Details of the Target

General Information of Target

Target ID LDTP14265
Target Name DNA (cytosine-5)-methyltransferase 3A (DNMT3A)
Gene Name DNMT3A
Gene ID 1788
Synonyms
DNA; cytosine-5)-methyltransferase 3A; Dnmt3a; EC 2.1.1.37; Cysteine methyltransferase DNMT3A; EC 2.1.1.-; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAG
RSLLEPLMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYI
ACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPD
WMFFCCFAGTFMFYCAHWQTYVSGTLRFGIIDVTEVQIFIIIMHLLAVIGGPPFWQSMIP
VLNIQMKIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLA
AMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLD
QYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKVSTAHSNHH
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
Subcellular location
Nucleus
Function
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Also has weak auto-methylation activity on Cys-710 in absence of DNA.
TTD ID
T29355
Uniprot ID
Q9Y6K1
DrugMap ID
TTJUALD
Ensemble ID
ENST00000264709.7
HGNC ID
HGNC:2978
ChEMBL ID
CHEMBL1992

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.A121T .
CCSW1 SNV: p.Q573H DBIA    Probe Info 
COLO792 SNV: p.S349L .
HCT15 SNV: p.M761I .
JHH7 SNV: p.A131P .
JURKAT SNV: p.R301W .
KO52 SNV: p.R882H .
LNCaP clone FGC SNV: p.A107V DBIA    Probe Info 
MOLT4 Deletion: p.G699AfsTer6 IA-alkyne    Probe Info 
NCIH1666 SNV: p.A107V .
NCIH1793 SNV: p.E725Ter DBIA    Probe Info 
NCIH23 SNV: p.G223Ter .
P31FUJ SNV: p.G10W .
SUPT1 SNV: p.E599Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C710(13.25)  LDD0171  [1]
DBIA
 Probe Info  		C136(3.19); C137(3.19); C557(2.96); C562(2.96)  LDD0080  [2]
IA-alkyne
 Probe Info  		C710(0.00); C911(0.00)  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
W1
 Probe Info  		N.A.  LDD0236  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C710(13.25)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C549(1.28); C554(1.28); C583(1.21); C586(1.21)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C549(1.07); C555(1.07); C583(1.02); C586(1.02)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C549(0.95); C554(0.95); C583(0.65); C586(0.65)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C549(1.03); C554(1.03); C583(0.69); C586(0.69)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C549(0.77); C554(0.77); C583(0.74); C586(0.74)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C549(1.23); C554(1.23); C583(1.00); C586(1.00)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C549(0.94); C554(0.94); C583(0.81); C586(0.81)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C549(1.10); C554(1.10); C583(0.78); C586(0.78)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C549(1.24); C554(1.24); C583(0.99); C586(0.99)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C549(1.21); C554(1.22); C583(0.71); C586(0.71)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C549(0.89); C554(1.26); C583(0.54); C586(0.54)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C549(1.30); C554(0.81); C583(0.70); C586(0.70)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C549(0.96); C555(0.96); C583(1.12); C586(1.12)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C549(1.02); C554(0.86); C583(0.67); C586(0.67)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C549(0.56); C554(0.83); C583(0.61); C586(0.61)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C549(1.01); C554(1.30); C583(0.67); C586(0.67)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C583(0.96); C586(0.96)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C583(1.04); C586(1.04)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C583(1.14); C586(1.14)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C583(1.20); C586(1.20)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C583(0.91); C586(0.91)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C583(0.97); C586(0.97)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C583(1.02); C586(1.02)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C549(1.04); C555(1.04); C583(1.28); C586(1.28)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C583(1.30); C586(1.30)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C583(0.88); C586(0.88)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C583(1.13); C586(1.13)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C583(0.98); C586(0.98)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C583(0.93); C586(0.93)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C583(1.11); C586(1.11)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C583(1.04); C586(1.04)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C583(0.96); C586(0.96)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C549(0.92); C583(1.12); C586(1.12)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C549(1.08); C583(1.07); C586(1.07)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C549(1.04); C583(1.27); C586(1.27)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C549(1.05); C583(1.20); C586(1.20)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C549(0.99); C583(1.32); C586(1.32)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C549(1.13); C583(1.73); C586(1.73)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C549(1.10); C583(1.13); C586(1.13)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C549(1.13); C583(1.10); C586(1.10)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C549(1.15); C583(0.90); C586(0.90)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C549(1.31); C583(1.19); C586(1.19)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C549(1.65); C583(1.12); C586(1.12)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C549(1.43); C583(1.10); C586(1.10)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C549(1.19); C555(1.19); C583(1.04); C586(1.04)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C549(1.28); C583(1.12); C586(1.12)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C549(1.34); C583(1.05); C586(1.05)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C549(1.19); C583(1.08); C586(1.08)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C549(0.88); C554(0.88); C555(0.88); C583(1.13)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C549(0.98); C554(0.98); C555(0.98); C586(1.31)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C549(0.76); C554(0.76); C555(0.76); C586(1.21)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C549(0.96); C554(0.96); C555(0.96); C583(1.16)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C549(0.84); C554(0.84); C555(0.84); C586(1.29)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C549(0.95); C554(0.95); C555(0.95); C586(1.60)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C549(0.95); C554(0.95); C555(0.95); C583(1.30)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C549(1.27); C555(1.27); C583(1.41); C586(1.41)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C549(0.92); C554(0.92); C555(0.92); C583(1.11)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C549(1.02); C554(1.02); C555(1.02); C586(1.05)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C549(0.86); C554(0.86); C555(0.86); C586(1.25)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C549(0.91); C554(0.91); C555(0.91); C583(1.44)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C549(0.90); C554(0.90); C555(0.90); C583(1.27)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C549(0.89); C554(0.89); C555(0.89); C583(1.11)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C549(0.90); C554(0.90); C555(0.90); C583(1.12)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C549(0.86); C554(0.86); C555(0.86); C583(1.11)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C583(0.81); C586(0.81)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C583(0.91); C586(0.91)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C583(0.90); C586(0.90)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C583(0.99); C586(0.99); C549(1.25); C554(1.25)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C583(0.92); C586(0.92)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C583(0.93); C586(0.93)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C583(0.87); C586(0.87)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C583(0.81); C586(0.81)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C583(0.93); C586(0.93)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C549(1.11); C555(1.11)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C549(1.36); C555(1.36)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C549(1.46); C555(1.46)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C549(1.76); C555(1.76)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C549(1.46); C555(1.46)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C583(1.07); C586(1.07); C549(1.18); C554(1.18)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C549(1.23); C555(1.23)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C549(1.41); C555(1.41)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C549(1.65); C555(1.65)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C549(1.30); C555(1.30)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C549(1.79); C555(1.79)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C549(0.76); C583(1.19); C586(1.02)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C549(0.96); C583(1.32); C586(1.08)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C549(0.99); C583(1.07); C586(0.95)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C549(0.92); C583(1.17); C586(1.01)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C549(0.86); C583(1.17); C586(1.07)  LDD0898  [2]
 LDCM0301  AC4 HCT 116 C583(1.06); C586(1.06); C549(1.42); C554(1.42)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C549(0.84); C583(1.12); C586(1.09)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C549(0.81); C583(0.98); C586(1.00)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C549(0.96); C583(0.97); C586(0.93)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C549(0.90); C583(1.15); C586(1.19)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C549(0.99); C583(0.97); C586(0.98)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C549(0.80); C583(1.05); C586(1.04)  LDD0905  [2]
 LDCM0308  AC46 HCT 116 C583(0.83); C586(0.83)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C583(0.91); C586(0.91)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C583(0.91); C586(0.91)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C583(1.05); C586(1.05)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C583(1.15); C586(1.15); C549(1.48); C554(1.48)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C583(0.99); C586(0.99)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C583(0.99); C586(0.99)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C583(0.88); C586(0.88)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C583(0.90); C586(0.90)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C583(1.02); C586(1.02)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C583(0.79); C586(0.79)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C583(1.12); C586(1.12)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C549(1.36); C554(1.36)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C549(1.34); C554(1.34)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C549(1.24); C554(1.24)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C549(1.03); C555(1.03); C583(1.03); C586(1.03)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C549(1.24); C554(1.24)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C549(1.43); C554(1.43)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C549(1.46); C554(1.46)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C549(1.28); C554(1.28)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C549(1.51); C554(1.51)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C549(1.66); C554(1.66)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C549(1.38); C554(1.38)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C549(1.62); C554(1.62)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C583(0.99); C586(0.99); C549(1.11); C554(1.11)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C583(0.92); C586(0.92); C549(0.99); C554(0.99)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C549(1.03); C555(1.03); C583(1.10); C586(1.10)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C583(0.86); C586(0.86); C549(1.37); C554(1.37)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C549(0.80); C554(0.80); C555(0.80); C583(1.14)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C549(0.77); C554(0.77); C555(0.77); C583(0.84)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C583(0.92); C586(0.92); C549(1.37); C554(1.37)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C583(0.83); C586(0.83); C549(1.41); C554(1.41)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C583(0.85); C586(0.85); C549(1.40); C554(1.40)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C583(0.88); C586(0.88); C549(0.98); C554(0.98)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C549(1.03); C554(1.03); C555(1.03); C583(1.04)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C549(0.86); C554(0.86); C555(0.86); C583(0.97)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C583(0.84); C586(0.84); C549(0.86); C554(0.86)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C549(0.96); C555(0.96); C583(1.23); C586(1.23)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C583(0.90); C586(0.90); C549(1.05); C554(1.05)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C549(0.90); C554(0.90); C555(0.90); C583(1.10)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C583(0.88); C586(0.88); C549(1.96); C554(1.96)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C583(1.01); C586(1.01)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C583(0.95); C586(0.95)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C583(1.19); C586(1.19)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C583(0.89); C586(0.89)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C583(0.84); C586(0.84)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C583(0.91); C586(0.91)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C583(1.05); C586(1.05)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C583(0.73); C586(0.73)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C583(0.89); C586(0.89)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C583(0.99); C586(0.99)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C583(1.05); C586(1.05)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C583(0.80); C586(0.80)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C583(0.76); C586(0.76)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C583(0.82); C586(0.82)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C583(1.01); C586(1.01)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C583(0.99); C586(0.99); C549(1.33); C554(1.33)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C583(0.61); C586(0.61); C549(1.12); C554(1.12)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C549(0.96); C555(0.96); C583(0.91); C586(0.91)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C549(0.73); C555(0.73); C583(1.25); C586(1.25)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C583(1.43); C586(1.43); C549(1.53); C555(1.53)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C583(1.21); C586(1.21)  LDD2171  [2]
 LDCM0632  CL-Sc Hep-G2 C387(20.00); C387(0.80)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C549(1.00); C554(1.66); C555(1.00); C583(0.83)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C549(1.38); C554(1.49); C555(0.90); C583(0.79)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C583(1.08); C586(1.08); C549(1.20); C554(1.20)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C583(1.17); C586(1.17); C549(1.70); C555(1.70)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C549(0.75); C555(0.75); C583(1.16); C586(1.16)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C549(1.03); C555(1.03); C583(1.13); C586(1.13)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C549(0.88); C555(0.88); C583(0.90); C586(0.90)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C583(0.84); C586(0.84)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C583(0.86); C586(0.86)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C583(0.97); C586(0.97)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C583(0.82); C586(0.82)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C583(1.05); C586(1.05)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C549(1.12); C554(1.43); C555(0.87); C583(0.66)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C583(0.73); C586(0.73)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C583(0.81); C586(0.81)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C549(1.18); C555(1.18)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C549(1.51); C555(1.51)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C549(1.10); C555(1.10)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C549(1.60); C555(1.60)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C549(1.46); C555(1.46)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C549(0.79); C583(1.23); C586(1.05)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C549(0.70); C583(1.13); C586(1.15)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C549(0.86); C583(1.05); C586(1.05)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C549(0.99); C554(1.13); C555(1.13); C583(0.96)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C549(0.87); C583(0.91); C586(0.94)  LDD0989  [2]
 LDCM0392  CL121 HCT 116 C583(0.89); C586(0.89)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C583(0.92); C586(0.92)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C583(0.73); C586(0.73)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C583(0.87); C586(0.87)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C549(1.01); C554(1.01)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C549(1.00); C554(1.00)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C549(0.97); C554(0.97)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C549(1.15); C554(1.15)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C549(0.96); C554(1.02); C555(0.93); C583(1.02)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C549(0.94); C554(1.30); C555(0.87); C583(0.92)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C549(1.18); C554(1.39); C555(1.44); C583(0.77)  LDD1000  [2]
 LDCM0403  CL16 HCT 116 C549(1.19); C554(1.19); C555(1.19); C583(1.32)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C549(0.80); C554(0.80); C555(0.80); C583(0.98)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C549(0.96); C554(0.96); C555(0.96); C583(1.11)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C549(1.17); C554(1.17); C555(1.17); C583(1.18)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C549(0.97); C554(1.22); C555(0.80); C583(0.89)  LDD1005  [2]
 LDCM0408  CL20 HCT 116 C549(1.16); C554(1.16); C555(1.16); C583(1.19)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C549(0.88); C554(0.88); C555(0.88); C583(1.18)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C549(0.94); C554(0.94); C555(0.94); C583(1.41)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C583(1.07); C586(1.07); C549(1.13); C554(1.13)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C583(1.19); C586(1.19); C549(1.47); C554(1.47)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C549(1.16); C554(1.16); C555(1.16); C583(1.06)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C549(1.38); C554(1.38); C555(1.38); C583(1.10)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C549(1.29); C554(1.29); C555(1.29); C583(1.08)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C549(1.45); C554(1.45); C555(1.45); C583(1.19)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C549(1.27); C554(1.27); C555(1.27); C583(1.28)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C549(1.08); C554(1.24); C555(1.03); C583(0.81)  LDD1016  [2]
 LDCM0419  CL30 HCT 116 C549(1.28); C554(1.28); C555(1.28); C583(1.33)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C583(1.04); C586(1.04)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C583(1.11); C586(1.11)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C583(1.06); C586(1.06)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C583(1.31); C586(1.31)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C583(1.19); C586(1.19)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C583(1.09); C586(1.09)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C583(1.33); C586(1.33)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C583(1.18); C586(1.18)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C549(1.01); C554(1.54); C555(1.07); C583(0.95)  LDD1027  [2]
 LDCM0430  CL40 HCT 116 C583(1.35); C586(1.35)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C583(1.04); C586(1.04)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C583(1.79); C586(1.79)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C583(1.34); C586(1.34)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C583(1.26); C586(1.26)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C583(1.41); C586(1.41)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C549(1.07); C554(1.07); C555(1.07); C583(0.96)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C549(1.12); C554(1.12); C555(1.12); C583(1.22)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C549(1.03); C554(1.03); C555(1.03); C583(1.21)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C549(1.08); C554(1.08); C555(1.08); C583(0.99)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C549(0.97); C554(1.29); C555(1.18); C583(0.87)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C549(1.03); C554(1.03); C555(1.03); C583(0.95)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C549(0.94); C554(0.94); C555(0.94); C583(1.16)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C549(0.96); C554(0.96); C555(0.96); C583(1.17)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C549(0.88); C554(0.88); C555(0.88); C583(1.09)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C549(1.07); C554(1.07); C555(1.07); C583(1.00)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C549(1.27); C554(1.27); C555(1.27); C583(0.91)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C549(0.98); C554(0.98); C555(0.98); C583(0.98)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C549(0.82); C554(0.82); C555(0.82); C583(0.95)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C549(1.16); C554(1.16); C555(1.16); C583(1.20)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C549(1.24); C554(1.24); C555(1.24); C583(1.04)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C549(0.99); C554(1.13); C555(1.22); C583(0.89)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C549(1.16); C554(1.16); C555(1.16); C583(1.04)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C549(0.99); C554(0.99); C555(0.56); C583(1.20)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C549(1.01); C554(1.01); C555(0.77); C583(1.26)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C549(1.35); C554(1.35); C555(1.21); C583(1.06)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C549(1.46); C554(1.46); C555(1.17); C583(1.17)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C549(1.34); C554(1.34); C555(0.92); C583(1.18)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C549(1.43); C554(1.43); C555(1.01); C583(1.54)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C549(1.27); C554(1.27); C555(0.81); C583(1.45)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C549(1.37); C554(1.37); C555(1.43); C583(1.38)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C549(1.29); C554(1.29); C555(0.89); C583(1.21)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C549(0.97); C554(1.38); C555(0.91); C583(0.78)  LDD1060  [2]
 LDCM0463  CL70 HCT 116 C549(1.29); C554(1.29); C555(1.13); C583(1.15)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C549(1.20); C554(1.20); C555(0.98); C583(1.17)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C549(1.20); C554(1.20); C555(0.87); C583(1.21)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C549(1.39); C554(1.39); C555(1.37); C583(1.37)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C549(1.27); C554(1.27); C555(0.65); C583(1.34)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C549(1.33); C554(1.33); C583(1.20); C586(1.20)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C549(0.93); C554(0.93); C583(1.19); C586(1.19)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C549(1.09); C554(1.09); C583(1.20); C586(1.20)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C549(1.32); C554(1.32); C583(1.23); C586(1.23)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C555(0.88); C583(0.85)  LDD1071  [2]
 LDCM0474  CL80 HCT 116 C549(0.99); C554(0.99); C583(0.97); C586(0.97)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C549(1.21); C554(1.21); C583(0.91); C586(0.91)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C549(1.69); C554(1.69); C583(1.02); C586(1.02)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C549(1.39); C554(1.39); C583(0.87); C586(0.87)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C549(1.60); C554(1.60); C583(0.95); C586(0.95)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C549(0.92); C554(0.92); C583(1.24); C586(1.24)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C549(0.98); C554(0.98); C583(0.98); C586(0.98)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C549(1.24); C554(1.24); C583(1.30); C586(1.30)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C549(1.29); C554(1.29); C583(1.24); C586(1.24)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C549(2.19); C554(2.19); C583(1.00); C586(1.00)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C555(0.95); C583(0.99)  LDD1082  [2]
 LDCM0485  CL90 HCT 116 C549(1.06); C554(1.06); C583(0.84); C586(0.84)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C549(1.22); C554(1.22); C583(1.09); C586(1.09)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C549(1.31); C554(1.31); C583(0.92); C586(0.92)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C549(1.30); C554(1.30); C583(1.11); C586(1.11)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C549(1.37); C554(1.37); C583(1.18); C586(1.18)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C549(1.44); C554(1.44); C583(1.09); C586(1.09)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C549(1.11); C554(1.11); C583(1.15); C586(1.15)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C549(1.28); C554(1.28); C583(1.29); C586(1.29)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C549(1.51); C554(1.51); C583(1.05); C586(1.05)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C549(1.12); C554(1.12); C583(1.05); C586(1.05)  LDD0811  [2]
 LDCM0634  CY-0357 Hep-G2 C387(0.81)  LDD2228  [6]
 LDCM0495  E2913 HEK-293T C387(1.02); C340(1.15); C818(0.91); C351(0.89)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C340(0.73)  LDD1702  [8]
 LDCM0468  Fragment33 HCT 116 C549(1.13); C554(1.13); C555(0.78); C583(1.26)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C583(1.71); C586(1.71)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C136(3.19); C137(3.19); C557(2.96); C562(2.96)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C136(1.93); C137(1.93); C557(12.53); C562(12.53)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C136(3.28); C137(3.28); C557(2.55); C562(2.55)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C583(1.21); C586(1.21)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) C5-methyltransferase family Q9Y6K1
DNA (cytosine-5)-methyltransferase 3B (DNMT3B) C5-methyltransferase family Q9UBC3
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Histone-lysine N-methyltransferase EZH2 (EZH2) Histone-lysine methyltransferase family Q15910
Histone-lysine N-methyltransferase SETDB1 (SETDB1) Histone-lysine methyltransferase family Q15047
E3 ubiquitin-protein ligase UHRF1 (UHRF1) . Q96T88
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-responsive element modulator (CREM) BZIP family Q03060
Zinc finger protein 513 (ZNF513) Krueppel C2H2-type zinc-finger protein family Q8N8E2
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Nuclear autoantigen Sp-100 (SP100) . P23497
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H3.3 (H3-3A; H3-3B) Histone H3 family P84243
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
Polycomb protein EED (EED) WD repeat ESC family O75530

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Decitabine Small molecular drug DB01262
Procaine Small molecular drug DB00721
Patented
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid27376512-compound-mtc-422 Nucleotide D0QY0N
Pmid27376512-compound-mtc-423 Nucleotide D0W9VZ
Pmid27376512-compound-mtc-424 Nucleotide D02WRM
Pmid27376512-compound-mtc-427 Nucleotide D0HA0J
Pmid27376512-compound-figure2aexample1 Small molecular drug D01LUJ
Pmid27376512-compound-figure3cg Small molecular drug D03LZO
Pmid27376512-compound-figure3cm Small molecular drug D0F8AB
Pmid27376512-compound-figure3cn Small molecular drug D02VTV

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761