Details of the Target

General Information of Target

Target ID LDTP10463
Target Name Syndetin (VPS50)
Gene Name VPS50
Gene ID 55610
Synonyms
CCDC132; KIAA1861; Syndetin; Coiled-coil domain-containing protein 132; EARP/GARPII complex subunit VPS50
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPHLKQWRQRMLFGIFAWGLLFLLIFIYFTDSNPAEPVPSSLSFLETRRLLPVQGKQRA
IMGAAHEPSPPGGLDARQALPRAHPAGSFHAGPGDLQKWAQSQDGFEHKEFFSSQVGRKS
QSAFYPEDDDYFFAAGQPGWHSHTQGTLGFPSPGEPGPREGAFPAAQVQRRRVKKRHRRQ
RRSHVLEEGDDGDRLYSSMSRAFLYRLWKGNVSSKMLNPRLQKAMKDYLTANKHGVRFRG
KREAGLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAVPLSQLHPRGLRSCAVVM
SAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHFIDSS
LYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNPNQPFYILHPKFIWQLWDI
IQENTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLG
AYHPLLYEKLLVQRLNMGTQGDLHRKGKVVLPGFQAVHCPAPSPVIPHS
Target Bioclass
Other
Family
Syndetin family
Subcellular location
Recycling endosome
Function
Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Uniprot ID
Q96JG6
Ensemble ID
ENST00000251739.9
HGNC ID
HGNC:25956

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.E367K .
AU565 SNV: p.M625I DBIA    Probe Info 
HCT15 SNV: p.I322S .
JURKAT SNV: p.T183R; p.F761L .
KMS11 SNV: p.E359Ter .
MDAMB453 SNV: p.K930R .
NCIH1299 SNV: p.S492F .
NCIH2172 SNV: p.E234Q .
NCIH716 SNV: p.T929A .
SW480 SNV: p.D916V .
THP1 SNV: p.N626I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.92  LDD0402  [1]
Probe 1
 Probe Info  		Y571(29.68); Y910(14.54)  LDD3495  [2]
BTD
 Probe Info  		C218(0.70)  LDD2091  [3]
HHS-475
 Probe Info  		Y216(0.70)  LDD0264  [4]
DBIA
 Probe Info  		C518(0.97); C472(0.86); C313(0.84); C324(0.84)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C218(0.00); C851(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C218(0.00); C851(0.00)  LDD0037  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		C218(0.00); C869(0.00); C939(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C851(0.64)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C206(1.18); C472(1.19); C851(1.11)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C324(0.96); C472(1.13); C851(0.83)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C324(0.95); C472(1.18); C851(0.92)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C324(0.94); C472(1.17); C851(0.86)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C324(0.98); C472(1.38); C851(0.91)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C324(1.00); C472(1.15); C851(0.94)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C324(1.09); C472(0.92); C851(1.40)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C324(1.59); C472(0.94); C851(1.35)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C324(0.97); C472(1.34); C851(0.70)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C324(1.15); C472(0.99); C851(0.98)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C324(1.11); C472(0.96); C851(1.09)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C206(0.93); C472(1.14); C851(1.49)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C324(1.15); C472(1.43); C851(1.19)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C324(1.31); C472(1.96); C851(1.31)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C324(1.07); C472(1.79); C851(1.08)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C313(0.80); C324(0.80); C518(1.11)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C313(0.79); C324(0.79); C518(1.14)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C313(0.98); C324(0.98); C518(1.08)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C313(0.90); C324(0.90); C518(1.11)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C313(0.91); C324(0.91); C518(1.23)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C313(0.74); C324(0.74); C518(1.12)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C313(0.80); C324(0.80); C518(1.16)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C206(0.99); C472(1.16); C851(1.24)  LDD0835  [5]
 LDCM0238  AC120 HCT 116 C313(0.83); C324(0.83); C518(1.30)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C313(1.02); C324(1.02); C518(1.20)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C313(0.96); C324(0.96); C518(1.02)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C313(0.95); C324(0.95); C518(0.96)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C313(0.88); C324(0.88); C518(0.98)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C313(0.98); C324(0.98); C518(1.16)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C313(0.93); C324(0.93); C518(1.21)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C313(0.89); C324(0.89); C518(1.05)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C430(1.26)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C430(1.19)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C430(1.22)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C430(1.39)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C430(1.21)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C430(1.30)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C430(1.18)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C430(1.41)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C430(1.26)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C430(1.22)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C430(1.20)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C430(1.35)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C206(0.90); C472(1.07); C851(1.04)  LDD0857  [5]
 LDCM0260  AC140 HCT 116 C430(1.38)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C430(1.26)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C430(1.24)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C313(0.71); C324(0.71)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C313(0.67); C324(0.67)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C313(0.76); C324(0.76)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C313(0.67); C324(0.67)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C313(0.74); C324(0.74)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C313(1.00); C324(1.00)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C313(0.76); C324(0.76)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C206(1.54); C472(1.09); C851(1.01)  LDD0868  [5]
 LDCM0271  AC150 HCT 116 C313(0.82); C324(0.82)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C313(0.74); C324(0.74)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C313(0.89); C324(0.89)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C313(0.58); C324(0.58)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C313(0.74); C324(0.74)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C313(0.74); C324(0.74)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C313(0.76); C324(0.76)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C313(0.82); C324(0.82)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C430(0.91); C939(1.06)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C430(0.87); C939(1.07)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C430(0.85); C939(1.03)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C851(0.80)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C430(0.86); C939(1.01)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C430(0.74); C939(0.94)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C430(0.87); C939(1.05)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C430(0.83); C939(0.88)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C430(0.91); C939(1.04)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C939(0.96); C430(1.01); C518(1.14)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C939(0.96); C430(0.98); C518(1.30)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C430(0.97); C939(1.15); C518(1.26)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C430(1.16); C518(1.17); C939(1.20)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C518(0.98); C430(1.02); C939(1.28)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C851(0.79)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C430(0.98); C518(1.03); C939(1.07)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C430(0.95); C939(1.16); C518(1.33)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C430(1.03); C939(1.10); C518(1.20)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C939(0.91); C430(1.01); C518(1.19)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C939(0.90); C430(0.90); C518(1.28)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C939(0.85); C518(1.18); C851(1.38)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C518(0.97); C939(1.05); C851(1.27)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C939(1.18); C851(1.24); C518(1.25)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C939(1.02); C851(1.04); C518(1.39)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C851(0.81); C939(1.05); C518(1.16)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C851(0.65)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C939(0.97); C851(0.98); C518(1.27)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C939(1.05); C851(1.12); C518(1.29)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C851(1.01); C939(1.04); C518(1.08)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C518(0.86); C851(0.89); C939(1.04)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C851(0.93); C518(0.98); C939(1.10)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C851(0.94); C518(0.96); C939(1.17)  LDD0624  [5]
 LDCM0308  AC46 HEK-293T C472(1.05)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C472(1.16)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C472(1.08)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C472(1.22)  LDD0909  [5]
 LDCM0312  AC5 HCT 116 C851(0.63)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C472(1.02)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C472(1.23)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C472(1.35)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C472(1.03)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C472(1.24)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C472(1.35)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C472(1.26)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C313(0.60); C324(0.60)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C313(0.64); C324(0.64)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C313(0.58); C324(0.58)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C206(1.47); C472(1.13); C851(1.00)  LDD0921  [5]
 LDCM0324  AC60 HCT 116 C313(0.83); C324(0.83)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C313(0.58); C324(0.58)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C313(0.60); C324(0.60)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C313(0.70); C324(0.70)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C313(0.72); C324(0.72)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C313(0.61); C324(0.61)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C313(0.54); C324(0.54)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C313(0.65); C324(0.65)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C313(1.04); C324(1.04)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C313(1.00); C324(1.00)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C206(0.92); C472(1.21); C851(1.01)  LDD0932  [5]
 LDCM0335  AC70 HCT 116 C313(1.02); C324(1.02)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C313(0.94); C324(0.94)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C313(0.99); C324(0.99)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C313(0.81); C324(0.81)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C313(1.09); C324(1.09)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C313(0.86); C324(0.86)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C313(0.99); C324(0.99)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C313(1.10); C324(1.10)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C313(0.98); C324(0.98)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C313(1.11); C324(1.11)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C206(1.42); C472(1.35); C851(1.00)  LDD0943  [5]
 LDCM0346  AC80 HCT 116 C313(1.08); C324(1.08)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C313(1.11); C324(1.11)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C313(1.36); C324(1.36)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C430(0.84); C939(0.98)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C430(0.94); C939(1.22)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C430(0.88); C939(1.01)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C430(0.82); C939(1.09)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C430(0.87); C939(0.96)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C430(0.90); C939(1.09)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C430(0.83); C939(0.94)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C430(0.96); C939(1.29)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C430(0.84); C939(1.16)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C430(0.80); C939(1.02)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C430(0.79); C939(1.15)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C430(1.22); C939(1.27)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C430(0.83); C939(0.87)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C430(0.92); C939(1.05)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C430(0.72); C939(1.17)  LDD0681  [5]
 LDCM0365  AC98 HEK-293T C324(1.20); C472(1.09); C851(1.02)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C324(1.15); C472(1.28); C851(0.91)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C206(1.48); C472(1.04); C851(1.30)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C206(0.96); C472(1.23); C851(1.16)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C206(1.62); C472(1.07); C851(0.98)  LDD0873  [5]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C518(0.97); C472(0.86); C313(0.84); C324(0.84)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C218(0.70)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C329(0.00); C472(0.00)  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C472(2.12)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C851(1.44)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C851(1.24)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C851(0.71)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C206(1.00); C472(1.35); C851(0.92)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C206(1.26); C472(1.09); C851(1.08)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C206(1.71); C472(1.35); C851(0.83)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C206(0.97); C472(1.41); C851(1.25)  LDD0971  [5]
 LDCM0374  CL105 HCT 116 C430(0.84); C939(1.04)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C430(0.85); C939(1.07)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C430(0.90); C939(1.08)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C430(0.89); C939(1.08)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C430(0.82); C939(1.06)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C851(1.01)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C430(0.80); C939(0.96)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C430(0.79); C939(0.85)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C518(0.90); C430(1.02); C939(1.04)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C430(1.00); C939(1.02); C518(1.22)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C430(0.89); C939(1.04); C518(1.10)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C430(0.94); C939(1.08); C518(1.33)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C430(0.99); C939(1.07); C518(1.40)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C518(0.72); C851(1.27); C939(1.28)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C851(1.02); C939(1.17); C518(1.28)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C939(1.00); C851(1.10); C518(1.12)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C851(0.95)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C851(0.96); C518(1.02); C939(1.15)  LDD0708  [5]
 LDCM0392  CL121 HEK-293T C472(1.15)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C472(1.10)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C472(1.09)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C472(1.16)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C313(0.52); C324(0.52)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C313(0.59); C324(0.59)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C313(0.62); C324(0.62)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C313(0.61); C324(0.61)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C851(1.33)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C851(1.13)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C851(1.16)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C851(0.97); C518(1.20)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C518(0.81); C851(0.88)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C851(1.02); C518(1.11)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C851(0.80); C518(0.97)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C851(1.05)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C851(1.11); C518(1.18)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C851(0.74); C518(1.17)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C851(0.95); C518(1.31)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C851(0.89); C518(1.24)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C518(0.85); C851(0.91)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C518(1.10); C851(0.93)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C518(1.47); C851(0.99)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C518(1.09); C851(0.79)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C518(1.05); C851(0.91)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C518(0.98); C851(1.03)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C851(1.11)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C518(1.04); C851(0.96)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C518(0.98); C939(1.19)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C518(0.91); C939(1.10)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C518(1.03); C939(0.92)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C518(0.96); C939(1.03)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C518(1.06); C939(0.97)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C518(0.96); C939(1.00)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C518(0.98); C939(1.03)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C518(0.94); C939(1.30)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C851(1.06)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C518(1.03); C939(1.02)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C518(0.95); C939(1.03)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C518(0.90); C939(1.11)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C518(1.05); C939(1.23)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C518(1.08); C939(0.99)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C518(0.94); C939(1.07)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C206(1.45); C472(1.32); C851(0.76)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C206(1.16); C472(1.17); C851(0.73)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C206(1.20); C472(1.30); C851(0.83)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C206(1.14); C472(1.35); C851(0.79)  LDD1037  [5]
 LDCM0440  CL5 HCT 116 C851(1.05)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C206(1.33); C472(1.66); C851(0.75)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C206(1.20); C472(1.28); C851(0.78)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C206(1.05); C472(1.00); C851(0.98)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C206(0.96); C472(0.97); C851(0.81)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C206(1.12); C472(1.20); C851(0.77)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C206(1.14); C472(1.39); C851(0.74)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C206(0.99); C472(1.13); C851(0.83)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C206(1.04); C472(1.12); C851(0.84)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C206(0.92); C472(1.07); C851(0.87)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C206(1.19); C472(1.49); C851(0.76)  LDD1048  [5]
 LDCM0451  CL6 HCT 116 C851(0.86)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C206(1.37); C472(1.77); C851(0.77)  LDD1050  [5]
 LDCM0453  CL61 HCT 116 C851(0.69); C939(1.03)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C851(0.73); C939(0.99)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C851(0.61); C939(1.10)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C851(0.71); C939(1.05)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C851(0.98); C939(1.01)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C851(0.60); C939(1.13)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C851(0.70); C939(1.15)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C851(0.63); C939(1.07)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C851(0.60); C939(0.88)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C851(1.07)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C851(0.68); C939(0.92)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C851(0.67); C939(1.00)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C851(0.77); C939(1.20)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C851(0.61); C939(0.98)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C851(0.62); C939(0.99)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C518(1.29); C851(0.80)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C518(1.07); C851(0.80)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C518(0.93); C851(0.92)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C518(0.99); C851(0.77)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C851(0.93)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C518(0.91); C851(0.84)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C518(1.03); C851(0.87)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C518(1.13); C851(0.75)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C518(0.99); C851(0.79)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C518(0.77); C851(0.76)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C518(0.97); C851(0.76)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C518(0.77); C851(0.98)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C518(0.87); C851(0.81)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C518(1.07); C851(0.70)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C518(0.89); C851(0.94)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C851(0.85)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C518(0.91); C851(0.97)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C851(0.87)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C851(0.73)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C851(0.94)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C851(0.75)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C851(0.69)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C851(0.78)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C851(0.81)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C851(0.72)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C851(0.81)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C218(1.03); C430(0.53); C939(0.97); C136(1.06)  LDD1698  [11]
 LDCM0625  F8 Ramos C430(0.79)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C430(0.97)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C430(0.00); C851(0.90)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C430(1.26)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C430(1.06)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C430(0.75); C851(1.68)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C430(1.82)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C430(0.68)  LDD2195  [12]
 LDCM0578  Fragment27 Ramos C430(0.77)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C430(0.80); C851(0.73)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C430(1.27)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C430(1.05)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C430(1.02)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C851(0.60); C939(0.98)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C430(0.63)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C430(0.95); C851(0.83)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C518(0.81); C939(1.08)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C430(1.33)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C430(0.88)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C851(0.51)  LDD2186  [12]
 LDCM0116  HHS-0101 DM93 Y216(0.70)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y216(0.57)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y216(0.47)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y216(0.56)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y216(0.69)  LDD0268  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C430(0.94); C939(0.92); C218(0.75); C472(0.84)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C430(0.98); C939(0.97); C218(0.84); C472(0.94)  LDD1497  [11]
 LDCM0024  KB05 IGR37 C518(2.45)  LDD3314  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Vacuolar protein sorting-associated protein 53 homolog (VPS53) VPS53 family Q5VIR6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840