Details of the Target

General Information of Target

Target ID LDTP13852
Target Name Afadin- and alpha-actinin-binding protein (SSX2IP)
Gene Name SSX2IP
Gene ID 117178
Synonyms
KIAA0923; Afadin- and alpha-actinin-binding protein; ADIP; Afadin DIL domain-interacting protein; SSX2-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERGKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNH
DREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQC
RLQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPALKTLEHLEHTYLPQVSHYRFC
KVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIVLQQPRI
GSKRKSKKDAYIIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLH
IYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHT
TQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVN
QLFDMLLEIRDQYSETLLKKWAGIFRNILDSDNYSPIPVTSEEMYKKVVGQFPFQDIELE
KQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSN
SLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFK
DARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGNKASDYLVDLIAFLRSTFAVFTHLP
GKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQE
DTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKMKDTSRKNNM
FAQFRKNERDKQKLIDTVAKQLRGLISSHHS
Target Type
Literature-reported
Target Bioclass
Other
Family
ADIP family
Subcellular location
Cell junction, adherens junction
Function
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin. Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling. Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Involved in ciliogenesis. It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia.
TTD ID
T75947
Uniprot ID
Q9Y2D8
DrugMap ID
TTZXB07
Ensemble ID
ENST00000342203.8
HGNC ID
HGNC:16509

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1419 Deletion: p.L601Ter .
HEC1B SNV: p.K444R .
HUH28 SNV: p.Q581Ter .
IGROV1 SNV: p.Q21H .
JHH1 SNV: p.K279M .
MDST8 SNV: p.L94V .
OVK18 SNV: p.Q400R .
SF295 SNV: p.P44T .
YSCCC SNV: p.L115V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C331(2.99)  LDD0168  [2]
DBIA
 Probe Info  		C547(1.17)  LDD0078  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		C547(0.00); C423(0.00)  LDD0147  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C331(2.99)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C423(2.40)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C331(1.12); C423(0.99); C547(0.86)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C331(1.08); C423(1.16); C547(0.86)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C331(1.00); C423(1.51); C547(0.89)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C331(1.07); C423(1.50); C547(0.77)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C331(1.06); C423(1.31); C547(0.71)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C331(1.04); C423(1.37); C547(1.17)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C331(1.09); C423(1.12); C547(0.85)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C331(0.99); C423(1.31); C547(0.74)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C331(1.06); C423(1.51); C547(0.72)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C331(1.05); C423(1.16); C547(1.12)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C331(0.96); C423(1.64); C547(0.70)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C331(1.03); C423(1.15); C547(0.62)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C331(1.22); C423(0.90); C547(0.97)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C331(1.01); C423(1.46); C547(0.73)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C331(1.04); C423(1.47); C547(1.05)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C331(1.10); C423(1.33); C547(0.82)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C331(0.84); C423(0.92)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C331(0.83); C423(0.93)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C331(0.96); C423(1.03)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C331(0.96); C423(1.15)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C331(0.85); C423(1.30)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C331(0.80); C423(1.16)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C331(1.10); C423(1.07)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C331(1.09); C423(0.82); C547(0.96)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C331(0.74); C423(0.84)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C331(0.79); C423(1.22)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C331(0.85); C423(0.91)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C331(0.65); C423(0.98)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C331(0.96); C423(1.17)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C331(0.68); C423(0.90)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C331(0.58); C423(0.79)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C331(0.65); C423(0.98)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C331(0.79); C423(0.76)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C331(0.78); C423(0.87)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C331(0.85); C423(0.97)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C331(0.79); C423(0.97)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C331(0.77); C423(1.43)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C331(0.86); C423(1.10)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C331(0.96); C423(1.19)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C331(1.00); C423(1.30)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C331(0.99); C423(1.11)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C331(0.83); C423(1.14)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C331(1.25); C423(1.58)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C331(1.07); C423(1.38)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C331(1.12); C423(1.07); C547(0.77)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C331(1.01); C423(1.71)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C331(1.02); C423(1.70)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C331(1.04); C423(1.27)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C331(0.88); C547(1.06); C423(1.18)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C423(1.04); C331(1.05); C547(1.07)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C331(1.14); C547(1.21); C423(1.41)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C423(0.63); C331(1.15); C547(1.35)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C423(0.85); C331(1.04); C547(1.25)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C423(0.99); C547(1.30); C331(1.53)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C423(0.78); C331(1.22); C547(1.43)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C423(0.88); C547(0.95); C331(1.09)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C423(0.94); C331(1.10); C547(1.16)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C423(0.77); C331(1.07); C547(1.12)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C423(0.72); C547(1.10); C331(1.22)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C423(1.03); C331(1.47); C547(1.82)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C331(1.08); C423(0.82); C547(1.19)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C331(1.07); C423(0.78); C547(1.18)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C331(0.94); C423(0.78); C547(1.56)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C331(0.89); C423(0.90); C547(1.05)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C547(0.34); C137(0.85); C331(0.93); C423(1.06)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C547(0.39); C137(0.87); C331(1.00); C423(1.04)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C547(0.33); C331(0.91); C137(0.93); C423(1.26)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C547(0.80); C331(1.08); C423(1.16)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C547(0.37); C137(0.91); C331(1.09); C423(1.12)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C547(0.40); C137(0.82); C423(1.00); C331(1.09)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C547(0.34); C137(0.82); C331(1.06); C423(1.12)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C547(0.39); C331(0.91); C423(1.09); C137(1.10)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C547(0.36); C137(0.80); C331(1.00); C423(1.26)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C331(0.88); C423(0.98)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C423(1.06); C331(1.16)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C331(1.12); C423(1.15)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C331(1.06); C423(1.24)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C331(1.06); C423(1.09)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C547(0.80); C423(1.02); C331(1.11)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C423(1.10); C331(1.11)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C331(1.00); C423(1.07)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C331(1.26); C423(1.30)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C331(1.11); C423(1.14)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C331(1.13); C423(1.18)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C137(0.94); C331(0.96); C423(1.11)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C331(0.96); C423(0.98); C137(1.09)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C331(0.94); C137(1.02); C423(1.09)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C423(1.10); C331(1.10); C137(1.22)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C137(0.84); C423(1.11); C331(1.19)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C547(0.77); C423(1.10); C331(1.11)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C137(0.89); C331(1.07); C423(1.24)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C423(0.99); C331(1.02); C137(1.11)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C137(1.09); C331(1.12); C423(1.17)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C137(0.89); C331(1.12); C423(1.13)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C137(1.20); C423(1.22); C331(1.29)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C137(0.97); C423(1.00); C331(1.30)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C331(0.92); C423(1.09)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C331(0.89); C423(0.98)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C423(1.02); C331(1.17)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C331(1.00); C423(1.26)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C547(0.69); C331(1.05); C423(1.06)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C423(1.16); C331(1.48)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C331(0.83); C423(0.90)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C331(0.96); C423(1.08)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C331(0.82); C423(1.24)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C331(0.88); C423(1.05)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C423(1.25); C331(1.67)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C331(1.44); C423(1.56)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C137(0.92); C547(1.01); C423(1.32)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C547(0.83); C137(0.98); C423(1.19)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C547(1.01); C137(1.14); C423(1.41)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C423(0.84); C547(0.95); C331(1.24)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C547(1.00); C137(1.13); C423(1.18)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C547(0.94); C137(1.04); C423(1.07)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C547(0.98); C137(1.26); C423(1.26)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C547(1.02); C423(1.17); C137(1.28)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C547(1.08); C137(1.10); C423(1.25)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C547(1.02); C137(1.04); C423(1.27)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C547(0.89); C423(1.07); C137(1.16)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C547(1.03); C137(1.17); C423(1.40)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C547(0.38); C423(0.92)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C547(0.44); C423(0.95)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C423(0.74); C547(0.84); C331(0.99)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C547(0.49); C423(1.05)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C547(0.54); C423(0.87)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C547(0.72); C423(1.00)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C423(1.09); C547(1.56)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C547(0.70); C423(0.89)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C547(0.94); C423(0.98)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C547(0.76); C423(0.88)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C547(0.52); C423(0.91)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C547(0.47); C423(0.87)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C547(0.72); C423(1.00)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C547(0.85); C423(0.98); C331(1.11)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C547(0.53); C423(0.86)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C547(0.60); C423(0.93)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C423(0.86); C547(1.19)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C423(1.10); C331(1.74); C547(1.94)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C423(1.00); C547(1.33); C331(1.54)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C423(1.08); C331(1.30); C547(1.55)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C423(1.18); C331(1.48); C547(1.54)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C423(1.12); C331(1.25); C547(1.47)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C423(1.13); C331(1.44); C547(1.94)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C423(1.26); C331(1.42); C547(2.62)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C547(1.08); C331(1.17); C423(1.18)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C423(0.78); C331(1.56); C547(2.51)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C423(1.08); C331(1.43); C547(2.19)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C423(1.27); C331(1.31); C547(2.45)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C423(0.86); C547(1.23); C331(1.60)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C423(1.21); C331(1.42); C547(2.27)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C423(0.86); C331(1.15); C547(2.30)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C423(1.29); C331(1.43); C547(2.83)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C547(1.19); C331(1.25); C423(1.33)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C547(0.68); C331(1.04); C423(1.17)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C331(1.02); C423(0.86); C547(0.88)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C423(0.89); C547(0.94); C331(1.07)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C547(1.04); C423(1.20); C331(1.30)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C547(1.17)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C137(1.00); C547(1.13); C423(1.24); C331(1.44)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C137(0.88); C547(1.13); C423(1.21); C331(1.52)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C547(0.79); C423(1.13); C331(1.18)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C547(0.91); C331(1.14); C423(1.28)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C423(0.82); C547(0.89); C331(1.00)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C547(0.85); C423(0.87); C331(1.10)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C547(0.85); C423(0.94); C331(1.03)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C547(0.37); C137(0.85); C423(0.93); C331(0.97)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C547(0.39); C423(0.85); C137(0.97); C331(1.07)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C547(0.43); C423(0.97); C137(1.05); C331(1.15)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C547(0.32); C137(0.84); C423(0.99); C331(1.08)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C547(0.42); C137(0.98); C331(1.10); C423(1.19)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C137(0.78); C331(1.13); C547(1.29); C423(1.37)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C547(0.32); C137(0.97); C331(1.20); C423(1.44)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C547(0.36); C137(0.91); C331(1.33); C423(1.66)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C331(0.93); C423(1.08)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C423(1.16); C331(1.29)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C423(1.01); C331(1.17)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C331(1.10); C423(1.18)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C423(1.06); C331(1.11)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C137(0.81); C423(1.12); C331(1.45)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C423(1.03); C137(1.05); C331(1.11)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C423(1.13); C137(1.21); C331(1.22)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C137(0.76); C547(0.97); C331(0.99); C423(1.27)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C331(1.01); C423(1.01); C137(1.12)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C331(1.06); C423(1.08)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C331(1.00); C423(1.10)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C331(1.31); C423(1.35)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C331(1.09); C423(1.40)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C547(0.97); C423(0.98); C137(0.98)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C547(0.73); C423(0.94); C137(0.98)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C423(0.95); C137(1.07); C547(1.08)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C137(1.03); C547(1.08); C423(1.45)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C137(0.77); C547(0.81); C331(1.03); C423(1.25)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C547(0.91); C137(0.95); C331(1.09); C423(1.34)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C547(0.77); C137(1.00); C331(1.13); C423(1.56)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C547(0.94); C423(0.99); C331(1.22)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C547(0.70); C137(0.98); C331(0.99); C423(1.17)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C547(0.88); C137(1.03); C423(1.15); C331(1.29)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C547(0.81); C137(0.97); C423(1.04); C331(1.17)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C137(0.80); C547(1.01); C423(1.03); C331(1.20)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C547(0.80); C137(1.08); C423(1.16); C331(1.30)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C547(0.70); C137(0.97); C423(1.19); C331(1.59)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C547(0.72); C423(0.98); C137(1.19); C331(1.25)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C547(0.73); C137(0.90); C331(0.91); C423(1.07)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C137(0.98); C331(1.39); C423(1.05); C547(0.93)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C137(0.83); C331(1.65); C423(0.99); C547(0.93)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C137(0.99); C331(1.07); C423(0.93); C547(0.91)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C137(0.94); C331(1.19); C423(0.81); C547(0.93)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C137(0.90); C331(0.90); C423(0.84); C547(0.87)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C137(1.06); C331(1.23); C423(0.94); C547(0.85)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C137(0.81); C331(1.13); C423(0.91); C547(0.97)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C137(0.82); C331(1.27); C423(0.80); C547(0.86)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C137(1.07); C331(1.16); C423(0.96)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C137(1.01); C331(0.91); C423(0.90); C547(0.91)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C137(1.10); C331(0.99); C423(1.12); C547(1.22)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C137(1.29); C331(0.97); C423(0.90); C547(0.84)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C137(1.57); C331(1.13); C423(0.90); C547(0.85)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C137(1.40); C331(1.37); C423(0.89); C547(0.76)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C137(1.47); C331(1.05); C423(0.84); C547(0.86)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C137(1.39); C331(1.00); C423(0.85); C547(0.91)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C137(1.11); C331(0.98); C423(1.19); C547(1.10)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C137(1.29); C331(1.07); C423(1.09); C547(0.90)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C137(1.28); C331(1.02); C423(0.85); C547(0.80)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C137(1.70); C331(1.06); C423(0.86); C547(0.78)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C137(1.34); C331(1.06); C423(0.84); C547(0.83)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C137(1.27); C331(1.03); C423(0.91); C547(0.77)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C137(1.52); C331(1.06); C423(1.06); C547(0.84)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C137(0.66); C331(0.68); C423(1.10); C547(0.99)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C137(0.87); C331(1.15); C423(1.05); C547(0.86)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C137(0.67); C331(0.95); C423(1.05); C547(0.80)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C137(0.63); C331(0.81); C423(1.19); C547(0.78)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C137(0.80); C331(0.98); C423(1.02); C547(0.98)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C137(0.71); C331(1.03); C423(1.29); C547(0.79)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C137(0.60); C331(1.13); C423(1.33); C547(0.86)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C137(0.72); C331(0.76); C423(1.19); C547(1.07)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C137(1.19); C331(1.46); C423(1.09); C547(0.95)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C137(0.70); C331(0.72); C423(1.12); C547(1.11)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C137(0.68); C331(0.57); C423(0.97); C547(1.02)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C137(0.69); C331(0.74); C423(0.98); C547(0.87)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C137(0.79); C331(1.64); C423(1.11); C547(0.77)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C137(0.56); C331(0.65); C423(1.12); C547(1.01)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C137(0.57); C331(1.00); C423(0.96); C547(0.86)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C137(0.76); C331(1.22); C423(1.09); C547(0.87)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C137(0.56); C331(0.96); C423(1.22); C547(0.87)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C137(0.99); C331(0.96); C423(1.14)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C137(0.86); C331(0.95); C423(0.98)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C137(0.89); C331(1.00); C423(1.14)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C137(0.87); C331(0.88); C423(1.10)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C137(0.96); C331(1.08); C423(1.15)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C137(0.79); C331(1.00); C423(1.21)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C137(0.92); C331(0.98); C423(1.21)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C137(1.38); C331(0.99); C423(1.06)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C137(1.07); C331(0.90); C423(1.05)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C137(0.66); C331(0.94); C423(0.96); C547(0.84)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C137(1.03); C331(0.94); C423(0.96)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C137(1.10); C331(1.07); C423(1.16)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C137(1.13); C331(0.88); C423(1.11)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C137(1.08); C331(0.91); C423(1.20)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C137(1.13); C331(1.00); C423(1.03)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C331(0.88); C423(1.13); C547(0.77)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C331(0.94); C423(1.19); C547(0.76)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C331(1.05); C423(1.13); C547(0.94)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C331(1.00); C423(1.21); C547(0.66)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C137(0.86); C331(1.18); C423(1.21); C547(1.72)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C331(0.96); C423(1.09); C547(0.73)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C331(0.92); C423(1.10); C547(0.76)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C331(0.94); C423(0.99); C547(0.62)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C331(0.84); C423(1.09); C547(0.82)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C331(1.03); C423(1.13); C547(0.84)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C331(0.99); C423(1.07); C547(0.81)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C331(0.84); C423(1.09); C547(0.69)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C331(0.83); C423(1.07); C547(0.66)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C331(0.87); C423(1.07); C547(0.81)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C331(0.91); C423(1.17); C547(0.75)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C137(0.86); C331(1.17); C423(1.16); C547(1.03)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C331(0.88); C423(1.28); C547(0.79)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C331(1.07); C423(1.40); C547(0.87)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C331(0.97); C423(1.32); C547(0.88)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C331(1.10); C423(0.97); C547(0.80)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C331(1.06); C423(1.46); C547(0.87)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C331(0.97); C423(1.33); C547(0.79)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C331(1.02); C423(1.20); C547(0.74)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C331(1.17); C423(1.11); C547(0.74)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C331(1.11); C423(1.11); C547(0.80)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C331(1.15); C423(0.97); C547(0.78)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C547(0.93); C423(1.05); C102(0.64)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C137(1.02); C331(0.96); C423(1.08)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C137(2.60); C331(0.95); C423(1.38); C547(0.78)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C423(2.71)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C423(2.87)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C423(2.65)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C595(1.49); C599(1.49); C547(1.09); C137(1.22)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Eukaryotic initiation factor 4A-II (EIF4A2) DEAD box helicase family Q14240
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
E3 ubiquitin-protein ligase XIAP (XIAP) IAP family P98170
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
GTP-binding protein GEM (GEM) RGK family P55040
Developmentally-regulated GTP-binding protein 1 (DRG1) OBG GTPase family Q9Y295
GTPase Era, mitochondrial (ERAL1) Era GTPase family O75616
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
DNA topoisomerase 3-beta-1 (TOP3B) Type IA topoisomerase family O95985
Apoptosis-enhancing nuclease (AEN) . Q8WTP8
E3 ubiquitin-protein ligase FANCL (FANCL) . Q9NW38
Ester hydrolase C11orf54 (C11orf54) . Q9H0W9
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (TSTD2) . Q5T7W7
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Pericentriolar material 1 protein (PCM1) PCM1 family Q15154
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Zinc finger protein 3 (ZNF3) Krueppel C2H2-type zinc-finger protein family P17036
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Zinc finger protein 202 (ZNF202) . O95125
Zinc finger protein 408 (ZNF408) . Q9H9D4
Other
Click To Hide/Show 42 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein A (ATOSA) ATOS family Q32MH5
Protein BEX2 (BEX2) BEX family Q9BXY8
Bystin (BYSL) Bystin family Q13895
Cyclin-H (CCNH) Cyclin family P51946
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Protein FAM124B (FAM124B) FAM124 family Q9H5Z6
Protein FAM161A (FAM161A) FAM161 family Q3B820
. GOLGA8 family Q08AF8
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Large ribosomal subunit protein mL53 (MRPL53) Mitochondrion-specific ribosomal protein mL53 family Q96EL3
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Nucleolar protein 12 (NOL12) RRP17 family Q9UGY1
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) SHFL family Q9NUL5
Protein SSX2 (SSX2; SSX2B) SSX family Q16385
Protein SSX3 (SSX3) SSX family Q99909
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
Actin-binding LIM protein 3 (ABLIM3) . O94929
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Factor associated with metabolism and energy (CCDC198) . Q9NVL8
FERM domain-containing protein 6 (FRMD6) . Q96NE9
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
INO80 complex subunit B (INO80B) . Q9C086
Kelch-like protein 42 (KLHL42) . Q9P2K6
MORN repeat-containing protein 4 (MORN4) . Q8NDC4
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Protein PIMREG (PIMREG) . Q9BSJ6
Rhombotin-2 (LMO2) . P25791
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Tetratricopeptide repeat protein 23 (TTC23) . Q5W5X9
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (ZRSR2) . Q15696
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395
WD repeat-containing protein WRAP73 (WRAP73) . Q9P2S5
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402