Details of the Target

General Information of Target

Target ID LDTP10169
Target Name Phosphopantothenoylcysteine decarboxylase (PPCDC)
Gene Name PPCDC
Gene ID 60490
Synonyms
COAC; Phosphopantothenoylcysteine decarboxylase; PPC-DC; EC 4.1.1.36; CoaC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEARRDSTSSLQRKKPPWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHIS
SPHHELRRPVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQV
LRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHT
PVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQRRS
FTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQAD
LTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPV
RKLFAREKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTYWLTFVHSLVTIL
AVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMR
QDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGH
KRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCC
IGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSL
FLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPA
GSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGL
FLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPF
TDKFCEKYELDAQLH
Target Bioclass
Enzyme
Family
HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily
Function Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A.
Uniprot ID
Q96CD2
Ensemble ID
ENST00000342932.8
HGNC ID
HGNC:28107

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.E183K .
NCIH1299 SNV: p.E163V m-APA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.75  LDD0402  [1]
STPyne
 Probe Info  		K169(0.80)  LDD0277  [2]
IA-alkyne
 Probe Info  		C7(1.41); C173(1.23)  LDD0304  [3]
AHL-Pu-1
 Probe Info  		C166(10.64)  LDD0170  [4]
IPM
 Probe Info  		C7(1.34)  LDD1701  [5]
DBIA
 Probe Info  		C7(1.09)  LDD0531  [6]
Lodoacetamide azide
 Probe Info  		C7(0.00); C173(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
Phosphinate-6
 Probe Info  		C173(0.00); C7(0.00)  LDD0018  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C166(0.00); C173(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C166(10.64)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C166(3.17); C173(3.66)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C7(1.09)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C7(1.01)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C7(1.59)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C7(1.00)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C7(0.99)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C7(2.09)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C7(0.99)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C7(1.06)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C7(0.99)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C7(1.22)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C7(1.22)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C7(1.04)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C7(0.86)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C7(1.30)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C7(1.03)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C7(0.93)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C7(1.29)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C7(1.17)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C7(1.11)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C7(1.49)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C7(1.46)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C7(1.30)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C7(1.39)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C7(0.85)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C7(1.20)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C7(1.77)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C7(1.13)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C7(1.00)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C7(1.32)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C7(1.10)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C7(1.13)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C7(1.44)  LDD0562  [6]
 LDCM0259  AC14 HCT 116 C7(0.80)  LDD0576  [6]
 LDCM0263  AC143 HCT 116 C7(1.03)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C7(0.98)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C7(0.88)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C7(1.19)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C7(0.95)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C7(1.01)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C7(1.02)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C7(0.89)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C7(1.08)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C7(1.05)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C7(1.02)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C7(1.25)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C7(1.27)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C7(1.14)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C7(1.21)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C7(1.33)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C7(1.17)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C7(1.83)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C7(1.25)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C7(1.14)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C7(1.46)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C7(3.33)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C7(2.74)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C7(1.55)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C7(3.09)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C7(1.01)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C7(1.06)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C7(1.07)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C7(1.20)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C7(1.25)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C7(0.87)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C7(0.91)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C7(1.06)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C7(1.71)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C7(1.49)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C7(1.23)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C7(1.03)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C7(0.95)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C7(0.98)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C7(0.92)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C7(0.96)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C7(1.00)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C7(0.95)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C7(1.18)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C7(0.92)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C7(1.07)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C7(1.05)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C7(1.08)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C7(0.85)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C7(0.71)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C7(0.72)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C7(0.80)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C7(1.02)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C7(0.85)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C7(0.75)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C7(0.77)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C7(0.76)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C7(0.66)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C7(0.94)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C7(0.76)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C7(1.21); C173(1.10)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C7(1.06); C166(1.13); C173(1.07)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C7(1.00); C173(1.08)  LDD1561  [12]
 LDCM0323  AC6 HCT 116 C7(1.03)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C7(1.07); C173(1.18)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C7(1.06); C166(1.13); C173(0.96)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C7(1.13); C166(0.87); C173(1.15)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C7(1.08); C173(1.11)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C7(0.97); C173(0.98)  LDD1567  [12]
 LDCM0334  AC7 HCT 116 C7(0.88)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C7(0.99)  LDD0662  [6]
 LDCM0349  AC83 HCT 116 C7(1.10)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C7(1.06)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C7(1.06)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C7(0.99)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C7(1.14)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C7(0.94)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C7(0.90)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C7(1.07)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C7(1.29)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C7(1.34)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C7(1.12)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C7(1.07)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C7(1.00)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C7(1.36)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C7(1.32)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C7(1.46)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C7(1.42)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C7(0.90)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C7(0.89)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C7(1.10)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.35  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C166(2.19); C7(1.97); C173(0.84); C173(0.68)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C7(1.01)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C7(1.13)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C7(1.08)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C7(0.91)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C7(0.94)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C7(0.87)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C7(0.87)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C7(1.36)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C7(1.65)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C7(2.96)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C7(1.98)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C7(1.90)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C7(0.86)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C7(1.69)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C7(1.20)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C7(0.98)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C7(1.24)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C7(0.98)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C7(1.12)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C7(1.26)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C7(0.88)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C7(1.10)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C7(0.97)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C7(1.46)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C7(0.98)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C7(0.89)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C7(0.82)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C7(0.70)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C7(0.74)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C7(1.05); C166(1.08); C173(1.10)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C7(1.02); C173(1.13)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C7(1.00); C173(0.99)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C7(0.98); C173(1.03)  LDD1603  [12]
 LDCM0400  CL13 HCT 116 C7(1.17)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C7(1.28)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C7(1.40)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C122(1.32)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C122(1.21)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C122(1.20)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C122(0.92)  LDD1004  [6]
 LDCM0407  CL2 HCT 116 C7(1.00)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C122(1.24)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C122(0.95)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C122(1.22)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C122(0.74)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C122(1.22)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C122(1.00)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C122(0.99)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C122(1.13)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C122(0.81)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C122(0.92)  LDD1015  [6]
 LDCM0418  CL3 HCT 116 C7(0.89)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C122(1.36)  LDD1017  [6]
 LDCM0420  CL31 HCT 116 C7(0.88)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C7(0.61)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C7(0.72)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C7(0.75)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C7(0.75)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C7(0.70)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C7(0.65)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C7(0.58)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C7(1.02)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C7(0.58)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C7(0.76)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C7(0.59)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C7(0.55)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C7(0.62)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C7(0.65)  LDD0752  [6]
 LDCM0436  CL46 HEK-293T C122(2.02)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C122(1.64)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C122(1.75)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C122(1.26)  LDD1037  [6]
 LDCM0440  CL5 HCT 116 C7(0.96)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C122(1.82)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C122(1.30)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C122(0.98)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C122(1.07)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C122(1.41)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C122(1.33)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C122(1.26)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C122(1.02)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C122(0.95)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C122(1.52)  LDD1048  [6]
 LDCM0451  CL6 HCT 116 C7(1.05)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C122(1.38)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C7(1.14); C166(1.53); C173(1.21)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C7(1.11); C173(1.32)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C7(1.08); C173(1.35)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C7(1.14); C173(1.19)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C7(1.39); C173(1.38)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C7(0.92); C166(0.78); C173(1.65)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C7(1.05); C173(0.99)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C7(1.10); C173(1.45)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C7(1.33); C166(1.24); C173(1.29)  LDD1664  [12]
 LDCM0462  CL7 HCT 116 C7(1.61)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C7(1.28); C166(1.37); C173(1.33)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C7(1.15); C173(1.29)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C7(2.58); C173(2.57)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C7(0.97); C166(1.08); C173(0.88)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C7(0.96); C173(0.88)  LDD1670  [12]
 LDCM0469  CL76 HCT 116 C7(1.48)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C7(1.13)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C7(1.14)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C7(1.30)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C7(0.75)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C7(1.39)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C7(1.38)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C7(1.20)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C7(1.16)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C7(1.01)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C7(1.46)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C7(1.42)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C7(1.09)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C7(0.98)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C7(1.10)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C7(1.01)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C7(0.93)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C7(1.12)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C7(0.87)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C7(1.54)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C7(0.93)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C7(0.94)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C7(0.93)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C7(1.11)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C7(1.02)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C7(1.18)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C7(1.19); C173(2.48)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C7(1.11)  LDD1702  [5]
 LDCM0625  F8 Ramos C166(0.96); C7(1.24)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C166(0.74); C7(1.25)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C166(3.06)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C166(0.64); C7(1.11)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C166(1.07); C7(0.90)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C166(0.42); C7(0.85)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C166(0.65); C7(0.91)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C166(0.91); C7(0.93)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C166(1.34); C7(1.28)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C7(0.84)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C166(0.56); C7(0.93)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C166(1.34); C7(0.98)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C7(1.09)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C7(1.99)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C7(0.99); C173(1.03)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C166(0.65); C7(0.98)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C166(0.69); C7(0.99)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C7(0.49)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C7(1.29)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C7(1.08)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C166(0.45); C7(0.75)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C166(0.84); C7(1.11)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C7(1.07)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C7(0.97)  LDD1497  [12]
 LDCM0024  KB05 SKMEL24 C7(1.50)  LDD3323  [14]
 LDCM0627  NUDT7-COV-1 HEK-293T C7(5.84)  LDD2206  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C173(0.76); C7(0.16)  LDD2207  [15]
 LDCM0131  RA190 MM1.R C7(1.41); C173(1.23)  LDD0304  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphopantothenoylcysteine decarboxylase (PPCDC) HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily Q96CD2
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
Protein-glutamine gamma-glutamyltransferase Z (TGM7) Transglutaminase family Q96PF1
Peptidyl-prolyl cis-trans isomerase G (PPIG) . Q13427
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 232 (ZNF232) Krueppel C2H2-type zinc-finger protein family Q9UNY5
Forkhead box protein R1 (FOXR1) . Q6PIV2
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Protein SREK1IP1 (SREK1IP1) . Q8N9Q2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Flavin Mononucleotide . DB03247
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pantothenoylaminoethenethiol . DB03738

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.