Details of the Target

General Information of Target

Target ID LDTP09609
Target Name NudC domain-containing protein 2 (NUDCD2)
Gene Name NUDCD2
Gene ID 134492
Synonyms
NudC domain-containing protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSAPFEERSGVVPCGTPWGQWYQTLEEVFIEVQVPPGTRAQDIQCGLQSRHVALSVGGRE
ILKGKLFDSTIADEGTWTLEDRKMVRIVLTKTKRDAANCWTSLLESEYAADPWVQDQMQR
KLTLERFQKENPGFDFSGAEISGNYTKGGPDFSNLEK
Target Bioclass
Other
Subcellular location
Chromosome, centromere, kinetochore
Function May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.
Uniprot ID
Q8WVJ2
Ensemble ID
ENST00000302764.9
HGNC ID
HGNC:30535

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y145(60.75)  LDD3495  [2]
BTD
 Probe Info  		C45(0.73)  LDD2099  [3]
HHS-475
 Probe Info  		Y145(5.16)  LDD0264  [4]
DBIA
 Probe Info  		C99(1.12)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C45(0.00); C99(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C45(0.00); C99(0.00); C14(0.00)  LDD0036  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C45(0.00); C99(0.00); C14(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		C14(0.00); C99(0.00)  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
PPMS
 Probe Info  		N.A.  LDD0008  [10]
1c-yne
 Probe Info  		K129(0.00); K147(0.00)  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		12.10  LDD0443  [15]
NAIA_5
 Probe Info  		C45(0.00); C14(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		Y145(0.00); K147(0.00)  LDD2240  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C45(0.66)  LDD2117  [3]
 LDCM0214  AC1 HCT 116 C45(0.86); C99(1.12)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C45(0.98); C99(1.68)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C45(0.50); C99(0.70)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C45(0.63); C99(0.83)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C45(0.55); C99(0.68)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C45(0.50); C99(0.88)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C45(0.36); C99(0.96)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C45(0.50); C99(0.77)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C45(0.46); C99(0.88)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C45(0.55); C99(1.01)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C45(0.71); C99(0.73)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C45(0.37); C99(0.86)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C45(1.03); C99(1.52)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C45(0.46); C99(0.84)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C45(0.63); C99(0.80)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C45(0.46); C99(0.70)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C45(0.93)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C45(0.91)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C45(0.87)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C45(1.00)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C45(1.02)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C45(1.14)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C45(0.91)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C45(0.95); C99(1.54)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C45(1.16)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C45(0.99)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C45(0.84)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C45(0.81)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C45(0.97)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C45(1.01)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C45(1.07)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C45(0.98)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C45(0.91)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C45(1.32)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C45(0.90)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C45(1.01)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C45(0.72)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C45(0.82)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C45(0.55)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C45(0.59)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C45(0.53)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C45(0.54)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C45(0.62)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C45(0.63)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C45(0.97); C99(1.97)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C45(0.66)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C45(0.65)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C45(0.57)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C45(0.76)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C45(0.87)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C45(0.82)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C45(0.71)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C45(0.87)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C45(0.76)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C45(0.65)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C45(1.09); C99(1.81)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C45(0.82)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C45(0.73)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C45(0.66)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C45(0.47)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C45(0.71)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C45(0.81)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C45(1.31)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C45(0.59)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C99(1.06); C45(1.08)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C45(0.83); C99(1.95)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C45(0.93); C99(0.94)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C45(0.97); C99(1.18)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C99(0.93); C45(0.96)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C45(0.89); C99(1.11)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C99(0.89); C45(1.07)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C45(0.94); C99(1.12)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C45(0.98); C99(1.31)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C45(0.98)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C45(0.76)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C45(0.69)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C45(0.80)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C45(0.58)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C99(1.15); C45(1.18)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C45(0.71)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C45(0.59)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C45(0.73)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C45(0.69)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C45(0.70)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C99(0.87); C45(1.29)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C99(0.66); C45(0.96)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C99(1.02); C45(1.17)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C99(0.93); C45(1.07)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C99(1.07); C45(1.11)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C45(1.12); C99(1.41)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C45(0.97); C99(1.26)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C45(1.06); C99(1.21)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C99(1.00); C45(1.14)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C45(0.99); C99(1.08)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C45(1.07); C99(1.11)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C45(1.01); C99(1.34)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C45(1.25)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C45(1.10)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C45(0.81)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C45(0.82)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C45(1.06); C99(1.47)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C45(0.87)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C45(1.66)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C45(1.62)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C45(0.88)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C45(1.50)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C45(0.95)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C45(0.62)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C45(0.97); C99(1.40)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C45(0.82); C99(1.63)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C45(0.75); C99(2.06)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C45(0.81); C99(2.08)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C45(0.63); C99(3.30)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C45(0.67); C99(1.13)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C45(0.79); C99(1.46)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C45(0.76); C99(1.68)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C45(0.64); C99(2.12)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C45(0.78); C99(2.04)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C45(0.76); C99(1.99)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C45(0.52); C99(2.09)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C45(1.15); C99(1.60)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C45(1.11); C99(2.11)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C45(0.87); C99(1.40)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C45(0.96); C99(1.41)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C99(1.34); C45(1.35)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C45(1.45); C99(1.65)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C45(0.75); C99(1.64)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C45(0.93); C99(2.00)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C45(0.75); C99(1.78)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C45(1.00); C99(1.23)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C45(0.88); C99(1.61)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C45(0.93); C99(1.17)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C99(1.32); C45(1.33)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C45(0.90); C99(1.39)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C45(1.15); C99(1.33)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C99(0.97); C45(1.27)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C45(0.81); C99(2.04)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C45(0.69); C99(1.71)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C45(0.70); C99(1.39)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C45(0.76); C99(1.17)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C45(1.22); C99(1.61)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C99(1.06); C45(1.27)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C45(1.08); C99(1.22)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C45(0.93); C99(1.13)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C45(1.61); C99(2.17)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C45(0.85); C99(1.20)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C45(0.88); C99(1.25)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C45(0.93); C99(0.93)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C99(0.87); C45(1.01)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C45(0.67); C99(0.93)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C45(0.74); C99(1.03)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C45(0.92); C99(1.14)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C45(0.15); C99(1.25)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C45(0.66); C99(0.67)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C45(0.90); C99(1.38)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C45(0.94); C99(1.59)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C45(0.90); C99(1.95)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C99(1.12)  LDD0078  [5]
 LDCM0630  CCW28-3 231MFP C14(1.53); C99(1.11)  LDD2214  [17]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C99(0.71); C45(0.74)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C45(0.91); C99(1.01)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C45(1.02); C99(1.04)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C45(1.12); C99(2.54)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C45(0.82); C99(1.24)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C45(1.14); C99(1.23)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C45(0.96); C99(1.31)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C45(0.94); C99(1.18)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C45(0.70); C99(1.47)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C45(1.04); C99(1.26)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C45(0.96); C99(1.42)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C45(0.87); C99(1.03)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C45(0.88); C99(1.12)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C45(0.79); C99(0.98)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C45(0.92); C99(1.07)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C45(0.87)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C45(0.68)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C45(0.61)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C45(0.70)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C45(0.64)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C45(0.97); C99(1.40)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C45(1.11); C99(1.26)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C45(0.92); C99(0.98)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C45(0.91); C99(1.26)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C99(0.83); C45(1.09)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C45(0.74)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C45(0.93)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C45(1.07)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C45(1.00)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C99(1.05); C45(1.06)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C45(1.13); C99(1.24)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C45(0.82); C99(1.17)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C45(0.95); C99(1.12)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C45(0.99); C99(1.13)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C99(0.78); C45(0.97)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C45(0.82); C99(1.26)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C45(0.94)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C45(0.92)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C45(1.01)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C45(1.01)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C45(0.64); C99(0.75)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C45(0.78)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C45(0.70)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C45(0.74)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C45(0.92)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C45(0.98)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C45(1.03)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C45(0.69)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C45(0.82)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C45(0.73)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C45(0.81)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C45(1.03); C99(0.98)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C45(0.71)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C45(0.94)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C45(0.59)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C45(0.62)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C45(0.68)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C45(0.93)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C45(0.63)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C45(0.76)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C45(0.88)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C45(0.65); C99(0.94)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C45(0.67)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C45(0.78)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C45(0.66)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C45(0.71)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C45(0.67)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C45(0.76)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C45(1.12); C99(0.73)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C45(1.26); C99(0.71)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C45(1.33); C99(0.64)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C45(1.42); C99(0.69)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C45(0.86); C99(0.99)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C45(1.05); C99(0.69)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C45(1.09); C99(0.87)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C45(1.13); C99(1.31)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C45(0.88); C99(0.72)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C45(0.96); C99(0.71)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C45(1.47); C99(0.85)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C45(1.21); C99(0.89)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C45(1.10); C99(0.72)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C45(1.40); C99(0.90)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C45(1.38); C99(1.11)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C45(0.76); C99(0.89)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C45(1.25); C99(0.92)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C45(0.82); C99(1.31)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C45(0.93); C99(1.04)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C45(0.64); C99(1.10)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C45(1.00); C99(1.17)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C45(0.85); C99(1.25)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C45(0.88); C99(1.77)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C45(0.93); C99(1.26)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C45(0.58); C99(1.27)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C45(0.51); C99(1.32)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C45(0.89); C99(1.20)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C45(0.77); C99(1.13)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C45(0.78); C99(1.23)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C45(0.84); C99(1.11)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C45(0.66); C99(1.30)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C45(0.74); C99(1.23)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C45(0.69); C99(1.76)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C45(0.72); C99(1.14)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C45(0.92); C99(1.48)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C45(0.80); C99(1.44)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C45(0.77); C99(1.55)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C45(0.87); C99(1.36)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C45(0.98); C99(1.43)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C45(0.84); C99(1.68)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C45(0.87); C99(1.92)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C45(0.82); C99(2.41)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C45(0.83); C99(1.40)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C45(0.83); C99(1.38)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C45(0.83); C99(1.50)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C45(0.91); C99(1.50)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C45(0.89); C99(2.39)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C45(0.85); C99(0.85)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C45(0.77); C99(1.20)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C45(1.06); C99(1.28)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C45(1.08); C99(0.92)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C45(1.09); C99(1.14)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C45(0.98); C99(1.09)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C45(1.12); C99(1.54)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C45(1.03); C99(0.94)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C45(0.84); C99(0.93)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C45(1.12); C99(1.30)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C45(1.11); C99(1.32)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C45(0.88); C99(1.03); C14(1.03)  LDD1698  [18]
 LDCM0625  F8 Ramos C45(0.78)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C45(0.64); C99(0.42)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C45(0.20)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C45(0.50); C99(0.43)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C45(0.95); C99(0.86)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C45(1.01)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C45(0.40); C99(0.48)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C45(1.04); C99(0.47)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C45(0.80); C99(0.45)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C45(1.04)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C45(0.62); C99(0.21)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C45(1.24); C99(0.71)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C45(1.24); C99(0.73)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C45(0.50)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C45(0.93); C99(0.81)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C45(1.03); C99(0.25)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C45(0.63)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C45(0.71)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C45(1.62)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C45(1.35); C99(0.40)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C45(0.51)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C45(0.49)  LDD2188  [19]
 LDCM0116  HHS-0101 DM93 Y145(5.16)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y145(3.10)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y145(2.42)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y145(3.54)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y145(3.04)  LDD0268  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 HCT 116 C99(1.05)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C99(1.03)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C99(1.28)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C45(0.73)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C45(1.13)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C45(0.80)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C45(0.49)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C45(0.73)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C45(0.77)  LDD2115  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C45(0.59)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C45(0.50)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C45(0.91)  LDD2127  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C45(1.04)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C45(0.88)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C45(0.57)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C45(0.69)  LDD2146  [3]
 LDCM0131  RA190 MM1.R C99(1.14); C45(1.02)  LDD0304  [20]
 LDCM0021  THZ1 HCT 116 C99(1.24)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Serine/threonine-protein kinase Nek8 (NEK8) NEK Ser/Thr protein kinase family Q86SG6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) WD repeat LIS1/nudF family P43034
F-box only protein 24 (FBXO24) . O75426

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.