Details of the Target

General Information of Target

Target ID LDTP09824
Target Name Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38)
Gene Name DHX38
Gene ID 9785
Synonyms
DDX38; KIAA0224; PRP16; Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; EC 3.6.4.13; ATP-dependent RNA helicase DHX38; DEAH box protein 38
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSRKKRELMKTPSISKKNRAGSPSPQPSGELPRKDGADAVFPGPSLEPPAGSSGVKATG
TLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGELPTEGAGPDVVEDISHLL
ADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVETLTAA
GTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSSTLLAVPPGDSS
QSMESLYGPGSEGTPPSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLI
SYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQDLEFGHSMVQAVGT
LQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAKQGYVQRCEDHDKAR
FLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQEL
EDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQY
ASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCT
EGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEELVD
PDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSY
VYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKK
CVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQL
PEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPP
ENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQA
RVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGC
RESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEA
TAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPPMRLRGGRMTLGSCRERQPEFV
Target Bioclass
Enzyme
Family
DEAD box helicase family, DEAH subfamily, PRP16 sub-subfamily
Subcellular location
Nucleus
Function Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome.
Uniprot ID
Q92620
Ensemble ID
ENST00000268482.8
HGNC ID
HGNC:17211

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.F696LfsTer33 DBIA    Probe Info 
COLO800 SNV: p.H910Y DBIA    Probe Info 
HCT15 SNV: p.L440M .
HEC1B SNV: p.V1123A .
HT Insertion: .
SNV: p.V609G		 DBIA    Probe Info 
HT1376 SNV: p.S979L DBIA    Probe Info 
KYSE410 SNV: p.P1004S DBIA    Probe Info 
MEWO SNV: p.R253Ter; p.S976F DBIA    Probe Info 
MFE319 SNV: p.A808T; p.I835T; p.C963R DBIA    Probe Info 
MOLT4 SNV: p.D346N IA-alkyne    Probe Info 
NCIH1155 Substitution: p.L1144G DBIA    Probe Info 
NCIH1793 SNV: p.R1200M DBIA    Probe Info 
NCIH2172 SNV: p.K595N DBIA    Probe Info 
NCIH2291 SNV: p.S234F DBIA    Probe Info 
RAMOS SNV: p.R45H .
REH SNV: p.L921V; p.Q926Ter DBIA    Probe Info 
RPMI8226 SNV: p.D572Y DBIA    Probe Info 
SKOV3 SNV: p.L812V .
SUPT1 SNV: p.R362C DBIA    Probe Info 
SW1271 SNV: p.M818I DBIA    Probe Info 
WM2664 Insertion: p.E670GfsTer43 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K357(0.91)  LDD0277  [1]
Probe 1
 Probe Info  		Y222(5.66); Y261(11.97); Y274(11.04)  LDD3495  [2]
m-APA
 Probe Info  		11.60  LDD0403  [3]
BTD
 Probe Info  		C582(0.64)  LDD2099  [4]
AHL-Pu-1
 Probe Info  		C20(2.44)  LDD0169  [5]
HHS-475
 Probe Info  		Y145(0.59); Y261(3.86)  LDD0264  [6]
HHS-465
 Probe Info  		Y274(10.00)  LDD2237  [7]
DBIA
 Probe Info  		C20(1.08); C27(1.08)  LDD0078  [8]
ATP probe
 Probe Info  		K1049(0.00); K512(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [11]
Lodoacetamide azide
 Probe Info  		C1062(0.00); C865(0.00); C582(0.00)  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0147  [12]
TFBX
 Probe Info  		C618(0.00); C865(0.00)  LDD0148  [12]
VSF
 Probe Info  		C27(0.00); C20(0.00)  LDD0007  [13]
1d-yne
 Probe Info  		N.A.  LDD0357  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		13.20  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C582(0.50)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C582(1.00)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C582(0.85)  LDD2117  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C20(2.44)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C1062(1.09); C1072(0.72); C1074(0.72); C20(0.80)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C1062(1.01); C1072(0.88); C1074(0.88); C20(0.90)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C1062(0.97); C1072(0.52); C1074(0.52); C20(0.86)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C1062(1.04); C1072(0.57); C1074(0.57); C20(0.90)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C1062(1.02); C1072(0.59); C1074(0.59); C20(0.95)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C1062(0.97); C1072(0.48); C1074(0.48); C20(1.38)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C1062(0.94); C1072(0.74); C1074(0.74); C20(1.08)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C1062(1.17); C1072(0.49); C1074(0.49); C20(1.28)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C1062(0.95); C1072(0.52); C1074(0.52); C20(1.14)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C1062(1.02); C1072(0.74); C1074(0.38); C20(1.19)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C1062(1.13); C1072(0.47); C1074(0.70); C20(0.80)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C1062(0.94); C1072(0.57); C1074(1.00); C20(0.68)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C1062(0.91); C1072(0.71); C1074(0.71); C20(1.39)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C1062(1.02); C1072(0.54); C1074(0.84); C20(0.87)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C1062(0.95); C1072(0.54); C1074(0.65); C20(1.05)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C1062(0.83); C1072(0.55); C1074(0.50); C20(1.05)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C1062(1.01); C20(0.74); C27(0.74); C618(0.99)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C1062(0.98); C20(1.05); C27(1.06); C618(0.96)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C1062(1.00); C20(0.86); C27(0.94); C618(1.08)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C1062(1.72); C20(0.94); C27(1.06); C618(1.09)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C1062(1.04); C20(1.01); C27(1.00); C618(0.96)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C1062(1.06); C20(0.86); C27(1.09); C618(1.04)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C1062(1.18); C20(0.79); C27(0.84); C618(1.01)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C1062(0.97); C1072(1.00); C1074(1.00); C20(1.17)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C1062(1.11); C20(0.69); C27(0.99); C618(1.04)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C1062(1.14); C20(1.11); C27(0.86); C618(0.92)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C1062(1.03); C20(0.55); C27(0.70); C618(1.02)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C1062(1.29); C20(0.49); C27(0.66); C618(0.87)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C1062(1.03); C20(0.71); C27(0.69); C618(1.01)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C1062(1.43); C20(0.52); C27(0.88); C618(1.10)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C1062(1.10); C20(0.68); C27(0.84); C618(1.01)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C1062(1.05); C20(0.71); C27(0.71); C618(0.98)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C1028(1.06); C1062(1.25); C20(1.08); C27(1.08)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C1028(1.10); C1062(1.45); C20(0.86); C27(0.86)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C1028(1.07); C1062(1.37); C20(0.98); C27(0.98)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C1028(1.40); C1062(1.38); C20(0.99); C27(0.99)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C1028(1.24); C1062(1.09); C20(0.80); C27(0.80)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C1028(1.17); C1062(1.23); C20(0.88); C27(0.88)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C1028(1.17); C1062(1.00); C20(1.15); C27(1.15)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C1028(1.29); C1062(1.13); C20(0.88); C27(0.88)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C1028(1.11); C1062(1.09); C20(0.92); C27(0.92)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C1028(1.11); C1062(1.01); C20(0.76); C27(0.76)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C1028(1.13); C1062(0.74); C20(0.91); C27(0.91)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C1028(1.30); C1062(0.76); C20(0.88); C27(0.88)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C1062(0.98); C1072(0.68); C1074(0.68); C20(1.27)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C1028(1.26); C1062(0.83); C20(0.89); C27(0.89)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C1028(1.20); C1062(0.89); C20(0.86); C27(0.86)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C1028(1.15); C1062(0.85); C20(0.76); C27(0.76)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C1028(0.85); C618(0.89); C865(1.00)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C1028(0.72); C865(0.99); C618(1.21)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C1028(0.80); C865(1.00); C618(1.52)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C1028(0.78); C618(0.90); C865(0.95)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C1028(0.91); C865(1.02); C618(1.15)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C1028(0.67); C865(0.81); C618(1.42)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C1028(0.76); C865(0.97); C618(1.00)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C1072(0.81); C1074(0.81); C618(0.88); C20(0.94)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C618(0.78); C865(0.84); C1028(1.09)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C618(0.87); C1028(0.94); C865(0.99)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C1028(0.74); C618(0.77); C865(0.88)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C1028(0.69); C865(0.97); C618(1.43)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C1028(0.75); C618(1.04); C865(0.98)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C1028(0.75); C618(1.02); C865(0.93)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C1028(0.82); C618(0.86); C865(0.82)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C1028(0.80); C618(1.22); C865(1.05)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C20(0.29); C27(0.29); C865(0.96); C618(1.09)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C20(0.46); C27(0.46); C1072(0.62); C1074(0.62)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C20(0.33); C27(0.33); C1072(0.97); C1074(0.97)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C1072(0.70); C1074(0.70); C1062(0.87); C865(0.96)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C20(0.27); C27(0.27); C1062(0.89); C618(0.94)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C20(0.31); C27(0.31); C1062(0.92); C618(0.97)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C20(0.30); C27(0.30); C618(0.98); C1062(0.99)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C20(0.30); C27(0.30); C1072(0.78); C1074(0.78)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C20(0.19); C27(0.19); C1072(0.89); C1074(0.89)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C1062(1.01); C865(1.15)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C1062(1.01); C865(1.18)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C865(0.99); C1062(1.08)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C1062(0.94); C865(0.95)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C1062(0.92); C865(1.20)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C20(0.96); C27(0.96); C1072(1.00); C1074(1.00)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C1062(0.97); C865(1.15)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C1062(0.89); C865(1.19)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C1062(0.87); C865(1.30)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C1062(1.02); C865(1.18)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C1062(1.09); C865(1.29)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C1072(1.17); C1074(1.17); C1062(1.20); C865(1.41)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C1072(0.97); C1074(0.97); C1062(1.20); C865(1.26)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C1072(0.83); C1074(0.83); C1062(1.02); C618(1.13)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C1062(1.02); C618(1.07); C865(1.09); C1072(1.25)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C1072(0.76); C1074(0.76); C618(0.97); C1062(1.09)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C20(0.77); C27(0.77); C1072(1.03); C1074(1.03)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C618(0.83); C1072(0.83); C1074(0.83); C1062(0.94)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C1072(0.81); C1074(0.81); C865(0.99); C1062(1.01)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C1072(0.85); C1074(0.85); C1062(0.99); C618(1.11)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C1072(0.75); C1074(0.75); C1062(0.91); C618(1.05)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C1072(0.84); C1074(0.84); C618(1.02); C865(1.04)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C618(0.84); C1072(0.87); C1074(0.87); C865(0.96)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C1028(0.85); C865(0.96); C1062(1.08)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C1028(0.79); C865(0.99); C1062(1.20)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C1028(0.62); C1062(0.98); C865(1.04)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C1028(0.75); C865(1.04); C1062(1.18)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C1072(0.80); C1074(0.80); C20(0.81); C27(0.81)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C1028(0.76); C865(1.01); C1062(1.03)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C1028(0.64); C865(0.77); C1062(1.09)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C1028(0.79); C865(0.90); C1062(1.17)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C1028(0.90); C865(0.92); C1062(1.05)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C1028(0.81); C865(0.90); C1062(1.12)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C1028(0.83); C865(0.92); C1062(0.94)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C1028(0.76); C1062(0.85); C865(1.08)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C865(1.01); C1062(1.01); C20(1.52); C27(1.52)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C865(0.63); C1062(1.11); C20(1.44); C27(1.44)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C1062(1.21); C865(1.48); C20(1.50); C27(1.50)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C1072(0.91); C1074(0.91); C1062(0.98); C618(1.00)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C1062(1.00); C865(1.36); C20(1.36); C27(1.36)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C865(0.86); C1062(0.87); C20(1.29); C27(1.29)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C1062(1.15); C865(1.18); C20(1.67); C27(1.67)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C1062(1.07); C865(1.14); C20(1.26); C27(1.26)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C1062(1.17); C865(1.21); C20(1.51); C27(1.51)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C20(0.44); C27(0.44); C865(1.30); C1062(1.38)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C20(0.48); C27(0.48); C1062(1.27); C865(1.48)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C20(0.55); C27(0.55); C865(1.04); C1062(1.09)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C20(0.75); C27(0.75); C1028(0.75); C1062(0.92)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C1062(0.81); C618(0.82); C1028(0.93); C20(1.00)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C618(0.86); C1072(0.92); C1074(0.92); C20(0.97)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C20(0.77); C27(0.77); C1028(0.82); C618(0.91)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C20(0.58); C27(0.58); C1062(0.92); C618(1.03)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C1028(0.91); C1062(0.96); C618(0.97); C865(1.34)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C1028(0.89); C1062(0.98); C618(0.99); C865(1.18)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C1062(1.00); C618(1.02); C865(1.06); C1028(1.21)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C1028(0.78); C618(0.94); C1062(1.09); C865(1.12)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C618(0.85); C1028(1.06); C20(1.07); C27(1.07)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C618(0.77); C1028(0.78); C1062(0.97); C20(1.27)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C618(0.91); C1028(0.96); C1062(0.99); C20(1.08)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C20(0.72); C27(0.72); C1028(0.78); C618(1.08)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C1072(0.76); C1074(0.76); C1062(0.88); C618(0.90)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C618(1.01); C1062(1.07); C1028(1.18); C865(1.21)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C1028(0.83); C1062(0.83); C20(0.89); C27(0.89)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C1062(0.84); C618(0.94); C865(1.05); C1028(1.12)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C1072(0.60); C1074(0.60); C865(0.80); C1028(1.05)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C1072(0.68); C1074(0.68); C865(0.88); C618(0.96)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C1072(0.55); C1074(0.55); C618(1.07); C1028(1.10)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C1072(0.76); C1074(0.76); C865(0.78); C1028(1.18)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C865(0.84); C618(1.11); C1072(1.11); C1074(1.11)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C865(0.77); C1072(0.94); C1074(0.94); C1028(1.09)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C865(0.90); C618(1.10); C1028(1.15); C1072(1.26)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C865(0.84); C20(0.97); C618(1.10); C1072(1.12)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C1072(0.91); C1074(0.91); C618(1.01); C1028(1.09)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C1072(0.92); C1074(0.92); C865(0.99); C618(1.11)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C1072(1.01); C1074(1.01); C618(1.03); C865(1.08)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C1072(0.92); C1074(0.92); C1028(1.06); C865(1.19)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C865(1.03); C1072(1.04); C1074(1.04); C618(1.14)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C1072(0.94); C1074(0.94); C865(0.96); C1028(1.03)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C618(1.10); C1072(1.14); C1074(1.14); C865(1.19)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C1072(0.41); C1074(0.41); C1062(0.96); C865(1.03)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C1072(0.70); C1074(0.70); C20(0.76); C27(0.76)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C1062(1.22); C1072(0.84); C1074(0.84); C20(1.16)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C1072(0.80); C1074(0.80); C618(0.91); C1062(0.96)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C1072(0.70); C1074(0.70); C1062(0.91); C20(0.97)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.60  LDD0403  [3]
 LDCM0020  ARS-1620 HCC44 C20(1.08); C27(1.08)  LDD0078  [8]
 LDCM0108  Chloroacetamide HeLa C1062(0.00); C20(0.00); C618(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C1062(0.88); C865(0.93); C618(0.97); C20(1.32)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C1062(0.70); C865(1.02); C618(1.12); C20(1.30)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C1072(0.68); C1074(0.68); C865(0.92); C20(0.98)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C1072(0.78); C1074(0.78); C618(0.97); C1062(1.02)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C618(0.93); C1072(0.95); C1074(0.95); C20(1.07)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C20(0.92); C27(0.92); C1062(0.92); C1072(1.05)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C1062(0.91); C618(0.98); C1072(1.08); C1074(1.08)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C20(0.30); C27(0.30); C1072(0.64); C1074(0.64)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C20(0.26); C27(0.26); C1072(0.48); C1074(0.48)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C20(0.31); C27(0.31); C1072(0.59); C1074(0.59)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C20(0.20); C27(0.20); C1072(0.71); C1074(0.71)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C20(0.40); C27(0.40); C618(0.88); C1062(0.98)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C1062(0.73); C618(1.01); C865(1.16); C20(1.26)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C20(0.22); C27(0.22); C1072(0.79); C1074(0.79)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C20(0.30); C27(0.30); C1072(0.86); C1074(0.86)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C865(0.94); C1062(0.95)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C1062(0.95); C865(1.16)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C1062(0.95); C865(1.21)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C1062(0.92); C865(1.20)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C1062(0.97); C865(1.14)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C1072(0.77); C1074(0.77); C618(0.78); C1062(0.92)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C1072(0.84); C1074(0.84); C618(0.92); C1062(0.97)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C618(0.87); C1072(1.04); C1074(1.04); C1062(1.07)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C1062(1.05); C618(1.22); C865(1.33); C20(1.42)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C1072(0.81); C1074(0.81); C1062(0.97); C618(1.04)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C865(0.68); C1028(0.69); C1062(1.07)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C1028(0.89); C1062(1.00); C865(1.04)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C1028(0.75); C865(0.82); C1062(1.01)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C1028(0.85); C1062(1.00); C865(1.14)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C865(0.66); C20(1.05); C27(1.05); C1062(1.09)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C865(0.73); C1062(1.06); C20(1.39); C27(1.39)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C865(0.87); C1062(0.93); C20(1.16); C27(1.16)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C1062(1.22); C20(1.24); C27(1.24); C865(1.75)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C20(0.91); C27(0.91); C1062(0.96); C618(1.02)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C1062(0.86); C618(0.96); C865(1.13); C20(1.20)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C618(0.91); C20(1.01); C27(1.01); C865(1.02)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C865(0.71); C1062(0.79); C618(0.91); C20(1.03)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C20(0.73); C27(0.73); C1062(0.81); C865(0.95)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C865(0.86); C1062(0.88); C618(0.95); C20(1.12)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C1062(0.79); C865(0.84); C20(0.92); C27(0.92)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C865(0.66); C1062(0.82); C618(1.00); C20(1.38)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C1062(0.73); C20(1.02); C27(1.02); C618(1.05)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C865(0.81); C20(0.85); C27(0.85); C1062(0.87)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C1062(0.74); C20(0.75); C27(0.75); C865(0.86)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C1062(0.84); C865(0.88); C618(1.02); C20(1.13)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C865(0.86); C1062(0.92); C618(0.93); C20(1.05)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C1062(0.92); C20(0.98); C27(0.98); C618(0.93)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C1062(0.89); C20(1.11); C27(1.11); C618(0.92)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C1062(1.05); C20(0.90); C27(0.90); C618(1.03)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C1062(0.67); C20(0.93); C27(0.93); C618(0.99)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C1062(0.88); C20(1.22); C27(1.22); C618(0.96)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C1062(0.63); C20(1.60); C27(1.60); C618(0.95)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C1062(0.99); C20(1.18); C27(1.18); C618(1.28)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C1062(0.93); C618(0.92); C865(0.97)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C1062(0.66); C20(1.16); C27(1.16); C618(0.91)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C1062(0.68); C20(0.96); C27(0.96); C618(0.88)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C1062(0.80); C20(1.02); C27(1.02); C618(1.05)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C1062(0.96); C20(1.23); C27(1.23); C618(0.99)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C1062(0.80); C20(0.77); C27(0.77); C618(0.96)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C1062(0.70); C20(1.00); C27(1.00); C618(1.02)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C1062(0.98); C20(1.13); C27(1.13); C618(0.95)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C1062(0.82); C20(1.44); C27(1.44); C618(0.98)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C1062(0.82); C20(0.76); C27(0.76); C618(0.93)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C1062(0.95); C20(1.13); C27(1.13); C618(0.92)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C1062(0.79); C20(0.78); C27(0.78); C618(1.02)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C1062(0.76); C20(0.96); C27(0.96); C618(0.96)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C1062(0.80); C20(0.82); C27(0.82); C618(1.00)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C1062(0.81); C20(0.90); C27(0.90); C618(1.05)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C1062(1.25); C20(0.74); C27(0.74); C618(1.14)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C1062(1.15); C20(0.74); C27(0.74); C618(1.02)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C1062(1.23); C20(0.73); C27(0.73); C618(1.01)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C1062(1.31); C20(0.85); C27(0.85); C618(1.22)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C1062(1.45); C20(1.37); C27(1.37); C618(1.01)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C1062(1.12); C20(0.86); C27(0.86); C618(1.01)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C1062(1.54); C20(0.82); C27(0.82); C618(1.04)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C1062(0.99); C20(1.49); C27(1.49); C618(1.11)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C1062(1.51); C20(0.84); C27(0.84); C618(0.94)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C1062(2.26); C20(1.01); C27(1.01); C618(0.98)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C1062(1.32); C20(0.78); C27(0.78); C618(1.07)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C1062(0.97); C20(0.82); C27(0.82); C618(0.96)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C1062(1.08); C20(0.66); C27(0.66); C618(1.05)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C1062(0.82); C20(0.74); C27(0.74); C618(1.01)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C1062(1.21); C20(0.98); C27(0.98); C618(1.05)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C1062(0.87); C20(1.83); C27(1.83); C618(0.87)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C1062(0.95); C20(1.06); C27(1.06); C618(1.03)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C1062(1.03); C618(1.01); C865(0.99)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C1062(0.97); C618(0.92); C865(0.82)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C1062(0.92); C618(1.03); C865(1.07)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C1062(0.94); C618(1.06); C865(1.05)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C1062(0.94); C618(1.09); C865(1.09)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C1062(0.95); C618(1.08); C865(1.16)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C1062(0.98); C618(1.13); C865(0.99)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C1062(0.86); C618(1.08); C865(0.95)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C1062(0.81); C618(1.20); C865(0.92)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C1062(0.96); C20(0.98); C27(0.98); C618(1.19)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C1062(0.87); C618(1.15); C865(1.32)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C1062(0.84); C618(1.11); C865(1.00)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C1062(0.87); C618(1.01); C865(1.04)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C1062(1.05); C618(1.05); C865(1.08)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C1062(0.94); C618(1.08); C865(1.16)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C1072(1.08); C1074(1.08); C618(0.81); C865(1.73)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C1072(1.44); C1074(1.44); C618(0.72); C865(1.56)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C1072(0.90); C1074(0.90); C618(0.81); C865(1.12)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C1072(1.40); C1074(1.40); C618(0.95); C865(2.17)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C1062(1.38); C20(1.12); C27(1.12); C618(0.70)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C1072(1.45); C1074(1.45); C618(0.78); C865(1.37)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C1072(1.48); C1074(1.48); C618(0.88); C865(1.34)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C1072(1.16); C1074(1.16); C618(0.90); C865(1.75)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C1072(1.41); C1074(1.41); C618(0.81); C865(1.54)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C1072(1.38); C1074(1.38); C618(0.83); C865(1.98)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C1072(1.12); C1074(1.12); C618(0.75); C865(1.34)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C1072(1.08); C1074(1.08); C618(0.78); C865(1.70)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C1072(1.20); C1074(1.20); C618(0.86); C865(1.59)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C1072(1.29); C1074(1.29); C618(0.92); C865(1.78)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C1072(1.07); C1074(1.07); C618(0.84); C865(1.88)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C1062(0.93); C20(1.21); C27(1.21); C618(1.03)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C1072(0.74); C1074(0.74); C618(0.69); C865(1.38)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C1062(1.25); C1072(0.90); C1074(0.90); C20(0.71)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C1062(1.19); C1072(0.86); C1074(0.86); C20(0.67)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C1062(1.06); C1072(0.95); C1074(0.95); C20(0.59)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C1062(1.04); C1072(0.69); C1074(0.69); C20(0.91)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C1062(1.32); C1072(0.67); C1074(0.67); C20(0.90)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C1062(1.23); C1072(0.90); C1074(0.90); C20(0.86)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C1062(0.91); C1072(1.09); C1074(1.09); C20(0.94)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C1062(0.85); C1072(0.77); C1074(0.77); C20(0.95)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C1062(1.12); C1072(1.10); C1074(1.10); C20(0.69)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C865(1.04); C1062(1.07); C618(1.09); C582(0.86)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C865(2.13)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C1062(0.90); C618(1.28); C865(0.98)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C1062(0.75); C20(0.88); C27(0.88); C618(0.95)  LDD0744  [8]
 LDCM0116  HHS-0101 DM93 Y145(0.59); Y261(3.86)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y145(0.34); Y261(4.13)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y145(0.30); Y261(1.57)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y145(0.59); Y261(3.59)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y145(0.42); Y261(5.97)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C865(2.38); C20(4.39); C27(4.39); C618(1.87)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C865(3.15); C20(2.41); C27(2.41); C618(2.77)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C865(2.99); C20(2.68); C27(2.68); C618(2.06)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0224  [15]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C582(0.64)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C582(0.33)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C582(0.52)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C865(1.40)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C582(0.67)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C582(0.62)  LDD2108  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C582(0.34)  LDD2115  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C865(0.57)  LDD2123  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C582(0.90)  LDD2127  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C582(0.57)  LDD2141  [4]
 LDCM0021  THZ1 HCT 116 C20(1.06); C27(1.06)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16) DEAD box helicase family O60231
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
NudC domain-containing protein 1 (NUDCD1) . Q96RS6
RNA-binding protein 10 (RBM10) . P98175

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402