Details of the Target

General Information of Target

Target ID LDTP10734
Target Name ATPase family AAA domain-containing protein 5 (ATAD5)
Gene Name ATAD5
Gene ID 79915
Synonyms
C17orf41; Elg1; FRAG1; ATPase family AAA domain-containing protein 5; Chromosome fragility-associated gene 1 protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSRKASENVEYTLRSLSSLMGERRRKQPEPDAASAAGECSLLAAAESSTSLQSAGAGGGG
VGDLERAARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQ
ELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLV
VGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRY
MLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIE
EEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDD
RLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILALGFVLSAQVSP
RITFKPIAPSGQNATCTRYSYCNECMLDPDCGFCYKMNKSTVIDSSCVPVNKASTNEAAW
GRCENETKFKTEDIFWAYNFCPTPYSWTALLGLILYLVFFAPGMGPMPWTVNSEIYPLWA
RSTGNACSSGINWIFNVLVSLTFLHTAEYLTYYGAFFLYAGFAAVGLLFIYGCLPETKGK
KLEEIESLFDNRLCTCGTSDSDEGRYIEYIRVKGSNYHLSDNDASDVE
Target Bioclass
Enzyme
Family
AAA ATPase family
Subcellular location
Nucleus
Function
Has an important role in DNA replication and in maintaining genome integrity during replication stress. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis. Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway. As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle. This seems to be dependent on its ATPase activity. Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner. Ultimately this enables replication fork regression, breakage, and eventual fork restart. Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks. Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks.
Uniprot ID
Q96QE3
Ensemble ID
ENST00000321990.5
HGNC ID
HGNC:25752
ChEMBL ID
CHEMBL1741209

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.N1019KfsTer7 .
A431 SNV: p.S1214L; p.S1532L DBIA    Probe Info 
CCK81 Deletion: p.I446SfsTer26; p.S1470PfsTer10 .
HCC1806 Insertion: p.T1387_A1388insMTer
SNV: p.L1386Ter		 .
HCC44 SNV: p.R1739T DBIA    Probe Info 
HCT116 Insertion: p.N1297KfsTer9 DBIA    Probe Info 
HT115 SNV: p.S422Y; p.N458H .
JHH4 SNV: p.L1641P DBIA    Probe Info 
KATOIII Insertion: p.N1297KfsTer9 .
KMCH1 SNV: p.D548Y DBIA    Probe Info 
MOLT4 Deletion: p.K970NfsTer32
SNV: p.S1716I		 .
SKMEL30 SNV: p.S248C DBIA    Probe Info 
SUPT1 Deletion: p.Q1161RfsTer11
SNV: p.A1290S		 DBIA    Probe Info 
SW1271 SNV: p.I1321M .
SW756 SNV: p.E1691D DBIA    Probe Info 
TFK1 SNV: p.R596T; p.E635Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C98(2.25); C433(6.61); C36(2.56); C1430(2.90)  LDD0168  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C827(0.99); C831(0.99)  LDD0078  [3]
IA-alkyne
 Probe Info  		C772(0.00); C1125(0.00); C1546(0.00); C36(0.00)  LDD0165  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
ENE
 Probe Info  		C831(0.00); C36(0.00)  LDD0006  [6]
IPM
 Probe Info  		C1734(0.00); C772(0.00)  LDD0005  [6]
TFBX
 Probe Info  		C1529(0.00); C909(0.00); C1720(0.00); C1145(0.00)  LDD0148  [7]
Phosphinate-6
 Probe Info  		C772(0.00); C395(0.00)  LDD0018  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C98(2.25); C433(6.61); C36(2.56); C1430(2.90)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C433(7.32); C1546(2.01)  LDD0169  [1]
 LDCM0214  AC1 HCT 116 C433(1.54)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C433(1.42)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C1391(0.60); C1458(0.60); C1734(1.01); C433(1.01)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C1391(0.95); C1458(0.95); C1734(1.60); C433(1.60)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C1391(0.74); C1458(0.74); C1734(1.19); C433(1.19)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C1391(0.57); C1458(0.57); C1734(2.20); C433(2.20)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C1391(0.44); C1458(0.44); C1734(1.11); C433(1.11)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C1391(0.75); C1458(0.75); C1734(0.99); C433(0.99)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C1391(0.93); C1458(0.93); C1734(1.30); C433(1.30)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C1391(0.78); C1458(0.78); C1734(2.28); C433(2.28)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C1391(0.99); C1458(0.99); C1734(2.58); C433(2.58)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C1391(0.80); C1458(0.80); C1734(1.29); C433(1.29)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C433(1.38)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C1391(0.37); C1458(0.37); C1734(2.12); C433(2.12)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C1391(0.18); C1458(0.18); C1734(1.88); C433(1.88)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C1391(0.29); C1458(0.29); C1734(1.50); C433(1.50)  LDD0827  [3]
 LDCM0230  AC113 HCT 116 C827(0.94); C831(0.94)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C827(0.95); C831(0.95)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C827(0.95); C831(0.95)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C827(1.35); C831(1.35)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C827(0.97); C831(0.97)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C827(0.91); C831(0.91)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C827(1.08); C831(1.08)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C433(1.00)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C827(0.92); C831(0.92)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C827(1.09); C831(1.09)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C827(1.10); C831(1.10)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C827(0.79); C831(0.79)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C827(1.04); C831(1.04)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C827(1.18); C831(1.18)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C827(1.24); C831(1.24)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C827(1.31); C831(1.31)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C827(0.67); C831(0.67)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C827(0.77); C831(0.77)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C827(0.84); C831(0.84)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C827(0.68); C831(0.68)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C827(0.73); C831(0.73)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C827(0.95); C831(0.95)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C827(0.95); C831(0.95)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C827(0.92); C831(0.92)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C827(0.76); C831(0.76)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C827(0.68); C831(0.68)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C827(0.77); C831(0.77)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C827(1.01); C831(1.01)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C433(1.10)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C827(0.93); C831(0.93)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C827(0.88); C831(0.88)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C827(0.75); C831(0.75)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C1454(0.99); C1458(0.99)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C1454(1.41); C1458(1.41)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C1454(1.09); C1458(1.09)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C1454(1.12); C1458(1.12)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C1454(1.36); C1458(1.36)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C1454(1.37); C1458(1.37)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C1454(1.11); C1458(1.11)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C433(1.18)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C1454(0.91); C1458(0.91)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C1454(1.03); C1458(1.03)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C1454(1.36); C1458(1.36)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C1454(1.72); C1458(1.72)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1454(1.24); C1458(1.24)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1454(1.46); C1458(1.46)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1454(1.42); C1458(1.42)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1454(1.37); C1458(1.37)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C433(1.27)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C433(1.13)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C433(1.20)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C433(1.27)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C433(1.18)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C433(1.07)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C433(0.71)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C433(1.03)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C433(0.85)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C827(1.05); C831(1.05)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C827(0.97); C831(0.97)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C827(0.99); C831(0.99)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C827(0.97); C831(0.97)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C827(1.08); C831(1.08)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C433(1.54)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C827(0.92); C831(0.92)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C827(1.09); C831(1.09)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C827(0.99); C831(0.99)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C827(1.03); C831(1.03)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C827(0.95); C831(0.95)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C827(1.07); C831(1.07)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C827(1.06); C831(1.06)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C827(1.05); C831(1.05)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C827(1.05); C831(1.05)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C827(1.01); C831(1.01)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C433(1.23)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C827(0.95); C831(0.95)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C827(0.95); C831(0.95)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C827(0.93); C831(0.93)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C827(0.71); C831(0.71)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C827(1.09); C831(1.09)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C827(1.17); C831(1.17)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C433(1.04)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C433(1.03)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C433(0.96)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C433(0.87)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C433(1.99)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C433(0.90)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C433(0.89)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C433(0.89)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C433(0.97)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C433(1.02)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C433(0.92)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C433(0.91)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C827(0.86); C831(0.86)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C827(0.92); C831(0.92)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C827(0.83); C831(0.83)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C433(1.06)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C827(0.93); C831(0.93)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C827(1.01); C831(1.01)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C827(0.84); C831(0.84)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C827(0.96); C831(0.96)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C827(1.11); C831(1.11)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C827(0.62); C831(0.62)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C827(0.59); C831(0.59)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C827(0.73); C831(0.73)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C433(0.52); C1454(0.90); C1458(0.90); C827(1.15)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C433(0.57); C1454(1.12); C1458(1.12); C827(1.17)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C433(1.13)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C433(0.66); C1454(1.08); C1458(1.08); C827(1.25)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C433(0.58); C1454(0.90); C1458(0.90); C827(1.03)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C433(0.71); C827(1.19); C831(1.19); C1454(1.35)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C433(0.77); C1454(1.43); C1458(1.43); C827(1.71)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C433(0.75); C1454(1.27); C1458(1.27); C827(1.69)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C433(0.83); C1454(1.42); C1458(1.42); C827(1.84)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C433(0.89); C1454(1.12); C1458(1.12); C827(1.33)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C433(0.50); C1454(1.08); C1458(1.08); C827(1.28)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C433(0.87); C1454(1.11); C1458(1.11); C827(1.16)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C433(0.69); C1454(0.96); C1458(0.96); C827(1.16)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C433(1.01)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C433(0.81); C1454(1.10); C1458(1.10); C827(1.16)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C433(0.70); C1454(0.90); C1458(0.90); C827(1.27)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C433(0.75); C1454(1.50); C1458(1.50); C827(2.07)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1454(0.29); C1458(0.29); C827(1.16); C831(1.16)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1454(0.35); C1458(0.35); C827(1.03); C831(1.03)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1454(0.30); C1458(0.30); C827(1.08); C831(1.08)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1454(0.37); C1458(0.37); C827(1.10); C831(1.10)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1454(0.44); C1458(0.44); C827(1.00); C831(1.00)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1454(0.40); C1458(0.40); C827(1.20); C831(1.20)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1454(0.35); C1458(0.35); C827(1.26); C831(1.26)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1454(0.43); C1458(0.43); C827(1.13); C831(1.13)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1454(0.38); C1458(0.38); C827(1.04); C831(1.04)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1454(0.29); C1458(0.29); C827(1.10); C831(1.10)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1454(0.43); C1458(0.43); C827(1.03); C831(1.03)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1454(0.41); C1458(0.41); C827(0.93); C831(0.93)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1454(0.37); C1458(0.37); C827(1.17); C831(1.17)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1454(0.40); C1458(0.40); C827(0.96); C831(0.96)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1454(0.33); C1458(0.33); C827(1.16); C831(1.16)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C1391(0.73); C1458(0.73); C1734(0.97); C433(0.97)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C1391(0.89); C1458(0.89); C1734(1.39); C433(1.39)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C433(1.03)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C433(1.18)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C433(1.43)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C827(0.99); C831(0.99)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C1454(0.92); C1458(0.92); C827(1.33); C831(1.33)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C1454(1.37); C1458(1.37); C827(1.53); C831(1.53)  LDD0966  [3]
 LDCM0369  CL100 HCT 116 C433(0.88)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C433(1.27)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C433(1.16)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C433(1.31)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C433(1.28)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C433(0.93)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C433(0.93)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C433(1.02)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C433(1.14)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C433(1.05)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C1454(0.86); C1458(0.86); C827(0.94); C831(0.94)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C433(0.68)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C433(0.95)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C827(1.15); C831(1.15)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C827(0.92); C831(0.92)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C827(1.04); C831(1.04)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C827(1.18); C831(1.18)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C827(0.89); C831(0.89)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C827(0.94); C831(0.94)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C827(0.95); C831(0.95)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C827(0.79); C831(0.79)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C1454(0.65); C1458(0.65); C827(1.08); C831(1.08)  LDD0988  [3]
 LDCM0391  CL120 HCT 116 C827(0.96); C831(0.96)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C433(0.88)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C433(0.84)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C433(1.00)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C433(0.93)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C827(0.83); C831(0.83)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C827(0.95); C831(0.95)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C827(0.81); C831(0.81)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C827(0.89); C831(0.89)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C1454(0.69); C1458(0.69); C827(1.19); C831(1.19)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C1454(0.94); C1458(0.94); C827(1.11); C831(1.11)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C1454(1.31); C1458(1.31); C827(1.54); C831(1.54)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C827(1.04); C831(1.04)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C827(0.86); C831(0.86)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C827(0.96); C831(0.96)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C827(0.93); C831(0.93)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C1454(0.84); C1458(0.84); C827(1.15); C831(1.15)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C827(1.03); C831(1.03)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C827(1.16); C831(1.16)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C827(0.81); C831(0.81)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C827(0.84); C831(0.84)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C827(1.09); C831(1.09)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C827(1.01); C831(1.01)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C827(0.93); C831(0.93)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C827(1.09); C831(1.09)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C827(0.84); C831(0.84)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C827(1.15); C831(1.15)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C1454(0.91); C1458(0.91); C827(0.82); C831(0.82)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C827(0.87); C831(0.87)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C1720(1.20); C827(1.18); C831(1.12)  LDD1018  [3]
 LDCM0421  CL32 HCT 116 C827(1.19); C831(1.19)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C827(1.67); C831(1.67)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C827(1.10); C831(1.10)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C827(1.06); C831(1.06)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C827(0.98); C831(0.98)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C827(1.00); C831(1.00)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C827(1.19); C831(1.19)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C1454(0.86); C1458(0.86); C827(1.08); C831(1.08)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C827(1.06); C831(1.06)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C827(1.11); C831(1.11)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C827(0.84); C831(0.84)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C827(0.97); C831(0.97)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C827(0.97); C831(0.97)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C827(1.06); C831(1.06)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C827(1.13); C831(1.13)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C827(1.16); C831(1.16)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C827(1.12); C831(1.12)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C827(0.99); C831(0.99)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C1454(0.90); C1458(0.90); C827(0.94); C831(0.94)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C827(1.10); C831(1.10)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C827(1.37); C831(1.37)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C827(1.12); C831(1.12)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C827(0.95); C831(0.95)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C827(1.28); C831(1.28)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C827(1.33); C831(1.33)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C827(0.97); C831(0.97)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C827(1.07); C831(1.07)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C827(1.27); C831(1.27)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C827(1.07); C831(1.07)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C1454(0.90); C1458(0.90); C827(1.08); C831(1.08)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C827(1.27); C831(1.27)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C827(0.92); C831(0.92)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C827(1.07); C831(1.07)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C827(0.88); C831(0.88)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C827(0.76); C831(0.76)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C827(0.98); C831(0.98)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C827(0.92); C831(0.92)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C827(0.93); C831(0.93)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C827(0.76); C831(0.76)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C827(0.95); C831(0.95)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C1454(0.78); C1458(0.78); C827(1.00); C831(1.00)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C827(0.91); C831(0.91)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C827(0.88); C831(0.88)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C827(0.92); C831(0.92)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C827(0.88); C831(0.88)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C827(0.94); C831(0.94)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C1454(1.01); C1458(1.01); C827(0.83); C831(0.83)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C1454(0.92); C1458(0.92); C827(0.79); C831(0.79)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C1454(0.96); C1458(0.96); C827(0.99); C831(0.99)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C1454(1.17); C1458(1.17); C827(0.94); C831(0.94)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C1454(0.73); C1458(0.32); C827(0.86); C831(0.86)  LDD1071  [3]
 LDCM0474  CL80 HCT 116 C1454(0.98); C1458(0.98); C827(1.11); C831(1.11)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C1454(0.83); C1458(0.83); C827(1.14); C831(1.14)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C1454(0.87); C1458(0.87); C827(0.80); C831(0.80)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C1454(1.02); C1458(1.02); C827(0.92); C831(0.92)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C1454(1.31); C1458(1.31); C827(0.93); C831(0.93)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C1454(1.33); C1458(1.33); C827(0.96); C831(0.96)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C1454(0.84); C1458(0.84); C827(0.72); C831(0.72)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C1454(0.95); C1458(0.95); C827(0.79); C831(0.79)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C1454(1.03); C1458(1.03); C827(0.79); C831(0.79)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C1454(1.14); C1458(1.14); C827(0.93); C831(0.93)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C1454(1.07); C1458(0.39); C827(0.94); C831(0.94)  LDD1082  [3]
 LDCM0485  CL90 HCT 116 C1454(0.91); C1458(0.91); C827(0.90); C831(0.90)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C433(0.82)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C433(0.80)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C433(1.02)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C433(1.06)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C433(0.99)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C433(1.12)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C433(1.19)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C433(1.52)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C433(1.50)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C772(0.90); C433(1.14)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C890(16.62); C1720(1.52)  LDD1702  [10]
 LDCM0468  Fragment33 HCT 116 C827(0.85); C831(0.85)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C827(1.08); C831(1.08)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C1454(11.36); C1458(11.36); C827(10.99); C831(10.99)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C1454(20.00); C1458(20.00); C827(20.00); C831(20.00)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C1454(20.00); C1458(20.00); C827(12.73); C831(12.73)  LDD0082  [3]
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761