Details of the Target

General Information of Target

Target ID LDTP12739
Target Name Nicotinamide riboside kinase 1 (NMRK1)
Gene Name NMRK1
Gene ID 54981
Synonyms
C9orf95; NRK1; Nicotinamide riboside kinase 1; NRK 1; NmR-K 1; EC 2.7.1.22; Nicotinic acid riboside kinase 1; EC 2.7.1.173; Ribosylnicotinamide kinase 1; RNK 1; Ribosylnicotinic acid kinase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDF
GRPIAMLVFPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSPRTLPRSITYVSIIIF
IMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCM
WYIPFFLILFMYFSGCFTASKAESLIPGPALLLVAPSGLYYWYLVTEGQIFILFIFTFFA
MLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPW
AFYTLHVSSRH
Target Bioclass
Enzyme
Family
Uridine kinase family, NRK subfamily
Function
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.
Uniprot ID
Q9NWW6
Ensemble ID
ENST00000361092.9
HGNC ID
HGNC:26057

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
PC14 SNV: p.E42D DBIA    Probe Info 
PC9 SNV: p.E42D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C72(1.26)  LDD0304  [1]
DBIA
 Probe Info  		C125(1.83); C72(1.68)  LDD0080  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
Lodoacetamide azide
 Probe Info  		C72(0.00); C125(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C72(1.25)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C72(1.23)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C72(0.95)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C72(1.16)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C72(1.00)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C72(1.00)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C72(1.08)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C72(1.24)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C72(1.11)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C72(0.87)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C72(1.29)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C72(0.89)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C72(1.23)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C72(1.21)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C72(1.03)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C72(0.91)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C72(1.07)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C72(0.95)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C72(1.10)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C72(1.22)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C72(1.13)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C72(0.95)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C72(1.13)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C72(1.01)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C72(1.46)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C72(0.84)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C72(1.01)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C72(0.85)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C72(0.83)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C72(1.17)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C72(1.21)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C72(1.16)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C72(0.94)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C72(0.91)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C72(1.08)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C72(0.96)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C72(0.87)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C72(1.13)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C72(0.98)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C72(1.31)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C72(1.18)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C72(1.52)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C72(1.94)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C72(1.63)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C72(1.22)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C72(1.40)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C72(1.48)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C72(1.07)  LDD0860  [2]
 LDCM0263  AC143 PaTu 8988t C72(1.30)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C72(1.10)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C72(1.17)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C72(1.29)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C72(1.05)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C72(1.47)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C72(1.66)  LDD1148  [2]
 LDCM0270  AC15 HCT 116 C72(1.14)  LDD0587  [2]
 LDCM0271  AC150 PaTu 8988t C72(1.31)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C72(1.95)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C72(1.28)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C72(1.55)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C72(1.75)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C72(1.66)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C72(1.46)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C72(1.37)  LDD2169  [2]
 LDCM0276  AC17 HCT 116 C72(1.31)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C72(1.76)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C72(1.22)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C72(1.32)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C72(1.14)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C72(1.09)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C72(1.00)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C72(1.17)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C72(1.10)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C72(1.04)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C72(1.20)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C72(1.18)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C72(1.27)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C72(1.27)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C72(1.22)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C72(1.34)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C72(1.36)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C72(1.66)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C72(1.48)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C72(1.77)  LDD0612  [2]
 LDCM0296  AC35 PaTu 8988t C125(1.33); C72(1.26)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C125(1.53); C72(1.44)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C125(1.76); C72(1.39)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C125(1.37); C72(1.57)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C125(1.45); C72(1.48)  LDD1179  [2]
 LDCM0301  AC4 HCT 116 C72(1.29)  LDD0618  [2]
 LDCM0302  AC40 PaTu 8988t C125(1.52); C72(1.82)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C125(1.35); C72(1.55)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C125(1.30); C72(1.51)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C125(1.43); C72(1.31)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C125(1.47); C72(2.30)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C125(1.51); C72(2.10)  LDD1186  [2]
 LDCM0308  AC46 HCT 116 C72(0.94)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C72(1.25)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C72(1.03)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C72(1.51)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C72(1.43)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C72(1.43)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C72(0.71)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C72(1.01)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C72(1.36)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C72(1.26)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C72(1.46)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C72(1.95)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C72(1.02)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C72(1.05)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C72(1.06)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C72(1.32)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C72(1.10)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C72(1.41)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C72(1.06)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C72(1.19)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C72(1.25)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C72(1.26)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C72(1.15)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C72(1.08)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C72(1.63)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C72(1.25)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C72(1.04)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C72(0.84)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C72(0.89)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C72(1.59)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C72(1.00)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C72(0.94)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C72(1.43)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C72(1.26)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C72(1.13)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C72(1.61)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C72(1.25)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C72(1.13)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C72(1.34)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C72(1.10)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C72(1.02)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C72(1.10)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C72(1.00)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C72(1.16)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C72(1.13)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C72(1.08)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C72(0.90)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C72(1.10)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C72(1.11)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C72(1.06)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C72(1.06)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C72(1.04)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C72(1.07)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C72(0.99)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C72(0.97)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C72(1.06)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C72(0.91)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C72(0.89)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C72(1.03)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C72(1.17)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C72(1.79)  LDD0592  [2]
 LDCM0632  CL-Sc Hep-G2 C125(20.00); C72(1.60); C125(0.76)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C72(0.86)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C72(1.51)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C72(1.29)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C72(1.24)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C72(1.05)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C72(1.04)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C72(1.08)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C72(1.40)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C72(1.92)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C72(1.63)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C72(1.91)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C72(1.45)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C72(1.51)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C72(1.72)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C72(1.56)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C72(1.04)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C72(1.55)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C72(1.18)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C72(1.49)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C72(1.26)  LDD0703  [2]
 LDCM0387  CL117 PaTu 8988t C125(1.80); C72(1.45)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C125(1.58); C72(1.48)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C125(1.42); C72(1.37)  LDD1268  [2]
 LDCM0390  CL12 HCT 116 C72(1.74)  LDD0707  [2]
 LDCM0391  CL120 PaTu 8988t C125(1.43); C72(1.16)  LDD1270  [2]
 LDCM0392  CL121 HCT 116 C72(1.11)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C72(1.23)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C72(1.52)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C72(1.42)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C72(1.10)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C72(1.27)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C72(1.09)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C72(1.12)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C72(1.51)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C72(1.32)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C72(1.43)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C72(0.96)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C72(1.16)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C72(1.05)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C72(1.19)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C72(0.95)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C72(1.27)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C72(1.37)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C72(1.51)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C72(1.01)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C72(1.26)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C72(1.17)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C72(1.01)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C72(1.02)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C72(1.18)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C72(1.13)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C72(1.03)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C72(1.07)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C72(1.21)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C72(1.54)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C72(0.75)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C72(1.83)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C72(2.07)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C72(1.86)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C72(1.99)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C72(1.86)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C72(1.04)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C72(1.66)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C72(1.77)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C72(2.96)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C72(2.11)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C72(1.85)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C72(2.24)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C72(0.76)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C72(0.72)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C72(0.71)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C72(0.85)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C72(1.16)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C72(0.74)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C72(0.72)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C72(0.80)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C72(0.71)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C72(0.72)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C72(0.72)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C72(0.91)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C72(0.70)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C72(0.70)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C72(0.82)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C72(1.20)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C72(0.91)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C72(1.07)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C72(1.08)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C72(1.11)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C72(1.27)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C72(1.11)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C72(1.54)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C72(1.33)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C72(1.14)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C72(1.06)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C72(1.45)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C72(1.19)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C72(1.25)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C72(1.06)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C72(1.23)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C72(1.20)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C72(0.95)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C72(0.92)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C72(0.98)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C72(0.97)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C72(1.72)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C72(0.91)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C72(0.98)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C72(0.95)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C72(0.97)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C72(1.01)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C72(0.97)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C72(0.94)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C72(0.90)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C72(0.87)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C72(0.85)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C72(1.34)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C72(0.92)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C72(1.16)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C72(0.97)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C72(0.95)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C72(1.16)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C72(1.07)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C72(1.02)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C72(1.13)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C72(1.27)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C72(1.30)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C125(1.27); C72(2.13)  LDD1698  [7]
 LDCM0625  F8 Ramos C125(0.91)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C125(0.34)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C125(10.81)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C125(1.24)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C125(0.79)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C125(0.94)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C125(1.06)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C125(0.81)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C125(1.06)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C125(1.02)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C125(0.34)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C125(0.75)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C125(1.92)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C125(1.34)  LDD2201  [8]
 LDCM0468  Fragment33 HCT 116 C72(1.18)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C125(0.91)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C125(0.91)  LDD2184  [8]
 LDCM0427  Fragment51 HCT 116 C72(2.38)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C125(0.97)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C125(0.56)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C125(1.43)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C125(0.70)  LDD2188  [8]
 LDCM0022  KB02 HCT 116 C125(1.83); C72(1.68)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C125(1.18); C72(1.09)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C125(1.63); C72(1.62)  LDD0082  [2]
 LDCM0131  RA190 MM1.R C72(1.26)  LDD0304  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
BTB/POZ domain-containing protein KCTD21 (KCTD21) . Q4G0X4
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578