Details of the Target

General Information of Target

Target ID LDTP09875
Target Name CREB-binding protein (CREBBP)
Gene Name CREBBP
Gene ID 1387
Synonyms
CBP; CREB-binding protein; Histone lysine acetyltransferase CREBBP; EC 2.3.1.48; Protein-lysine acetyltransferase CREBBP; EC 2.3.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARVAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLAAAYGHALEQYEGESWRESARYLE
AALRLHRLLRDSEAFCHANCSGPAPAAKPDPDGGRADEWACELRLFGRVLERAACLRRCK
RTLPAFQVPYPPRQLLRDFQSRLPYQYLHYALFKANRLEKAVAAAYTFLQRNPKHELTAK
YLNYYQGMLDVADESLTDLEAQPYEAVFLRAVKLYNSGDFRSSTEDMERALSEYLAVFAR
CLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGYFVDKFVATMYHYLQ
FAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEEEDFQPREEAMLYH
NQTAELRELLEFTHMYLQSDDEMELEETEPPLEPEDALSDAEFEGEGDYEEGMYADWWQE
PDAKGDEAEAEPEPELA
Target Type
Clinical trial
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Acetylates histones, giving a specific tag for transcriptional activation. Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region. Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway.
TTD ID
T03634
Uniprot ID
Q92793
DrugMap ID
TTFRCTK
Ensemble ID
ENST00000262367.10
HGNC ID
HGNC:2348
ChEMBL ID
CHEMBL5747

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.N192S .
AN3CA Deletion: p.I1084SfsTer15
SNV: p.A533T		 .
CAL27 SNV: p.T2390N .
CAL33 Substitution: p.Q1756G .
CAL62 SNV: p.E1541Ter .
CCK81 Deletion: p.R14EfsTer31
SNV: p.Q482R		 .
CHL1 SNV: p.G740E .
COLO792 SNV: p.P449L .
DU145 Deletion: p.Q1765RfsTer6 .
EFO27 Insertion: p.Q1765PfsTer201 .
GB1 SNV: p.G1469R .
HCC1395 SNV: p.H1297Q .
HCT15 SNV: p.P1150H .
HEC1B SNV: p.L555M .
IGROV1 SNV: p.M1160V .
Ishikawa (Heraklio) 02 ER Deletion: p.S1680del; p.G1815AfsTer58 DBIA    Probe Info 
JHH1 SNV: p.N831S; p.E1752Ter .
JURKAT Deletion: p.F1358LfsTer18
SNV: p.R1563S		 .
KARPAS422 Deletion: p.S1256HfsTer20
SNV: p.E1238Ter		 .
KMCH1 SNV: p.G2034R .
KPL1 SNV: p.Q1967P .
LNCaP clone FGC SNV: p.A110V DBIA    Probe Info 
MCC26 SNV: p.H397Q .
MFE319 SNV: p.T872K; p.Q929Ter; p.P2371L .
MOLM16 Deletion: p.Q2215_Q2216del .
MOLT4 SNV: p.V391I; p.R1682L .
NALM6 SNV: p.S1687P .
NCIH1048 Deletion: p.S1680del .
NCIH1703 SNV: p.W1472C .
NCIH2122 SNV: p.N83T .
OCIAML5 SNV: p.G221V .
OVCAR5 SNV: p.A1071T .
OVCAR8 SNV: p.S893Ter .
P31FUJ Insertion: p.Q1209TfsTer25 .
PEO1 SNV: p.E1238Ter DBIA    Probe Info 
RKO SNV: p.M866T .
SKMEL2 SNV: p.N1813D DBIA    Probe Info 
SNGM SNV: p.R1664H DBIA    Probe Info 
SNU869 SNV: p.R2190Q .
SUDHL6 Deletion: p.L470Ter .
SUPT1 SNV: p.Q1756R .
SW403 SNV: p.M775I .
SW756 SNV: p.S1436N .
TE1 Insertion: p.C1790AfsTer11 DBIA    Probe Info 
TE10 SNV: p.Y1539C DBIA    Probe Info 
TE8 Deletion: p.Q1765RfsTer6 .
VMRCRCW SNV: p.Q1756R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.76  LDD0402  [2]
Probe 1
 Probe Info  		Y1973(8.37)  LDD3495  [3]
IPM
 Probe Info  		C1710(2.44); C1219(1.90); C1237(0.75)  LDD1701  [4]
DBIA
 Probe Info  		C404(1.31); C409(1.31); C1775(1.14); C1785(1.14)  LDD0078  [5]
IA-alkyne
 Probe Info  		C1237(0.00); C1219(0.00); C1212(0.00); C404(0.00)  LDD0165  [6]
STPyne
 Probe Info  		N.A.  LDD0009  [7]
TFBX
 Probe Info  		C1775(0.00); C1237(0.00); C385(0.00)  LDD0148  [8]
AOyne
 Probe Info  		4.70  LDD0443  [9]
HHS-465
 Probe Info  		N.A.  LDD2240  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1212(1.05); C1213(1.06); C1707(1.03); C1710(1.03)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1212(1.11); C1213(0.97); C1219(1.12); C1707(1.19)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1212(1.02); C1213(0.81); C1710(1.00); C1775(0.87)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1212(1.14); C1213(0.91); C1710(0.77); C1775(0.90)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1212(1.09); C1213(0.89); C1710(0.84); C1775(0.97)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1212(1.07); C1213(0.82); C1710(1.52); C1775(0.99)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1212(1.04); C1213(0.93); C1710(1.44); C1775(0.98)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1212(1.16); C1213(0.85); C1710(1.20); C1775(1.01)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1212(1.04); C1213(0.90); C1710(0.95); C1775(1.11)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1212(1.12); C1213(0.93); C1710(0.89); C1775(1.09)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1212(0.87); C1213(0.81); C1710(1.92); C1775(0.79)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1212(0.81); C1213(0.71); C1710(2.01); C1775(0.83)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C1212(1.19); C1213(0.99); C1219(0.97); C1707(1.31)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1212(0.95); C1213(0.83); C1710(1.37); C1775(1.01)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1212(0.93); C1213(0.75); C1710(0.96); C1775(0.75)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1212(1.01); C1213(0.81); C1710(0.91); C1775(0.87)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1212(0.96); C1213(0.95); C1707(0.96); C1710(0.96)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1212(1.00); C1213(1.00); C1707(0.99); C1710(0.99)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1212(1.07); C1213(1.16); C1707(1.03); C1710(1.03)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1212(1.16); C1213(1.28); C1707(1.06); C1710(1.06)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1212(1.07); C1213(1.13); C1707(0.99); C1710(0.99)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1212(0.95); C1213(0.95); C1707(0.96); C1710(0.96)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1212(1.06); C1213(1.06); C1707(1.09); C1710(1.09)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1212(1.16); C1213(0.97); C1219(0.87); C1707(1.08)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1212(1.18); C1213(1.27); C1707(0.80); C1710(0.80)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1212(0.99); C1213(0.98); C1707(0.87); C1710(0.87)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1212(0.91); C1213(1.04); C1707(0.95); C1710(0.95)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1212(1.06); C1213(1.01); C1707(0.74); C1710(0.74)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1212(1.00); C1213(0.93); C1707(1.02); C1710(1.02)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1212(0.90); C1213(1.05); C1707(1.00); C1710(1.00)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1212(1.05); C1213(1.13); C1707(1.00); C1710(1.00)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1212(1.06); C1213(1.07); C1707(0.98); C1710(0.98)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C1212(1.43); C1213(1.43); C1707(1.27); C1710(1.25)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1212(0.98); C1213(0.98); C1707(0.91); C1710(0.96)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1212(0.96); C1213(0.96); C1707(1.26); C1710(1.16)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1212(1.09); C1213(1.09); C1707(0.92); C1710(0.88)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1212(0.80); C1213(0.80); C1707(0.78); C1710(0.82)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1212(0.87); C1213(0.87); C1707(1.19); C1710(1.21)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1212(0.88); C1213(0.88); C1707(1.22); C1710(1.15)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1212(0.97); C1213(0.97); C1707(1.32); C1710(1.27)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1212(0.78); C1213(0.78); C1707(1.07); C1710(0.96)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1212(1.04); C1213(1.04); C1707(0.87); C1710(0.90)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1212(1.01); C1213(1.01); C1707(1.17); C1710(1.12)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1212(0.84); C1213(0.84); C1707(1.04); C1710(1.04)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C1212(1.14); C1213(1.14); C1219(1.20); C1707(1.27)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C1212(0.88); C1213(0.88); C1707(1.24); C1710(1.14)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1212(0.87); C1213(0.87); C1707(1.19); C1710(1.13)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1212(0.86); C1213(0.86); C1707(0.97); C1710(0.93)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C1212(1.11); C1213(0.76); C1707(0.92); C1710(0.92)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C404(0.86); C409(0.86); C380(0.95); C385(0.95)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C380(0.74); C385(0.74); C1213(0.74); C430(0.89)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C380(0.94); C385(0.94); C1707(0.97); C1710(0.97)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C1213(0.67); C1785(0.82); C1707(0.88); C1710(0.88)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C380(0.91); C385(0.91); C1213(1.02); C404(1.14)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C1213(0.68); C380(1.05); C385(1.05); C1707(1.07)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C1213(1.04); C1816(1.06); C1819(1.06); C1790(1.07)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C1213(0.74); C380(0.93); C385(0.93); C1707(0.96)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C430(0.94); C1785(0.98); C427(0.99); C1816(1.03)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C1213(0.76); C1707(0.95); C1710(0.95); C380(0.97)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C1213(0.82); C380(0.92); C385(0.92); C1707(1.15)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C1212(1.34); C1213(0.87); C1707(1.07); C1710(1.07)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C1212(1.44); C1213(1.17); C1707(1.19); C1710(1.19)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C1212(1.11); C1213(1.02); C1707(1.12); C1710(1.12)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C1212(1.09); C1213(0.78); C1707(0.97); C1710(0.97)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1790(0.79); C1795(0.79); C1219(0.83); C404(0.84)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1790(0.70); C1795(0.70); C1219(0.94); C427(0.97)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C1219(0.79); C1790(0.83); C1795(0.83); C1212(0.96)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C427(0.86); C430(0.86); C1212(0.94); C1213(1.02)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C1219(0.35); C1790(0.77); C1795(0.77); C1240(0.88)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1219(0.48); C404(0.79); C409(0.79); C1790(0.87)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1219(0.50); C404(0.75); C409(0.75); C1790(0.82)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1219(0.54); C1790(0.69); C1795(0.69); C1816(0.81)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1219(0.49); C1790(0.70); C1795(0.70); C1710(0.94)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C1240(0.82); C1816(0.92); C1819(0.92); C404(0.96)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C1816(0.91); C1819(0.91); C1213(1.00); C1212(1.01)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C404(0.92); C409(0.92); C1790(1.04); C1795(1.04)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C1816(0.98); C1819(0.98); C1240(0.99); C1790(0.99)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1240(0.78); C1790(1.05); C1795(1.05); C1816(1.07)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C427(0.85); C430(0.85); C1212(0.98); C1213(1.02)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1790(1.09); C1795(1.09); C1213(1.10); C1212(1.17)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C1240(1.05); C1212(1.11); C1816(1.12); C1819(1.12)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1790(1.15); C1795(1.15); C1240(1.17); C1816(1.28)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1240(1.07); C404(1.08); C409(1.08); C1790(1.18)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C404(0.85); C409(0.85); C1816(1.05); C1819(1.05)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C1775(0.72); C1783(0.72); C1219(0.73); C427(0.84)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C1219(0.64); C1775(0.88); C1783(0.88); C427(0.91)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C1219(0.88); C1775(0.95); C1783(0.95); C1212(0.97)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C427(0.84); C430(0.84); C1775(0.90); C1783(0.90)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1775(0.86); C1783(0.86); C1219(0.89); C1213(0.96)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C427(1.04); C430(1.04); C1212(1.12); C1707(1.12)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C1775(0.89); C1783(0.89); C1219(0.98); C1213(1.05)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C1219(0.77); C1775(0.92); C1783(0.92); C427(0.94)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C1219(0.71); C427(0.94); C430(0.94); C1775(0.99)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C1219(0.91); C427(0.97); C430(0.97); C1775(1.01)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C1816(1.07); C1819(1.07); C1219(1.10); C1775(1.10)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C1219(1.14); C1775(1.15); C1783(1.15); C1707(1.19)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C1790(0.84); C1795(0.84); C1710(0.91); C1775(0.93)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C1775(0.77); C1783(0.77); C1213(0.88); C1710(0.88)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C1212(0.72); C1213(0.74); C1775(0.80); C1783(0.80)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C1710(0.96); C1707(0.98); C1213(1.09); C1775(1.11)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C385(0.94); C427(0.98); C430(0.98); C1212(1.06)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C1775(0.98); C1783(0.98); C1710(1.00); C1707(1.02)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C1212(0.70); C1213(0.74); C1710(0.77); C1790(0.82)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C1212(0.80); C1213(0.80); C1775(0.83); C1783(0.83)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C1775(0.65); C1783(0.65); C1710(0.82); C1816(0.87)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C1775(0.68); C1783(0.68); C1710(0.80); C1707(0.87)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C1707(0.86); C1775(0.86); C1783(0.86); C1710(1.05)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C1775(0.56); C1783(0.56); C1707(0.82); C1710(0.94)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C1240(0.96); C1816(0.96); C1819(0.96); C380(1.09)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C1816(0.92); C1819(0.92); C1240(1.01); C1790(1.06)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1816(0.80); C1819(0.80); C1240(1.13); C1790(1.13)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C1790(1.04); C1795(1.04); C1213(1.08); C1816(1.14)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1816(0.94); C1819(0.94); C1240(1.03); C1213(1.06)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1240(0.89); C380(0.98); C385(0.98); C1816(1.01)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1240(0.89); C1816(0.94); C1819(0.94); C380(1.06)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1816(0.96); C1819(0.96); C1240(0.99); C1775(1.03)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1816(0.91); C1819(0.91); C1775(1.04); C1783(1.04)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C1816(0.89); C1819(0.89); C1790(1.08); C1795(1.08)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1775(0.89); C1783(0.89); C1785(0.89); C380(0.90)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1240(1.05); C1790(1.06); C1795(1.06); C1213(1.08)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C404(0.84); C409(0.84); C1775(0.85); C1783(0.85)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C404(0.66); C409(0.66); C1707(0.99); C1710(0.99)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C1816(0.93); C1819(0.93); C380(0.95); C385(0.95)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C404(0.40); C409(0.40); C1707(1.04); C1710(1.04)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C404(0.64); C409(0.64); C1790(0.77); C1795(0.77)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C404(0.41); C409(0.41); C1775(0.95); C1783(0.95)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C404(0.49); C409(0.49); C1775(1.10); C1783(1.10)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C404(0.63); C409(0.63); C427(1.07); C430(1.07)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C404(0.50); C409(0.50); C1707(1.16); C1710(1.16)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C404(0.45); C409(0.45); C1707(0.96); C1710(0.96)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C404(0.85); C409(0.85); C1707(1.02); C1710(1.02)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C404(0.69); C409(0.69); C1790(0.89); C1795(0.89)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C404(0.56); C409(0.56); C1790(0.82); C1795(0.82)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C1816(0.99); C1819(0.99); C1790(1.04); C1795(1.04)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C404(0.56); C409(0.56); C1775(0.98); C1783(0.98)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C404(0.49); C409(0.49); C1707(0.88); C1710(0.88)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C404(0.41); C409(0.41); C1775(1.12); C1783(1.12)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C404(1.11); C409(1.11); C1785(1.16); C1790(1.19)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C404(1.07); C409(1.07); C1790(1.10); C1795(1.10)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1785(0.87); C1790(0.91); C1795(0.91); C1775(0.94)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C1790(0.93); C1795(0.93); C1785(0.96); C1816(0.98)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1816(0.91); C1819(0.91); C1790(0.93); C1795(0.93)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C1785(0.84); C1213(0.91); C1212(0.93); C1790(0.94)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C404(1.06); C409(1.06); C1816(1.13); C1819(1.13)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C380(0.70); C385(0.70); C1213(0.75); C1212(0.75)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C404(1.11); C409(1.11); C1212(1.29); C1790(1.30)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C1790(1.22); C1795(1.22); C404(1.23); C409(1.23)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1790(0.98); C1795(0.98); C1785(0.99); C1816(1.03)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1816(0.91); C1819(0.91); C427(0.92); C430(0.92)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C1785(0.88); C1775(1.04); C1783(1.04); C404(1.04)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C427(1.04); C430(1.04); C1816(1.06); C1819(1.06)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C404(1.05); C409(1.05); C1790(1.09); C1795(1.09)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C409(0.82); C404(0.89); C1213(1.09); C1790(1.10)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C1790(0.72); C1795(0.72); C1213(0.75); C427(0.76)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C1212(1.16); C1213(0.95); C1219(1.36); C1707(1.11)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C380(0.99); C385(0.99); C1790(1.08); C1795(1.08)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C380(1.08); C385(1.08); C1816(1.13); C1819(1.13)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C404(1.31); C409(1.31); C1775(1.14); C1785(1.14)  LDD0078  [5]
 LDCM0367  CL1 HCT 116 C380(0.84); C385(0.84); C1707(0.88); C1710(0.88)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C380(0.60); C385(0.60); C427(1.22); C430(1.22)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C385(0.88); C427(0.95); C430(0.95); C1213(1.04)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C1816(1.11); C1819(1.11); C1219(1.15); C1213(1.20)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C1213(0.92); C1816(0.97); C1819(0.97); C1212(1.01)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C1790(1.08); C1795(1.08); C1707(1.09); C1710(1.09)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C1219(0.82); C1213(0.89); C427(1.01); C430(1.01)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C1790(0.78); C1795(0.78); C404(0.89); C409(0.89)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C404(0.75); C409(0.75); C1790(0.91); C1795(0.91)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C404(0.67); C409(0.67); C1790(0.84); C1795(0.84)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C404(0.65); C409(0.65); C1790(0.85); C1795(0.85)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1219(0.51); C1790(0.75); C1795(0.75); C404(0.76)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C380(0.46); C385(0.46); C1240(1.22); C1790(1.23)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C404(0.67); C409(0.67); C1790(0.74); C1795(0.74)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1790(0.66); C1795(0.66); C1219(0.87); C1816(0.95)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C1240(0.71); C1816(0.84); C1819(0.84); C1790(0.92)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1240(0.85); C1790(1.08); C1795(1.08); C1816(1.09)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1790(0.88); C1795(0.88); C1816(0.89); C1819(0.89)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C1240(0.92); C1790(0.93); C1795(0.93); C1816(1.03)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1790(0.97); C1795(0.97); C404(1.03); C409(1.03)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C1775(0.76); C1783(0.76); C1816(1.07); C1819(1.07)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1219(0.82); C1775(1.00); C1783(1.00); C427(1.11)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1775(0.95); C1783(0.95); C1707(1.03); C1710(1.11)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C380(0.60); C385(0.60); C1240(1.08); C1213(1.11)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C1775(0.90); C1783(0.90); C1219(0.94); C427(0.96)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C1710(0.66); C1775(0.81); C1783(0.81); C1707(0.95)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C1775(0.62); C1783(0.62); C1710(0.78); C1707(0.81)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C1775(0.70); C1783(0.70); C1710(0.79); C1707(0.86)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C1775(0.71); C1783(0.71); C1707(0.85); C1710(0.89)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C1240(0.77); C1816(0.79); C1819(0.79); C1213(0.82)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1240(0.70); C1816(0.87); C1819(0.87); C1775(0.90)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1240(0.67); C1816(0.86); C1819(0.86); C1213(0.96)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1240(0.98); C380(0.98); C385(0.98); C1816(1.09)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C1790(1.15); C1795(1.15); C380(1.20); C385(1.20)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C380(0.75); C385(0.75); C1707(0.75); C1710(0.75)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C380(1.08); C385(1.08); C1707(1.09); C1710(1.09)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C380(0.89); C385(0.89); C1816(1.03); C1819(1.03)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C380(0.96); C385(0.96); C1790(1.14); C1795(1.14)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C380(1.06); C385(1.06); C1775(1.09); C1783(1.09)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C1707(1.09); C1710(1.09); C1775(1.15); C1783(1.15)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C1707(0.86); C1710(0.86); C1240(0.86); C1213(1.00)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C1775(1.13); C1783(1.13); C380(1.18); C385(1.18)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C380(1.00); C385(1.00); C1775(1.18); C1783(1.18)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1775(1.09); C1783(1.09); C380(1.43); C385(1.43)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C1775(0.92); C1783(0.92); C380(0.93); C385(0.93)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C1775(0.91); C1783(0.91); C380(1.05); C385(1.05)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1212(1.76); C1213(1.70); C1707(1.41); C1710(1.41)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1212(1.37); C1213(1.29); C1707(1.24); C1710(1.24)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1212(1.10); C1213(1.10); C1707(1.15); C1710(1.15)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1212(1.40); C1213(1.37); C1707(1.44); C1710(1.44)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1212(1.23); C1213(1.25); C1707(1.32); C1710(1.32)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1212(0.94); C1213(0.91); C1240(0.88); C1707(0.98)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1212(1.17); C1213(1.12); C1707(1.32); C1710(1.32)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1219(0.92); C1707(1.12); C1710(1.12); C1775(1.02)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1212(1.14); C1219(0.94); C1707(1.26); C1710(1.26)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1212(1.50); C1219(0.67); C1707(1.02); C1710(1.02)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1212(1.05); C1219(0.94); C1707(1.36); C1710(1.36)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1212(1.24); C1219(0.81); C1707(1.19); C1710(1.19)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1212(0.87); C1219(0.93); C1707(1.00); C1710(1.00)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1212(1.20); C1219(0.88); C1707(1.21); C1710(1.21)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1212(1.20); C1219(0.84); C1707(1.19); C1710(1.19)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1212(1.18); C1213(1.08); C1240(0.80); C1707(1.10)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1212(1.00); C1219(0.65); C1707(1.10); C1710(1.10)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1212(0.83); C1219(0.62); C1707(1.13); C1710(1.13)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1212(1.15); C1219(0.67); C1707(1.32); C1710(1.32)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1212(0.99); C1219(1.14); C1707(1.22); C1710(1.22)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1212(1.10); C1219(0.94); C1707(1.11); C1710(1.11)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1212(0.95); C1219(0.87); C1707(1.65); C1710(1.65)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1212(0.93); C1213(0.93); C1707(0.89); C1710(0.89)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1212(0.81); C1213(0.81); C1707(0.83); C1710(0.83)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1212(0.80); C1213(0.80); C1707(0.79); C1710(0.79)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1212(0.97); C1213(0.97); C1707(0.92); C1710(0.92)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1212(1.07); C1213(1.06); C1240(0.98); C1707(0.98)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1212(1.10); C1213(1.10); C1707(0.77); C1710(0.77)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1212(0.91); C1213(0.91); C1707(0.83); C1710(0.83)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1212(0.89); C1213(0.89); C1707(1.04); C1710(1.04)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1212(0.95); C1213(0.95); C1707(0.68); C1710(0.68)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1212(1.05); C1213(1.05); C1707(0.69); C1710(0.69)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1212(0.87); C1213(0.87); C1707(0.88); C1710(0.88)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1212(1.12); C1213(1.12); C1707(1.06); C1710(1.06)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1212(1.03); C1213(1.03); C1707(0.88); C1710(0.88)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1212(0.92); C1213(0.92); C1707(0.92); C1710(0.92)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1212(1.01); C1213(1.01); C1707(0.90); C1710(0.90)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1212(1.32); C1213(1.28); C1240(1.25); C1707(1.04)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1212(1.08); C1213(1.08); C1707(0.93); C1710(0.93)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1212(0.98); C1213(0.98); C1707(1.16); C1710(1.16)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1212(0.95); C1213(0.95); C1707(1.13); C1710(1.13)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1212(1.12); C1213(1.12); C1707(1.25); C1710(1.25)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1212(1.34); C1213(1.34); C1707(1.24); C1710(1.24)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1212(1.06); C1213(1.06); C1707(1.13); C1710(1.13)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1212(1.56); C1213(1.56); C1707(1.41); C1710(1.41)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1212(1.54); C1213(1.54); C1707(1.35); C1710(1.35)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1212(1.34); C1213(1.34); C1707(1.34); C1710(1.34)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1212(1.49); C1213(1.49); C1707(1.12); C1710(1.12)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1212(1.19); C1213(1.11); C1240(1.25); C1707(1.27)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1212(1.28); C1213(1.28); C1707(1.20); C1710(1.20)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1212(1.26); C1213(1.26); C1707(1.20); C1710(1.20)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1212(1.15); C1213(1.15); C1707(1.12); C1710(1.12)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1212(1.27); C1213(1.27); C1707(1.16); C1710(1.16)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1212(1.35); C1213(1.35); C1707(1.22); C1710(1.22)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1212(0.99); C1213(1.28); C1707(1.13); C1710(1.13)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1212(0.89); C1213(1.15); C1707(0.91); C1710(0.91)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1212(0.97); C1213(1.16); C1707(1.03); C1710(1.03)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1212(1.14); C1213(1.32); C1707(1.11); C1710(1.11)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1212(1.63); C1213(1.74); C1240(1.25); C1707(1.16)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1212(1.13); C1213(1.33); C1707(1.03); C1710(1.03)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1212(1.10); C1213(1.17); C1707(1.07); C1710(1.07)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1212(1.40); C1213(1.60); C1707(1.26); C1710(1.26)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1212(1.35); C1213(1.37); C1707(1.20); C1710(1.20)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1212(1.60); C1213(1.74); C1707(1.50); C1710(1.50)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1212(0.98); C1213(1.01); C1707(1.09); C1710(1.09)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1212(0.85); C1213(0.93); C1707(1.03); C1710(1.03)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1212(0.98); C1213(1.17); C1707(1.27); C1710(1.27)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1212(1.09); C1213(1.44); C1707(1.21); C1710(1.21)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1212(1.61); C1213(2.10); C1707(1.53); C1710(1.53)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1212(1.24); C1213(1.11); C1240(0.81); C1707(1.00)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1212(1.01); C1213(1.29); C1707(0.85); C1710(0.85)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1212(1.06); C1213(1.07); C1707(1.04); C1710(1.04)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1212(1.06); C1213(1.08); C1707(0.84); C1710(0.84)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1212(1.01); C1213(0.99); C1707(0.97); C1710(0.97)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1212(1.28); C1213(1.32); C1707(1.15); C1710(1.15)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1212(1.30); C1213(1.37); C1707(0.91); C1710(0.91)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1212(1.09); C1213(1.06); C1707(1.01); C1710(1.01)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1212(1.15); C1213(1.17); C1707(1.14); C1710(1.14)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1212(1.06); C1213(1.03); C1707(1.08); C1710(1.08)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1212(1.11); C1213(1.11); C1707(1.13); C1710(1.13)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C1283(0.86); C1690(1.04); C1658(0.93); C1219(1.23)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1775(1.50); C1710(1.24); C1219(0.91)  LDD1702  [4]
 LDCM0573  Fragment11 Ramos 0.15  LDD2190  [12]
 LDCM0576  Fragment14 Ramos 0.47  LDD2193  [12]
 LDCM0580  Fragment21 Ramos C1219(1.97)  LDD2195  [12]
 LDCM0586  Fragment28 Ramos C1219(1.18); 0.76  LDD2198  [12]
 LDCM0589  Fragment31 Ramos C1219(20.00)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C1219(13.78)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C1212(1.67); C1213(1.67); C1707(1.23); C1710(1.23)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C1219(8.06)  LDD2203  [12]
 LDCM0427  Fragment51 HCT 116 C1212(0.90); C1219(0.64); C1707(1.29); C1710(1.29)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C1219(2.05)  LDD2204  [12]
 LDCM0569  Fragment7 Ramos 1.28  LDD2186  [12]
 LDCM0022  KB02 HCT 116 C1775(4.66); C1785(4.66); C1783(4.66); C1826(1.95)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C1775(8.54); C1785(8.54); C1783(8.54); C1826(2.63)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C1775(8.54); C1785(8.54); C1783(8.54); C1826(4.51)  LDD0082  [5]
 LDCM0021  THZ1 HCT 116 C404(2.45); C409(2.45); C1775(1.64); C1783(1.64)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT2B (KAT2B) Acetyltransferase family Q92831
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 1 (CREB1) BZIP family P16220
Interferon regulatory factor 3 (IRF3) IRF family Q14653
Interferon regulatory factor 5 (IRF5) IRF family Q13568
Krueppel-like factor 1 (KLF1) Krueppel C2H2-type zinc-finger protein family Q13351
Androgen receptor (AR) Nuclear hormone receptor family P10275
Sterol regulatory element-binding protein 2 (SREBF2) SREBP family Q12772
Endothelial transcription factor GATA-2 (GATA2) . P23769
Forkhead box protein O1 (FOXO1) . Q12778
Forkhead box protein O3 (FOXO3) . O43524
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665
T-box transcription factor TBX21 (TBX21) . Q9UL17
Transcription factor p65 (RELA) . Q04206
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon alpha/beta receptor 2 (IFNAR2) Type II cytokine receptor family P48551
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
COP9 signalosome complex subunit 2 (COPS2) CSN2 family P61201
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Nucleosome assembly protein 1-like 1 (NAP1L1) Nucleosome assembly protein (NAP) family P55209
Nuclear receptor coactivator 6 (NCOA6) . Q14686
Protein LYRIC (MTDH) . Q86UE4

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ccs1477 Small molecular drug DIY4C2
C 82 . D0DA5M
Pri-724 . D0Q0ZY
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ft-7051 . DT8IL6
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Colforsin Small molecular drug DB02587
I-cbp112 Small molecular drug D0J3JI
Ischemin Small molecular drug D00DXI
Sgc-cbp30 Small molecular drug D03XXT
9-acetyl-2349-tetrahydro-1h-carbazol-1-one . DB08655
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyrrolo-pyrrolone Derivative 6 Small molecular drug D0O9WQ

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578