Details of the Target

General Information of Target

Target ID LDTP11980
Target Name Speckle targeted PIP5K1A-regulated poly(A) polymerase (TUT1)
Gene Name TUT1
Gene ID 64852
Synonyms
RBM21; Speckle targeted PIP5K1A-regulated poly(A) polymerase; Star-PAP; EC 2.7.7.19; RNA-binding motif protein 21; RNA-binding protein 21; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase; EC 2.7.7.52
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIH
QQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVL
RFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQN
PFKIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL
Target Bioclass
Enzyme
Family
DNA polymerase type-B-like family
Subcellular location
Nucleus, nucleolus
Function
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
Uniprot ID
Q9H6E5
Ensemble ID
ENST00000476907.6
HGNC ID
HGNC:26184

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C574(1.23)  LDD2111  [1]
IPM
 Probe Info  		C566(1.79)  LDD1701  [1]
DBIA
 Probe Info  		C669(2.87); C670(2.87)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
AOyne
 Probe Info  		9.30  LDD0443  [5]
NAIA_5
 Probe Info  		C768(0.00); C633(0.00); C372(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C372(2.56)  LDD0372  [7]
 LDCM0214  AC1 HCT 116 C351(0.89); C473(1.04); C574(0.74); C633(1.24)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C351(0.96); C399(1.20); C473(1.07); C574(0.66)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C351(1.50); C574(0.34); C633(1.12)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C351(0.95); C574(0.36); C633(0.89)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C351(0.95); C574(0.30); C633(1.05)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C351(1.80); C574(0.31); C633(1.03)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C351(1.22); C574(0.29); C633(0.97)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C351(0.95); C574(0.26); C633(0.99)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C351(0.80); C574(0.28); C633(1.06)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C351(0.75); C574(0.38); C633(0.99)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C351(0.86); C574(0.39); C633(0.79)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C351(1.52); C574(0.52); C633(0.69)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C351(0.95); C399(1.05); C473(0.77); C574(0.53)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C351(0.71); C574(0.39); C633(0.85)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C351(1.09); C574(0.41); C633(0.86)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C351(0.98); C574(0.32); C633(1.03)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C351(0.85); C399(1.05); C574(0.88); C669(0.94)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C351(0.90); C399(0.87); C574(0.81); C669(0.91)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C351(0.92); C399(0.63); C574(0.82); C669(1.09)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C351(1.22); C399(0.71); C574(0.80); C669(0.97)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C351(1.00); C399(0.71); C574(0.84); C669(0.87)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C351(0.95); C399(0.88); C574(0.69); C669(0.91)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C351(0.83); C399(0.75); C574(0.81); C669(0.92)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C351(0.92); C399(0.87); C473(0.96); C574(0.74)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C351(0.82); C399(0.63); C574(0.96); C669(0.70)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C351(1.07); C399(0.82); C574(1.06); C669(0.96)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C351(0.89); C399(0.72); C574(1.11); C669(1.03)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C351(1.04); C399(0.98); C574(0.85); C669(0.78)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C351(0.90); C399(1.07); C574(0.92); C669(0.81)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C351(0.83); C399(0.79); C574(0.87); C669(0.95)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C351(1.01); C399(0.75); C574(0.82); C669(1.00)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C351(1.10); C399(0.84); C574(0.80); C669(1.06)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C351(0.93); C473(1.27); C633(1.55); C669(0.61)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C351(0.88); C473(1.21); C633(1.11); C669(0.64)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C351(0.80); C473(1.08); C633(1.22); C669(0.72)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C351(0.84); C473(1.08); C633(1.01); C669(0.69)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C351(0.98); C473(1.10); C633(1.20); C669(0.90)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C351(0.91); C473(1.28); C633(1.24); C669(0.71)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C351(1.00); C473(1.24); C633(1.33); C669(0.73)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C351(0.90); C473(1.12); C633(1.33); C669(0.77)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C351(1.00); C473(1.10); C633(1.24); C669(0.73)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C351(0.94); C473(1.06); C633(1.07); C669(0.70)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C351(0.83); C473(1.30); C633(1.32); C669(0.68)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C351(1.12); C473(1.40); C633(1.36); C669(0.86)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C351(0.94); C399(0.87); C473(0.81); C574(0.55)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C351(0.86); C473(1.47); C633(1.41); C669(0.82)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C351(1.10); C473(1.11); C633(1.34); C669(0.92)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C351(0.97); C473(1.23); C633(1.14); C669(0.81)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C633(0.73); C574(0.94); C669(0.99); C670(0.99)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C574(0.59); C351(0.80); C633(0.86); C669(1.28)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C633(0.77); C574(0.79); C351(1.02); C669(1.11)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C633(0.80); C574(0.93); C351(1.05); C669(1.17)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C574(0.97); C633(0.98); C351(1.06); C669(1.42)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C574(0.70); C633(0.71); C351(1.27); C669(1.76)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C633(0.61); C574(0.65); C351(0.83); C669(1.40)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C574(0.56); C633(0.84); C399(0.89); C351(0.98)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C633(0.74); C669(1.02); C670(1.02); C351(1.23)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C633(0.87); C574(1.05); C669(1.11); C670(1.11)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C633(0.65); C351(0.91); C574(1.18); C669(1.34)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C633(0.57); C574(1.19); C351(1.27); C669(1.99)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C351(0.86); C574(0.90); C633(0.67); C669(1.28)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C351(0.97); C574(2.12); C633(0.59); C669(1.20)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C351(1.36); C574(1.88); C633(0.81); C669(1.08)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C351(0.88); C574(1.30); C633(0.68); C669(1.21)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C669(0.88); C351(0.89); C670(0.92); C633(0.96)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C574(0.81); C633(0.85); C669(0.92); C351(0.95)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C574(0.80); C351(0.81); C633(0.98); C669(1.01)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C670(0.61); C574(0.69); C351(0.94); C473(0.94)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C574(0.88); C669(0.91); C351(0.93); C633(0.95)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C574(0.89); C351(0.96); C473(0.98); C633(1.04)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C633(0.86); C351(0.97); C574(1.00); C473(1.11)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C574(0.81); C351(0.87); C633(0.90); C669(0.97)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C351(0.83); C574(0.94); C633(0.95); C399(1.05)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C633(0.75); C574(0.85); C473(0.89); C669(1.06)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C574(0.71); C633(0.73); C473(0.94); C669(1.26)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C574(0.66); C473(0.76); C633(0.83); C669(1.15)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C633(0.70); C574(0.73); C473(0.90); C669(1.30)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C633(0.64); C574(0.68); C473(0.89); C669(1.26)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C670(0.72); C574(0.74); C351(0.97); C473(1.03)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C574(0.63); C473(0.69); C633(0.73); C669(1.28)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C574(0.62); C633(0.77); C473(1.08); C669(1.24)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C574(0.56); C633(0.67); C473(0.85); C669(1.37)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C574(0.65); C633(0.70); C473(0.90); C669(1.24)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C473(0.67); C574(0.69); C633(0.70); C669(1.14)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C669(0.67); C670(0.67); C574(1.11); C351(1.14)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C669(0.80); C670(0.80); C574(1.02); C473(1.03)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C669(0.91); C670(0.91); C574(0.93); C351(0.94)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C351(0.96); C574(0.97); C669(0.97); C670(0.97)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C574(0.95); C669(0.96); C670(0.96); C351(1.10)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C670(0.64); C574(0.83); C351(0.88); C473(1.12)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C574(0.89); C669(0.98); C670(0.98); C351(1.09)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C669(0.83); C670(0.83); C574(0.93); C351(1.05)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C669(0.91); C670(0.91); C574(0.91); C473(0.97)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C669(0.83); C670(0.83); C574(1.07); C351(1.08)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C669(0.87); C670(0.87); C574(0.99); C351(1.10)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C574(0.89); C669(1.07); C670(1.07); C351(1.12)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C633(0.90); C351(0.98); C574(1.11); C473(1.11)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C351(0.91); C473(0.94); C633(0.97); C574(1.15)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C633(0.73); C473(0.95); C574(0.97); C351(1.20)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C633(0.92); C473(1.09); C574(1.23); C351(1.34)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C574(0.72); C351(0.88); C473(1.02); C670(1.03)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C473(1.05); C633(1.10); C574(1.13); C351(1.15)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C633(0.78); C473(0.98); C351(1.13); C574(1.30)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C633(0.78); C473(0.92); C351(0.98); C574(1.06)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C473(0.90); C351(1.07); C574(1.10); C633(1.11)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C633(0.87); C574(1.08); C473(1.09); C351(1.24)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C574(1.02); C633(1.06); C473(1.08); C351(1.26)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C473(0.92); C633(1.08); C574(1.35); C351(1.54)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C574(0.58); C399(1.04); C669(1.11); C670(1.11)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C574(0.58); C473(1.14); C399(1.17); C669(1.30)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C574(0.50); C473(1.23); C669(1.25); C670(1.25)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C574(0.71); C633(0.86); C669(0.95); C670(0.95)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C574(0.53); C399(0.83); C669(1.05); C670(1.05)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C574(0.52); C669(1.01); C670(1.01); C399(1.04)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C574(0.49); C473(1.10); C669(1.34); C670(1.34)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C574(0.48); C473(0.99); C399(1.06); C669(1.13)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C574(0.50); C399(0.84); C473(1.11); C669(1.18)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C574(0.48); C669(0.93); C670(0.93); C473(1.14)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C574(0.49); C669(0.88); C670(0.88); C473(1.28)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C574(0.49); C669(1.04); C670(1.04); C399(1.15)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C473(0.88); C574(0.98); C669(0.99); C670(0.99)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C574(0.91); C473(0.96); C669(1.05); C670(1.05)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C574(0.65); C633(0.85); C669(0.93); C670(0.93)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C473(0.94); C351(0.99); C574(1.03); C669(1.75)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C669(0.87); C670(0.87); C574(0.97); C473(1.03)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C669(0.92); C670(0.92); C574(0.92); C473(0.95)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C473(0.93); C574(1.14); C351(1.21); C669(1.52)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C574(1.06); C473(1.09); C669(1.31); C670(1.31)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C473(1.03); C351(1.24); C574(1.27); C669(1.58)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C574(0.88); C473(0.89); C351(1.17); C669(1.21)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C574(0.86); C473(0.92); C351(1.14); C669(1.27)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C473(0.92); C574(0.97); C351(0.98); C669(1.05)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C669(0.79); C670(0.79); C574(1.06); C351(1.07)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C574(0.89); C633(0.92); C351(0.92); C473(0.98)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C574(0.90); C351(0.93); C669(1.00); C670(1.00)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C669(0.67); C670(0.67); C473(0.91); C351(1.00)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C473(0.99); C574(1.16); C351(1.30); C669(1.36)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C574(0.62); C399(0.97); C351(1.03); C473(1.06)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C574(0.66); C399(0.77); C351(0.91); C473(1.14)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C574(0.66); C399(0.89); C351(0.98); C473(1.00)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C574(0.72); C399(0.86); C351(0.92); C669(1.13)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C669(0.80); C670(0.80); C399(0.91); C574(0.92)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C399(0.78); C574(0.92); C633(0.95); C351(1.09)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C574(0.70); C399(0.78); C351(0.99); C633(1.19)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C399(0.93); C574(1.00); C473(1.01); C351(1.11)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C574(0.69); C399(0.89); C473(1.06); C351(1.08)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C399(0.73); C574(0.75); C351(1.07); C473(1.24)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C574(0.76); C399(0.78); C473(0.98); C351(1.00)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C399(0.73); C574(0.88); C351(1.03); C669(1.10)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C574(0.70); C399(0.84); C633(0.91); C351(0.95)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C399(0.66); C574(0.67); C351(0.83); C633(1.04)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C574(0.68); C399(0.83); C351(0.96); C633(1.01)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C574(0.30); C633(0.95); C351(1.02)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C574(0.41); C633(0.99); C351(1.45)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C351(1.11); C399(0.96); C473(0.96); C574(0.86)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C574(0.75); C633(0.95); C399(0.97); C473(0.98)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C574(0.62); C351(0.95); C399(0.98); C669(1.06)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C574(1.06)  LDD2171  [2]
 LDCM0367  CL1 HCT 116 C670(0.73); C351(0.86); C669(0.91); C633(0.97)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C351(0.95); C574(0.97); C473(1.08); C633(1.12)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C670(0.66); C574(0.67); C351(0.87); C473(1.06)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C574(0.73); C473(0.84); C633(0.86); C351(0.88)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C669(0.82); C670(0.82); C473(0.83); C633(0.89)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C351(0.86); C669(0.89); C670(0.89); C633(0.90)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C574(0.73); C473(0.82); C351(0.85); C669(0.90)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C574(0.66); C351(0.89); C669(0.90); C633(0.95)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C574(0.72); C351(0.90); C473(1.17); C399(1.34)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C574(0.69); C633(0.89); C351(1.02); C669(1.02)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C574(0.77); C351(0.92); C633(1.07); C669(1.09)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C574(0.83); C633(0.84); C351(1.00); C473(1.06)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C351(1.02); C473(1.03); C574(1.04); C633(1.19)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C574(0.69); C351(0.90); C633(1.01); C399(1.02)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C574(0.78); C351(0.88); C633(0.90); C399(0.90)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C633(0.82); C574(0.88); C473(0.91); C669(0.99)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C574(0.55); C633(0.70); C473(0.81); C669(1.15)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C574(0.63); C633(0.66); C473(0.87); C669(1.00)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C574(0.67); C633(0.75); C473(0.77); C669(1.09)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C574(0.66); C633(0.75); C473(0.79); C669(0.98)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C574(1.03); C473(1.12); C669(1.18); C670(1.18)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C669(0.82); C670(0.82); C574(0.85); C351(0.97)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C669(0.84); C670(0.84); C574(0.97); C351(1.07)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C633(0.95); C574(1.05); C351(1.11); C473(1.23)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C669(0.86); C670(0.86); C574(0.86); C473(0.93)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C633(0.67); C473(0.92); C574(0.99); C351(1.08)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C351(0.95); C574(0.98); C473(1.00); C633(1.05)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C473(0.83); C633(0.85); C574(0.96); C351(1.12)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C473(0.84); C633(1.09); C574(1.13); C351(1.19)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C574(0.67); C669(0.88); C670(0.88); C399(1.02)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C574(0.75); C669(0.97); C670(0.97); C473(1.01)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C574(0.59); C669(0.94); C670(0.94); C473(0.99)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C574(0.62); C399(0.92); C473(1.16); C669(1.25)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C574(0.84); C351(1.00); C633(1.05); C473(1.12)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C351(0.82); C633(1.05); C670(1.08); C473(1.09)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C574(0.83); C351(0.90); C473(1.00); C633(1.15)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C574(0.67); C351(0.96); C473(1.14); C669(1.20)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C574(0.65); C351(0.89); C473(0.97); C669(1.00)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C574(0.53); C351(0.95); C473(1.09); C669(1.32)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C574(0.68); C351(0.98); C669(1.22); C670(1.22)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C670(0.78); C351(0.90); C669(0.90); C473(1.02)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C574(0.64); C351(0.96); C473(1.18); C669(1.49)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C574(0.60); C351(0.99); C473(1.14); C669(1.34)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C574(0.70); C473(1.04); C351(1.16); C669(1.63)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C574(0.52); C351(0.95); C473(1.11); C669(1.24)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C351(1.08); C473(1.11); C574(0.61); C669(1.46)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C351(1.07); C473(1.13); C574(0.65); C669(1.52)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C351(0.95); C473(1.20); C574(0.81); C669(1.15)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C351(1.03); C473(1.18); C574(0.61); C669(1.51)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C351(1.01); C473(1.11); C574(0.60); C669(1.51)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C351(1.04); C473(1.08); C574(0.61); C669(1.53)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C351(0.95); C473(1.05); C574(1.06); C633(1.12)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C351(0.98); C473(1.15); C574(0.68); C669(1.23)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C351(0.80); C399(1.22); C473(1.20); C574(0.76)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C351(0.80); C399(1.05); C574(0.86); C669(0.86)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C351(0.87); C399(1.05); C574(0.74); C669(0.95)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C351(0.86); C399(1.21); C574(0.88); C669(0.91)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C351(0.74); C399(1.00); C574(0.86); C669(0.50)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C351(0.75); C399(0.90); C574(0.85); C669(0.62)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C351(0.87); C399(1.35); C574(0.98); C669(0.61)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C351(0.91); C399(1.02); C574(0.89); C669(0.48)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C351(0.92); C473(1.05); C574(1.11); C633(1.13)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C351(0.71); C399(1.27); C574(0.77); C669(0.53)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C351(0.82); C399(1.22); C574(0.70); C669(0.58)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C351(0.85); C399(1.36); C574(0.85); C669(0.60)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C351(0.79); C399(1.01); C574(0.84); C669(0.53)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C351(0.81); C399(1.07); C574(0.99); C669(0.45)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C351(0.91); C399(1.15); C574(0.92); C669(0.47)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C473(0.93); C574(0.84); C669(0.93); C670(0.93)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C473(0.89); C574(0.78); C669(0.92); C670(0.92)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C473(1.00); C574(1.05); C669(0.83); C670(0.83)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C473(0.90); C574(0.80); C669(1.08); C670(1.08)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C351(0.86); C473(1.12); C574(0.88); C633(1.23)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C473(0.90); C574(0.88); C669(0.87); C670(0.87)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C473(0.98); C574(0.84); C669(0.93); C670(0.93)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C473(0.92); C574(0.86); C669(1.08); C670(1.08)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C473(1.03); C574(0.72); C669(0.78); C670(0.78)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C473(0.92); C574(0.97); C669(0.92); C670(0.92)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C473(0.86); C574(0.83); C669(0.83); C670(0.83)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C473(0.85); C574(0.74); C669(0.78); C670(0.78)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C473(0.91); C574(0.77); C669(0.78); C670(0.78)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C473(0.88); C574(0.85); C669(1.00); C670(1.00)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C473(0.87); C574(0.88); C669(1.09); C670(1.09)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C351(0.93); C473(0.91); C574(0.85); C633(1.13)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C473(0.91); C574(0.94); C669(0.90); C670(0.90)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C574(0.93); C669(1.25); C670(1.00)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C574(1.07); C669(1.37); C670(1.25)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C574(0.74); C669(1.74); C670(2.10)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C574(0.75); C669(1.46); C670(1.60)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C574(0.77); C669(1.28); C670(1.29)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C574(0.60); C669(1.30); C670(1.27)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C574(0.62); C669(1.28); C670(1.28)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C574(0.62); C669(1.29); C670(1.20)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C574(1.00); C669(1.63); C670(1.92)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C351(0.92); C473(1.21); C574(1.14); C633(1.11)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C574(0.63); C669(1.62); C670(2.03)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C574(0.77); C669(1.65); C670(2.00)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C574(1.21); C669(1.16); C670(0.80)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C574(0.91); C669(1.32); C670(1.11)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C574(0.83); C669(1.33); C670(1.40)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C351(0.78); C473(1.07); C574(0.96); C633(0.78)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C351(0.73); C473(1.02); C574(1.09); C633(0.69)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C351(0.99); C473(1.06); C574(0.80); C633(1.00)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C351(1.14); C473(1.12); C574(0.96); C633(0.83)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C351(1.02); C473(1.08); C574(1.07); C633(1.02)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C351(0.88); C473(1.18); C574(1.16); C633(1.13)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C351(0.83); C473(1.02); C574(0.80); C633(0.97)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C351(1.10); C473(1.44); C574(0.90); C633(0.85)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C351(0.94); C473(1.17); C574(1.00); C633(0.89)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C351(1.56); C473(0.98); C574(0.97); C633(1.01)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C351(0.76); C473(1.01); C574(0.88); C633(0.79)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C351(1.00); C473(1.04); C574(0.88); C633(0.88)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C351(0.80); C473(1.38); C574(1.00); C633(0.76)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C351(0.90); C473(1.10); C574(1.11); C633(0.75)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C351(1.30); C473(1.13); C574(0.95); C633(0.94)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C351(0.91); C473(0.96); C574(0.85); C633(1.19)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C351(0.72); C473(1.09); C574(0.87); C633(0.73)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C351(0.98); C473(0.96); C574(0.72); C633(1.01)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C351(1.06); C473(0.94); C574(0.71); C633(0.96)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C351(0.85); C473(1.05); C574(0.99); C633(0.90)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C351(0.93); C473(1.07); C574(0.89); C633(1.22)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C351(0.94); C473(0.88); C574(0.74); C633(0.93)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C351(0.91); C473(0.89); C574(0.80); C633(1.07)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C351(0.85); C473(0.91); C574(0.73); C633(1.02)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C351(0.83); C473(0.98); C574(0.81); C633(1.21)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C351(0.91); C473(1.07); C574(0.85); C633(1.27)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C574(0.67); C669(1.49); C670(1.64)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C351(0.70); C399(1.18); C574(0.88); C669(0.54)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C669(2.87); C670(2.87)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C669(1.71); C670(1.71)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C669(2.26); C670(2.26)  LDD0082  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C574(1.23)  LDD2111  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C574(2.35)  LDD2144  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C574(0.97)  LDD2146  [1]
 LDCM0021  THZ1 HCT 116 C574(1.06)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) . Q99755
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KATNB1-like protein 1 (KATNBL1) . Q9H079

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625