Details of the Target

General Information of Target

Target ID LDTP10840
Target Name Bifunctional polynucleotide phosphatase/kinase (PNKP)
Gene Name PNKP
Gene ID 11284
Synonyms
Bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase; EC 3.1.3.32; 2'(3')-polynucleotidase; Polynucleotide 5'-hydroxyl-kinase; EC 2.7.1.78)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVRETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQ
KAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPP
SLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQH
GLYYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHS
RSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSS
SSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFK
KFGKVTSVQIHGTSEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWIGPETESEN
EFRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAF
LQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRY
GPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCME
KSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFYSE
WETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERR
PIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKS
RLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQ
ENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLK
AKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKA
RKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQP
DVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRP
SSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDET
PERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVD
EYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGG
SPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQM
ADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPS
DSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTI
TPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKI
RTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRI
YGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTP
ESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVS
EEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGA
SFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPP
ASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG
EAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPV
KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG
WRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSE
QKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAV
SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSP
EATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIG
SIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATE
SSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRR
KRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTS
DLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVT
PPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPP
DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK
PLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLA
KPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVL
TGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTV
TMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYS
GQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANV
ATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPP
VLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNH
VPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAA
GIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSP
RAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVM
QSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAK
AAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSG
ELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQST
QPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQ
RAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQP
APKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPL
SEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFI
TYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIV
IASV
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
DNA 3' phosphatase family
Subcellular location
Nucleus
Function
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
TTD ID
T13319
Uniprot ID
Q96T60
DrugMap ID
TTHR3IE
Ensemble ID
ENST00000322344.8
HGNC ID
HGNC:9154
ChEMBL ID
CHEMBL4523434

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P101L DBIA    Probe Info 
HEC1 SNV: p.G292Ter; p.A322T; p.R439Q DBIA    Probe Info 
HEC1B SNV: p.G292Ter .
IGROV1 SNV: p.T490A DBIA    Probe Info 
JURKAT SNV: p.R348H .
LNCaP clone FGC Insertion: p.G223RfsTer103 DBIA    Probe Info 
MFE280 SNV: p.P502Q DBIA    Probe Info 
NCIH358 SNV: p.Q77H DBIA    Probe Info 
SNGM SNV: p.L315I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K226(10.00)  LDD0277  [1]
BTD
 Probe Info  		C353(1.74)  LDD1700  [2]
DBIA
 Probe Info  		C353(1.27); C516(0.99)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C445(0.00); C447(0.00); C308(0.00); C353(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
Lodoacetamide azide
 Probe Info  		C445(0.00); C447(0.00); C308(0.00); C353(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C353(0.93); C437(0.89)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C353(1.26)  LDD2152  [2]
 LDCM0214  AC1 HCT 116 C308(0.85); C447(0.88)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C405(0.54); C409(0.54); C353(1.04); C516(1.09)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C405(0.32); C409(0.32); C353(1.05); C447(0.69)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C405(0.36); C409(0.36); C353(1.14); C447(0.67)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C405(0.22); C409(0.22); C353(0.99); C447(0.54)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C405(0.06); C409(0.06); C353(1.01); C447(0.35)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C405(0.08); C409(0.08); C353(0.88); C447(0.50)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C405(0.07); C409(0.07); C353(0.97); C447(0.42)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C405(0.07); C409(0.07); C353(1.08); C447(0.40)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C405(0.06); C409(0.06); C353(0.48); C447(0.55)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C405(0.59); C409(0.59); C353(2.01); C447(0.38)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C405(0.81); C409(0.81); C353(2.82); C447(0.63)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C405(0.48); C409(0.48); C353(1.05); C516(1.12)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C405(0.47); C409(0.47); C353(3.01); C447(0.40)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C405(0.47); C409(0.47); C353(3.42); C447(0.43)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C405(0.15); C409(0.15); C353(0.79); C447(0.41)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C405(1.11); C409(1.11); C308(0.98); C447(1.07)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C405(0.76); C409(0.76); C308(0.60); C447(0.79)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C405(0.56); C409(0.68); C308(0.20); C447(0.59)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C405(0.59); C409(0.57); C308(0.21); C447(0.62)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C405(0.70); C409(0.80); C308(0.99); C447(0.84)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C405(0.81); C409(0.80); C308(1.01); C447(0.95)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C405(0.70); C409(0.82); C308(0.56); C447(0.80)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C405(0.86); C409(0.86); C353(1.01); C516(1.00)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C405(0.71); C409(0.75); C308(0.41); C447(0.61)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C405(0.83); C409(0.93); C308(1.25); C447(0.92)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C405(0.83); C409(0.91); C308(1.61); C447(1.00)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C405(1.01); C409(1.09); C308(1.16); C447(1.00)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C405(1.02); C409(0.95); C308(0.89); C447(1.08)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C405(0.86); C409(0.91); C308(0.81); C447(1.17)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C405(0.63); C409(0.72); C308(0.33); C447(0.74)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C405(0.61); C409(0.65); C308(0.41); C447(0.73)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C405(0.73); C409(0.73); C308(0.68); C447(1.06)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C405(1.66); C409(1.66); C308(2.81); C447(1.67)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C405(0.66); C409(0.66); C308(0.82); C447(1.14)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C405(1.37); C409(1.37); C308(3.47); C447(1.50)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C405(1.53); C409(1.53); C308(3.20); C447(1.37)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C405(0.73); C409(0.73); C308(1.04); C447(1.22)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C405(0.52); C409(0.52); C308(0.72); C447(0.90)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C405(0.58); C409(0.58); C308(0.65); C447(1.01)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C405(0.64); C409(0.64); C308(0.98); C447(0.92)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C405(0.96); C409(0.96); C308(2.28); C447(1.08)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C405(0.57); C409(0.57); C308(0.87); C447(0.90)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C405(0.66); C409(0.66); C308(0.85); C447(1.10)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C405(0.65); C409(0.65); C353(1.01); C516(1.09)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C405(0.48); C409(0.48); C308(0.72); C447(0.96)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C405(0.61); C409(0.61); C308(1.05); C447(1.00)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C405(1.81); C409(1.81); C308(6.07); C447(1.77)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C405(0.83); C409(0.83); C308(0.90); C447(0.88)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C405(0.14); C409(0.14); C308(0.17); C447(0.51)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C405(0.50); C409(0.50); C308(0.60); C447(0.69)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C405(0.26); C409(0.26); C308(0.36); C447(0.58)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C405(0.11); C409(0.11); C308(0.14); C447(0.46)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C405(0.13); C409(0.13); C308(0.18); C447(0.45)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C405(0.12); C409(0.12); C308(0.16); C447(0.50)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C405(0.44); C409(0.44); C516(0.97); C353(1.02)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C447(0.75); C308(0.84); C516(1.01); C405(1.06)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C447(0.75); C405(0.90); C409(0.90); C308(0.93)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C405(0.11); C409(0.11); C308(0.13); C447(0.43)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C405(0.14); C409(0.14); C308(0.18); C447(0.48)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C405(0.17); C409(0.17); C308(0.21); C447(0.57)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C405(0.21); C409(0.21); C308(0.22); C447(0.63)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C405(1.02); C409(1.02); C308(0.77); C447(0.84)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C405(1.22); C409(1.22); C308(0.82); C447(0.94)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C516(1.02); C405(1.12); C409(1.12)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C405(0.24); C409(0.24); C516(1.03)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C405(0.71); C409(0.71); C516(0.97)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C308(0.60); C447(1.06)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C405(0.71); C409(0.71); C516(1.21)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C516(1.28); C405(1.43); C409(1.43)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C516(1.06); C405(1.58); C409(1.58)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C405(0.93); C409(0.93); C516(1.08)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C405(0.96); C409(0.96); C516(1.02)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C308(0.80); C516(0.94); C447(1.18); C405(1.27)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C405(0.56); C409(0.56); C447(0.89); C308(0.91)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C405(0.46); C409(0.46); C447(0.85); C308(1.03)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C405(0.34); C409(0.34); C447(0.70); C308(1.06)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C405(0.39); C409(0.39); C447(0.92); C308(0.96)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C308(0.57); C447(1.25)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C405(0.49); C409(0.49); C447(0.79); C308(0.99)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C405(0.72); C409(0.72); C447(0.84); C308(0.95)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C405(0.17); C409(0.17); C447(0.34); C308(1.05)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C405(0.29); C409(0.29); C447(0.48); C308(1.16)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C405(0.14); C409(0.14); C447(0.36); C308(0.99)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C516(0.91); C308(1.00); C447(1.58); C405(2.33)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C516(0.98); C308(1.04); C405(1.59); C409(1.59)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C516(0.86); C308(1.00); C405(1.59); C409(1.59)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C308(0.98); C516(1.07); C405(1.94); C409(1.94)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C405(0.93); C409(0.93); C447(0.99); C516(1.05)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C308(0.48); C447(0.80)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C405(0.76); C409(0.76); C516(1.04); C447(1.15)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C516(1.07); C405(1.14); C409(1.14); C447(1.33)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C405(0.73); C409(0.73); C447(1.07); C516(1.17)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C516(1.09); C405(1.20); C409(1.20); C447(1.33)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C405(0.77); C409(0.77); C447(1.12); C308(1.13)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C405(0.71); C409(0.71); C447(1.19); C516(1.36)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C308(0.75); C447(1.19); C405(1.27); C409(1.27)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C405(0.81); C409(0.81); C308(0.88); C447(0.98)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C308(0.81); C447(1.56); C405(4.22); C409(4.22)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C405(0.57); C409(0.57); C308(0.76); C447(0.78)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C308(0.42); C447(0.71)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C405(0.54); C409(0.54); C447(0.82); C308(0.87)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C308(0.82); C447(1.68); C405(4.54); C409(4.54)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C405(0.60); C409(0.60); C308(0.85); C447(0.88)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C405(0.55); C409(0.55); C447(0.82); C308(1.44)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C405(0.50); C409(0.50); C447(0.77); C308(0.95)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C405(0.58); C409(0.58); C447(1.05); C308(1.09)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C405(0.77); C409(0.77); C308(0.94); C447(1.00)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C405(0.09); C409(0.09); C308(0.26); C447(0.37)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C405(0.08); C409(0.08); C308(0.34); C447(0.40)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C405(0.06); C409(0.06); C308(0.24); C447(0.29)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C405(0.46); C409(0.46); C353(0.91); C516(1.04)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C405(0.12); C409(0.12); C308(0.48); C447(0.55)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C405(0.20); C409(0.20); C447(0.93); C516(1.05)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C405(0.07); C409(0.07); C308(0.23); C447(0.40)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C405(0.10); C409(0.10); C308(0.33); C447(0.40)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C405(0.06); C409(0.06); C308(0.30); C447(0.31)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C405(0.06); C409(0.06); C308(0.30); C447(0.39)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C405(0.08); C409(0.08); C308(0.39); C447(0.44)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C405(0.06); C409(0.06); C308(0.34); C447(0.36)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C308(0.45); C516(0.86); C405(0.88); C409(0.88)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C308(0.49); C447(0.83); C516(0.86); C405(0.91)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C405(0.71); C409(0.71); C353(0.87); C516(1.04)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C308(0.42); C405(0.64); C409(0.64); C447(0.79)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C516(1.06); C405(1.30); C409(1.30); C447(1.35)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C308(0.37); C405(0.68); C409(0.68); C447(0.72)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C308(0.51); C405(0.71); C409(0.71); C447(0.92)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C308(0.53); C447(1.02); C516(1.05); C405(1.13)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C308(0.61); C405(0.80); C409(0.80); C516(1.13)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C308(0.43); C447(0.80); C516(0.97); C405(1.03)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C308(0.42); C405(0.74); C409(0.74); C516(0.83)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C516(1.08); C405(1.18); C409(1.18); C447(1.81)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C308(0.54); C405(0.78); C409(0.78); C447(0.87)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C405(0.56); C409(0.56); C353(0.96); C516(1.07)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C308(0.38); C447(0.71); C405(1.02); C409(1.02)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C405(1.04); C409(1.04); C447(1.10); C516(1.13)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C308(0.58); C405(0.97); C409(0.97); C516(1.22)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C447(0.44); C405(0.54); C409(0.54); C516(0.87)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C447(0.38); C405(0.49); C409(0.49); C516(0.93)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C405(0.67); C409(0.67); C447(0.76); C516(1.06)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C405(0.47); C409(0.47); C447(0.83); C516(0.90)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C405(0.78); C409(0.78); C516(0.99); C447(1.06)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C405(0.54); C409(0.54); C516(0.91); C447(0.92)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C405(0.42); C409(0.42); C447(0.51); C516(0.93)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C516(0.91); C405(1.43); C409(1.43); C447(1.84)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C447(0.43); C405(0.72); C409(0.72); C516(0.89)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C447(0.45); C405(0.58); C409(0.58); C516(0.82)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C405(0.58); C409(0.58); C447(0.68); C516(0.90)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C447(0.86); C516(0.99); C405(1.10); C409(1.10)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C405(0.69); C409(0.69); C516(0.99); C447(1.10)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C447(0.73); C405(0.89); C409(0.89); C516(0.89)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C405(0.36); C409(0.36); C447(0.37); C516(0.93)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C405(0.08); C409(0.08); C447(0.37); C516(0.87)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C405(0.51); C409(0.51); C447(0.58); C516(0.95)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C405(1.04); C409(1.04); C353(1.17); C516(1.03)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C405(0.71); C409(0.71); C353(0.87); C516(1.14)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C405(0.13); C409(0.13); C516(0.83); C353(1.05)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C353(1.27); C516(0.99)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C516(0.79); C353(0.88); C447(0.97); C308(1.09)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C405(0.41); C409(0.41); C308(0.64); C447(0.77)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C308(0.51); C447(0.68)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C405(0.36); C409(0.36); C516(0.90); C353(1.01)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C405(0.79); C409(0.79); C516(0.86); C353(0.93)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C405(0.79); C409(0.79); C516(0.88); C353(1.02)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C405(0.77); C409(0.77); C516(0.97); C353(1.20)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C405(0.50); C409(0.50); C516(1.37)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C405(0.24); C409(0.24); C516(1.27)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C405(0.15); C409(0.15); C516(1.21)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C405(0.16); C409(0.16); C516(1.08)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C405(0.51); C409(0.51); C516(1.19)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C405(0.41); C409(0.41); C308(0.59); C447(0.65)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C405(0.32); C409(0.32); C516(1.07)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C405(0.81); C409(0.81); C516(1.10)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C447(0.99); C516(1.10); C308(1.32); C405(20.00)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C405(0.22); C409(0.22); C447(0.43); C308(0.92)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C405(0.59); C409(0.59); C447(0.93); C308(1.06)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C405(0.54); C409(0.54); C447(0.85); C516(1.17)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C405(0.52); C409(0.52); C447(0.87); C308(0.96)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C405(0.81); C409(0.81); C516(1.01); C308(1.02)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C405(0.91); C409(0.91); C447(0.95); C516(0.97)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C405(0.76); C409(0.76); C516(0.93); C447(1.01)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C405(0.42); C409(0.42); C308(0.75); C447(0.82)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C516(1.07); C308(1.17); C447(1.31); C405(1.32)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C447(0.85); C405(1.05); C409(1.05); C308(1.10)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C405(0.61); C409(0.61); C308(0.80); C447(0.97)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C405(0.52); C409(0.52); C447(0.68); C308(0.89)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C405(0.52); C409(0.52); C447(0.76); C308(0.85)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C405(0.48); C409(0.48); C516(0.99); C447(1.27)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C405(0.32); C409(0.32); C447(0.91); C308(0.97)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C405(0.33); C409(0.33); C447(0.92); C516(1.07)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C405(0.07); C409(0.07); C308(0.27); C447(0.31)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C405(0.47); C409(0.47); C308(0.67); C447(0.82)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C308(0.74); C405(0.74); C409(0.74); C447(0.80)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C405(0.85); C409(0.85); C447(0.93); C308(1.01)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C308(0.45); C405(0.71); C409(0.71); C447(0.77)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C308(0.56); C405(0.71); C409(0.71); C516(0.95)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C405(0.64); C409(0.64); C308(0.86); C447(0.94)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C405(0.46); C409(0.46); C308(0.50); C447(0.80)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C353(0.95); C447(0.97); C516(1.03); C308(1.05)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C308(0.17); C405(0.19); C409(0.19); C447(0.49)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C405(0.19); C409(0.19); C308(0.20); C447(0.40)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C405(0.25); C409(0.25); C308(0.28); C447(0.60)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C308(0.22); C405(0.24); C409(0.24); C447(0.46)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C308(0.20); C405(0.21); C409(0.21); C447(0.40)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C405(0.19); C409(0.19); C308(0.18); C353(1.44)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C405(0.28); C409(0.28); C308(0.24); C353(1.50)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C405(0.32); C409(0.32); C308(0.27); C353(1.63)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C405(0.25); C409(0.25); C308(0.20); C353(1.75)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C405(0.22); C409(0.22); C308(0.22); C353(1.66)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C405(1.11); C409(1.11); C308(0.76); C353(0.87)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C405(0.59); C409(0.59); C308(0.48); C353(1.88)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C405(0.57); C409(0.57); C353(0.99); C447(0.35)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C405(0.66); C409(0.66); C353(1.15); C447(0.49)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C405(0.66); C409(0.66); C353(0.93); C447(0.50)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C405(0.44); C409(0.44); C353(1.23); C447(0.30)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C405(0.45); C409(0.45); C353(1.08); C447(0.29)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C405(0.49); C409(0.49); C353(1.33); C447(0.33)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C405(0.46); C409(0.46); C353(1.29); C447(0.35)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C405(0.45); C409(0.45); C353(1.32); C447(0.36)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C405(0.83); C409(0.83); C308(0.72); C353(0.89)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C405(0.52); C409(0.52); C353(1.04); C447(0.29)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C405(0.44); C409(0.44); C353(1.39); C447(0.42)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C405(0.47); C409(0.47); C353(1.28); C447(0.40)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C405(0.42); C409(0.42); C353(1.43); C447(0.31)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C405(0.61); C409(0.61); C353(1.28); C447(0.39)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C405(0.50); C409(0.50); C353(1.54); C447(0.30)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C447(0.87); C516(1.05)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C447(0.93); C516(1.09)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C447(0.77); C516(1.18)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C447(0.99); C516(0.93)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C405(0.55); C409(0.55); C308(0.77); C353(0.97)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C447(0.86); C516(1.08)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C447(1.16); C516(0.98)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C447(0.71); C516(0.95)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C447(0.87); C516(1.10)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C447(0.84); C516(1.18)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C447(0.94); C516(1.00)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C447(1.05); C516(1.08)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C447(1.05); C516(1.01)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C447(0.78); C516(0.95)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C447(1.05); C516(0.91)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C405(0.94); C409(0.94); C308(0.89); C353(1.01)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C447(0.85); C516(0.95)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C405(0.83); C409(0.83); C353(1.18); C447(0.89)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C405(0.74); C409(0.74); C353(1.20); C447(0.63)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C405(0.48); C409(0.48); C353(1.18); C447(0.60)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C405(0.23); C409(0.23); C353(0.68); C447(0.38)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C405(0.63); C409(0.63); C353(1.18); C447(0.71)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C405(0.13); C409(0.13); C353(1.30); C447(0.30)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C405(0.19); C409(0.19); C353(1.24); C447(0.32)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C405(0.40); C409(0.40); C353(1.38); C447(0.63)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C405(1.08); C409(1.08); C353(1.06); C447(0.98)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C405(0.40); C409(0.40); C308(0.78); C353(1.20)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C405(0.49); C409(0.49); C353(1.16); C447(0.76)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C405(0.32); C409(0.32); C353(1.16); C447(0.49)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C405(0.69); C409(0.69); C353(1.07); C447(0.74)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C405(0.36); C409(0.36); C353(1.28); C447(0.55)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C405(0.30); C409(0.30); C353(1.45); C447(0.51)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C405(0.61); C409(0.61); C308(0.57); C353(1.27)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C405(0.57); C409(0.57); C308(0.55); C353(0.91)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C405(0.38); C409(0.38); C308(0.49); C353(1.07)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C405(0.13); C409(0.13); C308(0.44); C353(1.42)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C405(0.37); C409(0.37); C308(0.45); C353(0.93)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C405(0.65); C409(0.65); C308(0.70); C353(0.91)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C405(0.26); C409(0.26); C308(0.54); C353(1.29)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C405(0.13); C409(0.13); C308(0.38); C353(1.58)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C405(0.13); C409(0.13); C308(0.38); C353(1.46)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C405(0.15); C409(0.15); C308(0.45); C353(1.34)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C405(0.26); C409(0.26); C308(0.37); C353(1.20)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C405(0.53); C409(0.53); C308(0.55); C353(1.06)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C405(0.21); C409(0.21); C308(0.40); C353(1.39)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C405(0.13); C409(0.13); C308(0.33); C353(1.25)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C405(0.17); C409(0.17); C308(0.35); C353(1.55)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C405(0.45); C409(0.45); C308(0.64); C353(1.07)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C405(1.00); C409(1.00); C308(0.59); C353(0.95)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C308(0.59); C447(1.09)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C308(0.54); C447(0.93)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C308(0.75); C447(0.89)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C308(0.56); C447(0.78)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C308(0.39); C447(0.65)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C308(0.43); C447(0.83)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C308(0.49); C447(0.95)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C308(0.38); C447(0.66)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C308(0.42); C447(0.74)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C353(0.99)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C353(2.89); C445(1.69)  LDD1702  [2]
 LDCM0625  F8 Ramos C353(2.49)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C353(0.65)  LDD2189  [10]
 LDCM0574  Fragment12 Ramos C353(4.43)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C353(4.91)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C353(0.55)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C353(3.59)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C353(6.36)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C353(5.12)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C353(0.61)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C353(0.67)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C353(5.38)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C353(0.61)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C353(0.62)  LDD2201  [10]
 LDCM0468  Fragment33 HCT 116 C405(0.33); C409(0.33); C353(1.25); C447(0.58)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C353(5.32)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C353(0.46)  LDD2184  [10]
 LDCM0427  Fragment51 HCT 116 C405(0.47); C409(0.47); C353(1.46); C447(0.37)  LDD0744  [3]
 LDCM0614  Fragment56 Ramos C353(5.82)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C353(0.48)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C353(2.87)  LDD2188  [10]
 LDCM0022  KB02 HCT 116 C405(1.41); C409(1.41)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C405(1.73); C409(1.73)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C405(0.99); C409(0.99)  LDD0082  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C353(0.99)  LDD2089  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C437(1.33)  LDD2090  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C353(0.99)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C353(1.01); C437(0.91)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C437(1.61)  LDD2100  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C437(1.01)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C353(0.77); C437(0.59); C445(0.55)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C353(0.99); C437(0.62)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C353(1.86); C437(1.30)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C353(1.21)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C353(0.74); C437(0.73)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C353(0.97); C437(0.84)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C353(1.22); C437(0.75)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C353(1.20)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C353(0.93); C437(0.99)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C353(1.28); C437(0.83)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C353(1.74)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C353(0.72); C437(0.75)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C353(1.73); C437(2.90)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C353(0.90); C437(0.86)  LDD2146  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C437(2.35)  LDD2153  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fatty acid desaturase 6 (FADS6) Fatty acid desaturase type 1 family Q8N9I5
Microsomal glutathione S-transferase 2 (MGST2) MAPEG family Q99735
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium channel flower homolog (CACFD1) Calcium channel flower family Q9UGQ2
Sorting nexin-2 (SNX2) Sorting nexin family O60749
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
TBC1 domain family member 1 (TBC1D1) . Q86TI0
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 639 (ZNF639) Krueppel C2H2-type zinc-finger protein family Q9UID6
Transcription factor Sp4 (SP4) Sp1 C2H2-type zinc-finger protein family Q02446
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Forkhead box protein O3 (FOXO3) . O43524
Myb/SANT-like DNA-binding domain-containing protein 4 (MSANTD4) . Q8NCY6
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Colorectal mutant cancer protein (MCC) MCC family P23508
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Protein reprimo (RPRM) Reprimo family Q9NS64
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Synaptogyrin-3 (SYNGR3) Synaptogyrin family O43761
RISC-loading complex subunit TARBP2 (TARBP2) TARBP2 family Q15633
DNA repair protein XRCC4 (XRCC4) XRCC4-XLF family Q13426
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrobin (CNTROB) . Q8N137
Collagen alpha-1(XVII) chain (COL17A1) . Q9UMD9
DNA repair protein XRCC1 (XRCC1) . P18887
Kelch-like protein 12 (KLHL12) . Q53G59
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
PRKCA-binding protein (PICK1) . Q9NRD5
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578