3]
 LDCM0418  CL3 PaTu 8988t C169(0.73); C177(0.73)  LDD1297  [3]
 LDCM0419  CL30 HCT 116 C190(0.90)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C190(1.16)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C190(1.28)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C190(1.39)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C190(1.31)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C190(1.24)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C190(1.72)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C190(1.29)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C190(1.33)  LDD0745  [3]
 LDCM0429  CL4 PaTu 8988t C169(0.86); C177(0.86)  LDD1308  [3]
 LDCM0430  CL40 HCT 116 C190(1.27)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C190(1.09)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C190(1.49)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C190(1.16)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C190(0.98)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C190(1.26)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C190(0.96)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C190(1.31)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C190(1.13)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C190(1.16)  LDD0756  [3]
 LDCM0440  CL5 PaTu 8988t C169(0.71); C177(0.71)  LDD1319  [3]
 LDCM0441  CL50 HCT 116 C190(1.01)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C190(0.95)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C190(1.08)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C190(1.03)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C190(1.31)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C190(0.81)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C190(1.18)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C190(1.22)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C190(0.84)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C190(1.20)  LDD0767  [3]
 LDCM0451  CL6 PaTu 8988t C169(0.77); C177(0.77)  LDD1330  [3]
 LDCM0452  CL60 HCT 116 C190(1.28)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C190(1.13)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C190(1.34)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C190(1.43)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C190(1.59)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C190(1.16)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C190(1.50)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C190(1.31)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C190(1.44)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C190(1.21)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C169(0.73); C177(0.73)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C190(1.21)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C190(1.44)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C190(1.10)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C190(1.28)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C190(1.23)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C190(1.02)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C190(1.01)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C190(0.92)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C190(1.11)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C169(0.74); C177(0.74)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C190(0.96)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C190(1.06)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C190(1.14)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C190(1.24)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C190(1.36)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C190(1.12)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C190(1.03)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C190(1.23)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C190(0.97)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C190(1.18)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C169(0.81); C177(0.81)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C190(1.29)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C190(1.21)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C190(1.43)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C190(1.42)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C190(1.55)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C190(1.36)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C190(1.33)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C190(1.60)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C190(1.71)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C190(1.34)  LDD0811  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C190(16.41)  LDD1702  [1]
 LDCM0625  F8 Ramos C5(0.93)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C5(2.62)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C5(2.10)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C5(5.13)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C5(0.97)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C5(2.09)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C5(2.79)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C5(1.51)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C5(0.89)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C5(1.64)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C5(2.08)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C5(1.78)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C5(1.42)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C5(4.25)  LDD2201  [2]
 LDCM0468  Fragment33 HCT 116 C190(1.31)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C5(4.79)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C5(1.46)  LDD2184  [2]
 LDCM0427  Fragment51 HCT 116 C190(1.33)  LDD0744  [3]
 LDCM0614  Fragment56 Ramos C5(0.57)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C5(3.01)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C5(4.12)  LDD2188  [2]
 LDCM0022  KB02 769-P C190(3.31)  LDD2246  [5]
 LDCM0023  KB03 MDA-MB-231 C190(19.55)  LDD1701  [1]
 LDCM0024  KB05 OAW-28 C190(4.22)  LDD3368  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C190(0.93)  LDD2102  [1]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C190(0.70)  LDD2089  [1]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C190(1.38)  LDD2090  [1]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C190(0.73)  LDD2097  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C190(0.95)  LDD2099  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C190(2.41)  LDD2100  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C190(2.30)  LDD2104  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C190(0.86)  LDD2105  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C190(1.56)  LDD2106  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C190(1.01)  LDD2107  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C190(0.66)  LDD2109  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C190(1.14)  LDD2111  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C190(1.38)  LDD2114  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C190(0.92)  LDD2123  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C190(0.76)  LDD2125  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C190(0.88)  LDD2127  [1]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C190(1.06)  LDD2133  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C190(0.46)  LDD2134  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C190(1.02)  LDD2135  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C190(0.98)  LDD2136  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C190(0.74)  LDD2137  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C190(1.07)  LDD2140  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C190(1.40)  LDD2141  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C190(0.64)  LDD2146  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C190(0.75)  LDD2148  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sphingosine-1-phosphate lyase 1 (SGPL1) Group II decarboxylase family O95470
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Protein eva-1 homolog A (EVA1A) EVA1 family Q9H8M9
MyoD family inhibitor (MDFI) MDFI family Q99750
Phospholipid scramblase 4 (PLSCR4) Phospholipid scramblase family Q9NRQ2
Transmembrane protein 106A (TMEM106A) TMEM106 family Q96A25
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Nuclear receptor subfamily 4 group A member 3 (NR4A3) Nuclear hormone receptor family Q92570
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chordin (CHRD) Chordin family Q9H2X0
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Progranulin (GRN) Granulin family P28799
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Keratin-associated protein 4-5 (KRTAP4-5) KRTAP type 4 family Q9BYR2
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Late cornified envelope protein 1A (LCE1A) LCE family Q5T7P2
Late cornified envelope protein 2B (LCE2B) LCE family O14633
Late cornified envelope protein 2D (LCE2D) LCE family Q5TA82
Late cornified envelope protein 3A (LCE3A) LCE family Q5TA76
Late cornified envelope protein 3C (LCE3C) LCE family Q5T5A8
Late cornified envelope protein 3D (LCE3D) LCE family Q9BYE3
Late cornified envelope protein 4A (LCE4A) LCE family Q5TA78
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Tektin-4 (TEKT4) Tektin family Q8WW24
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Leucine-rich repeat-containing protein 25 (LRRC25) . Q8N386

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840