Details of the Target

General Information of Target

Target ID LDTP15348
Target Name Probable ATP-dependent RNA helicase DHX40 (DHX40)
Gene Name DHX40
Gene ID 79665
Synonyms
DDX40; Probable ATP-dependent RNA helicase DHX40; EC 3.6.4.13; DEAH box protein 40; Protein PAD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRATAPCWFPPGYPEAKKVAEEAALEASRHLGGEQSQAGAPEGSKMLRATAPCWFRPGY
PEAKKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPPGYPEAKKVAEEAALEA
PEFPLPSHQPAQSFGLWVPQMHKQASAFVDIQAEPQNRGPAVPPAWPKMVTESCYFPAQR
GSACRLPAAPRLTERPSGVRISAPRKRKTIAHSSSPCLVTGYTDAKRTRVASSSQRSRGS
KVGRQPGKTRNRSGMACKTTATTSSKRIVRRASLPSLSLKKPIILRSSGCQVPTVLRRGY
LQLFTEECLKFCASKQEAEEKALNEEKVAYDCSPNKNRYLNVVLNTLKRLKGLTPSSMPG
LSRAALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTGQGKGPGDSSCRVCCRCGTE
YLVSSSGRCVRDQLCYYHWGRVRSSQVAGGRVSQYTCCAAAPGSVGCQVAKQHVRDGRKE
SLDGFVETFKKELSRDAYPGIYALDCEMCYTTHGLELTRVTVVDADMRVVYDTFVKPDNE
IVDYNTRFSGVTEADVAKTSITLPQVQAILLSFFSAQTILIGHSLESDLLALKLIHSTVV
DTAVLFPHYLGFPYKRSLRNLAADYLAQIIQDSQDGHNSSEDASACLQLVMWKVRQRAQI
QPRHRSASPAALACP
Target Bioclass
Enzyme
Family
DEAD box helicase family, DEAH subfamily
Function Probable ATP-dependent RNA helicase.
Uniprot ID
Q8IX18
Ensemble ID
ENST00000251241.9
HGNC ID
HGNC:18018

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.R633Q DBIA    Probe Info 
HEC1 SNV: p.Q769H DBIA    Probe Info 
ONS76 SNV: p.F702Y DBIA    Probe Info 
SH4 SNV: p.P54S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y532(8.29)  LDD0257  [1]
m-APA
 Probe Info  		11.33  LDD0403  [2]
BTD
 Probe Info  		C685(1.01)  LDD2123  [3]
AHL-Pu-1
 Probe Info  		C417(3.50); C33(2.35)  LDD0168  [4]
DBIA
 Probe Info  		C641(1.04)  LDD0078  [5]
ATP probe
 Probe Info  		K367(0.00); K108(0.00); K82(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C242(0.00); C139(0.00); C42(0.00); C225(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C139(0.00); C470(0.00); C153(0.00); C33(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C563(0.00); C242(0.00); C42(0.00); C225(0.00)  LDD0037  [7]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		C242(0.00); C153(0.00); C139(0.00)  LDD0148  [9]
Acrolein
 Probe Info  		C33(0.00); C641(0.00)  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		9.80  LDD0443  [11]
NAIA_5
 Probe Info  		C507(0.00); C563(0.00); C242(0.00); C417(0.00)  LDD2223  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C417(3.50); C33(2.35)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C417(2.52); C33(3.06)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C139(0.69); C153(1.00); C225(0.52); C242(1.08)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C139(0.92); C153(1.57); C225(0.55); C242(1.06)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C139(1.01); C153(1.07); C242(0.85); C33(1.35)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C139(0.85); C153(1.04); C242(0.72); C33(1.13)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C139(0.93); C153(1.00); C242(0.70); C33(1.02)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C139(0.81); C153(1.06); C242(0.75); C33(1.48)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C139(0.87); C153(0.95); C242(0.69); C33(1.13)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C139(0.93); C153(1.05); C242(0.68); C33(1.33)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C139(0.93); C153(1.06); C242(0.75); C33(1.43)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C139(0.87); C153(0.90); C242(0.78); C33(1.22)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C139(1.02); C153(1.06); C242(0.82); C33(1.23)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C139(1.00); C153(1.12); C242(0.92); C33(0.93)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C139(0.79); C153(0.83); C225(0.57); C242(0.70)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C139(0.85); C153(0.91); C242(0.81); C33(0.94)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C139(0.78); C153(0.92); C242(0.78); C33(0.98)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C139(0.81); C153(1.05); C242(0.76); C33(1.49)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C139(1.04); C153(1.21); C225(0.98); C242(1.13)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C139(1.38); C153(0.88); C225(0.51); C242(1.07)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C139(1.10); C153(1.01); C225(0.45); C242(0.98)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C139(0.76); C153(0.94); C225(0.45); C242(0.94)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C139(0.99); C153(1.38); C225(0.62); C242(1.06)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C139(1.42); C153(1.05); C225(0.61); C242(1.09)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C139(0.86); C153(1.14); C225(0.57); C242(1.04)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C139(0.90); C153(0.96); C225(0.74); C242(0.98)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C139(1.01); C153(0.76); C225(0.54); C242(0.96)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C139(1.35); C153(1.43); C225(0.79); C242(1.10)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C139(1.10); C153(0.90); C225(0.48); C242(0.91)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C139(1.29); C153(0.83); C225(0.61); C242(1.14)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C139(1.09); C153(1.61); C225(0.75); C242(1.15)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C139(1.61); C153(0.87); C225(0.66); C242(1.05)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C139(1.26); C153(0.82); C225(0.52); C242(1.05)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C139(1.08); C153(1.12); C225(0.59); C242(1.08)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C139(1.23); C153(1.41); C242(1.24); C417(1.46)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C139(1.16); C153(1.49); C242(1.26); C417(0.86)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C139(1.05); C153(1.32); C242(1.02); C417(1.21)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C139(0.92); C153(1.34); C242(1.12); C417(0.83)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C139(1.41); C153(1.50); C242(1.19); C417(0.99)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C139(1.25); C153(1.32); C242(1.04); C417(1.13)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C139(1.30); C153(1.25); C242(1.06); C417(1.24)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C139(1.44); C153(1.33); C242(1.09); C417(1.24)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C139(1.22); C153(1.29); C242(1.03); C417(1.08)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C139(1.22); C153(1.29); C242(1.10); C417(0.99)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C139(1.34); C153(1.34); C242(1.05); C417(1.02)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C139(1.24); C153(1.28); C242(1.16); C417(1.09)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C139(0.98); C153(0.79); C225(0.52); C242(0.77)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C139(1.39); C153(1.39); C242(1.15); C417(1.24)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C139(1.30); C153(1.47); C242(1.03); C417(1.06)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C139(1.17); C153(1.36); C242(0.98); C417(0.90)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C153(1.15); C225(0.91); C242(0.98); C417(1.00)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C225(0.47); C622(0.58); C624(0.58); C153(0.86)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C622(0.69); C624(0.69); C225(0.77); C153(0.99)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C225(0.43); C622(0.48); C624(0.48); C42(0.86)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C225(0.52); C622(0.59); C624(0.59); C153(0.87)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C225(0.45); C622(0.69); C624(0.69); C42(0.88)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C225(0.46); C622(0.51); C624(0.51); C153(0.80)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C225(0.52); C470(0.76); C622(0.78); C624(0.78)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C622(0.74); C624(0.74); C225(0.78); C42(0.84)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C225(0.72); C622(0.73); C624(0.73); C582(0.90)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C225(0.44); C622(0.62); C624(0.62); C153(0.84)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C225(0.41); C622(0.60); C624(0.60); C42(0.78)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C153(0.83); C225(0.53); C242(0.98); C417(1.07)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C153(0.87); C225(0.50); C242(0.98); C417(1.12)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C153(1.05); C225(1.01); C242(1.02); C417(0.91)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C153(0.90); C225(0.75); C242(1.03); C417(0.89)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C641(0.80); C622(0.92); C624(0.92); C470(0.93)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C573(0.56); C225(0.66); C641(0.74); C139(0.82)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C225(0.80); C622(0.88); C624(0.88); C153(0.93)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C573(0.72); C225(0.80); C242(0.93); C470(0.95)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C641(0.86); C225(0.94); C622(0.99); C624(0.99)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C641(0.76); C225(0.80); C139(0.88); C573(0.89)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C641(0.74); C225(0.96); C139(0.97); C153(0.97)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C641(0.65); C225(0.79); C622(0.88); C624(0.88)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C641(0.72); C153(0.96); C470(0.98); C417(0.99)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C622(0.81); C624(0.81); C225(0.83); C470(0.89)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C622(0.56); C624(0.56); C225(0.75); C582(0.85)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C622(0.67); C624(0.67); C225(0.83); C573(0.85)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C622(0.54); C624(0.54); C470(0.75); C582(0.76)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C622(0.58); C624(0.58); C582(0.78); C225(0.81)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C573(0.72); C225(0.74); C139(0.88); C622(0.95)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C622(0.61); C624(0.61); C225(0.77); C573(0.81)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C622(0.42); C624(0.42); C225(0.61); C573(0.71)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C622(0.49); C624(0.49); C225(0.64); C573(0.80)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C622(0.56); C624(0.56); C225(0.62); C573(0.80)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C622(0.54); C624(0.54); C225(0.64); C139(0.77)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C153(0.83); C42(0.84); C641(0.86); C417(0.95)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C153(0.83); C42(0.84); C440(0.87); C417(0.92)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C622(0.82); C624(0.82); C573(0.84); C42(0.87)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C440(0.76); C42(0.89); C153(0.90); C417(0.91)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C153(0.80); C440(0.86); C573(0.86); C622(0.94)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C225(0.61); C573(0.69); C139(0.88); C440(0.98)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C440(0.83); C153(0.85); C582(0.89); C573(0.89)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C582(0.82); C153(0.93); C622(0.95); C624(0.95)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C622(0.84); C624(0.84); C573(0.86); C440(0.94)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C153(0.77); C582(0.79); C622(0.83); C624(0.83)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C573(0.89); C622(0.92); C624(0.92); C417(0.93)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C622(0.90); C624(0.90); C225(0.91); C153(0.93)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C573(0.82); C622(0.84); C624(0.84); C582(0.92)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C225(0.79); C153(0.90); C139(0.90); C573(0.94)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C622(0.52); C624(0.52); C470(0.62); C573(0.64)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C225(0.75); C470(0.85); C139(0.90); C573(0.94)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C225(0.67); C573(0.74); C139(0.96); C440(0.97)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C225(0.72); C139(0.81); C622(0.83); C624(0.83)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C33(0.77); C417(0.90); C641(0.90); C573(1.00)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C225(0.81); C470(0.94); C33(0.95); C641(0.99)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C622(0.75); C624(0.75); C225(0.78); C139(0.84)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C225(0.77); C139(0.84); C470(0.90); C573(0.90)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C225(0.74); C622(0.81); C624(0.81); C139(0.87)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C225(0.66); C470(0.79); C139(0.82); C573(0.87)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C622(0.51); C624(0.51); C225(0.65); C573(0.67)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C622(0.36); C624(0.36); C573(0.46); C225(0.67)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C622(0.59); C624(0.59); C573(0.65); C225(0.72)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C225(0.60); C622(0.65); C624(0.65); C470(0.78)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C622(0.33); C624(0.33); C573(0.34); C242(0.71)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C573(0.28); C622(0.36); C624(0.36); C582(0.59)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C622(0.59); C624(0.59); C573(0.63); C225(0.83)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C573(0.39); C622(0.45); C624(0.45); C582(0.70)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C573(0.46); C622(0.49); C624(0.49); C225(0.76)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C622(0.45); C624(0.45); C573(0.56); C582(0.91)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C622(0.42); C624(0.42); C573(0.56); C225(0.81)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C573(0.33); C622(0.36); C624(0.36); C225(0.63)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C624(0.64); C225(0.70); C242(0.76); C622(0.80)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C225(0.66); C153(0.80); C242(0.87); C470(0.88)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C470(0.67); C225(0.74); C641(0.87); C242(0.89)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C225(0.59); C624(0.69); C242(0.70); C153(0.74)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C624(0.50); C42(0.80); C622(0.80); C242(0.84)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C624(0.67); C242(0.74); C225(0.81); C153(0.85)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C225(0.72); C624(0.73); C470(0.85); C153(0.86)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C624(0.47); C225(0.60); C622(0.77); C242(0.81)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C225(0.68); C624(0.69); C153(0.81); C622(0.88)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C225(0.78); C153(0.82); C470(0.91); C242(0.94)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C624(0.39); C622(0.66); C470(0.80); C153(0.80)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C624(0.39); C622(0.63); C242(0.68); C225(0.72)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C242(0.78); C153(0.86); C225(0.92); C470(1.04)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C225(0.60); C470(0.63); C153(0.75); C139(0.79)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C624(0.77); C225(0.77); C153(0.78); C242(0.85)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C624(0.58); C242(0.69); C582(0.71); C470(0.81)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C624(0.44); C225(0.55); C622(0.71); C573(0.81)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C573(0.83); C242(0.83); C139(0.83); C622(0.86)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C573(0.77); C242(0.81); C139(0.86); C622(0.90)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C242(0.74); C573(0.74); C582(0.82); C139(0.84)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C242(0.94); C573(0.94); C153(0.96); C470(0.96)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C242(0.83); C622(0.83); C582(0.85); C624(0.85)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C242(0.94); C139(0.94); C582(0.98); C622(0.99)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C242(0.81); C139(0.84); C624(0.91); C573(0.92)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C641(0.97); C153(0.99); C470(1.05); C417(1.05)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C242(0.91); C470(0.92); C139(0.93); C153(0.94)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C242(0.92); C139(0.94); C573(1.00); C153(1.04)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C242(0.88); C139(0.92); C641(0.99); C470(0.99)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C242(0.85); C582(0.87); C573(0.95); C153(0.97)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C582(0.64); C622(0.65); C242(0.69); C573(0.70)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C582(0.80); C242(0.87); C573(0.89); C153(0.90)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C242(0.83); C139(0.85); C153(0.96); C573(0.97)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C573(0.55); C242(0.55); C139(0.67); C582(0.78)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C622(0.73); C624(0.73); C242(0.77); C573(0.79)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C139(1.07); C153(1.47); C225(0.77); C242(1.03)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C225(0.64); C622(0.71); C624(0.71); C470(0.71)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C225(0.39); C573(0.67); C470(0.69); C622(0.89)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.33  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C641(1.04)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C33(0.34)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C42(0.86); C641(0.90); C417(0.99); C470(1.03)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C573(0.56); C225(0.68); C139(0.73); C242(0.80)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C225(0.66); C573(0.68); C139(0.77); C622(0.84)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C225(0.49); C573(0.73); C139(0.75); C417(0.79)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C573(0.66); C225(0.70); C139(0.79); C641(0.79)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C225(0.62); C470(0.65); C139(0.76); C641(0.80)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C225(0.72); C470(0.77); C139(0.77); C417(0.82)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C225(0.63); C573(0.75); C622(0.78); C624(0.78)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C225(0.40); C573(0.44); C622(0.48); C624(0.48)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C225(0.55); C622(0.82); C624(0.82); C573(0.89)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C225(0.61); C622(0.74); C624(0.74); C573(0.75)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C225(0.67); C641(0.75); C622(0.77); C624(0.77)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C622(0.53); C624(0.53); C573(0.59); C225(0.61)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C225(0.54); C573(0.65); C622(0.72); C624(0.72)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C225(0.74); C622(0.76); C624(0.76); C573(0.82)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C622(0.61); C624(0.61); C582(0.78); C417(0.87)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C622(0.54); C624(0.54); C225(0.68); C139(0.86)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C622(0.54); C624(0.54); C573(0.75); C582(0.80)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C622(0.58); C624(0.58); C225(0.68); C573(0.81)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C622(0.49); C624(0.49); C225(0.76); C573(0.77)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C440(0.76); C417(0.78); C139(0.79); C573(0.87)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C153(0.91); C573(0.95); C139(0.95); C470(0.97)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C153(0.90); C139(0.94); C242(0.96); C573(0.98)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C225(0.75); C573(0.77); C139(0.87); C622(0.93)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C573(0.91); C622(0.94); C624(0.94); C153(0.95)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C225(0.53); C242(0.71); C470(0.73); C573(0.74)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C622(0.65); C624(0.65); C225(0.68); C470(0.74)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C225(0.72); C622(0.75); C624(0.75); C573(0.83)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C225(0.74); C573(0.88); C139(0.95); C470(0.95)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C622(0.60); C624(0.60); C582(0.78); C470(0.90)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C622(0.67); C624(0.67); C573(0.74); C242(0.87)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C573(0.63); C582(0.82); C139(0.85); C225(0.86)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C573(0.63); C622(0.73); C624(0.73); C225(0.82)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C573(0.49); C622(0.58); C624(0.58); C225(0.60)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C622(0.82); C624(0.82); C573(0.84); C42(0.85)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C573(0.44); C225(0.62); C622(0.63); C624(0.63)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C225(0.69); C139(0.80); C622(0.81); C624(0.81)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C225(0.60); C622(0.62); C624(0.62); C573(0.72)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C225(0.30); C622(0.58); C624(0.58); C440(0.63)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C225(0.53); C622(0.78); C624(0.78); C153(0.91)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C470(0.88); C42(0.88); C440(0.90); C641(0.91)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C225(0.48); C622(0.64); C624(0.64); C573(0.72)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C225(0.41); C622(0.65); C624(0.65); C139(0.74)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C225(0.44); C622(0.68); C624(0.68); C573(0.71)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C225(0.64); C622(0.82); C624(0.82); C139(0.88)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C225(0.46); C622(0.76); C624(0.76); C242(0.88)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C139(0.89); C153(1.06); C225(0.49); C242(0.85)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C139(0.97); C153(1.04); C225(0.54); C242(0.88)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C139(0.97); C153(0.95); C225(0.57); C242(0.98)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C139(0.98); C153(0.88); C225(0.44); C242(0.80)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C139(0.85); C153(0.92); C225(0.45); C242(0.94)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C139(0.88); C153(1.00); C225(1.00); C242(1.05)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C139(0.96); C153(1.08); C225(0.65); C242(0.92)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C139(0.88); C153(0.98); C225(0.66); C242(1.09)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C139(0.83); C153(0.83); C225(0.35); C242(1.10)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C139(0.68); C153(0.87); C225(0.46); C242(0.93)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C139(0.70); C153(0.93); C225(0.46); C242(1.17)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C139(0.78); C153(0.93); C225(0.53); C242(1.07)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C139(0.71); C153(0.92); C225(0.54); C242(1.14)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C139(0.85); C153(0.92); C225(0.53); C242(1.12)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C139(1.00); C153(0.95); C225(0.52); C242(1.19)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C139(0.95); C153(0.94); C225(0.94); C242(1.00)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C139(0.91); C153(0.91); C225(0.50); C242(1.10)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C139(0.80); C153(0.86); C225(0.57); C242(1.18)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C139(0.84); C153(1.01); C225(0.47); C242(1.32)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C139(0.97); C153(0.88); C225(0.45); C242(1.13)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C139(0.92); C153(0.83); C225(0.36); C242(1.04)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C139(0.95); C153(0.90); C225(0.38); C242(0.97)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C139(0.96); C153(0.89); C225(1.52); C242(1.14)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C139(0.85); C153(0.90); C225(1.26); C242(0.97)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C139(0.92); C153(0.93); C225(1.27); C242(1.12)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C139(1.07); C153(0.95); C225(1.41); C242(0.91)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C139(0.92); C153(1.00); C225(0.87); C242(0.97)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C139(0.92); C153(0.91); C225(1.19); C242(1.07)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C139(1.10); C153(0.95); C225(1.19); C242(1.12)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C139(0.97); C153(0.89); C225(1.33); C242(1.13)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C139(0.68); C153(0.85); C225(1.25); C242(1.09)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C139(0.72); C153(0.87); C225(1.36); C242(0.87)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C139(0.75); C153(0.89); C225(1.49); C242(0.95)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C139(0.65); C153(0.89); C225(1.09); C242(0.91)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C139(0.63); C153(0.82); C225(1.13); C242(0.91)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C139(0.72); C153(0.89); C225(1.44); C242(1.04)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C139(0.66); C153(0.86); C225(1.22); C242(1.10)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C139(0.77); C153(0.83); C225(0.62); C242(0.83)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C139(0.80); C153(0.85); C225(1.20); C242(1.14)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C139(1.19); C225(0.86); C242(0.98); C33(1.55)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C139(1.21); C225(0.71); C242(0.87); C33(1.39)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C139(0.95); C225(0.57); C242(0.86); C33(0.92)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C139(1.10); C225(0.56); C242(0.94); C33(1.29)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C139(1.05); C225(0.64); C242(1.01); C33(1.08)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C139(0.96); C225(0.47); C242(0.85); C33(1.17)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C139(0.82); C225(0.52); C242(0.96); C33(0.91)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C139(0.67); C225(0.44); C242(0.78); C33(0.75)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C139(0.65); C225(0.44); C242(0.63); C33(1.10)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C139(0.82); C153(1.02); C225(0.77); C242(0.94)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C139(0.73); C225(0.55); C242(0.86); C33(0.91)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C139(0.80); C225(0.58); C242(0.93); C33(1.09)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C139(0.84); C225(0.96); C242(1.00); C33(1.19)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C139(0.76); C225(0.75); C242(0.86); C33(0.97)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C139(0.78); C225(0.62); C242(0.97); C33(1.15)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C153(1.03); C225(0.60); C242(1.17); C33(0.48)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C153(1.31); C225(1.03); C242(1.12); C33(0.54)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C153(1.21); C225(0.63); C242(1.11); C33(0.66)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C153(1.05); C225(0.55); C242(1.21); C33(0.68)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C139(0.73); C153(1.06); C225(0.80); C242(0.93)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C153(1.01); C225(0.57); C242(1.12); C33(1.05)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C153(0.96); C225(0.66); C242(1.30); C33(0.97)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C153(1.43); C225(0.46); C242(1.32); C33(0.74)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C153(1.10); C225(0.51); C242(1.25); C33(0.52)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C153(1.01); C225(0.47); C242(1.03); C33(0.88)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C153(1.00); C225(0.65); C242(1.11); C33(0.51)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C153(1.21); C225(0.99); C242(1.15); C33(0.57)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C153(1.23); C225(0.56); C242(1.32); C33(0.66)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C153(0.93); C225(0.55); C242(1.41); C33(0.50)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C153(1.09); C225(0.43); C242(1.21); C33(0.64)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C139(0.88); C153(1.01); C225(0.85); C242(0.92)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C153(1.31); C225(0.98); C242(1.14); C33(0.45)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C139(0.94); C153(1.01); C225(0.64); C242(1.10)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C139(0.86); C153(1.10); C225(0.68); C242(0.92)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C139(1.01); C153(1.01); C225(0.80); C242(1.04)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C139(0.91); C153(0.94); C225(0.58); C242(0.89)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C139(0.77); C153(0.92); C225(0.59); C242(1.17)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C139(0.79); C153(0.99); C225(0.64); C242(0.95)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C139(0.81); C153(0.91); C225(0.62); C242(0.86)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C139(0.79); C153(1.03); C225(0.61); C242(1.01)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C139(0.77); C153(0.94); C225(0.61); C242(1.17)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C33(1.65)  LDD2228  [12]
 LDCM0495  E2913 HEK-293T C641(0.95); C42(0.82); C153(1.35); C582(1.07)  LDD1698  [13]
 LDCM0468  Fragment33 HCT 116 C139(0.84); C225(0.55); C242(0.84); C33(1.33)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C139(0.72); C153(0.90); C225(0.44); C242(1.26)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C153(1.89); C641(1.47); C33(1.78); C42(1.67)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C153(1.72); C641(1.17); C33(2.34); C42(1.47)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C153(2.61); C641(2.12); C33(1.53); C42(1.26)  LDD0082  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C685(1.01)  LDD2123  [3]
 LDCM0021  THZ1 HCT 116 C641(1.06); C139(1.04)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402