Details of the Target

General Information of Target

Target ID LDTP13186
Target Name Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS)
Gene Name AASS
Gene ID 10157
Synonyms
Alpha-aminoadipic semialdehyde synthase, mitochondrial; LKR/SDH) [Includes: Lysine ketoglutarate reductase; LKR; LOR; EC 1.5.1.8; Saccharopine dehydrogenase; SDH; EC 1.5.1.9)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGE
GHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREE
DEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPPLDESERDGGSED
QVEDPALSEPGEEPQRPSPSEPGT
Target Bioclass
Enzyme
Family
AlaDH/PNT family; Saccharopine dehydrogenase family
Subcellular location
Mitochondrion
Function Bifunctional enzyme that catalyzes the first two steps in lysine degradation.
Uniprot ID
Q9UDR5
Ensemble ID
ENST00000393376.5
HGNC ID
HGNC:17366

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.69  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
BTD
 Probe Info  		C342(0.72)  LDD2104  [3]
HHS-482
 Probe Info  		Y490(0.94); Y556(0.06); Y578(1.30)  LDD0285  [4]
HHS-475
 Probe Info  		Y578(0.77); Y556(0.94); Y490(1.27)  LDD0264  [5]
DBIA
 Probe Info  		C534(0.96)  LDD0078  [6]
ATP probe
 Probe Info  		K286(0.00); K48(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C87(0.00); C342(0.00); C240(0.00); C765(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C87(0.00); C240(0.00); C765(0.00); C534(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0005  [10]
SF
 Probe Info  		Y578(0.00); Y556(0.00)  LDD0028  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [10]
Phosphinate-6
 Probe Info  		C633(0.00); C534(0.00)  LDD0018  [12]
AOyne
 Probe Info  		10.70  LDD0443  [13]
HHS-465
 Probe Info  		K584(0.00); Y556(0.00); Y578(0.00); K564(0.00)  LDD2240  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C342(0.83); C534(1.21); C633(1.09)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C342(0.87); C534(1.39)  LDD0813  [6]
 LDCM0216  AC100 HEK-293T C534(0.95)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C534(1.17)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C534(1.53)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C534(1.11)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C534(1.07)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C534(0.98)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C534(1.11)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C534(1.24)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C534(1.03)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C534(1.12)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C342(0.99); C534(1.08)  LDD0824  [6]
 LDCM0227  AC110 HEK-293T C534(1.39)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C534(2.21)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C534(1.70)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C342(1.04); C534(0.81)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C342(1.10); C534(0.89)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C342(1.05); C534(0.94)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C342(0.87); C534(0.86)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C342(0.81); C534(0.89)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C342(0.79); C534(1.05)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C342(0.70); C534(0.90)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C342(0.76); C534(1.10)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C342(0.72); C534(0.97)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C342(0.78); C534(0.98)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C342(0.69); C534(0.86)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C342(0.60); C534(0.98)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C342(0.70); C534(1.00)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C342(0.68); C534(0.88)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C342(0.63); C534(1.12)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C342(0.69); C534(0.94)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C534(0.92)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C534(1.11)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C534(1.07)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C534(1.00)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C534(1.06)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C534(1.31)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C534(1.09)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C534(1.15)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C534(1.01)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C534(1.23)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C534(1.45)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C534(1.58)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C342(0.75); C534(1.39)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C534(1.25)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C534(1.28)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C534(1.17)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C534(1.07)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C534(1.20)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C534(1.21)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C534(1.30)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C534(1.23)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C534(1.17)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C534(0.96)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C342(0.56); C534(0.91)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C534(1.07)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C534(1.14)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C534(1.12)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C534(1.13)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C534(1.00)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C534(1.15)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C534(1.23)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C534(1.26)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C342(0.66); C534(1.35); C633(2.02)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C342(0.78); C534(1.36); C633(1.21)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C342(0.85); C534(1.32); C633(1.35)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C342(0.70); C534(1.29); C633(1.23)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C342(0.68); C534(1.38); C633(1.36)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C342(0.74); C534(1.14); C633(1.38)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C342(0.71); C534(1.43); C633(1.60)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C342(0.60); C534(1.62); C633(2.11)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C342(0.80); C534(1.24); C633(1.48)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C534(0.84)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C534(0.86)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C534(0.94)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C534(0.75)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C534(0.97)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C342(1.02); C534(1.05); C633(1.01)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C534(0.85)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C534(0.76)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C534(0.88)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C534(0.89)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C534(0.81)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C342(1.06); C534(0.85)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C342(0.78); C534(0.77)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C342(0.75); C534(0.97)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C342(0.81); C534(0.93)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C342(0.82); C534(0.90)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C342(0.99); C534(1.04); C633(1.07)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C342(0.81); C534(0.90)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C342(0.83); C534(0.89)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C342(0.84); C534(0.83)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C342(0.76); C534(0.89)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C342(0.75); C534(1.07)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C342(0.78); C534(0.97)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C342(1.02); C534(0.91)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C342(0.85); C534(0.89)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C342(0.86); C534(0.88)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C342(0.87); C534(0.87)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C342(0.78); C534(1.14); C633(1.21)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C342(0.81); C534(0.84)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C342(0.70); C534(1.08)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C342(0.65); C534(0.89)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C342(0.91); C534(0.80)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C342(0.69); C534(1.04)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C342(0.70); C534(1.20)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C342(0.79); C534(1.02)  LDD0917  [6]
 LDCM0320  AC57 HEK-293T C534(0.98); C633(1.08)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C534(1.00); C633(1.05)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C534(1.05); C633(1.08)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C342(0.88); C534(1.04)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C534(1.34); C633(0.92)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C534(1.08); C633(1.22)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C534(1.03); C633(1.07)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C534(1.19); C633(1.34)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C534(1.17); C633(0.86)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C534(1.15); C633(1.15)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C534(1.01); C633(0.97)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C534(1.07); C633(1.19)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C534(0.99); C633(1.17)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C534(1.13); C633(1.59)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C342(0.84); C534(1.06)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C534(1.04); C633(1.26)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C534(1.02); C633(1.37)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C534(1.14); C633(1.56)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C534(1.16); C633(1.34)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C534(0.96); C633(1.19)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C534(1.04); C633(1.36)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C534(0.90); C633(1.17)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C534(0.89); C633(1.33)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C534(0.91); C633(1.41)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C534(0.90); C633(1.14)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C342(0.52); C534(1.53)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C534(0.99); C633(1.50)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C534(0.86); C633(1.52)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C534(0.93); C633(1.97)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C534(0.87)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C534(1.15)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C534(0.97)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C534(1.19)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C534(1.13)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C534(1.13)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C534(1.20)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C534(1.13)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C534(1.07)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C534(0.92)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C534(1.05)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C534(1.48)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C534(1.17)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C534(0.97)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C534(1.49)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C534(1.04)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C534(0.96)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C342(0.76); C534(1.47)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C342(0.60); C534(1.14)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C342(0.61); C534(1.23)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 11.43  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C534(0.96)  LDD0078  [6]
 LDCM0367  CL1 HEK-293T C342(0.77); C534(1.51); C633(1.08)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C342(0.48); C534(1.97); C633(2.99)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C342(0.73); C534(1.33); C633(1.48)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C342(0.47); C534(1.12)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C342(0.55); C534(1.18)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C342(0.54); C534(1.30)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C342(0.60); C534(1.21)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C342(1.07); C534(1.25); C633(1.23)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C342(0.89); C534(1.17); C633(1.46)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C342(0.85); C534(1.27); C633(1.24)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C342(0.81); C534(1.37); C633(1.47)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C342(0.85); C534(1.51); C633(1.09)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C342(0.43); C534(1.99); C633(2.50)  LDD0977  [6]
 LDCM0380  CL110 HEK-293T C342(0.78); C534(1.74); C633(1.27)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C342(0.85); C534(1.37); C633(1.14)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C534(0.97)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C534(0.85)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C534(0.87)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C534(1.02)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C534(0.89)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C342(0.84); C534(0.90)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C342(0.86); C534(0.91)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C342(0.70); C534(0.83)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C342(0.74); C534(1.38); C633(1.16)  LDD0988  [6]
 LDCM0391  CL120 HEK-293T C342(0.83); C534(0.91)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C342(0.37); C534(0.97)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C342(0.79); C534(1.11)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C342(0.80); C534(1.40)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C342(0.84); C534(0.93)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C534(1.09); C633(1.12)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C534(1.12); C633(1.06)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C534(0.97); C633(0.80)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C534(0.98); C633(1.05)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C342(0.69); C534(1.09); C633(1.21)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C342(0.68); C534(1.37); C633(1.26)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C342(0.52); C534(1.90); C633(1.51)  LDD1000  [6]
 LDCM0403  CL16 HEK-293T C342(2.06); C534(1.06)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C342(1.49); C534(1.22)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C342(1.00); C534(1.03)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C342(1.52); C534(1.16)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C342(0.81); C534(1.66); C633(1.17)  LDD1005  [6]
 LDCM0408  CL20 HEK-293T C342(1.17); C534(1.24)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C342(1.25); C534(1.38)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C342(0.99); C534(1.16)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C342(0.91); C534(0.98)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C342(1.46); C534(1.05)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C342(1.05); C534(1.18)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C342(1.09); C534(1.15)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C342(1.49); C534(1.02)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C342(1.56); C534(1.07)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C342(1.06); C534(1.14)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C342(0.85); C534(1.18); C633(1.27)  LDD1016  [6]
 LDCM0419  CL30 HEK-293T C342(0.81); C534(1.17)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C534(1.33)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C534(1.10)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C534(1.40)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C534(1.15)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C534(1.30)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C534(1.24)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C534(1.34)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C534(1.57)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C342(0.73); C534(1.26); C633(1.26)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C534(1.28)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C534(1.96)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C534(1.77)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C534(1.96)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C534(1.36)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C534(1.52)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C534(0.96)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C534(0.90)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C534(0.99)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C534(1.00)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C342(0.57); C534(1.49); C633(1.37)  LDD1038  [6]
 LDCM0441  CL50 HEK-293T C534(0.91)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C534(1.04)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C534(1.00)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C534(0.85)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C534(0.91)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C534(1.04)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C534(0.99)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C534(0.95)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C534(1.06)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C534(1.02)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C342(0.80); C534(1.33); C633(1.15)  LDD1049  [6]
 LDCM0452  CL60 HEK-293T C534(1.07)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C534(1.06); C633(1.25)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C534(1.19); C633(1.22)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C534(1.36); C633(1.31)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C534(1.32); C633(1.21)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C534(1.22); C633(1.41)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C534(1.34); C633(1.20)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C534(1.19); C633(1.07)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C534(1.36); C633(1.17)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C534(1.29); C633(1.00)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C342(0.55); C534(1.39); C633(1.73)  LDD1060  [6]
 LDCM0463  CL70 HEK-293T C534(1.14); C633(1.00)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C534(1.37); C633(1.46)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C534(1.04); C633(1.47)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C534(1.37); C633(1.01)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C534(1.77); C633(2.29)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C342(0.87); C534(0.96)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C342(0.78); C534(0.97)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C342(0.68); C534(1.00)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C342(0.62); C534(1.09)  LDD1070  [6]
 LDCM0473  CL8 HEK-293T C534(1.33); C633(1.82)  LDD1071  [6]
 LDCM0474  CL80 HEK-293T C342(0.74); C534(0.98)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C342(0.67); C534(0.99)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C342(0.93); C534(1.01)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C342(0.85); C534(0.95)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C342(0.68); C534(0.98)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C342(0.68); C534(1.04)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C342(0.62); C534(1.11)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C342(0.68); C534(1.06)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C342(0.75); C534(1.12)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C342(0.73); C534(0.97)  LDD1081  [6]
 LDCM0484  CL9 HEK-293T C534(1.52); C633(1.65)  LDD1082  [6]
 LDCM0485  CL90 HEK-293T C342(0.61); C534(1.12)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C342(1.21); C534(0.99); C633(1.22)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C342(0.99); C534(1.30); C633(1.15)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C342(0.89); C534(1.16); C633(1.21)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C342(0.65); C534(1.48); C633(1.82)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C342(0.56); C534(1.65); C633(1.83)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C342(0.76); C534(1.33); C633(1.26)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C342(0.86); C534(1.22); C633(1.25)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C342(0.86); C534(1.22); C633(1.23)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C342(0.95); C534(1.23); C633(1.11)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C342(0.94); C534(0.90); C240(0.93); C765(1.03)  LDD1698  [15]
 LDCM0468  Fragment33 HEK-293T C534(1.60); C633(1.74)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C534(1.14)  LDD1025  [6]
 LDCM0116  HHS-0101 DM93 Y578(0.77); Y556(0.94); Y490(1.27)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y578(0.89); Y556(1.00); Y490(1.68)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y556(0.44); Y578(0.99)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y578(1.01); Y556(1.02)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y578(0.72); Y556(2.05)  LDD0268  [5]
 LDCM0123  JWB131 DM93 Y490(0.94); Y556(0.06); Y578(1.30)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y490(0.79); Y556(0.13); Y578(1.61)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y490(0.91); Y556(0.43); Y578(1.62)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y490(2.05); Y556(0.69); Y578(5.26)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y490(0.54); Y556(1.14); Y578(2.53)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y490(0.09); Y556(0.17); Y578(0.06)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y490(0.30); Y556(0.07); Y578(1.51)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y490(0.61); Y556(0.21); Y578(1.20)  LDD0292  [4]
 LDCM0022  KB02 HCT 116 C534(1.44)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C534(1.61)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C534(1.51)  LDD0082  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C342(0.72)  LDD2104  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C534(1.11)  LDD2136  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutamic Acid Small molecular drug DB00142
Nadh Small molecular drug DB00157
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadph Small molecular drug DB02338
L-saccharopine . DB04207

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402