Details of the Target

General Information of Target

Target ID LDTP09947
Target Name snRNA-activating protein complex subunit 3 (SNAPC3)
Gene Name SNAPC3
Gene ID 6619
Synonyms
SNAP50; snRNA-activating protein complex subunit 3; SNAPc subunit 3; Proximal sequence element-binding transcription factor subunit beta; PSE-binding factor subunit beta; PTF subunit beta; Small nuclear RNA-activating complex polypeptide 3; snRNA-activating protein complex 50 kDa subunit; SNAPc 50 kDa subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKI
RIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYR
VRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFFETSAAYRYYIDDVFHALVR
EIRRKEKEAVLAMEKKSKPKNSVWKRLKSPFRKKKDSVT
Target Bioclass
Other
Family
SNAPC3/SRD2 family
Subcellular location
Nucleus
Function
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Uniprot ID
Q92966
Ensemble ID
ENST00000380821.8
HGNC ID
HGNC:11136

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0403  [1]
DBIA
 Probe Info  		CAmbiguous(7.59)  LDD0209  [2]
HHS-475
 Probe Info  		Y201(2.14)  LDD0265  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
HHS-465
 Probe Info  		K199(0.00); Y201(0.00)  LDD2240  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C11(2.34)  LDD0372  [9]
 LDCM0214  AC1 HCT 116 C27(0.80); C334(1.03)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C11(0.58); C334(1.14)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C11(1.38); C27(1.01); C334(0.66)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C11(1.53); C27(1.01); C334(0.66)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C11(1.27); C27(0.81); C334(0.82)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C11(1.66); C27(0.88); C334(0.65)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C11(1.15); C27(0.98); C334(0.65)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C11(1.20); C27(0.99); C334(0.62)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C11(1.49); C27(0.89); C334(0.77)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C11(1.68); C27(1.07); C334(0.76)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C11(1.48); C27(0.93); C334(0.62)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C11(1.66); C27(0.89); C334(0.60)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C11(0.46); C334(1.10)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C11(2.21); C27(0.90); C334(0.54)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C11(1.70); C27(1.01); C334(0.58)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C11(2.52); C27(1.39); C334(0.70)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C11(1.00); C27(1.35)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C11(0.78); C27(1.44)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C11(0.89); C27(1.87)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C11(0.68); C27(1.62)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C11(0.58); C27(1.64)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C11(0.93); C27(1.57)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C11(0.65); C27(1.65)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C11(0.82); C334(1.12)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C11(0.46); C27(1.78)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C11(0.67); C27(1.08)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C11(1.04); C27(1.37)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C11(0.23); C27(1.32)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C11(0.24); C27(1.44)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C11(0.34); C27(1.67)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C11(0.20); C27(2.48)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C11(0.38); C27(2.30)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C334(0.81)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C334(1.11)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C334(0.99)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C334(1.20)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C334(1.35)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C334(1.33)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C334(1.11)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C334(0.99)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C334(1.04)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C334(1.06)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C334(1.05)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C334(1.18)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C11(0.44); C334(1.27)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C334(1.18)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C334(1.07)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C334(1.46)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C11(1.09)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C11(1.21)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C11(0.90)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C11(1.03)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C11(1.17)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C11(0.97)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C11(0.96)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C11(0.45); C334(0.95)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C11(1.28)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C11(1.14)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C11(1.04)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C11(0.76)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C11(1.39)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C11(0.67)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C11(1.03)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C11(1.32)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C27(0.83); C11(1.18)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C27(0.99); C11(1.73)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C27(0.99); C11(1.16)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C334(1.03); C27(1.03)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C27(0.93); C11(1.07)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C27(0.71); C11(1.18)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C11(0.94); C27(1.24)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C27(0.90); C11(1.09)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C11(1.03); C27(1.12)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C334(0.99)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C334(1.00)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C334(1.09)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C334(1.18)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C334(0.90)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C27(0.98); C334(1.19)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C334(0.85)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C334(0.97)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C334(0.91)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C334(1.05)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C334(0.82)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C11(0.54); C27(0.87); C334(1.01)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C11(0.40); C334(1.15); C27(1.17)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C11(0.51); C27(1.04); C334(1.20)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C11(0.47); C334(1.06); C27(1.25)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C11(0.52); C334(0.97); C27(1.13)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C334(1.11); C27(1.31)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C11(0.76); C334(0.97); C27(0.99)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C11(0.63); C27(1.05); C334(1.32)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C11(0.47); C334(1.11); C27(1.37)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C11(0.69); C334(1.22); C27(1.97)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C11(0.59); C27(0.78); C334(1.17)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C27(0.61); C11(1.05); C334(1.11)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C334(1.05)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C334(1.17)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C334(1.09)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C334(0.87)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C27(1.07); C334(1.17)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C334(0.78)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C334(1.09)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C334(1.04)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C334(0.88)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C334(0.92)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C334(0.81)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C334(0.74)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C27(0.78)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C27(0.86)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C27(0.87)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C11(0.53); C334(0.80)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C27(1.23)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C27(0.67)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C27(0.96)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C27(1.07)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C27(0.97)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C27(0.80)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C27(0.73)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C27(1.06)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C334(0.90)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C11(0.81); C334(0.82)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C11(0.43); C334(1.01)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C11(0.66); C334(0.66)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C11(0.62); C334(0.99)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C11(0.72); C334(0.89)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C334(0.62); C11(1.05)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C11(0.60); C334(0.74)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C334(0.73); C11(0.75)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C11(0.73); C334(0.79)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C334(0.72); C11(0.79)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C11(0.73); C334(0.93)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C334(0.95); C11(0.96)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C11(0.50); C334(0.92)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C11(0.68); C334(0.92)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C11(0.47); C334(0.96)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C334(0.64); C11(0.88)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C27(1.90)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C27(1.62)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C27(1.55)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C27(1.11)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C27(0.84)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C27(1.23)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C27(1.37)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C27(1.00)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C27(1.88)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C27(1.88)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C27(1.09)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C27(1.66)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C27(1.26)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C27(1.53)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C27(1.52)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C334(0.43); C27(1.00); C11(1.26)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C334(0.86); C27(0.90); C11(1.71)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C11(0.79); C334(1.19)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C11(0.39); C334(1.14)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C11(0.52); C334(0.88)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C27(0.95)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C27(0.86)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C27(0.94); C334(1.03)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C11(0.41); C334(1.10)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C334(0.89); C11(0.90)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C11(0.42); C334(1.32)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C11(0.53); C334(1.04)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C27(0.77); C11(1.33)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C27(0.62); C11(1.94)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C27(0.78); C11(1.64)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C27(0.74); C11(1.72)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C27(0.90); C11(1.34)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C27(1.09)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C27(0.98); C11(1.62)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C27(1.16); C11(1.37)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C334(0.92)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C334(0.76)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C334(0.65)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C334(0.75)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C334(0.91)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C11(0.45); C334(1.00); C27(1.19)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C11(0.77); C334(1.13); C27(1.22)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C11(0.83); C334(1.12); C27(2.12)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C27(1.02)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C11(0.56); C27(1.21); C334(1.25)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C334(1.22)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C334(0.89)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C334(0.88)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C334(0.81)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C27(0.81)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C27(0.84)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C27(0.94)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C27(0.96)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C27(1.05)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C27(0.81)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C27(1.09)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C334(0.78)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C11(0.41); C334(0.67); C27(0.97)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C11(0.57); C334(0.75); C27(1.07)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C11(0.51); C334(0.71); C27(0.94)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C27(0.77)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C11(0.38); C334(0.84); C27(1.37)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C11(0.45); C334(0.95); C27(1.59)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C11(0.19); C334(0.77); C27(1.05)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C11(0.33); C334(0.92); C27(1.03)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C11(0.47); C27(1.24); C334(0.68)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C11(0.49); C27(0.97); C334(0.77)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C11(0.17); C27(1.08); C334(0.76)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C11(0.12); C27(0.85); C334(0.82)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C11(0.23); C27(1.13); C334(0.77)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C11(0.09); C27(1.08); C334(0.93)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C27(0.65)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C11(0.17); C27(1.38); C334(0.83)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C11(0.77); C27(0.90); C334(1.03)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C11(1.04); C334(0.85)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C11(1.08); C334(0.89)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C11(1.15); C334(0.92)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C11(1.22); C334(0.79)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C11(1.21); C334(0.82)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C11(1.17); C334(0.78)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C11(0.98); C334(0.90)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C27(1.02)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C11(1.20); C334(1.05)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C11(1.05); C334(0.90)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C11(1.04); C334(0.78)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C11(1.09); C334(0.76)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C11(1.21); C334(0.92)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C11(1.09); C334(0.81)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C27(1.03)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C27(1.35)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C27(1.01)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C27(1.02)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C27(0.74)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C27(1.04)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C27(1.08)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C27(1.05)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C27(1.21)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C27(0.85)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C27(0.97)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C27(0.90)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C27(0.95)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C27(1.03)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C27(0.95)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C27(0.79)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C27(1.35)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C334(0.79)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C334(0.92)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C334(0.81)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C334(0.99)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C334(0.97)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C334(0.96)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C334(1.03)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C334(0.71)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C334(0.80)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C27(0.88)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C334(0.93)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C334(0.87)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C334(0.91)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C334(0.85)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C334(0.84)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C334(0.93)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C334(0.78)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C334(0.89)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C334(0.97)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C27(0.83)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C334(1.04)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C334(0.83)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C334(0.82)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C334(0.87)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C334(0.73)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C334(1.06)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C334(1.05)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C334(1.10)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C334(0.87)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C334(0.69)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C27(0.93)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C334(1.04)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C27(1.05); C334(0.99)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C27(0.95); C334(0.96)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C27(0.78); C334(1.09)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C27(1.15); C334(1.04)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C27(1.21); C334(0.87)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C27(1.11); C334(1.06)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C27(0.96); C334(1.10)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C27(0.98); C334(1.06)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C27(0.95); C334(1.05)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C317(0.87)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C334(0.78)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C11(1.37); C334(0.81)  LDD0744  [10]
 LDCM0117  HHS-0201 DM93 Y201(2.14)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y201(0.68)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y201(3.28)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y201(4.46)  LDD0268  [3]
 LDCM0022  KB02 HEK-293T C11(0.95); C111(1.08)  LDD1492  [11]
 LDCM0023  KB03 Jurkat CAmbiguous(7.59)  LDD0209  [2]
 LDCM0024  KB05 COLO792 C11(3.15)  LDD3310  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
Tetratricopeptide repeat protein 4 (TTC4) TTC4 family O95801
KATNB1-like protein 1 (KATNBL1) . Q9H079
RING finger protein 11 (RNF11) . Q9Y3C5
snRNA-activating protein complex subunit 1 (SNAPC1) . Q16533

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840