Details of the Target

General Information of Target

Target ID LDTP17791
Target Name Maestro heat-like repeat-containing protein family member 1 (MROH1)
Gene Name MROH1
Gene ID 727957
Synonyms
HEATR7A; KIAA1833; Maestro heat-like repeat-containing protein family member 1; HEAT repeat-containing protein 7A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYIKSNLELYQQYTAMAPKLLARISKLLMICQNAGISVPKGIRNIFEFTWEELISDPSV
PTPSDILGLEVSFGAPLVVLMEPTFVQVPTLKKPLPPPPPAPPRPVLLATTGAAKRSTLS
PTMARQVRTHQETLNRFQQQSIHLLTELLRLKMKAMVESMSVGANPLDITRRFVEASQLL
HLNAKEMAFNCLISTAGRSGYSSGQLWKESLANMSAIGVNSPYQLIYHSSTACLSFSLSA
GKEAKKKIGKSRTTEDVSMPPLHRGVGTPANSLEFSDPCPEAREKLQELCRHIEAERATW
KGRNISYPMILRNYKAKMPSHLMLARKGDSQTPGLHYPPTAGAQTLSPTSHPSSANHHFS
QHCQEGKAPKKAFKFHYTFYDGSSFVYYPSGNVAVCQIPTCCRGRTITCLFNDIPGFSLL
ALFNTEGQGCVHYNLKTSCPYVLILDEEGGTTNDQQGYVVHKWSWTSRTETLLSLEYKVN
EEMKLKVLGQDSITVTFTSLNETVTLTVSANNCPHGMAYDKRLNRRISNMDDKVYKMSRA
LAEIKKRFQKTVTQFINSILLAAGLFTIEYPTKKEEEEFVRFKMRSRTHPERLPKLSLYS
GESLLRSQSGHLESSIAETLKDEPESAPVSPVRKTTKIHTKAKVTSRGKAREGRSPTRWA
ALPSDCPLVLRKLMLKEDTRAGCKCLVKAPLVSDVELERFLLAPRDPSQVLVFGIISSQN
YTSTGQLQWLLNTLYNHQQRGRGSPCIQCRYDSYRLLQYDLDSPLQEDPPLMVKKNSVVQ
GMILMFAGGKLIFGGRVLNGYGLSKQNLLKQIFRSQQDYKMGYFLPDDYKFSVPNSVLSL
EDSESVKKAESEDIQGSSSSLALEDYVEKELSLEAEKTREPEVELHPLSRDSKITSWKKQ
ASKK
Target Bioclass
Other
Uniprot ID
Q8NDA8
Ensemble ID
ENST00000326134.10
HGNC ID
HGNC:26958

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.T847A DBIA    Probe Info 
GB1 SNV: p.M1076V .
HCT116 Deletion: p.E884del DBIA    Probe Info 
HUPT4 SNV: p.H1025P .
JEKO1 SNV: p.H1025P .
JVM3 SNV: p.H1025P .
KASUMI2 SNV: p.L492H .
LS180 SNV: p.A944T .
MOLT4 SNV: p.R496C .
NALM6 SNV: p.M1207L .
NCIH1155 SNV: p.L1184V .
NCIH1650 SNV: p.H375Q DBIA    Probe Info 
NCIH1944 SNV: p.P320L .
NCIH2172 SNV: p.V113F .
NCIH358 SNV: p.E260G DBIA    Probe Info 
OVCAR8 SNV: p.E128D; p.E448V .
OVISE SNV: p.A1128T .
OVK18 SNV: p.H1025P .
RKO Deletion: p.E901del DBIA    Probe Info 
RL952 SNV: p.F156L .
SNU5 SNV: p.E260G .
TE11 SNV: p.A1128T .
THP1 SNV: p.R955C .
TOV21G SNV: p.G427V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K275(10.00); K276(0.84); K514(10.00); K667(7.54)  LDD0277  [1]
BTD
 Probe Info  		C1263(1.03)  LDD2111  [2]
DBIA
 Probe Info  		C1376(287.34)  LDD0209  [3]
IA-alkyne
 Probe Info  		C1233(6.39)  LDD1703  [4]
IPM
 Probe Info  		C651(1.00); C1394(0.28)  LDD1701  [2]
NAIA_4
 Probe Info  		C1329(0.00); C1394(0.00)  LDD2226  [5]
NAIA_5
 Probe Info  		C1079(0.00); C1394(0.00); C743(0.00); C1329(0.00)  LDD2224  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1394(1.39); C1521(1.04); C1527(1.04)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C338(0.94); C344(0.94); C1394(1.14); C1521(0.75)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C505(0.57); C888(0.93)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C505(0.66); C888(1.09)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C505(0.58); C888(1.59)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C505(0.49); C888(1.53)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C505(0.70); C888(0.99)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C505(0.69); C888(1.24)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C505(0.49); C888(1.04)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C505(0.83); C888(0.96)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C505(0.56); C888(1.05)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C505(0.53); C888(1.10)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C338(0.91); C344(0.91); C1394(1.03); C1521(0.76)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C505(0.46); C888(1.39)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C505(0.54); C888(1.11)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C505(0.78); C888(0.81)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C338(0.88); C344(0.88); C1521(0.95); C1527(0.95)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C338(0.97); C344(0.97); C1521(0.76); C1527(0.76)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C338(1.06); C344(1.06); C1521(0.77); C1527(0.77)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C338(1.05); C344(1.05); C1521(0.78); C1527(0.78)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C338(1.07); C344(1.07); C1521(0.91); C1527(0.91)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C338(1.11); C344(1.11); C1521(0.91); C1527(0.91)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C338(0.93); C344(0.93); C1521(0.94); C1527(0.94)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C338(0.95); C344(0.95); C1394(1.05); C1521(0.79)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C338(1.02); C344(1.02); C1521(0.69); C1527(0.69)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C338(1.07); C344(1.07); C1521(0.86); C1527(0.86)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C338(0.89); C344(0.89); C1521(0.97); C1527(0.97)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C338(1.36); C344(1.36); C1521(1.09); C1527(1.09)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C338(1.15); C344(1.15); C1521(0.92); C1527(0.92)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C338(1.10); C344(1.10); C1521(0.81); C1527(0.81)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C338(1.29); C344(1.29); C1521(0.80); C1527(0.80)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C338(1.20); C344(1.20); C1521(0.75); C1527(0.75)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C1394(1.14); C1521(1.00); C1527(1.00)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C1394(0.78); C1521(1.02); C1527(1.02)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C1394(1.07); C1521(0.95); C1527(0.95)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C1394(0.87); C1521(1.06); C1527(1.06)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C1394(0.89); C1521(0.92); C1527(0.92)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C1394(0.95); C1521(0.93); C1527(0.93)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C1394(0.98); C1521(0.86); C1527(0.86)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C1394(1.00); C1521(0.93); C1527(0.93)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C1394(0.98); C1521(0.90); C1527(0.90)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C1394(0.99); C1521(0.97); C1527(0.97)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C1394(0.96); C1521(1.05); C1527(1.05)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C1394(1.03); C1521(0.93); C1527(0.93)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C338(1.17); C344(1.17); C1394(1.10); C1521(0.81)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C1394(1.04); C1521(0.90); C1527(0.90)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C1394(0.97); C1521(0.97); C1527(0.97)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C1394(0.84); C1521(1.01); C1527(1.01)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C338(0.93); C344(0.93); C1521(0.90); C1527(0.90)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C1521(0.97); C1527(0.97); C1394(0.98); C338(0.99)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C338(0.89); C344(0.89); C1521(0.93); C1527(0.93)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C338(0.94); C344(0.94); C1521(0.99); C1527(0.99)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C338(0.94); C344(0.94); C1394(1.10); C888(1.11)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C338(0.92); C344(0.92); C1521(1.12); C1527(1.12)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C338(0.85); C344(0.85); C1521(0.85); C1527(0.85)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C1521(0.80); C1527(0.80); C888(1.00); C338(1.04)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C338(0.85); C344(0.85); C1521(0.91); C1527(0.91)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C1521(0.85); C1527(0.85); C1394(0.99); C338(1.30)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C338(0.78); C344(0.78); C1521(0.94); C1527(0.94)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C1521(0.97); C1527(0.97); C338(1.00); C344(1.00)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C338(1.16); C344(1.16); C1394(1.14); C1521(1.60)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C338(0.98); C344(0.98); C1394(1.06); C1521(0.94)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C338(0.83); C344(0.83); C1394(0.94); C1521(1.10)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C338(1.03); C344(1.03); C1394(1.29); C1521(1.11)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C1521(0.80); C1527(0.80); C1394(0.94); C338(0.97)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C1521(0.83); C1527(0.83); C976(0.93); C338(1.08)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C1521(0.89); C1527(0.89); C791(1.04); C797(1.04)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C1521(1.08); C1527(1.08); C1394(1.64)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C1521(0.78); C1527(0.78); C791(0.90); C797(0.90)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C1521(0.77); C1527(0.77); C976(0.96); C1394(0.96)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C1521(0.82); C1527(0.82); C1394(0.89); C791(0.89)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C338(0.81); C344(0.81); C1521(0.83); C1527(0.83)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C888(0.92); C1521(0.98); C1527(0.98); C1394(1.01)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C505(0.63); C1394(0.98); C1521(1.03); C1527(1.03)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C505(0.76); C1521(0.97); C1527(0.97); C888(1.08)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C505(0.73); C791(0.86); C797(0.86); C1521(0.97)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C505(0.69); C1394(1.02); C1521(1.07); C1527(1.07)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C791(0.91); C797(0.91); C1521(0.91); C1527(0.91)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C1521(1.04); C1527(1.04); C1394(1.70)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C791(0.96); C797(0.96); C1521(0.98); C1527(0.98)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C1521(1.00); C1527(1.00); C1394(1.08); C505(1.10)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C505(0.91); C1521(0.96); C1527(0.96); C791(1.15)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C505(0.75); C791(0.90); C797(0.90); C1521(0.94)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C505(0.63); C791(0.74); C797(0.74); C1521(0.90)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C338(0.67); C344(0.67); C976(0.77); C888(0.86)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C1394(0.82); C791(0.97); C797(0.97); C888(0.98)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C1394(0.83); C791(0.89); C797(0.89); C1521(0.96)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C1394(0.90); C888(1.07); C1521(1.10); C1527(1.10)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C338(0.91); C344(0.91); C1521(0.99); C1527(0.99)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C1521(1.00); C1527(1.00); C1394(1.52)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C1394(1.02); C1521(1.12); C1527(1.12); C338(1.24)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C1394(0.85); C1521(1.00); C1527(1.00); C976(1.04)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C1394(0.96); C1521(1.00); C1527(1.00); C976(1.01)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C791(0.88); C797(0.88); C1394(0.89); C1521(0.99)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C1394(0.98); C791(0.99); C797(0.99); C1521(1.02)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C1394(0.97); C1521(1.16); C1527(1.16); C888(1.21)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C888(0.77); C1394(0.93); C1521(0.98); C1527(0.98)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C338(0.74); C344(0.74); C1394(0.93); C1521(0.96)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C338(0.54); C344(0.54); C1521(0.90); C1527(0.90)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C888(1.03); C1521(1.10); C1527(1.10); C1394(1.33)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C1521(1.11); C1527(1.11); C1394(1.77)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C1394(1.07); C1521(1.12); C1527(1.12); C338(1.21)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C888(0.86); C338(0.95); C344(0.95); C1394(0.96)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C338(0.72); C344(0.72); C1521(0.89); C1527(0.89)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C338(0.90); C344(0.90); C1521(1.02); C1527(1.02)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C338(0.88); C344(0.88); C1394(0.90); C1521(1.09)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C338(0.87); C344(0.87); C1394(1.15); C1521(1.15)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C1521(1.22); C1527(1.22); C1394(1.41); C888(1.63)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C1521(0.78); C1527(0.78); C791(1.44); C797(1.44)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C1521(0.77); C1527(0.77); C888(1.54); C791(1.61)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C1521(0.71); C1527(0.71); C888(1.66); C791(1.82)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C1521(0.74); C1527(0.74); C888(1.13); C1394(1.14)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C1521(0.68); C1527(0.68); C791(1.28); C797(1.28)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C1521(0.74); C1527(0.74); C791(1.37); C797(1.37)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C1521(0.83); C1527(0.83); C791(1.59); C797(1.59)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C1521(0.65); C1527(0.65); C791(1.52); C797(1.52)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C1521(0.73); C1527(0.73); C791(1.66); C797(1.66)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C1521(0.88); C1527(0.88); C888(2.33); C791(2.39)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C1521(0.86); C1527(0.86); C791(2.16); C797(2.16)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C1521(0.89); C1527(0.89); C791(2.88); C797(2.88)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C791(1.09); C797(1.09); C338(1.14); C344(1.14)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C791(1.13); C797(1.13); C338(1.29); C344(1.29)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C1521(0.80); C1527(0.80); C888(1.00); C1394(1.09)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C791(1.04); C797(1.04); C338(1.42); C344(1.42)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C791(1.04); C797(1.04); C338(1.07); C344(1.07)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C791(1.24); C797(1.24); C338(1.27); C344(1.27)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C338(1.57); C344(1.57); C791(1.58); C797(1.58)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C338(1.04); C344(1.04); C791(1.43); C797(1.43)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C338(1.47); C344(1.47); C791(1.56); C797(1.56)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C338(1.26); C344(1.26); C791(1.34); C797(1.34)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C791(1.10); C797(1.10); C338(1.25); C344(1.25)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C791(0.95); C797(0.95); C338(0.98); C344(0.98)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C338(0.87); C344(0.87); C791(1.15); C797(1.15)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C1521(0.76); C1527(0.76); C338(0.79); C344(0.79)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C791(1.24); C797(1.24); C338(1.70); C344(1.70)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C791(0.82); C797(0.82); C338(0.96); C344(0.96)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C791(1.87); C797(1.87); C338(2.43); C344(2.43)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C976(0.61); C888(0.84); C1521(0.88); C1527(0.88)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C976(0.71); C1521(0.89); C1527(0.89); C888(0.98)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C1521(0.85); C1527(0.85); C976(0.96); C888(1.01)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C888(0.72); C976(0.79); C1521(0.87); C1527(0.87)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C976(0.78); C888(0.81); C1521(1.03); C1527(1.03)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C976(0.77); C1521(0.91); C1527(0.91); C888(0.95)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C976(0.83); C888(0.89); C1521(0.92); C1527(0.92)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C976(0.88); C888(0.94); C1394(0.99); C1521(1.15)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C976(0.85); C1521(0.90); C1527(0.90); C888(0.98)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C976(0.78); C1521(1.01); C1527(1.01); C888(1.15)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C976(0.78); C1521(0.87); C1527(0.87); C1394(0.98)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C976(0.85); C1521(0.87); C1527(0.87); C1394(1.09)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1521(0.84); C1527(0.84); C1394(0.97); C976(1.11)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C976(0.94); C1521(0.96); C1527(0.96); C1394(1.01)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C976(0.92); C1521(0.98); C1527(0.98); C1394(1.12)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C505(0.81); C888(2.02)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C505(0.62); C888(0.90)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C338(1.26); C344(1.26); C1394(1.12); C1521(0.85)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C1521(0.74); C1527(0.74); C888(0.90); C338(1.02)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C1521(0.91); C1527(0.91); C888(1.15); C1394(1.31)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C791(1.15); C797(1.15)  LDD2171  [7]
 LDCM0632  CL-Sc Hep-G2 C1079(20.00); C1394(1.43); C743(1.02); C1329(0.52)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C1394(0.90); C888(0.98); C976(1.09); C1521(1.13)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C1394(1.09); C1521(1.12); C1527(1.12); C976(1.43)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C1521(0.92); C1527(0.92); C1394(1.55)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C1521(0.72); C1527(0.72); C888(1.14); C1394(1.16)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C1521(0.86); C1527(0.86); C1394(1.01); C888(1.03)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C1521(0.83); C1527(0.83); C1394(1.02); C888(1.14)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C1521(0.82); C1527(0.82); C1394(1.09); C888(1.13)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C1521(0.70); C1527(0.70); C1394(0.98); C976(1.02)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C1521(0.76); C1527(0.76); C791(1.16); C797(1.16)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C1521(0.69); C1527(0.69); C1394(1.27); C791(1.29)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C1521(0.72); C1527(0.72); C888(1.01); C976(1.04)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C1521(0.77); C1527(0.77); C1394(1.00); C791(1.10)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C1521(1.18); C1527(1.18); C976(1.21); C1394(1.29)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C1521(0.75); C1527(0.75); C1394(0.97); C338(1.01)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C1521(0.73); C1527(0.73); C976(0.86); C1394(0.97)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C505(0.93); C1521(0.96); C1527(0.96); C1394(0.97)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C791(0.72); C797(0.72); C1521(0.85); C1527(0.85)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C791(0.80); C797(0.80); C1521(0.85); C1527(0.85)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C791(0.78); C797(0.78); C1521(0.90); C1527(0.90)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C505(0.73); C1521(0.96); C1527(0.96); C791(0.98)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C1394(1.21); C1521(1.34); C1527(1.34); C976(1.41)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C1394(0.92); C976(1.02); C791(1.12); C797(1.12)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C1394(0.89); C976(1.01); C1521(1.05); C1527(1.05)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C1521(1.14); C1527(1.14); C1394(1.30); C976(1.49)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C1394(0.89); C791(0.95); C797(0.95); C1521(0.97)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C888(0.60); C338(0.63); C344(0.63); C1394(0.68)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C1521(0.97); C1527(0.97); C888(1.06); C338(1.07)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C338(0.91); C344(0.91); C1521(1.05); C1527(1.05)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C338(0.88); C344(0.88); C1521(0.93); C1527(0.93)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C1521(0.78); C1527(0.78); C791(1.03); C797(1.03)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C1521(0.69); C1527(0.69); C791(1.38); C797(1.38)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C1521(0.78); C1527(0.78); C791(1.30); C797(1.30)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C1521(0.69); C1527(0.69); C791(1.46); C797(1.46)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C1521(1.09); C1527(1.09); C1394(1.19); C976(1.45)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C888(1.01); C1521(1.05); C1527(1.05); C1394(1.08)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C976(1.02); C1394(1.09); C1521(1.18); C1527(1.18)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C976(0.67); C1394(0.89); C1521(0.91); C1527(0.91)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C976(0.80); C1521(0.86); C1527(0.86); C1394(0.86)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C1521(0.84); C1527(0.84); C1394(0.90); C976(0.97)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C976(0.80); C1521(0.89); C1527(0.89); C1394(0.96)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C976(0.82); C888(0.96); C1394(1.03); C1521(1.15)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C1521(0.92); C1527(0.92); C1394(0.93); C976(0.97)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C1394(0.99); C1521(0.99); C1527(0.99); C976(1.16)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C1521(1.14); C1527(1.14); C1394(1.16); C976(1.58)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C1521(0.80); C1527(0.80); C976(0.85); C1394(0.94)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C1521(0.93); C1527(0.93); C976(0.98); C1394(1.02)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C338(0.91); C344(0.91); C1394(0.98); C1521(0.87)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C338(0.92); C344(0.92); C1394(1.00); C1521(0.91)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C338(1.15); C344(1.15); C1394(1.00); C1521(0.81)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C338(1.59); C344(1.59); C1394(0.96); C1521(0.89)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C338(1.43); C344(1.43); C1394(0.97); C1521(0.84)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C338(1.74); C344(1.74); C1394(0.97); C1521(1.17)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C338(1.29); C344(1.29); C1394(0.95); C1521(0.79)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C338(0.96); C344(0.96); C1394(1.07); C1521(0.92)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C338(0.84); C344(0.84); C1394(1.04); C1521(0.86)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C338(0.87); C344(0.87); C1394(1.04); C1521(0.92)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C338(1.34); C344(1.34); C1394(1.30); C1521(0.97)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C338(1.02); C344(1.02); C1394(1.06); C1521(1.06)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C338(1.13); C344(1.13); C1394(1.04); C1521(0.94)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C338(1.40); C344(1.40); C1394(1.13); C1521(1.04)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C338(1.01); C344(1.01); C1394(1.17); C1521(0.88)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C338(1.68); C344(1.68); C1394(1.12); C1521(1.11)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C338(1.12); C344(1.12); C1394(1.16); C1521(0.94)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C338(1.22); C344(1.22); C1394(1.02); C1521(0.90)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C338(1.49); C344(1.49); C1394(1.14); C1521(1.07)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C338(1.45); C344(1.45); C1394(1.19); C1521(1.14)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C338(1.24); C344(1.24); C1394(1.21); C1521(0.94)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C338(1.02); C344(1.02); C1394(1.20); C1521(0.96)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C1394(1.06); C1521(1.05); C1527(1.05); C791(1.08)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C1394(0.89); C1521(0.95); C1527(0.95); C791(1.08)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C1394(0.94); C1521(1.08); C1527(1.08); C791(0.91)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C1394(1.06); C1521(0.89); C1527(0.89); C791(1.21)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C338(1.31); C344(1.31); C1394(1.05); C1521(1.12)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C1394(0.89); C1521(0.89); C1527(0.89); C791(0.96)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C1394(0.98); C1521(0.85); C1527(0.85); C791(1.10)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C1394(1.03); C1521(0.94); C1527(0.94); C791(1.03)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C1394(0.96); C1521(0.92); C1527(0.92); C791(0.97)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C1394(0.92); C1521(1.07); C1527(1.07); C791(0.97)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C1394(0.87); C1521(0.97); C1527(0.97); C791(0.94)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C1394(1.06); C1521(1.03); C1527(1.03); C791(1.00)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C1394(0.92); C1521(0.99); C1527(0.99); C791(1.35)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C1394(0.99); C1521(1.06); C1527(1.06); C791(1.07)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C1394(1.05); C1521(0.92); C1527(0.92); C791(1.02)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C338(1.61); C344(1.61); C1394(1.21); C1521(1.02)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C1394(0.95); C1521(0.98); C1527(0.98); C791(1.15)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C338(0.81); C344(0.81); C1394(1.07); C1521(0.91)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C338(0.82); C344(0.82); C1394(1.01); C1521(0.85)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C338(0.81); C344(0.81); C1394(1.18); C1521(0.76)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C338(0.81); C344(0.81); C1394(1.17); C1521(0.75)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C338(0.75); C344(0.75); C1394(1.06); C1521(0.86)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C338(0.95); C344(0.95); C1394(1.29); C1521(0.90)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C338(0.95); C344(0.95); C1394(1.22); C1521(0.84)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C338(0.73); C344(0.73); C1394(1.27); C1521(0.76)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C338(0.66); C344(0.66); C1394(1.20); C1521(0.83)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C338(1.84); C344(1.84); C1394(1.38); C1521(1.06)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C338(0.84); C344(0.84); C1394(1.29); C1521(0.79)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C338(0.67); C344(0.67); C1394(1.10); C1521(0.71)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C338(0.60); C344(0.60); C1394(1.70); C1521(0.87)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C338(0.60); C344(0.60); C1394(1.17); C1521(0.76)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C338(0.87); C344(0.87); C1394(1.09); C1521(0.78)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C338(1.23); C344(1.23); C1394(0.99); C888(1.34)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C338(1.19); C344(1.19); C1394(0.74); C888(1.99)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C338(1.09); C344(1.09); C1394(1.02); C888(1.88)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C338(1.25); C344(1.25); C1394(1.08); C888(1.38)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C338(2.92); C344(2.92); C1394(1.33); C1521(1.49)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C338(1.19); C344(1.19); C1394(0.95); C888(3.84)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C338(1.18); C344(1.18); C1394(1.01); C888(1.21)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C338(1.26); C344(1.26); C1394(1.15); C888(2.18)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C338(1.63); C344(1.63); C1394(1.33); C888(2.17)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C338(1.57); C344(1.57); C1394(1.41); C888(2.18)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C338(1.15); C344(1.15); C1394(1.17); C888(2.00)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C338(1.16); C344(1.16); C1394(1.02); C888(1.02)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C338(1.39); C344(1.39); C1394(1.23); C888(1.67)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C338(1.33); C344(1.33); C1394(1.19); C888(1.48)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C338(1.57); C344(1.57); C1394(1.41); C888(1.98)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C338(1.50); C344(1.50); C1394(1.05); C1521(1.08)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C338(1.15); C344(1.15); C1394(1.01); C888(3.71)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C1394(1.22); C1521(0.80); C1527(0.80)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C1394(1.33); C1521(0.82); C1527(0.82)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C1394(1.18); C1521(0.91); C1527(0.91)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C1394(1.34); C1521(0.89); C1527(0.89)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C1394(1.37); C1521(0.71); C1527(0.71)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C1394(1.17); C1521(0.83); C1527(0.83)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C1394(1.37); C1521(0.91); C1527(0.91)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C1394(1.63); C1521(1.01); C1527(1.01)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C1394(1.49); C1521(1.02); C1527(1.02)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C1376(1.13); C1572(0.84)  LDD1698  [8]
 LDCM0625  F8 Ramos C505(1.13); C1394(1.00)  LDD2187  [9]
 LDCM0575  Fragment13 Ramos C505(0.66)  LDD2192  [9]
 LDCM0580  Fragment21 Ramos C505(1.53)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C505(0.97)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C505(0.70)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C505(1.16); C1394(0.59)  LDD2198  [9]
 LDCM0589  Fragment31 Ramos C505(1.34)  LDD2200  [9]
 LDCM0468  Fragment33 HCT 116 C338(0.81); C344(0.81); C1394(0.92); C1521(0.84)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C505(1.10)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C1394(2.55)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C338(1.59); C344(1.59); C1394(1.09); C1521(1.14)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C505(2.13)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C505(1.08)  LDD2205  [9]
 LDCM0022  KB02 HEK-293T C1394(0.95)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C1376(287.34)  LDD0209  [3]
 LDCM0024  KB05 COLO792 C505(4.08); C186(4.13)  LDD3310  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1263(1.03)  LDD2111  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C505(1.04)  LDD2125  [2]
 LDCM0021  THZ1 HCT 116 C791(1.15); C797(1.15)  LDD2173  [7]

References

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Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840