Details of the Target

General Information of Target

Target ID LDTP14227
Target Name Cilia- and flagella-associated protein 20 (CFAP20)
Gene Name CFAP20
Gene ID 29105
Synonyms
BUG22; C16orf80; GTL3; Cilia- and flagella-associated protein 20; Basal body up-regulated protein 22; Transcription factor IIB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL
QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL
FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM
QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL
REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF
IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES
LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA
PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD
PVLCTLRPRGWQPAPPPPPC
Target Bioclass
Other
Family
CFAP20 family
Subcellular location
Nucleus
Function
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.
Uniprot ID
Q9Y6A4
Ensemble ID
ENST00000262498.8
HGNC ID
HGNC:29523

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K190(9.98); K35(0.15)  LDD0277  [2]
Probe 1
 Probe Info  		Y108(10,488.34); Y172(8.98); Y184(13.72)  LDD3495  [3]
BTD
 Probe Info  		C160(2.41)  LDD1700  [4]
HHS-475
 Probe Info  		Y184(1.20)  LDD0267  [5]
HHS-465
 Probe Info  		Y184(5.15)  LDD2237  [6]
DBIA
 Probe Info  		C119(1.27)  LDD0531  [7]
ATP probe
 Probe Info  		K190(0.00); K192(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C119(0.00); C160(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C61(0.00); C119(0.00); C160(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C61(0.00); C119(0.00)  LDD0037  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
NAIA_5
 Probe Info  		C61(0.00); C119(0.00); C160(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C160(0.75); C119(0.77)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C160(1.25); C119(1.16)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C119(1.27)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C119(0.97)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C119(0.55)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C119(0.59)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C119(0.73)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C119(0.62)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C119(0.76)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C119(0.69)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C119(0.53)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C119(0.55)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C119(0.54)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C119(0.90)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C119(0.82)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C119(0.55)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C119(0.55)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C119(0.54)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C119(0.75)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C119(0.78)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C119(0.72)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C119(0.69)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C119(0.81)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C119(0.91)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C119(0.72)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C119(0.95)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C119(0.77)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C119(1.25)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C119(0.91)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C119(1.25)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C119(1.23)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C119(1.21)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C119(1.19)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C119(1.23)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C119(1.88); C160(1.73)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C119(1.46); C160(1.33)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C119(1.16); C160(1.02)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C119(1.15); C160(1.19)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C119(0.90); C160(0.92)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C119(1.04); C160(1.03)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C119(1.04); C160(1.01)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C119(1.25); C160(1.14)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C119(0.95); C160(0.93)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C119(1.16); C160(0.99)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C119(1.01); C160(0.92)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C119(0.93); C160(0.84)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C119(0.96)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C119(1.04); C160(0.90)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C119(1.04); C160(0.99)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C119(1.07); C160(0.88)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C119(0.72)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C119(1.17)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C119(1.20)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C119(1.22)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C119(1.02)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C119(1.14)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C119(1.40)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C119(1.02)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C119(1.09)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C119(1.26)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C119(1.36)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C119(1.65)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C119(1.17)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C119(1.30)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C119(1.25)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C119(1.43)  LDD2161  [7]
 LDCM0276  AC17 HEK-293T C119(0.85)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C119(1.00)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C119(0.95); C160(1.00)  LDD1517  [12]
 LDCM0279  AC2 HCT 116 C119(1.01)  LDD0596  [7]
 LDCM0280  AC20 HEK-293T C119(1.01); C160(1.06)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C119(1.06); C160(0.97)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C119(0.99)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C119(1.01)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C119(0.91)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C119(0.99)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C119(1.03)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C119(0.97); C160(0.94)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C119(0.97); C160(1.07)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C119(1.02); C160(0.94)  LDD1528  [12]
 LDCM0290  AC3 HCT 116 C119(1.40)  LDD0607  [7]
 LDCM0291  AC30 HEK-293T C119(1.00)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C119(1.00)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C119(0.98)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C119(0.99)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C119(0.99)  LDD1534  [12]
 LDCM0296  AC35 HCT 116 C119(1.12)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C119(0.90)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C119(1.31)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C119(0.96)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C119(0.82)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C119(1.62)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C119(0.97)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C119(0.87)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C119(0.93)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C119(0.80)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C119(1.41)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C119(1.32)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C119(0.68)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C119(0.75)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C119(0.61)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C119(0.69)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C119(1.43)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C119(0.68)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C119(0.70)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C119(0.69)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C119(0.91)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C119(0.80)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C119(1.10)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C119(0.79)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C160(0.74)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C160(0.93)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C160(0.68)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C119(0.94)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C160(0.63)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C160(0.56)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C160(0.58)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C160(0.55)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C160(0.65)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C160(0.59)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C160(0.63)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C160(0.44)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C119(1.04)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C119(1.07)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C119(1.05)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C119(0.92)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C119(1.31)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C119(0.94)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C119(0.83)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C119(1.12)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C119(0.87)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C119(1.04)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C119(1.01)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C119(0.99)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C119(1.03)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C119(0.94)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C119(1.07)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C119(1.17)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C119(1.07)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C160(0.82)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C160(0.97)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C160(1.08)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C160(0.78)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C160(0.79)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C160(0.72)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C160(0.84)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C160(0.68)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C160(1.04)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C160(0.97)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C160(0.88)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C160(1.84)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C160(0.68)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C160(1.62)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C160(0.74)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C119(0.51)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C119(0.54)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C160(0.64)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C119(0.90)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C119(0.83)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C119(0.92)  LDD0592  [7]
 LDCM0498  BS-3668 MDA-MB-231 C160(1.03)  LDD2091  [4]
 LDCM0367  CL1 HCT 116 C119(0.87)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C119(0.75)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C119(1.08)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C119(0.99)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C119(1.08)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C119(1.15)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C119(1.00)  LDD0690  [7]
 LDCM0374  CL105 HEK-293T C119(1.04)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C119(0.93)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C119(1.07)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C119(1.05)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C119(1.16)  LDD1582  [12]
 LDCM0379  CL11 HCT 116 C119(0.96)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C119(1.01)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C119(0.59)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C119(0.99)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C119(1.01)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C119(1.03)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C119(1.02)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C119(0.99)  LDD1590  [12]
 LDCM0387  CL117 HCT 116 C119(0.85)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C119(0.80)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C119(0.71)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C119(0.82)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C119(0.76)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C119(0.85)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C119(0.84)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C119(0.78)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C119(0.70)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C160(0.73)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C160(0.85)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C160(0.67)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C160(0.72)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C119(1.03)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C119(0.86)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C119(1.15)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C160(0.95)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C119(0.75); C160(0.76)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C160(0.79); C119(0.87)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C160(0.79); C119(0.89)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C119(0.81)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C119(0.56); C160(0.70)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C160(0.67); C119(0.78)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C160(0.83); C119(0.97)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C160(0.73); C119(1.18)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C160(0.82); C119(0.95)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C119(1.17); C160(0.74)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C119(1.11); C160(0.70)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C119(1.03); C160(0.91)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C119(0.78); C160(0.84)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C119(0.73); C160(0.78)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C119(0.88)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C119(1.43); C160(0.83)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C119(0.95)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C119(0.96)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C119(0.54)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C119(0.54)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C119(0.50)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C119(0.44)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C119(0.58)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C119(0.51)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C119(0.99)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C119(0.43)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C119(0.40)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C119(0.40)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C119(0.48)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C119(0.42)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C119(0.45)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C119(0.70); C160(0.76)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C119(0.73); C160(1.13)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C119(0.81); C160(1.09)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C119(1.02); C160(0.90)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C119(0.95)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C119(0.92); C160(0.74)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C119(0.96); C160(0.80)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C119(0.80); C160(0.67)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C119(0.74); C160(0.90)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C119(0.75); C160(0.73)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C119(0.75); C160(0.75)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C119(0.80); C160(0.78)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C119(0.81); C160(0.77)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C119(0.89); C160(0.64)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C119(0.83); C160(0.68)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C119(0.75)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C119(0.87); C160(0.63)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C119(1.08)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C119(0.99)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C119(1.07)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C119(0.96)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C119(0.85)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C119(0.97)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C119(0.91); C160(0.88)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C119(0.92); C160(1.03)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C119(0.93); C160(0.93)  LDD1664  [12]
 LDCM0462  CL7 HCT 116 C119(0.96)  LDD0779  [7]
 LDCM0463  CL70 HEK-293T C119(0.90)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C119(0.95)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C119(0.90)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C119(1.02)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C119(1.26)  LDD1670  [12]
 LDCM0469  CL76 HCT 116 C119(1.03); C160(0.75)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C119(1.17); C160(0.83)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C119(0.92); C160(0.83)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C119(1.23); C160(0.80)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C119(0.85)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C119(1.06); C160(0.59)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C119(1.21); C160(0.67)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C119(1.21); C160(0.59)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C119(1.28); C160(0.60)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C119(1.23); C160(0.52)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C119(0.97); C160(0.56)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C119(1.15); C160(0.51)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C119(1.47); C160(0.58)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C119(1.37); C160(0.64)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C119(1.26); C160(0.65)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C119(0.73)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C119(1.50); C160(0.51)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C119(0.95)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C119(1.03)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C119(1.07)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C119(0.96)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C119(1.06)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C119(1.01)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C119(0.87)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C119(1.08)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C119(1.20)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C119(1.15)  LDD1698  [12]
 LDCM0625  F8 Ramos C119(0.97)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C119(0.74)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C119(1.03)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C119(0.76)  LDD2191  [13]
 LDCM0576  Fragment14 Ramos C119(0.73)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C119(0.59)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C119(1.04)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C119(1.48)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C119(2.34)  LDD2197  [13]
 LDCM0588  Fragment30 Ramos C119(1.69)  LDD2199  [13]
 LDCM0590  Fragment32 Ramos C119(0.81)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C119(1.00)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C119(1.87)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C119(0.64)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C119(0.50)  LDD0744  [7]
 LDCM0614  Fragment56 Ramos C119(2.31)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C119(0.56)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C119(0.57)  LDD2188  [13]
 LDCM0119  HHS-0401 DM93 Y184(1.20)  LDD0267  [5]
 LDCM0022  KB02 Ramos C119(0.45)  LDD2182  [13]
 LDCM0023  KB03 Ramos C119(0.63)  LDD2183  [13]
 LDCM0024  KB05 COLO792 C119(1.37); C160(1.59)  LDD3310  [14]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C160(1.10); C119(1.15)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C160(0.57)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C160(0.72)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C160(0.81); C119(0.92)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C160(0.74)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C160(1.31)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C160(0.97); C119(0.75)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C160(1.82); C119(1.34)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C160(0.77); C119(0.56)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C160(0.18)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C160(0.81); C119(0.45)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C160(0.77)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C160(1.25)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C160(0.36); C119(0.55)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C119(0.92)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C160(0.70)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C160(0.77)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C160(2.41)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C160(0.67)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C160(2.19)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C160(0.87); C119(1.02)  LDD2146  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C160(0.35)  LDD2149  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 2-binding protein (ARL2BP) ARL2BP family Q9Y2Y0
CLK4-associating serine/arginine rich protein (CLASRP) Splicing factor SR family Q8N2M8

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840