Details of the Target

General Information of Target

Target ID LDTP15616
Target Name Serine/threonine-protein phosphatase 4 regulatory subunit 1 (PPP4R1)
Gene Name PPP4R1
Gene ID 9989
Synonyms
MEG1; PP4R1; Serine/threonine-protein phosphatase 4 regulatory subunit 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAAVKEEISLEDEAVDKNIFRDCNKIAFYRRQKQWLSKKSTYQALLDSVTTDEDSTRFQ
IINEASKVPLLAEIYGIEGNIFRLKINEETPLKPRFEVPDVLTSKPSTVRLISCSGDTGS
LILADGKGDLKCHITANPFKVDLVSEEEVVISINSLGQLYFEHLQILHKQRAAKENEEET
SVDTSQENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNT
GDGDAYRLYNLDVYGYQIYDKMGIYGSVPYLLAHKLGRTIGIFWLNASETLVEINTEPAV
EYTLTQMGPVAAKQKVRSRTHVHWMSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPPL
FSLGYHQCRWNYEDEQDVKAVDAGFDEHDIPYDAMWLDIEHTEGKRYFTWDKNRFPNPKR
MQELLRSKKRKLVVISDPHIKIDPDYSVYVKAKDQGFFVKNQEGEDFEGVCWPGLSSYLD
FTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHREL
HNIYGFYHQMATAEGLIKRSKGKERPFVLTRSFFAGSQKYGAVWTGDNTAEWSNLKISIP
MLLTLSITGISFCGADIGGFIGNPETELLVRWYQAGAYQPFFRGHATMNTKRREPWLFGE
EHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPDELKTFDMEDEYMLGSA
LLVHPVTEPKATTVDVFLPGSNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQRGGSVIP
IKTTVGKSTGWMTESSYGLRVALSTKGSSVGELYLDDGHSFQYLHQKQFLHRKFSFCSSV
LINSFADQRGHYPSKCVVEKILVLGFRKEPSSVTTHSSDGKDQPVAFTYCAKTSILSLEK
LSLNIATDWEVRII
Target Bioclass
Other
Function
Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.
Uniprot ID
Q8TF05
Ensemble ID
ENST00000400555.7
HGNC ID
HGNC:9320

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.G657R DBIA    Probe Info 
HCT15 SNV: p.L260I .
HT115 SNV: p.R759Ter .
JHH4 SNV: p.G17R DBIA    Probe Info 
MCC13 SNV: p.K567I DBIA    Probe Info 
MELJUSO SNV: p.L725S .
MEWO SNV: p.Q313Ter .
MOLT4 SNV: p.R211C IA-alkyne    Probe Info 
SNU308 SNV: p.S538R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K643(7.69)  LDD0277  [2]
Probe 1
 Probe Info  		Y430(108.01)  LDD3495  [3]
BTD
 Probe Info  		C790(1.03)  LDD2099  [4]
AHL-Pu-1
 Probe Info  		C566(2.11)  LDD0170  [5]
HHS-475
 Probe Info  		Y54(1.46)  LDD0268  [6]
IPM
 Probe Info  		C198(2.18)  LDD1701  [4]
DBIA
 Probe Info  		C566(0.94); C281(0.88); C284(0.88)  LDD0078  [7]
CY-1
 Probe Info  		N.A.  LDD0246  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C84(0.00); C790(0.00); C198(0.00); C174(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C790(0.00); C174(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C84(0.00); C790(0.00); C566(0.00); C174(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		13.70  LDD0443  [15]
NAIA_5
 Probe Info  		C645(0.00); C835(0.00); C198(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C566(2.11)  LDD0170  [5]
 LDCM0214  AC1 HCT 116 C224(1.24); C222(1.24); C261(1.12); C272(0.69)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C224(1.04); C218(1.01); C222(1.11); C261(1.32)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C224(0.86); C218(0.84); C221(0.85); C222(0.96)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C224(1.04); C218(0.92); C221(0.69); C222(0.96)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C224(0.90); C218(0.93); C221(0.87); C222(1.02)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C224(0.93); C218(0.82); C221(0.78); C222(0.84)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C224(0.92); C218(0.96); C221(1.02); C222(0.93)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C224(1.03); C218(1.07); C221(1.01); C222(1.09)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C224(0.97); C218(0.96); C221(1.05); C222(0.88)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C224(0.91); C218(0.83); C221(0.74); C222(0.92)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C224(1.10); C218(1.05); C221(0.90); C222(0.97)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C224(0.88); C218(0.96); C221(0.89); C222(1.03)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C224(1.02); C218(1.02); C222(1.02); C261(1.17)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C224(0.99); C218(1.01); C221(0.93); C222(0.91)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C224(0.97); C218(0.99); C221(1.06); C222(0.88)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C224(0.98); C218(0.82); C221(0.71); C222(0.85)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C224(0.75); C218(0.79); C222(0.76); C233(1.11)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C224(0.79); C218(0.70); C222(0.76); C233(0.99)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C224(0.75); C218(0.64); C222(0.73); C233(0.85)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C224(0.85); C218(0.88); C222(0.85); C233(0.86)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C224(1.01); C218(1.86); C222(0.93); C233(0.90)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C224(0.88); C218(1.03); C222(0.80); C233(0.77)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C224(0.86); C218(1.45); C222(0.81); C233(0.84)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C224(0.98); C218(1.03); C222(0.95); C261(1.27)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C224(0.85); C218(0.91); C222(0.78); C233(0.66)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C224(1.00); C218(1.68); C222(0.90); C233(0.85)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C224(0.85); C218(0.95); C222(0.80); C233(0.82)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C224(0.80); C218(0.65); C222(0.65); C233(0.81)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C224(0.84); C218(1.74); C222(0.75); C233(0.72)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C224(0.78); C218(0.81); C222(0.73); C233(0.84)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C224(0.81); C218(0.71); C222(0.80); C233(0.88)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C224(0.85); C218(1.63); C222(0.81); C233(0.91)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C224(0.86); C218(1.09); C221(1.02); C222(0.94)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C224(1.05); C218(1.07); C221(1.05); C222(0.93)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C224(0.98); C218(0.94); C221(0.90); C222(0.91)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C224(1.15); C218(1.06); C221(0.97); C222(0.97)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C224(1.16); C218(1.08); C221(1.01); C222(1.02)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C224(1.00); C218(0.95); C221(0.89); C222(0.89)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C224(1.22); C218(1.12); C221(1.02); C222(1.18)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C224(1.14); C218(1.07); C221(0.99); C222(1.04)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C224(1.17); C218(0.96); C221(0.75); C222(1.02)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C224(1.09); C218(0.93); C221(0.78); C222(1.01)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C224(1.21); C218(1.04); C221(0.86); C222(1.17)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C224(1.26); C218(1.10); C221(0.95); C222(1.17)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C224(1.08); C218(1.08); C222(1.16); C261(1.03)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C224(1.34); C218(1.15); C221(1.01); C222(1.31)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C224(1.26); C218(1.15); C221(1.04); C222(1.18)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C224(1.18); C218(1.11); C221(1.04); C222(1.10)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C224(1.15); C281(0.81); C284(0.93); C261(0.96)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C261(0.81); C281(0.90); C218(0.98); C222(1.17)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C281(0.74); C78(0.89); C84(0.89); C261(0.92)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C78(0.73); C84(0.73); C261(0.84); C218(0.87)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C261(0.79); C281(0.79); C78(0.84); C84(0.84)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C218(0.88); C78(0.90); C84(0.90); C281(0.95)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C78(0.64); C84(0.64); C281(0.82); C261(0.86)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C663(1.04); C261(1.05); C284(1.05); C222(1.07)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C78(0.61); C84(0.61); C281(0.85); C218(0.96)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C78(0.90); C84(0.90); C261(0.92); C663(0.96)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C261(0.80); C78(0.88); C84(0.88); C272(0.89)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C281(0.73); C78(0.90); C84(0.90); C218(0.93)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C224(1.35); C218(1.01); C222(1.10); C261(0.88)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C224(1.28); C218(1.48); C222(1.26); C261(0.92)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C224(0.96); C218(1.00); C222(0.95); C261(0.85)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C224(1.01); C218(1.06); C222(0.94); C261(1.14)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C84(0.75); C78(0.89); C221(0.95); C663(0.95)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C221(0.67); C84(0.84); C233(0.85); C241(0.85)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C261(0.75); C663(0.88); C84(0.96); C78(0.98)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C272(0.70); C281(0.70); C78(0.70); C84(0.70)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C272(0.86); C663(1.01); C261(1.02); C222(1.03)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C221(0.74); C233(0.83); C241(0.83); C222(0.92)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C272(0.77); C221(0.91); C281(0.91); C284(0.94)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C221(0.76); C261(0.77); C84(0.84); C663(0.87)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C272(0.87); C78(0.89); C663(0.91); C84(0.92)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C663(0.66); C84(0.76); C272(0.82); C275(0.82)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C663(0.61); C272(0.65); C275(0.65); C84(0.73)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C663(0.61); C233(0.74); C241(0.74); C84(0.76)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C663(0.51); C84(0.64); C233(0.79); C241(0.79)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C84(0.62); C663(0.66); C261(0.77); C272(0.81)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C272(0.62); C281(0.62); C78(0.73); C84(0.73)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C84(0.60); C663(0.74); C261(0.78); C78(0.84)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C84(0.67); C663(0.68); C272(0.68); C275(0.68)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C84(0.61); C663(0.64); C233(0.78); C241(0.78)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C84(0.66); C261(0.82); C663(0.89); C78(0.93)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C84(0.58); C261(0.82); C233(0.85); C241(0.85)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C281(0.70); C284(0.70); C198(0.74); C663(0.77)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C233(0.51); C241(0.51); C281(0.69); C284(0.71)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C284(0.65); C281(0.67); C566(0.67); C233(0.72)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C233(0.64); C241(0.64); C198(0.77); C663(0.85)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C275(0.67); C663(0.78); C233(0.79); C241(0.79)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C272(0.60); C281(0.60); C78(0.95); C84(0.95)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C233(0.76); C241(0.76); C281(0.90); C284(0.90)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C233(0.66); C241(0.66); C281(0.74); C284(0.74)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C233(0.62); C241(0.62); C281(0.84); C284(0.87)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C233(0.60); C241(0.60); C198(0.81); C78(0.83)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C233(0.67); C241(0.67); C566(0.75); C198(0.83)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C566(0.67); C233(0.82); C241(0.82); C261(1.01)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C663(0.74); C275(0.88); C261(0.93); C284(0.96)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C78(0.87); C84(0.87); C261(0.99); C663(1.06)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C78(0.63); C84(0.63); C663(0.76); C261(1.00)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C663(0.60); C275(0.86); C78(0.91); C84(0.91)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C272(0.62); C281(0.62); C78(0.76); C84(0.76)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C663(0.79); C78(0.92); C84(0.92); C275(0.95)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C663(0.71); C284(0.88); C566(0.89); C275(0.90)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C663(0.57); C78(0.83); C84(0.83); C275(0.83)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C663(0.70); C275(0.90); C78(0.95); C84(0.95)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C663(0.69); C78(0.87); C84(0.87); C261(1.01)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C663(0.61); C275(0.66); C78(0.94); C84(0.94)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C663(0.81); C275(0.86); C78(1.01); C84(1.01)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C78(0.82); C84(0.82); C261(0.94); C281(1.09)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C78(0.77); C84(0.77); C261(0.87); C222(0.95)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C78(0.85); C84(0.85); C261(0.87); C222(1.10)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C78(0.95); C284(0.95); C218(0.96); C222(0.99)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C78(0.85); C84(0.85); C261(0.87); C218(1.15)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C78(0.85); C84(0.85); C261(0.92); C222(1.07)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C78(0.81); C84(0.81); C261(0.94); C218(1.27)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C78(0.64); C84(0.64); C261(0.90); C281(1.02)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C78(0.68); C84(0.68); C261(1.09); C222(1.24)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C78(0.66); C84(0.66); C261(0.98); C663(1.03)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C78(0.70); C84(0.70); C663(1.02); C261(1.04)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C78(0.71); C84(0.71); C261(0.96); C222(1.14)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C198(0.77); C261(0.96); C284(0.97); C272(0.98)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C198(0.92); C284(0.97); C272(0.97); C281(0.98)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C284(0.72); C281(0.75); C222(0.91); C218(0.93)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C272(0.90); C261(0.93); C284(0.93); C663(0.94)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C281(0.81); C284(0.84); C272(0.88); C233(1.02)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C663(0.74); C284(0.95); C281(0.97); C272(1.01)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C663(0.86); C284(0.99); C281(1.00); C272(1.04)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C281(1.02); C284(1.03); C272(1.07); C233(1.21)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C663(0.99); C272(1.13); C284(1.14); C198(1.16)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C281(0.98); C284(1.00); C663(1.04); C78(1.06)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C198(0.77); C272(0.87); C233(0.92); C241(0.92)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C284(0.80); C272(0.80); C281(0.81); C198(0.93)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C284(0.91); C281(0.92); C272(0.96); C233(1.00)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C281(0.89); C222(0.90); C284(0.93); C218(0.94)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C281(0.89); C284(0.92); C663(0.95); C272(0.98)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C233(0.93); C241(0.93); C663(1.03); C78(1.03)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C663(0.77); C284(1.16); C281(1.16); C272(1.17)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C281(1.01); C284(1.01); C78(1.01); C84(1.01)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C78(0.91); C84(0.91); C218(1.04); C261(1.07)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C663(0.82); C222(0.96); C224(0.99); C218(1.01)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C78(0.84); C84(0.84); C663(0.89); C222(1.08)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C78(0.89); C84(0.89); C663(0.91); C224(1.00)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C663(0.95); C224(0.99); C222(1.01); C218(1.05)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C78(0.81); C84(0.81); C663(0.83); C218(1.02)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C663(0.64); C78(0.81); C84(0.81); C281(0.84)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C663(0.64); C78(0.84); C84(0.84); C222(1.07)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C663(0.58); C78(0.92); C84(0.92); C224(1.01)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C663(0.78); C218(0.82); C222(0.84); C281(0.92)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C78(0.67); C84(0.67); C281(0.82); C284(0.82)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C663(0.75); C281(0.89); C284(0.89); C78(0.91)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C78(0.90); C84(0.90); C224(0.93); C218(0.98)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C663(0.59); C222(0.95); C218(0.97); C78(0.98)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C78(0.61); C84(0.61); C221(0.84); C663(0.87)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C78(0.61); C84(0.61); C566(0.86); C218(0.88)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C224(1.02); C218(1.15); C222(1.14); C261(1.12)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C663(0.78); C284(0.83); C281(0.90); C84(1.09)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C284(0.84); C281(0.89); C663(0.94); C84(1.00)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.88  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C566(0.94); C281(0.88); C284(0.88)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C261(1.01); C663(1.03); C198(1.04); C566(1.05)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C566(0.85); C261(1.11); C78(1.12); C84(1.12)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C272(0.67); C281(0.67); C78(0.71); C84(0.71)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C218(0.93); C224(1.07); C222(1.09); C261(1.12)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C218(0.95); C284(1.00); C78(1.01); C281(1.02)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C284(0.96); C218(0.97); C281(0.97); C84(1.00)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C222(0.93); C218(0.95); C224(0.96); C284(1.08)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C233(0.76); C241(0.76); C84(0.86); C261(0.86)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C272(0.86); C233(0.91); C241(0.91); C261(0.94)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C84(0.70); C233(0.82); C241(0.82); C261(0.83)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C84(0.83); C272(0.87); C233(0.94); C241(0.94)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C221(0.86); C261(0.94); C84(0.94); C233(0.96)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C566(0.82); C261(1.03); C233(1.09); C241(1.09)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C84(0.88); C233(0.91); C241(0.91); C261(1.01)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C272(0.70); C221(0.77); C261(0.80); C84(0.84)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C84(0.69); C663(0.87); C198(0.90); C261(0.91)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C84(0.56); C233(0.74); C241(0.74); C261(0.75)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C261(0.74); C233(0.74); C241(0.74); C84(0.84)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C84(0.69); C233(0.82); C241(0.82); C261(0.82)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C84(0.72); C233(0.75); C241(0.75); C663(0.83)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C198(0.85); C281(0.95); C284(1.03); C233(1.07)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C233(0.67); C241(0.67); C281(0.73); C284(0.74)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C233(0.70); C241(0.70); C663(0.82); C261(0.95)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C566(0.72); C261(1.07); C78(1.11); C84(1.11)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C233(0.72); C241(0.72); C284(0.83); C281(0.84)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C261(0.86); C663(0.86); C566(0.94); C284(0.94)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C78(0.74); C84(0.74); C663(0.82); C275(0.90)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C275(0.47); C663(0.59); C261(0.96); C224(0.98)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C663(0.54); C275(0.79); C78(0.84); C84(0.84)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C78(0.88); C84(0.88); C261(0.92); C281(0.96)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C78(0.77); C84(0.77); C281(0.92); C284(0.92)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C78(0.87); C84(0.87); C261(0.91); C218(0.96)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C78(0.79); C84(0.79); C261(0.95); C218(1.09)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C566(0.88); C261(0.99); C663(1.05); C78(1.07)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C566(0.79); C261(0.93); C233(0.95); C241(0.95)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C663(0.80); C566(0.81); C261(0.94); C78(1.03)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C272(0.65); C233(0.77); C241(0.77); C281(0.77)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C663(0.58); C272(0.75); C233(0.78); C241(0.78)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C663(0.60); C272(0.76); C261(0.80); C78(0.81)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C663(0.69); C261(0.85); C78(0.87); C84(0.87)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C663(0.90); C261(0.93); C566(0.95); C78(0.99)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C663(0.58); C272(0.84); C261(0.87); C78(0.95)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C663(0.58); C272(0.63); C78(0.91); C84(0.91)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C272(0.66); C284(1.02); C281(1.08); C224(1.09)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C272(0.70); C78(0.75); C84(0.75); C663(0.78)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C272(0.72); C663(0.74); C261(0.92); C284(0.93)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C224(1.08); C218(1.90); C222(1.53); C233(0.81)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C224(1.29); C218(1.62); C222(1.34); C233(0.93)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C224(1.10); C218(1.43); C222(1.28); C233(1.00)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C224(1.33); C218(1.39); C222(1.40); C233(0.89)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C224(1.08); C218(1.90); C222(1.49); C233(0.94)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C224(1.19); C198(1.11); C218(1.33); C222(1.33)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C224(1.09); C218(1.07); C222(1.08); C233(0.91)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C224(1.89); C222(1.07); C261(0.95); C272(1.18)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C224(1.04); C218(0.96); C222(0.96); C261(0.91)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C224(1.68); C218(1.10); C222(1.10); C261(0.77)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C224(2.03); C218(1.30); C222(1.30); C261(1.07)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C224(2.45); C218(1.24); C222(1.24); C261(0.98)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C224(2.05); C218(1.13); C222(1.13); C261(0.90)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C224(3.35); C218(1.27); C222(1.27); C261(0.97)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C224(1.74); C218(1.05); C222(1.05); C261(0.96)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C224(1.10); C198(0.94); C218(1.17); C222(1.17)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C224(1.98); C218(1.26); C222(1.26); C261(0.98)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C224(2.32); C218(1.29); C222(1.29); C261(0.94)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C224(2.66); C218(1.07); C222(1.07); C261(1.16)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C224(2.39); C218(1.00); C222(1.00); C261(1.00)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C224(2.15); C218(1.24); C222(1.24); C261(0.98)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C224(1.85); C218(1.22); C222(1.22); C261(0.93)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C224(1.76); C218(2.28); C222(2.28); C261(1.13)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C224(1.44); C218(1.62); C222(1.62); C261(1.04)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C224(1.08); C218(1.02); C222(1.02); C261(1.03)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C224(0.91); C218(1.13); C222(1.13); C261(1.01)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C224(1.24); C198(0.97); C218(1.46); C222(1.46)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C224(0.84); C218(0.73); C222(0.73); C261(1.04)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C224(1.16); C218(1.15); C222(1.15); C261(0.99)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C224(1.17); C218(0.94); C222(0.94); C261(0.98)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C224(1.02); C218(0.57); C222(0.57); C261(0.97)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C224(0.78); C218(0.60); C222(0.60); C261(0.91)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C224(0.96); C218(0.99); C222(0.99); C261(1.02)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C224(0.87); C218(0.63); C222(0.63); C261(0.98)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C224(1.06); C218(0.86); C222(0.86); C261(0.91)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C224(1.01); C218(1.10); C222(1.10); C261(0.96)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C224(0.95); C218(0.80); C222(0.80); C261(1.05)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C224(1.27); C198(1.05); C218(1.52); C222(1.52)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C224(1.08); C218(0.70); C222(0.70); C261(1.02)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C224(1.08); C198(1.04); C218(1.06); C222(1.06)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C224(0.94); C198(0.97); C218(0.93); C222(0.93)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C224(1.15); C198(0.97); C218(0.94); C222(0.94)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C224(0.93); C198(1.02); C218(0.91); C222(0.91)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C224(0.90); C198(1.15); C218(1.00); C222(1.00)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C224(0.98); C198(1.21); C218(1.19); C222(1.19)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C224(1.15); C198(1.05); C218(1.24); C222(1.24)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C224(1.13); C198(1.08); C218(1.16); C222(1.16)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C224(1.07); C198(0.97); C218(1.11); C222(1.11)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C224(1.15); C198(1.01); C218(1.42); C222(1.42)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C224(0.83); C198(0.90); C218(0.85); C222(0.85)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C224(1.03); C198(1.01); C218(0.93); C222(0.93)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C224(0.98); C198(1.12); C218(0.86); C222(0.86)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C224(1.12); C198(1.06); C218(1.20); C222(1.20)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C224(1.01); C198(1.11); C218(1.07); C222(1.07)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C224(1.37); C233(0.87); C241(0.87); C261(0.87)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C224(1.31); C233(0.90); C241(0.90); C261(0.80)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C224(1.06); C233(0.88); C241(0.88); C261(0.93)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C224(1.78); C233(1.77); C241(1.77); C261(0.91)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C224(1.19); C198(1.03); C218(1.18); C222(1.18)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C224(1.50); C233(1.12); C241(1.12); C261(0.83)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C224(1.51); C233(1.04); C241(1.04); C261(0.81)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C224(1.36); C233(1.23); C241(1.23); C261(1.02)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C224(0.78); C233(1.13); C241(1.13); C261(0.99)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C224(0.97); C233(1.13); C241(1.13); C261(1.12)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C224(1.01); C233(1.10); C241(1.10); C261(0.82)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C224(0.84); C233(1.06); C241(1.06); C261(0.93)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C224(0.87); C233(0.93); C241(0.93); C261(0.87)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C224(0.96); C233(1.17); C241(1.17); C261(0.92)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C224(0.69); C233(1.43); C241(1.43); C261(1.30)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C224(1.34); C198(0.93); C218(1.46); C222(1.46)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C224(1.01); C233(1.12); C241(1.12); C261(0.91)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C224(1.35); C222(1.35); C261(1.06); C272(0.92)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C224(1.46); C222(1.46); C261(0.93); C272(1.12)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C224(1.19); C222(1.19); C261(0.87); C272(0.93)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C224(1.67); C222(1.67); C261(0.79); C272(1.07)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C224(1.71); C222(1.71); C261(0.91); C272(0.90)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C224(1.11); C222(1.11); C261(0.91); C272(0.89)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C224(1.12); C222(1.12); C261(0.90); C272(0.83)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C224(1.76); C222(1.76); C261(1.10); C272(0.71)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C224(1.37); C222(1.37); C261(0.98); C272(0.67)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C198(1.00); C905(0.87); C174(1.03); C790(0.97)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C198(2.03)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C224(1.09); C198(1.12); C218(0.96); C222(0.96)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C224(2.79); C218(1.12); C222(1.12); C261(0.99)  LDD0744  [7]
 LDCM0120  HHS-0701 DM93 Y54(1.46)  LDD0268  [6]
 LDCM0022  KB02 HCT 116 C224(2.36); C222(1.59)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C224(1.60); C222(1.26)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C224(2.56); C222(1.93)  LDD0082  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C790(1.03)  LDD2099  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C198(0.74)  LDD2111  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C198(7.74); C790(1.29)  LDD2127  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C790(1.19)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C198(1.30)  LDD2137  [4]
 LDCM0021  THZ1 HCT 116 C222(1.23); C224(1.23); C566(0.98)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 4 catalytic subunit (PPP4C) PPP phosphatase family P60510

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402