Details of the Target

General Information of Target

Target ID LDTP15885
Target Name Leucine-rich repeat-containing protein 1 (LRRC1)
Gene Name LRRC1
Gene ID 55227
Synonyms
LANO; Leucine-rich repeat-containing protein 1; LANO adapter protein; LAP and no PDZ protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGRGKQGGKVRAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESQKTKSK
Target Bioclass
Other
Subcellular location
Cytoplasm
Uniprot ID
Q9BTT6
Ensemble ID
ENST00000370888.6
HGNC ID
HGNC:14307

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.D201Y .
LS123 Insertion: p.G333_C334insGGG DBIA    Probe Info 
SNGM SNV: p.G333R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K19(7.18)  LDD0277  [1]
m-APA
 Probe Info  		12.80  LDD0403  [2]
AHL-Pu-1
 Probe Info  		C425(10.46)  LDD0168  [3]
DBIA
 Probe Info  		C413(0.78); C425(0.78)  LDD0531  [4]
IA-alkyne
 Probe Info  		C4(0.00); C22(0.00)  LDD0162  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
NHS
 Probe Info  		N.A.  LDD0010  [7]
PF-06672131
 Probe Info  		N.A.  LDD0017  [8]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
W1
 Probe Info  		C104(0.00); C22(0.00); C224(0.00)  LDD0236  [10]
AOyne
 Probe Info  		10.30  LDD0443  [11]
NAIA_5
 Probe Info  		C10(0.00); C288(0.00); C4(0.00)  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C210
 Probe Info  		44.94  LDD1884  [12]
C362
 Probe Info  		25.28  LDD2023  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C425(10.46)  LDD0168  [3]
 LDCM0214  AC1 HCT 116 C413(0.78); C425(0.78)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C413(1.01); C425(1.01)  LDD0532  [4]
 LDCM0226  AC11 HCT 116 C413(1.00); C425(1.00)  LDD0543  [4]
 LDCM0230  AC113 HCT 116 C413(0.94); C425(0.94)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C413(1.12); C425(1.12)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C413(1.02); C425(1.02)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C413(0.91); C425(0.91)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C413(0.84); C425(0.84)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C413(1.10); C425(1.10)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C413(0.95); C425(0.95)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C413(1.10); C425(1.10)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C413(1.01); C425(1.01)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C413(1.01); C425(1.01)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C413(1.35); C425(1.35)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C413(1.11); C425(1.11)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C413(0.99); C425(0.99)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C413(1.00); C425(1.00)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C413(0.92); C425(0.92)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C413(0.98); C425(0.98)  LDD0562  [4]
 LDCM0259  AC14 HCT 116 C413(1.16); C425(1.16)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C413(0.55); C425(0.55)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C413(0.52); C425(0.52)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C413(0.56); C425(0.56)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C413(0.66); C425(0.66)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C413(0.57); C425(0.57)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C413(0.60); C425(0.60)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C413(0.49); C425(0.49)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C413(1.12); C425(1.12)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C413(0.82); C425(0.82)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C413(0.54); C425(0.54)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C413(0.49); C425(0.49)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C413(0.65); C425(0.65)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C413(0.49); C425(0.49)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C413(0.69); C425(0.69)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C413(1.16); C425(1.16)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C413(0.59); C425(0.59)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C413(0.76); C425(0.76)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C413(1.12); C425(1.12)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C413(0.92); C425(0.92)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C413(0.87); C425(0.87)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C413(0.90); C425(0.90)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C413(0.66); C425(0.66)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C413(0.63); C425(0.63)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C413(0.69); C425(0.69)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C413(1.74); C425(1.74)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C413(0.77); C425(0.77)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C413(1.18); C425(1.18)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C413(0.81); C425(0.81)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C413(0.64); C425(0.64)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C413(1.07); C425(1.07)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C413(1.01); C425(1.01)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C413(1.23); C425(1.23)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C413(1.48); C425(1.48)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C413(0.93); C425(0.93)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C413(0.87); C425(0.87)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C413(0.83); C425(0.83)  LDD0612  [4]
 LDCM0296  AC35 PaTu 8988t C413(0.79); C425(0.79)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C413(0.89); C425(0.89)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C413(0.83); C425(0.83)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C413(0.86); C425(0.86)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C413(0.98); C425(0.98)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C413(0.79); C425(0.79)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C413(0.88); C425(0.88)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C413(0.90); C425(0.90)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C413(1.06); C425(1.06)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C413(1.00); C425(1.00)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C413(0.98); C425(0.98)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C413(0.95); C425(0.95)  LDD1186  [4]
 LDCM0308  AC46 PaTu 8988t C413(0.84); C425(0.84)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C413(0.76); C425(0.76)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C413(0.67); C425(0.67)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C413(0.76); C425(0.76)  LDD1190  [4]
 LDCM0312  AC5 HCT 116 C413(0.84); C425(0.84)  LDD0629  [4]
 LDCM0313  AC50 PaTu 8988t C413(0.70); C425(0.70)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C413(0.78); C425(0.78)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C413(0.79); C425(0.79)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C413(0.69); C425(0.69)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C413(0.73); C425(0.73)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C413(0.85); C425(0.85)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C413(0.67); C425(0.67)  LDD1198  [4]
 LDCM0320  AC57 HCT 116 C413(0.67); C425(0.67)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C413(0.82); C425(0.82)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C413(0.79); C425(0.79)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C413(0.98); C425(0.98)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C413(0.63); C425(0.63)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C413(0.75); C425(0.75)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C413(0.86); C425(0.86)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C413(0.97); C425(0.97)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C413(0.73); C425(0.73)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C413(0.79); C425(0.79)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C413(0.79); C425(0.79)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C413(0.68); C425(0.68)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C413(1.21); C425(1.21)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C413(1.05); C425(1.05)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C413(0.94); C425(0.94)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C413(0.79); C425(0.79)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C413(1.20); C425(1.20)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C413(0.96); C425(0.96)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C413(0.91); C425(0.91)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C413(0.89); C425(0.89)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C413(0.99); C425(0.99)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C413(0.93); C425(0.93)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C413(0.90); C425(0.90)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C413(0.99); C425(0.99)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C413(1.02); C425(1.02)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C413(0.99); C425(0.99)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C413(1.22); C425(1.22)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C413(1.30); C425(1.30)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C413(1.08); C425(1.08)  LDD0665  [4]
 LDCM0248  AKOS034007472 HCT 116 C413(1.05); C425(1.05)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C413(0.93); C425(0.93)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C413(0.98); C425(0.98)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 12.80  LDD0403  [2]
 LDCM0367  CL1 HEK-293T C22(1.14); C224(1.05); C432(1.03); C288(1.09)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C224(0.57); C432(0.91); C288(0.67); C104(0.96)  LDD1572  [13]
 LDCM0369  CL100 HCT 116 C413(0.87); C425(0.87)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C413(1.01); C425(1.01)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C413(1.23); C425(1.23)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C413(1.00); C425(1.00)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C413(1.20); C425(1.20)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C413(0.65); C425(0.65)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C413(0.80); C425(0.80)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C413(0.92); C425(0.92)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C413(0.77); C425(0.77)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C413(1.01); C425(1.01)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C224(0.95); C432(0.82); C288(1.05); C425(0.93)  LDD1583  [13]
 LDCM0380  CL110 HCT 116 C413(0.67); C425(0.67)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C413(0.72); C425(0.72)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C413(1.51); C425(1.51)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C413(0.78); C425(0.78)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C413(1.01); C425(1.01)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C413(1.55); C425(1.55)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C413(0.97); C425(0.97)  LDD0703  [4]
 LDCM0387  CL117 PaTu 8988t C413(0.88); C425(0.88)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C413(1.01); C425(1.01)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C413(0.92); C425(0.92)  LDD1268  [4]
 LDCM0390  CL12 HEK-293T C22(1.21); C224(1.11); C432(1.13); C288(1.03)  LDD1594  [13]
 LDCM0391  CL120 PaTu 8988t C413(0.85); C425(0.85)  LDD1270  [4]
 LDCM0392  CL121 PaTu 8988t C413(0.94); C425(0.94)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C413(0.65); C425(0.65)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C413(0.86); C425(0.86)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C413(0.78); C425(0.78)  LDD1274  [4]
 LDCM0396  CL125 HCT 116 C413(0.90); C425(0.90)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C413(0.71); C425(0.71)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C413(0.63); C425(0.63)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C413(0.86); C425(0.86)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C22(1.14); C224(1.08); C432(1.30); C288(1.29)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C432(1.08); C288(1.12); C104(1.00)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C224(1.07); C432(1.17); C288(1.02); C104(1.26)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C224(1.14); C432(0.97); C288(1.18); C104(1.06)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C224(0.84); C432(0.93); C288(0.88); C104(1.10)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C224(1.27); C432(1.32); C288(1.07); C104(1.25)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C22(1.40); C224(1.07); C432(0.95); C288(0.93)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C432(0.94); C288(0.99); C104(1.07)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C224(1.01); C432(1.01); C288(0.96); C425(1.01)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C224(0.94); C432(0.90); C288(0.65); C104(1.09)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C224(1.16); C432(1.00); C288(0.90); C104(0.89)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C224(1.03); C432(0.88); C288(1.10); C425(1.04)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C22(1.18); C224(1.30); C432(1.00); C288(1.07)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C22(0.93); C224(1.08); C432(0.97); C288(0.86)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C432(0.96); C288(1.08); C104(1.04)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C224(1.15); C432(1.04); C288(1.01); C104(1.22)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C224(1.05); C432(0.96); C288(0.95); C104(1.10)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C224(1.01); C432(0.95); C288(1.01); C104(1.13)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C224(1.17); C432(0.96); C288(1.06); C104(1.20)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C224(1.20); C432(1.16); C288(0.83); C104(1.14)  LDD1623  [13]
 LDCM0420  CL31 PaTu 8988t C413(0.63); C425(0.63)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C413(0.65); C425(0.65)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C413(1.41); C425(1.41)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C413(0.57); C425(0.57)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C413(0.48); C425(0.48)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C413(1.32); C425(1.32)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C413(1.00); C425(1.00)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C413(0.95); C425(0.95)  LDD1307  [4]
 LDCM0429  CL4 HEK-293T C224(1.26); C432(1.02); C288(0.87); C104(1.08)  LDD1633  [13]
 LDCM0430  CL40 PaTu 8988t C413(0.82); C425(0.82)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C413(0.82); C425(0.82)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C413(0.77); C425(0.77)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C413(0.79); C425(0.79)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C413(0.63); C425(0.63)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C413(0.76); C425(0.76)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C224(1.15); C432(0.95); C288(0.96); C104(0.79)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C224(1.10); C432(0.75); C288(1.00); C425(0.85)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C22(1.05); C224(1.24); C432(1.13); C288(0.96)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C22(1.03); C224(1.07); C432(0.70); C288(1.31)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C224(1.07); C432(1.00); C288(0.93); C104(1.13)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C432(1.15); C288(1.05); C104(0.95)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C224(1.03); C432(0.89); C288(0.88); C104(1.05)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C224(0.95); C432(0.81); C288(0.86); C104(1.12)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C224(1.32); C432(0.82); C288(0.82); C104(1.22)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C22(1.05); C224(1.19); C432(0.72); C288(0.95)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C224(1.06); C432(0.97); C288(1.02); C425(0.87)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C224(0.98); C432(0.93); C288(0.78); C104(1.13)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C224(1.20); C432(0.89); C288(0.91); C104(0.97)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C224(1.06); C432(0.82); C288(1.17); C425(1.16)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C224(1.14); C432(0.83); C288(0.88); C104(1.15)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C22(1.07); C224(1.16); C432(1.04); C288(1.06)  LDD1655  [13]
 LDCM0453  CL61 HCT 116 C413(0.96); C425(0.96)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C413(1.14); C425(1.14)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C413(1.02); C425(1.02)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C413(0.89); C425(0.89)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C413(0.99); C425(0.99)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C413(1.04); C425(1.04)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C413(0.87); C425(0.87)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C413(0.86); C425(0.86)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C413(1.04); C425(1.04)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C22(0.97); C224(1.01); C432(0.81); C288(0.98)  LDD1665  [13]
 LDCM0463  CL70 HCT 116 C413(0.85); C425(0.85)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C413(0.92); C425(0.92)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C413(1.03); C425(1.03)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C413(0.89); C425(0.89)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C413(1.14); C425(1.14)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C413(0.86); C425(0.86)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C413(0.94); C425(0.94)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C413(1.03); C425(1.03)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C413(0.89); C425(0.89)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C224(0.99); C432(0.88); C288(0.81); C425(0.86)  LDD1676  [13]
 LDCM0474  CL80 HCT 116 C413(0.86); C425(0.86)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C413(0.82); C425(0.82)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C413(0.84); C425(0.84)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C413(0.80); C425(0.80)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C413(0.76); C425(0.76)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C413(0.94); C425(0.94)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C413(1.00); C425(1.00)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C413(0.97); C425(0.97)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C413(0.90); C425(0.90)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C413(0.88); C425(0.88)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C224(0.94); C432(0.83); C288(0.73); C104(1.12)  LDD1687  [13]
 LDCM0485  CL90 HCT 116 C413(1.07); C425(1.07)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C413(0.82); C425(0.82)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C413(0.87); C425(0.87)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C413(0.74); C425(0.74)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C413(0.84); C425(0.84)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C413(0.79); C425(0.79)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C413(0.87); C425(0.87)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C413(0.88); C425(0.88)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C413(0.95); C425(0.95)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C413(0.93); C425(0.93)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C224(1.15); C432(1.27); C288(1.01); C104(1.07)  LDD1698  [13]
 LDCM0468  Fragment33 HCT 116 C413(0.86); C425(0.86)  LDD0785  [4]
 LDCM0427  Fragment51 PaTu 8988t C413(0.83); C425(0.83)  LDD1306  [4]
 LDCM0022  KB02 HEK-293T C224(0.89); C288(1.01)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C224(1.14); C288(0.99)  LDD1497  [13]
 LDCM0024  KB05 HMCB C288(2.25); C224(4.83)  LDD3312  [14]

References

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Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840