Details of the Target

General Information of Target

Target ID LDTP00248
Target Name NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2)
Gene Name WWP2
Gene ID 11060
Synonyms
NEDD4-like E3 ubiquitin-protein ligase WWP2; EC 2.3.2.26; Atrophin-1-interacting protein 2; AIP2; HECT-type E3 ubiquitin transferase WWP2; WW domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI
GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT
LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ
PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT
TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD
ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQR
PTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRV
YYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFE
SGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDL
RRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPD
HLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE
NNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQ
TKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFW
QVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFN
RLDLPPYKSYEQLREKLLYAIEETEGFGQE
Target Type
Literature-reported
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
TTD ID
T73502
Uniprot ID
O00308
DrugMap ID
TTO0DKT
Ensemble ID
ENST00000356003.6
HGNC ID
HGNC:16804

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G135R .
FTC133 SNV: p.D648N .
HCT116 SNV: p.P599L DBIA    Probe Info 
MEWO SNV: p.Q530Ter .
MFE319 SNV: p.D320N DBIA    Probe Info 
MOLT4 SNV: p.A594T IA-alkyne    Probe Info 
PC14 SNV: p.G344A .
PC9 SNV: p.G344A .
SKMEL28 SNV: p.P537S DBIA    Probe Info 
YSCCC SNV: p.Q78H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K17(7.14)  LDD0277  [1]
Probe 1
 Probe Info  		Y556(18.76)  LDD3495  [2]
HHS-475
 Probe Info  		Y347(0.83)  LDD0264  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C186(0.79)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C802(0.00); C838(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C802(0.00); C838(0.00)  LDD0036  [6]
IPM
 Probe Info  		C838(0.00); C186(0.00)  LDD0147  [7]
TFBX
 Probe Info  		C186(0.00); C802(0.00); C506(0.00)  LDD0148  [7]
W1
 Probe Info  		C838(0.00); C802(0.00)  LDD0236  [8]
NAIA_5
 Probe Info  		C802(0.00); C838(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		N.A.  LDD2240  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C838(2.18)  LDD0372  [11]
 LDCM0214  AC1 HCT 116 C186(0.79)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C186(0.97)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C186(1.01)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C186(1.10)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C186(1.10)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C186(1.38)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C186(1.24)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C186(1.19)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C186(1.23)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C186(1.16)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C186(0.99)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C186(0.88)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C186(0.89)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C186(0.97)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C186(0.98)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C186(1.18)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C186(0.92)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C186(0.86)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C186(0.88)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C186(1.09)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C186(0.86)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C186(0.86)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C186(0.91)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C186(0.95)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C186(1.00)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C186(0.83)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C186(0.90)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C186(0.97)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C186(0.87)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C186(0.91)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C186(0.88)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C186(0.85)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C186(1.04)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C186(0.83)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C186(0.98)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C186(0.89)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C186(0.88)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C186(0.93)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C186(1.16)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C186(1.04)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C186(0.99)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C186(0.91)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C186(1.05)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C186(1.00)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C186(0.95)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C186(1.15)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C186(1.10)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C186(0.92)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C186(1.15)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C186(1.37)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C186(1.16)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C186(1.25)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C186(1.34)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C186(1.52)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C186(1.39)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C186(0.96)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C186(1.10)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C186(1.17)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C186(1.40)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C186(1.68)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C186(1.30)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C186(1.24)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C186(1.11)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C186(1.08)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C186(1.08)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C186(1.49)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C186(1.10)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C186(0.93)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C186(1.03)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C186(1.13)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C186(1.01)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C186(1.07)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C186(0.96)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C186(1.02)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C186(1.11)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C186(1.17)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C186(1.19)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C186(1.33)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C186(0.82)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C186(1.26)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C186(1.07)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C186(1.31)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C186(1.26)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C186(1.47)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C186(0.88)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C186(0.93)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C186(0.89)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C186(0.96)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C186(0.99)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C186(0.77)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C186(1.18)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C186(0.97)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C186(1.10)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C186(1.01)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C186(1.06)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C186(1.17)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C186(1.06)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C186(0.99)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C186(0.95)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C186(1.36)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C186(0.80)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C186(1.30)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C186(0.89)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C186(1.02)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C186(1.33)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C186(1.21)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C186(1.31)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C186(1.76)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C186(1.25)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C186(1.45)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C186(1.45)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C186(1.00)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C186(1.36)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C186(1.22)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C186(1.35)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C186(1.27)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C186(1.35)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C186(1.18)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C186(1.24)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C186(1.34)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C186(1.13)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C186(1.17)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C186(0.97)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C186(1.25)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C186(1.06)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C186(1.23)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C186(1.52)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C186(1.42)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C186(1.69)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C186(1.17)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C186(1.29)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C186(1.11)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C186(1.15)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C186(1.07)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C186(1.19)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C186(1.15)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C186(1.78)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C186(0.92)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C186(1.03)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C186(1.03)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C186(0.99)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C186(0.93)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C186(0.89)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C186(0.93)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C186(0.92)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C186(0.96)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C186(0.94)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C186(0.92)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C186(0.93)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C186(0.95)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C186(1.01)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C186(1.17)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C186(1.62)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C186(0.98)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C186(0.99)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C186(1.00)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C186(1.06)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HCT 116 C186(1.07)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C186(1.17)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C186(0.90)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C186(1.04)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C186(1.08)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C186(0.87)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C186(0.97)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C186(1.25)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C186(1.50)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C186(1.35)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C186(1.52)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C186(1.26)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C186(1.34)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C186(1.38)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C186(1.28)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C186(1.10)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C186(1.27)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C186(1.32)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C186(1.33)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C186(1.20)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C186(1.50)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C186(1.03)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C186(1.06)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C186(1.57)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C186(0.98)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C186(1.08)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C186(1.24)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C186(1.39)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C186(1.37)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C186(0.99)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C186(1.08)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C186(1.05)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C186(1.27)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C186(1.12)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C186(1.15)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C186(1.18)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C186(1.13)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C186(1.23)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C186(1.18)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C186(1.23)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C186(1.03)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C186(1.40)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C186(1.65)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C186(1.96)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C186(1.28)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C186(1.47)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C186(1.46)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C186(1.20)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C186(1.20)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C186(1.32)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C186(1.28)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C186(0.98)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C186(1.08)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C186(0.93)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C186(1.05)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C186(1.17)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C186(1.03)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C186(1.11)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C186(1.08)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C186(1.12)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C186(1.08)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C186(1.15)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C186(1.28)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C186(1.11)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C186(1.03)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C186(1.04)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C186(1.04)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C186(0.96)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C186(0.93)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C186(0.86)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C186(0.82)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C186(0.89)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C186(1.04)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C186(0.89)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C186(0.97)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C186(0.98)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C186(1.04)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C186(0.92)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C186(0.89)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C186(0.87)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C186(0.92)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C186(0.88)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C186(0.93)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C186(1.14)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C186(0.87)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C186(0.98)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C186(1.04)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C186(1.19)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C186(1.24)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C186(1.01)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C186(1.23)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C186(1.36)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C186(1.14)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C186(1.19)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C186(1.22)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C186(1.20)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C186(1.14)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C186(1.06)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C186(1.23)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C186(1.37)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C186(1.06)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C186(1.29)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C186(1.10)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C186(1.26)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C186(1.67)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C186(1.12)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C186(1.17)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C186(1.34)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C186(1.40)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C186(1.71)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C186(1.13)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C186(1.04)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C186(1.18)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C186(1.47)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C186(1.67)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C186(1.15)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C186(1.00)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C186(0.91)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C186(0.99)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C186(0.84)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C186(0.81)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C186(0.86)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C186(0.81)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C186(0.89)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C186(0.94)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C186(0.88)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C666(0.97)  LDD1698  [12]
 LDCM0625  F8 Ramos C186(1.01)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C186(0.37)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C186(0.51)  LDD2191  [13]
 LDCM0576  Fragment14 Ramos C186(0.95)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C186(0.35)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C186(0.56)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C186(0.39)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C186(0.32)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C186(0.71)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C186(0.59)  LDD2199  [13]
 LDCM0468  Fragment33 HCT 116 C186(1.26)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C186(0.52)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C186(0.89)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C186(2.31)  LDD0744  [5]
 LDCM0614  Fragment56 Ramos C186(0.25)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C186(3.23)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C186(0.45)  LDD2188  [13]
 LDCM0116  HHS-0101 DM93 Y347(0.83)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y347(0.59)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y347(2.28)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y347(0.53)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y347(0.49)  LDD0268  [3]
 LDCM0022  KB02 HEK-293T C186(0.96)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C186(1.03)  LDD1497  [12]
 LDCM0024  KB05 MOLM-13 C70(2.58)  LDD3333  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal ATPase PEX1 (PEX1) AAA ATPase family O43933
Arrestin domain-containing protein 1 (ARRDC1) Arrestin family Q8N5I2
Beta-hexosaminidase subunit beta (HEXB) Glycosyl hydrolase 20 family P07686
Cathepsin D (CTSD) Peptidase A1 family P07339
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Dexamethasone-induced Ras-related protein 1 (RASD1) RasD family Q9Y272
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Ubiquitin-like modifier-activating enzyme 1 (UBA1) Ubiquitin-activating E1 family P22314
Ubiquitin-conjugating enzyme E2 E2 (UBE2E2) Ubiquitin-conjugating enzyme family Q96LR5
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
Double-stranded RNA-specific editase 1 (ADARB1) . P78563
Tripeptidyl-peptidase 1 (TPP1) . O14773
Ubiquitin domain-containing protein 1 (UBTD1) . Q9HAC8
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Alpha-synuclein (SNCA) Synuclein family P37840
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) . Q9NWW5
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) . Q15599
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 2 (SMAD2) Dwarfin/SMAD family Q15796
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
Mothers against decapentaplegic homolog 7 (SMAD7) Dwarfin/SMAD family O15105
POU domain, class 5, transcription factor 1 (POU5F1) POU transcription factor family Q01860
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204
Endosomal transmembrane epsin interactor 1 (ENTREP1) ENTREP family Q15884
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Submaxillary gland androgen-regulated protein 3A (SMR3A) PROL1/PROL3 family Q99954
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
T-complex protein 1 subunit epsilon (CCT5) TCP-1 chaperonin family P48643
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
WAS/WASL-interacting protein family member 1 (WIPF1) Verprolin family O43516
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Galectin-9B (LGALS9B) . Q3B8N2
Gametogenetin (GGN) . Q86UU5
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) . Q9BUJ2
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
RING finger protein 11 (RNF11) . Q9Y3C5
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (ANKRD44) . Q8N8A2
TAR DNA-binding protein 43 (TARDBP) . Q13148

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 103669 Antisense drug D02LZA
Isis 103671 Antisense drug D0M4LN
Isis 103701 Antisense drug D08CYT
Isis 103708 Antisense drug D07WFF
Isis 103736 Antisense drug D0F5YL
Isis 103747 Antisense drug D0J2ZI
Isis 103752 Antisense drug D0DR3J
Isis 103771 Antisense drug D08CQR
Isis 103803 Antisense drug D04WJM
Isis 103806 Antisense drug D03IWY
Isis 103819 Antisense drug D0F8GZ

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840